This list of sequenced archaeal genomes contains all the archaea known to have publicly available complete genome sequences that have been assembled, annotated and deposited in public databases. Methanococcus jannaschii was the first archaeon whose genome was sequenced, in 1996. [1]
Currently in this list there are 39 genomes belonging to Crenarchaeota species, 105 belonging to the Euryarchaeota, 1 genome belonging to Korarchaeota and to the Nanoarchaeota, 3 belonging to the Thaumarchaeota and 1 genome belonging to an unclassified Archaea, totalling 150 Archaeal genomes.
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Acidilobus saccharovorans | 345-15 | 1,496,000 | 1,547 | [2] | CP001742 | 2010 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Aeropyrum pernix | K1 | 1,669,695 | 2,694 | [3] | NC_000854 (NCBI Reference Sequence) | 1999 |
Desulfurococcus kamchatkensis | 1221n | 1,365,000 | 1,521 | [4] | CP001140 | 2009 |
Hyperthermus butylicus | DSM 5456 | 1,667,000 | 1,669 | [5] | CP000493 | 2007 |
Ignicoccus hospitalis | KIN4/I, DSM 18386 | 1,297,000 | 1,496 | [6] | CP000816 | 2008 |
Ignisphaera aggregans | AQ1.S1, DSM 17230 | 1,875,000 | 2,042 | [7] | CP002098 | 2010 |
Pyrolobus fumarii | 1A, DSM 11204 | 1,843,000 | 2,038 | [8] | CP002838 | 2011 |
Staphylothermus hellenicus | P8, DSM 12710 | 1,580,000 | 1,716 | [9] | CP002051 | 2011 |
Staphylothermus marinus | F1, DSM 3639 | 1,570,000 | 1,659 | [10] | CP000575 | 2011 |
Thermosphaera aggregans | M11TL, DSM 11486 | 1,316,000 | 1,457 | [11] | CP001939 | 2010 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Acidianus hospitalis | W1 | 2,137,000 | 2,424 | [12] | CP002535 | 2011 |
Metallosphaera cuprina | Ar-4 | 1,840,000 | 2,077 | [13] | CP002656 | 2011 |
Metallosphaera sedula | DSM 5348 | 2,191,000 | 2,347 | [14] | CP000682 | 2008 |
Sulfolobus acidocaldarius | DSM 639 | 2,225,959 | 2,223 | [15] | CP000077 | 2005 |
Sulfolobus islandicus | HVE10/4 | 2,655,000 | [16] | CP002426 | 2011 | |
Sulfolobus islandicus | L.D.8.5 | 2,722,000 | 2,996 | [17] | Chromosome CP001731 Plasmid pLD8501 CP001732 | 2009 |
Sulfolobus islandicus | L.S.2.15 | 2,736,000 | 3,068 | [17] | CP001399 | 2009 |
Sulfolobus islandicus | M.14.25 | 2,608,000 | 2,900 | [17] | CP001400 | 2009 |
Sulfolobus islandicus | M.16.27 | 2,692,000 | 2,956 | [17] | CP001401 | 2009 |
Sulfolobus islandicus | M.16.4 | 2,586,000 | 2,869 | [17] | CP001402 | 2009 |
Sulfolobus islandicus | REY15A | 2,522,000 | [16] | CP002425 | 2011 | |
Sulfolobus islandicus | Y.G.57.14 | 2,702,000 | 3,079 | [17] | CP001403 | 2009 |
Sulfolobus islandicus | Y.N.15.51 | 2,812,000 | 3,318 | [17] | Chromosome CP001404 Plasmid pYN01 CP001405 | 2009 |
Sulfolobus islandicus | LAL14/1 | 2,465,177 | 2,601 | [18] | CP003928 | 2013 |
Sulfolobus solfataricus | P2 | 2,992,245 | 2,995 | [19] | AE006641 | 2001 |
Sulfolobus solfataricus | 98/2 | 2,668,000 | 2,728 | DOE Joint Genome Institute | CP001800 | 2009 |
Sulfolobus tokodaii | 7 | 2,694,765 | 2,826 | [20] | BA000023 | 2001 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Caldivirga maquilingensis | IC-167 | 2,077,000 | 2,011 | DOE Joint Genome Institute | CP000852 | 2007 |
Pyrobaculum aerophilum | IM2 | 2,222,430 | 2,605 | [21] | AE009441 | 2002 |
Pyrobaculum arsenaticum | PZ6, DSM 13514 | 2,121,000 | 2,410 | DOE Joint Genome Institute | CP000660 | 2007 |
Pyrobaculum calidifontis | JCM 11548 | 2,009,000 | 2,213 | DOE Joint Genome Institute | CP000561 | 2007 |
Pyrobaculum islandicum | DSM 4184 | 1,826,000 | 2,063 | DOE Joint Genome Institute | CP000504 | 2006 |
Pyrobaculum sp. 1860 | Unpublished [22] | CP003098 | 2011 | |||
Thermofilum pendens | Hrk 5 | 1,781,000 | 1,930 | [23] | Chromosome CP000505 Plasmid pTPEN01 CP000506 | 2008 |
Thermoproteus neutrophilus | V24Sta | 1,769,000 | 2,053 | DOE Joint Genome Institute | CP001014 | 2008 |
Thermoproteus tenax | Kra1 | 1,841,000 | 2,100 | [24] | FN869859 | 2011 |
Thermoproteus uzoniensis | 768-20 | 1,936,000 | 2,229 | [25] | CP002590 | 2011 |
Vulcanisaeta distributa | DSM 14429 | 2,374,000 | 2,592 | [26] | CP002100 | 2010 |
Vulcanisaeta moutnovskia | 768-28 | 2,298,000 | 2,393 | [27] | CP002529 | 2011 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Archaeoglobus fulgidus | DSM4304 | 2,178,400 | 2,407 | [28] | AE000782 | 1997 |
Archaeoglobus veneficus | SNP6, DSM 11195 | 1,901,000 | 2,194 | DOE Joint Genome Institute | CP002588 | 2011 |
Archaeoglobus profundus | Av18, DSM 5631 | 1,563,000 | 1,911 | [29] | Chromosome CP001857 Plasmid pArcpr01 CP001858 | 2010 |
Ferroglobus placidus | AEDII12DO, DSM 10642 | 2,196,000 | 2,622 | [30] | CP001899 | 2011 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Halalkalicoccus jeotgali | B3, DSM 18796 | 3,690,000 | 3925 | [31] | Chromosome I CP002062 Plasmid 1 CP002063 | 2010 |
Haloarcula hispanica | CGMCC 1.2049 | 3,484,000 | 3,561 | [32] | Chromosome I CP002921 | 2011 |
Haloarcula marismortui | ATCC 43049 | 3,131,724 | 3,131 | [33] | Chromosome I AY596297 Chromosome II AY596298 | 2004 |
Halobacterium salinarum | R1, DSM 671 | 2,000,000 | 2,801 | [34] | Chromosome NC_010364 Plasmid PHS1 NC_010366 | 2008 |
Halobacterium species | NRC-1 | 2,014,239 | 2,058 | [35] | Chromosome NC_002607 | 2000 |
Halobiforma lacisalsi | AJ5, JCM 12983 | 4,320,000 | 4,682 | [36] | AGFZ00000000 | 2011 |
Haloferax volcanii | DS2 | [37] | Chromosome CP001956 Plasmid pHV1 CP001957 | 2010 | ||
Halogeometricum borinquense | PR3, DSM 11551 | 3,920,000 | 4,059 | [38] | Chromosome CP001690 Plasmid pHBOR01 CP001691 | 2009 |
Halomicrobium mukohataei | arg-2, DSM 12286 | 3,332,000 | 3,475 | [39] | Chromosome CP001688 Plasmid pHmuk01 CP001689 | 2009 |
Halopiger xanaduensis | SH-6 | 3,668,000 | 3,685 | DOE Joint Genome Institute | Chromosome CP002839 Plasmid pHALXA01 CP002840 | 2011 (Chromosome) |
Haloquadratum walsbyi | C23, DSM 16854 | 3,148,000 | [40] | Chromosome FR746099 Plasmid PL6A FR746101 | 2011 | |
Haloquadratum walsbyi | HBSQ001, DSM 16790 | 3,132,000 | 2,914 | [41] | Chromosome AM180088 Plasmid PL47 AM180089 | 2006 |
Halorhabdus tiamatea | SARL4B | 3,840,000 | 4,034 | [42] | AFNT00000000 | 2011 |
Halorhabdus utahensis | AX-2, DSM 12940 | 3116 Kb | 3076 | [43] | CP001687 | 2009 |
Halorubrum lacusprofundi | ATCC 49239 | 4,300,000 | 3,725 | DOE Joint Genome Institute | Chromosome 1 CP001365 | 2009 (Chromosomes 1 and 2) |
Haloterrigena turkmenica | VKM B-1734, DSM 5511 | 5,440,000 | 5,351 | [44] | Chromosome CP001860 Plasmid pHTUR01 CP001861 | 2010 |
Natrialba asiatica | ATCC 700177 | [45] | Survey | 2004 | ||
Natrialba magadii | ATCC 43099 | 3,751,000 | 4,364 | DOE Joint Genome Institute | CP001932 | 2010 |
Natronomonas pharaonis | DSM2160 | 2,595,221 | 2,675 | [46] | Chromosome CR936257 | 2005 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Methanocaldococcus fervens | AG86 | 1,485,000 | 1,663 | DOE Joint Genome Institute | Chromosome CP001696 Plasmid pMEFER01 CP001697 | 2009 (Chromosome) |
Methanocaldococcus infernus | ME | 1,328,000 | 1,513 | DOE Joint Genome Institute | CP002009 | 2010 |
Methanocaldococcus jannaschii | DSM 2661 | 1,664,970 | 1,715 | [54] | Chromosome: L77117 | 1996 |
Methanocaldococcus vulcanius | M7, DSM 12094 | 1,746,000 | 1,808 | DOE Joint Genome Institute | Chromosome CP001787 | 2009 |
Methanocaldococcus sp. FS406-22 | 1,760,000 | 1,893 | DOE Joint Genome Institute | Chromosome CP001901 Plasmid pFS01 CP001902 | 2010 (Chromosome) | |
Methanococcus aeolicus | Nankai-3 | 1,569,000 | 1,554 | DOE Joint Genome Institute | CP000743 | 2007 |
Methanococcus maripaludis | C5 | 1,780,000 | 1,896 | DOE Joint Genome Institute | CP000609 | 2007 |
Methanococcus maripaludis | C6 | 1,744,000 | 1,874 | DOE Joint Genome Institute | CP000867 | 2007 |
Methanococcus maripaludis | C7 | 1,772,000 | 1,858 | DOE Joint Genome Institute | CP000745 | 2007 |
Methanococcus maripaludis | S2 | 1,661,137 | 1,722 | [55] | NC_005791 (NCBI Reference Sequence) | 2004 |
Methanococcus maripaludis | X1 | 1,746,000 | 1,892 | [56] | CP002913 | 2011 |
Methanococcus vannielii | SB | 1,720,000 | 1,755 | DOE Joint Genome Institute | CP000742 | 2007 |
Methanococcus voltae | A3 | 1,936,000 | 1,768 | DOE Joint Genome Institute | CP002057 | 2010 |
Methanothermococcus okinawensis | IH1 | 1,662,000 | 1,662 | DOE Joint Genome Institute | Chromosome CP002792 Plasmid pMETOK01 CP002793 | 2011 (Chromosome) |
Methanotorris igneus | Kol5, DSM 5666 | 1,854,000 | 1,843 | DOE Joint Genome Institute | CP002737 | 2011 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Candidatus Methanoregula boonei | 6A8 | 2,542,000 | 2,518 | DOE Joint Genome Institute [57] | CP000780 | 2007 |
Methanocella sp. Rice Cluster I (RC-I) | MRE50 | 3,179,916 | 3103 | Genome sequence, [58] then taxonomic placement [59] | AM114193 | 2005 |
Methanocella paludicola | SANAE | 2,957,635 | 3004 | [60] | AP011532 | 2011 |
Methanocella conradii | HZ254 | 1,316,380 | 2512 | [61] | CP003243 | 2012 |
Methanococcoides burtonii | DSM6242 | 2,575,032 | 2,273 | [62] | CP000300 | 2009 |
Methanocorpusculum labreanum | Z | 1,804,000 | 1,830 | [63] | CP000559 | 2009 |
Methanoculleus marisnigri | JR1, DSM 1498 | 2,478,000 | 2,560 | [64] | CP000562 | 2009 |
Methanohalobium evestigatum | Z-7303 | 2,406,232 | 2,254 | DOE Joint Genome Institute [65] | Chromosome: CP002069 Plasmid pMETEV01: CP002070 | 2010 (Chromosome) |
Methanohalophilus mahii | SLP, DSM 5219 | 2,012,000 | 2,095 | [66] | CP001994 | 2010 |
Methanoplanus petrolearius | SEBR 4847, DSM 11571 | 2,843,000 | 2,881 | [67] | CP002117 | 2011 |
Methanosalsum zhilinae | WeN5, DSM 4017 | 2,138,000 | 2,086 | CP002101 | 2010 | |
Methanosaeta concilii | GP-6 | 3,008,000 | [68] | CP002565 | 2010 | |
Methanosaeta harundinacea | 6Ac | 2,559,000 | [22] | CP003117 | 2011 | |
Methanosaeta thermophila | PT | 1,879,000 | 1,785 | DOE Joint Genome Institute | CP000477 | 2006 |
Methanosarcina acetivorans | C2A | 5,751,492 | 4,540 | [69] | AE010299 | 2002 |
Methanosarcina barkeri | Fusaro, DSM 804 | 4,837,408 | 3,607 | [70] | Chromosome CP000099 Plasmid 1 CP000098 | 2006 (Chromosome) |
Methanosarcina mazei | Go1 | 4,096,345 | 3,371 | [71] | AE008384 | 2002 |
Methanosphaerula palustris | E1-9c, DSM 19958 | 2,922,000 | 2,859 | DOE Joint Genome Institute | CP001338 | 2008 |
Methanospirillum hungatei | JF-1 | 3,544,738 | 3,139 | DOE Joint Genome Institute | CP000254 | 2006 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Methanopyrus kandleri | AV19 | 1,694,969 | 1,691 | [72] | AE009439 | 2002 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Pyrococcus abyssi | GE5 | 1,765,118 | 1,784 | [73] | NC_000868 (NCBI Reference Sequence) | 2000 |
Pyrococcus furiosus | DSM 3638 | 1,908,256 | 2,065 | [74] | AE009950 | 1999 |
Pyrococcus horikoshii | OT3 | 1,738,505 | 2,061 | [75] | NC_000961 (NCBI Reference Sequence) | 1998 |
Pyrococcus sp. NA2 | 1,861,000 | 1,984 | [22] | CP002670 | 2011 | |
Pyrococcus yayanosii | CH1 | 1,716,000 | 1,952 | [76] | CP002779 | 2011 |
Thermococcus barophilus | MP, DSM 11836 | 2,010,000 | 2,196 | [77] | CP002372 | 2011 |
Thermococcus gammatolerans | EJ3 | 2,045,000 | 2,206 | [78] | CP001398 | 2009 |
Thermococcus kodakaraensis | KOD1 | 2,088,737 | 2,306 | [79] | AP006878 | 2005 |
Thermococcus onnurineus | NA1 | 1,847,000 | 2,027 | [80] | NC_011529 (NCBI Reference Sequence) | 2008 |
Thermococcus sibiricus | MM 739 | 1,845,000 | 2,085 | [81] | CP001463 | 2009 |
Thermococcus sp. 4557 | 2,011,000 | 2,181 | [82] | CP002920 | 2011 | |
Thermococcus sp. AM4 | 2,086,000 | 2,279 | [83] | CP002952 | 2011 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Ferroplasma acidarmanus | Fer1 | 1,865,000 | 1,742 | [84] | AABC00000000 | 2007 |
Picrophilus torridus | DSM 9790 | 1,545,895 | 1,535 | [85] | AE017261 | 2004 |
Thermoplasma acidophilum | DSM 1728 | 1,564,906 | 1,478 | [86] | NC_002578 (NCBI Reference Sequence) | 2000 |
Thermoplasma volcanium | GSS1 | 1,584,804 | 1,526 | [87] | NC_002689 (NCBI Reference Sequence) | 2000 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Aciduliprofundum boonei | T469 | 1,486,000 | 1,587 | DOE Joint Genome Institute | CP001941 | 2010 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Candidatus Korarchaeum cryptofilum | OPF8 | 1,590,000 | 1,661 | [88] | CP000968 | 2008 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Nanoarchaeum equitans | Kin4-M | 490,885 | 536 | [89] | AE017199 | 2003 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Cenarchaeum symbiosum | A | 2,045,000 | 2,066 | [90] | DP000238 | 2006 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
Candidatus Nitrosoarchaeum limnia | SFB1 | 1,769,000 | 2,171 | [91] | AEGP00000000 | 2011 |
Nitrosopumilus maritimus | SCM1 | 1,645,000 | 1,842 | [92] | CP000866 | 2010 |
Species | Strain | Base Pairs | Genes | Reference | GenBank identifier | Publication year |
---|---|---|---|---|---|---|
halophilic archaeon sp. DL31 | Unpublished [22] | CP002988 | 2011 |
Ferroglobus is a genus of the Archaeoglobaceae.
Pyrococcus furiosus is a heterotrophic, strictly anaerobic, extremophilic, model species of archaea. It is classified as a hyperthermophile because it thrives best under extremely high temperatures, and is notable for having an optimum growth temperature of 100 °C. P. furiosus belongs to the Pyrococcus genus, most commonly found in extreme environmental conditions of hydrothermal vents. It is one of the few prokaryotic organisms that has enzymes containing tungsten, an element rarely found in biological molecules.
In taxonomy, Thermococcus is a genus of thermophilic Archaea in the family the Thermococcaceae.
Aeropyrum is a genus of archaea in the family Desulfurococcaceae.
In taxonomy, Methanolacinia is a genus of the Methanomicrobiaceae. The cells are bar-shaped and irregular 0.6 μm in diameter and 1.5–2.5 μm in length. They do not form endospores. Most are non-motile, but some have a single flagellum. They are strictly anaerobic. They produce methane through the reduction of carbon dioxide with hydrogen and cannot use formate, acetate or methyl compounds as substrates.
Ignisphaera is a genus of the Desulfurococcales. Ignisphaera aggregans is a coccoid- shaped, fourth type strain that is strictly anaerobes with anaerobic respiration.
Archaea is a domain of single-celled organisms. These microorganisms lack cell nuclei and are therefore prokaryotic. Archaea were initially classified as bacteria, receiving the name archaebacteria, but this term has fallen out of use.
The Nitrososphaerota are a phylum of the Archaea proposed in 2008 after the genome of Cenarchaeum symbiosum was sequenced and found to differ significantly from other members of the hyperthermophilic phylum Thermoproteota. Three described species in addition to C. symbiosum are Nitrosopumilus maritimus, Nitrososphaera viennensis, and Nitrososphaera gargensis. The phylum was proposed in 2008 based on phylogenetic data, such as the sequences of these organisms' ribosomal RNA genes, and the presence of a form of type I topoisomerase that was previously thought to be unique to the eukaryotes. This assignment was confirmed by further analysis published in 2010 that examined the genomes of the ammonia-oxidizing archaea Nitrosopumilus maritimus and Nitrososphaera gargensis, concluding that these species form a distinct lineage that includes Cenarchaeum symbiosum. The lipid crenarchaeol has been found only in Nitrososphaerota, making it a potential biomarker for the phylum. Most organisms of this lineage thus far identified are chemolithoautotrophic ammonia-oxidizers and may play important roles in biogeochemical cycles, such as the nitrogen cycle and the carbon cycle. Metagenomic sequencing indicates that they constitute ~1% of the sea surface metagenome across many sites.
Thermococcus kodakarensis is a species of thermophilic archaea. The type strain T. kodakarensis KOD1 is one of the best-studied members of the genus.
Pyrobaculum aerophilum is a single-celled microorganism in the genus Pyrobaculum. The first Pyrobaculum species to be sequenced was P. aerophilum. It is a rod-shaped hyperthermophilic archaeum first isolated from a boiling marine water hole at Maronti Beach, Ischia. It forms characteristic terminal spherical bodies like Thermoproteus and Pyrobaculum. Its type strain is IM2; DSM 7523). Its optimum temperature for growth is around boiling point for water. Its optimum pH for growth is 7.0. Sulfur was found to inhibit its growth.
Methanothermus fervidus is a species of methanogen. It is notable for being extremely thermophilic. Its cells are rod-shaped; its complex cell envelope exhibits two layers, each about 12 nm thick; the inner represents the pseudomurein sacculus and the outer a protein envelope. The type strain is Methanothermus fervidus Stetter 1982. The cells are motile, strictly anaerobic and stain Gram positive. They can grow at temperatures as high as 97 °C. Strain V24ST can subsist on carbon dioxide and hydrogen alone. Its genome is 1,243,342 bp in length.
Sulfobacillus acidophilus is a species of moderately thermophilic mineral-sulphide-oxidizing bacteria. It is Gram-positive, acidophilic and ferrous-iron-oxidising as well.
Syntrophobacter fumaroxidans is a species of syntrophic propionate-degrading sulfate-reducing bacterium. Strain MPOBT is the type strain. Its genome has been fully sequenced.
"Syntrophothermus lipocalidus" is a bacterium, the type species and only currently described species in its genus. It is thermophilic, syntrophic, fatty-acid-oxidizing and anaerobic, and utilises isobutyrate. TGB-C1T is its type strain. Its genome has been fully sequenced.
Thermococcus barophilus is a piezophilic and hyperthermophilic archaeon isolated from a deep-sea hydrothermal vent. It is anaerobic and sulfur-metabolising, with type strain MPT.
Saccharolobus solfataricus is a species of thermophilic archaeon. It was transferred from the genus Sulfolobus to the new genus Saccharolobus with the description of Saccharolobus caldissimus in 2018.
Starkeya novella is a chemolithoautotrophic and methylotrophic bacteria from the family Xanthobacteraceae which has been isolated from soil. Starkeya novella has the ability to oxidise thiosulfate. The complete genome of Starkeya novella is sequenced.
The Coriobacteriia are a class of Gram-positive bacteria within the Actinomycetota phylum. Species within this group are nonsporulating, strict or facultative anaerobes that are capable of thriving in a diverse set of ecological niches. Gordonibacter species are the only members capable of motility by means of flagella within the class. Several species within the Coriobacteriia class have been implicated with human diseases that range in severity. Atopobium, Olsenella, and Cryptobacterium species have responsible for human oral infections including periodontitis, halitosis, and other endodontic infections. Eggerthella species have been associated with severe blood bacteraemia and ulcerative colitis.
Vibrio tubiashii is a Gram-negative, rod-shaped (0.5 um-1.5 um) marine bacterium that uses a single polar flagellum for motility. It has been implicated in several diseases of marine organisms.