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Names | |
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IUPAC name 17-Oxo-5α-androstan-3α-yl β-D-glucopyranosiduronic acid | |
Systematic IUPAC name (2S,3S,4S,5R,6R)-6-{[(3aS,3bR,5aS,7R,9aS,9bS,11aS)-9a,11a-Dimethyl-1-oxohexadecahydro-1H-cyclopenta[a]pheananthren-7-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid | |
Other names ADT-G; 5α-Androstan-3α-ol-17-one 3-glucuronide | |
Identifiers | |
3D model (JSmol) | |
ChEBI | |
ChemSpider | |
KEGG | |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C25H38O8 | |
Molar mass | 466.571 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Androsterone glucuronide (ADT-G) is a major circulating and urinary metabolite of testosterone and dihydrotestosterone (DHT). [1] It accounts for 93% of total androgen glucuronides in women. [1] ADT-G is formed from androsterone by UDP-glucuronosyltransferases, with the major enzymes being UGT2B15 and UGT2B17. [1] It is a marker of acne in women while androstanediol glucuronide is a marker of hirsutism (excess hair growth) in women. [2]
Quantification of ADT-G and 3α-diol-G levels in Serum (blood) is an effective means of assessing androgen content in blood and androgenic activity in women. [3] Androsterone glucuronide content can be estimated using Liquid chromatography–mass spectrometry. [3] [4] If an unusual level of ADT-G is observed in the blood (either an elevated or decreased amount), proper treatment plans can be developed in order to treat related symptoms. [3]
Elevated levels of androsterone glucuronide in the blood have been observed in adult females who present with inflammatory acne. [5] The introduction of therapeutic antiandrogen treatment and the use of an oral Contraceptive by women who are affected with androsterone related acne can decrease the amount of inflammatory acne present. [5]