Malaria is a mosquito-borne infectious disease that affects humans and other vertebrates. Human malaria causes symptoms that typically include fever, fatigue, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. Symptoms usually begin 10 to 15 days after being bitten by an infected Anopheles mosquito. If not properly treated, people may have recurrences of the disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial resistance disappears over months to years if the person has no continuing exposure to malaria.
Orangutans are great apes native to the rainforests of Indonesia and Malaysia. They are now found only in parts of Borneo and Sumatra, but during the Pleistocene they ranged throughout Southeast Asia and South China. Classified in the genus Pongo, orangutans were originally considered to be one species. From 1996, they were divided into two species: the Bornean orangutan and the Sumatran orangutan. A third species, the Tapanuli orangutan, was identified definitively in 2017. The orangutans are the only surviving species of the subfamily Ponginae, which diverged genetically from the other hominids between 19.3 and 15.7 million years ago.
Plasmodium is a genus of unicellular eukaryotes that are obligate parasites of vertebrates and insects. The life cycles of Plasmodium species involve development in a blood-feeding insect host which then injects parasites into a vertebrate host during a blood meal. Parasites grow within a vertebrate body tissue before entering the bloodstream to infect red blood cells. The ensuing destruction of host red blood cells can result in malaria. During this infection, some parasites are picked up by a blood-feeding insect, continuing the life cycle.
Anopheles is a genus of mosquito first described by J. W. Meigen in 1818. Its members are sometimes called nail mosquitoes or marsh mosquitoes. Many are vectors of the Plasmodium parasite of malaria in birds, reptiles, and mammals including humans. Anopheles gambiae is among the best known, as it transmits one of the most dangerous human malaria parasites, Plasmodium falciparum. No other mosquito genus is a vector of human malaria.
The Plasmodiidae are a family of apicomplexan parasites, including the type genus Plasmodium, which is responsible for malaria. This family was erected in 1903 by Mesnil and is one of the four families in the order Haemospororida.
Plasmodium malariae is a parasitic protozoan that causes malaria in humans. It is one of several species of Plasmodium parasites that infect other organisms as pathogens, also including Plasmodium falciparum and Plasmodium vivax, responsible for most malarial infection. Found worldwide, it causes a so-called "benign malaria", not nearly as dangerous as that produced by P. falciparum or P. vivax. The signs include fevers that recur at approximately three-day intervals – a quartan fever or quartan malaria – longer than the two-day (tertian) intervals of the other malarial parasite.
Plasmodium knowlesi is a parasite that causes malaria in humans and other primates. It is found throughout Southeast Asia, and is the most common cause of human malaria in Malaysia. Like other Plasmodium species, P. knowlesi has a life cycle that requires infection of both a mosquito and a warm-blooded host. While the natural warm-blooded hosts of P. knowlesi are likely various Old World monkeys, humans can be infected by P. knowlesi if they are fed upon by infected mosquitoes. P. knowlesi is a eukaryote in the phylum Apicomplexa, genus Plasmodium, and subgenus Plasmodium. It is most closely related to the human parasite Plasmodium vivax as well as other Plasmodium species that infect non-human primates.
The Sumatran orangutan is one of the three species of orangutans. Critically endangered, and found only in the north of the Indonesian island of Sumatra, it is rarer than the Bornean orangutan but more common than the recently identified Tapanuli orangutan, also found in Sumatra. Its common name is based on two separate local words, "orang" and "hutan" ("forest"), derived from Malay, and translates as 'person of the forest'.
Plasmodium berghei is a single-celled parasite causing rodent malaria. It is in the Plasmodium subgenus Vinckeia.
The Bornean orangutan is a species of orangutan endemic to the island of Borneo. Together with the Sumatran orangutan and Tapanuli orangutan, it belongs to the only genus of great apes native to Asia. It is the largest of the three species of orangutans. Like the other great apes, orangutans are highly intelligent, displaying tool use and distinct cultural patterns in the wild. Orangutans share approximately 97% of their DNA with humans. Also called mias by the local population, the Bornean orangutan is a critically endangered species, with deforestation, palm oil plantations, and hunting posing a serious threat to its continued existence.
Plasmodium yoelii is a parasite of the genus Plasmodium subgenus Vinckeia. As in all Plasmodium species, P. yoelii has both vertebrate and insect hosts. The vertebrate hosts for this parasite are mammals.
Vinckeia is a subgenus of the genus Plasmodium — all of which are parasitic alveolates. The subgenus Vinckeia was created by Cyril Garnham in 1964 to accommodate the mammalian parasites other than those infecting the primates.
Plasmodium basilisci is a parasite of the genus Plasmodium subgenus Carinamoeba.
Avian malaria is a parasitic disease of birds, caused by parasite species belonging to the genera Plasmodium and Hemoproteus. The disease is transmitted by a dipteran vector including mosquitoes in the case of Plasmodium parasites and biting midges for Hemoproteus. The range of symptoms and effects of the parasite on its bird hosts is very wide, from asymptomatic cases to drastic population declines due to the disease, as is the case of the Hawaiian honeycreepers. The diversity of parasites is large, as it is estimated that there are approximately as many parasites as there are species of hosts. As research on human malaria parasites became difficult, Dr. Ross studied avian malaria parasites. Co-speciation and host switching events have contributed to the broad range of hosts that these parasites can infect, causing avian malaria to be a widespread global disease, found everywhere except Antarctica.
Plasmodium vaughani is a parasite of the genus Plasmodium, and the type species of the subgenus Novyella. As in all Plasmodium species, P. vaughani has both vertebrate and insect hosts. The vertebrate hosts for this parasite are birds.
Hepatocystis is a genus of parasites transmitted by midges of the genus Culicoides. Hosts include Old World primates, bats, hippopotamus and squirrels. This genus is not found in the New World. The genus was erected by Levaditi and Schoen, 1932, as Hepatocystes.
Percy Cyril Claude Garnham CMG FRS, was a British biologist and parasitologist. On his 90th birthday, he was called the "greatest living parasitologist".
Thioester containing protein 1, often called TEP1 is a key component of the arthropod innate immune system. TEP1 was first identified as a key immunity gene in 2001 through functional studies on Anopheles gambiae mosquitoes.
