PAPSS1

Last updated
PAPSS1
Protein PAPSS1 PDB 1x6v.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PAPSS1 , ATPSK1, PAPSS, SK1, 3'-phosphoadenosine 5'-phosphosulfate synthase 1
External IDs OMIM: 603262; MGI: 1330587; HomoloGene: 81740; GeneCards: PAPSS1; OMA:PAPSS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005443

NM_001289477
NM_001289478
NM_001289479
NM_011863

RefSeq (protein)

NP_005434

NP_001276406
NP_001276407
NP_001276408
NP_035993

Location (UCSC) Chr 4: 107.59 – 107.72 Mb Chr 3: 131.27 – 131.35 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 is an enzyme that in humans is encoded by the PAPSS1 gene. [5] [6] [7]

Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM] [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000138801 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028032 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Girard JP, Baekkevold ES, Amalric F (May 1998). "Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase". FASEB Journal. 12 (7): 603–612. doi: 10.1096/fasebj.12.7.603 . PMID   9576487. S2CID   19530341.
  6. Faiyaz ul Haque M, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, et al. (October 1998). "Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse". Nature Genetics. 20 (2): 157–162. doi:10.1038/2458. PMID   9771708. S2CID   13108930.
  7. 1 2 "Entrez Gene: PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1".

Further reading