Mucin 5AC

Last updated

MUC5AC
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases MUC5AC , MUC5, TBM, leB, mucin, mucin 5AC, oligomeric mucus/gel-forming
External IDs OMIM: 158373; MGI: 104697; HomoloGene: 137237; GeneCards: MUC5AC; OMA:MUC5AC - orthologs
Orthologs
SpeciesHumanMouse
Entrez

4586

17833

Ensembl

ENSG00000215182
ENSG00000283158

ENSMUSG00000037974

UniProt

P98088

n/a

RefSeq (mRNA)

NM_017511
NM_001304359

NM_010844

RefSeq (protein)

NP_001291288

n/a

Location (UCSC) Chr 11: 1.16 – 1.2 Mb Chr 7: 141.34 – 141.37 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mucin-5AC(MUC-5AC) is a protein that is encoded by the MUC5AC gene in humans. [5] [6] [7]

Contents

MUC-5AC is a large gel-forming glycoprotein. In the respiratory tract, it protects against infection by binding to inhaled pathogens, which are subsequently removed by mucociliary clearance. Overproduction of MUC-5AC can contribute to diseases such as asthma and chronic obstructive pulmonary disease, [8] and has also been associated with greater protection against influenza infection. [9]

Clinical relevance

This gene has been linked to mucus hypersecretion in the respiratory tract and is associated to chronic obstructive pulmonary disease (COPD). [10]

References

  1. 1 2 3 ENSG00000283158 GRCh38: Ensembl release 89: ENSG00000215182, ENSG00000283158 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037974 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (Feb 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J. 305 (Pt 1): 211–9. doi:10.1042/bj3050211. PMC   1136451 . PMID   7826332.
  6. ↑ van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (Jun 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochem Biophys Res Commun. 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID   9588204.
  7. ↑ "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".
  8. ↑ Samsuzzaman M, Uddin MS, Shah MA, Mathew B (August 2019). "Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production". Life Sciences. 231: 116485. doi:10.1016/j.lfs.2019.05.041. PMID   31116959. S2CID   162182150.
  9. ↑ Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, Sallenave JM, Pickles RJ, Boucher RC (2012-10-09). "Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs". Proceedings of the National Academy of Sciences of the United States of America. 109 (41): 16528–16533. Bibcode:2012PNAS..10916528E. doi: 10.1073/pnas.1206552109 . ISSN   1091-6490. PMC   3478656 . PMID   23012413.
  10. ↑ Li J, Ye Z (September 2020). "The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease". Molecules. 25 (19). Basel, Switzerland: 4437. doi: 10.3390/molecules25194437 . PMC   7582261 . PMID   32992527.
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