Small nucleolar RNA Z102/R77

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Small nucleolar RNA Z102/R77
RF00359.jpg
Predicted secondary structure and sequence conservation of snoZ102_R77
Identifiers
SymbolsnoZ102_R77
Rfam RF00359
Other data
RNA type Gene; snRNA; snoRNA; CD-box
Domain(s) Eukaryota
GO GO:0006396 GO:0005730
SO SO:0000593
PDB structures PDBe

In molecular biology, Small nucleolar RNA RZ102/R77 refers to a group of related non-coding RNA (ncRNA) molecules which function in the biogenesis of other small nuclear RNAs (snRNAs). These small nucleolar RNAs (snoRNAs) are modifying RNAs and usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis.

These two snoRNAs R77 and Z102 were identified in the plant Arabidopsis thaliana [1] and rice Oryza sativa [2] respectively. These related snoRNAs are predicted to belong to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [3]

Z102 and R77 and are members of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] [2] [3]

References

  1. 1 2 Barneche F, Gaspin C, Guyot R, Echeverría M (2001). "Identification of 66 box C/D snoRNAs in Arabidopsis thaliana: extensive gene duplications generated multiple isoforms predicting new ribosomal RNA 2'-O-methylation sites". J. Mol. Biol. 311 (1): 57–73. doi:10.1006/jmbi.2001.4851. PMID   11469857.
  2. 1 2 Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH (2003). "The high diversity of snoRNAs in plants: identification and comprative study of 120 snoRNA genes from Oryza sativa". Nucleic Acids Res. 31 (10): 2601–13. doi:10.1093/nar/gkg373. PMC   156054 . PMID   12736310.
  3. 1 2 Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology . 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC   134041 . PMID   12215523.