TRAF5

TRAF5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GJH
Identifiers
Aliases	TRAF5 , MGC:39780, RNF84, TNF receptor associated factor 5
External IDs	OMIM: 602356 MGI: 107548 HomoloGene: 27079 GeneCards: TRAF5
Gene location (Human)
Chr.	Chromosome 1 (human)
End	211,374,946 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	191,776,868 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; body of pancreas; ; superficial temporal artery; ; lymph node; ; gastric mucosa; ; ascending aorta; ; right coronary artery; ; left uterine tube; ; appendix; ; myometrium;
	Top expressed in
	spleen; ; urinary bladder; ; bone marrow; ; proximal tubule; ; lung; ; esophagus; ; islet of Langerhans; ; zone of skin; ; thymus; ; wall of urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	thioesterase binding ; zinc ion binding ; protein binding ; ubiquitin protein ligase binding ; metal ion binding ; identical protein binding ; tumor necrosis factor receptor binding ;
Cellular component	cytosol ; cytoplasmic side of plasma membrane ; centrosome ; CD40 receptor complex ; cytoplasm ; protein-containing complex ;
Biological process	regulation of apoptotic process ; positive regulation of I-kappaB kinase/NF-kappaB signaling ; positive regulation of DNA-binding transcription factor activity ; positive regulation of NF-kappaB transcription factor activity ; signal transduction ; apoptotic process ;
	Sources:Amigo / QuickGO
Orthologs
	7188
	22033
	ENSG00000082512
	ENSMUSG00000026637
	O00463
	P70191
	NM_001033910 ; NM_004619 ; NM_145759 ; NM_001319207
	NM_011633
	NP_001029082 ; NP_001306136 ; NP_004610 ; NP_665702
	NP_035763
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 23, 2023

TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene.^[5]

Function

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.^[6]

Interactions

TRAF5 has been shown to interact with:

Related Research Articles

<span class="mw-page-title-main">CD30</span> Mammalian protein found in Homo sapiens

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and a tumor marker.

Receptor activator of nuclear factor κ B (RANK), also known as TRANCE receptor or TNFRSF11A, is a member of the tumor necrosis factor receptor (TNFR) molecular sub-family. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It is associated with bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. Osteoprotegerin (OPG) is a decoy receptor for RANKL, and regulates the stimulation of the RANK signaling pathway by competing for RANKL. The cytoplasmic domain of RANK binds TRAFs 1, 2, 3, 5, and 6 which transmit signals to downstream targets such as NF-κB and JNK.

Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell; without CD28, expression of OX40 is delayed and of fourfold lower levels.

TRAF6 is a TRAF human protein.

TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.

Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.

Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response to an array of stresses such as oxidative stress, endoplasmic reticulum stress and calcium influx. ASK1 has been found to be involved in cancer, diabetes, rheumatoid arthritis, cardiovascular and neurodegenerative diseases.

Lymphotoxin beta receptor (LTBR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3), is a cell surface receptor for lymphotoxin involved in apoptosis and cytokine release. It is a member of the tumor necrosis factor receptor superfamily.

CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule, and is the target of an anti-cancer drug in clinical trials.

IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB gene.

Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and CD120a, is a ubiquitous membrane receptor that binds tumor necrosis factor-alpha (TNFα).

TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene.

TNF receptor-associated factor (TRAF3) is a protein that in humans is encoded by the TRAF3 gene.

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions in a variety of cellular pathways related to both cell survival and death. In terms of cell death, RIPK1 plays a role in apoptosis and necroptosis. Some of the cell survival pathways RIPK1 participates in include NF-κB, Akt, and JNK.

Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an enzyme that in humans is encoded by the MAP3K14 gene.

TBK1 is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. It is encoded by the TBK1 gene in humans. This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity. Insufficient regulation of TBK1 activity leads to autoimmune, neurodegenerative diseases or tumorigenesis.

Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily.

TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.

TRAF family member-associated NF-kappa-B activator is a protein that in humans is encoded by the TANK gene.

Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and CD120b, is one of two membrane receptors that binds tumor necrosis factor-alpha (TNFα). Like its counterpart, tumor necrosis factor receptor 1 (TNFR1), the extracellular region of TNFR2 consists of four cysteine-rich domains which allow for binding to TNFα. TNFR1 and TNFR2 possess different functions when bound to TNFα due to differences in their intracellular structures, such as TNFR2 lacking a death domain (DD).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000082512 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026637 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tang XX, Pleasure DE, Ikegaki N (Apr 1997). "cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors". Genomics. 41 (1): 17–24. doi: 10.1006/geno.1997.4615 . PMID 9126477.
↑ "Entrez Gene: TRAF5 TNF receptor-associated factor 5".
↑ Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (Sep 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Molecular Cell. 2 (3): 389–95. doi: 10.1016/s1097-2765(00)80283-x . PMID 9774977.
↑ Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR (Oct 1999). "Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)". Oncogene. 18 (42): 5814–20. doi:10.1038/sj.onc.1202975. PMID 10523862. S2CID 12132452.
↑ Kawamata S, Hori T, Imura A, Takaori-Kondo A, Uchiyama T (Mar 1998). "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation". The Journal of Biological Chemistry. 273 (10): 5808–14. doi: 10.1074/jbc.273.10.5808 . PMID 9488716.
↑ Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T (Jan 1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". The Journal of Biological Chemistry. 272 (4): 2042–5. doi: 10.1074/jbc.272.4.2042 . PMID 8999898.
↑ Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J (Feb 1999). "Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1234–9. Bibcode:1999PNAS...96.1234T. doi: 10.1073/pnas.96.4.1234 . PMC 15446 . PMID 9990007.
↑ Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J (Sep 1996). "TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling". Proceedings of the National Academy of Sciences of the United States of America. 93 (18): 9437–42. Bibcode:1996PNAS...93.9437I. doi: 10.1073/pnas.93.18.9437 . PMC 38446 . PMID 8790348.
↑ Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB (Aug 1998). "Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase". The Journal of Biological Chemistry. 273 (32): 20551–5. doi: 10.1074/jbc.273.32.20551 . PMID 9685412.
↑ Darnay BG, Ni J, Moore PA, Aggarwal BB (Mar 1999). "Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif". The Journal of Biological Chemistry. 274 (12): 7724–31. doi: 10.1074/jbc.274.12.7724 . PMID 10075662.
↑ Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC (Dec 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". The Journal of Biological Chemistry. 273 (51): 34120–7. doi: 10.1074/jbc.273.51.34120 . PMID 9852070.
↑ Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H (Jul 2000). "TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation". The Journal of Experimental Medicine. 192 (1): 137–43. doi:10.1084/jem.192.1.137. PMC 1887716 . PMID 10880535.
↑ Hsu H, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle WJ (May 1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". The Journal of Biological Chemistry. 272 (21): 13471–4. doi: 10.1074/jbc.272.21.13471 . PMID 9153189.
↑ Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". The Journal of Biological Chemistry. 272 (22): 14029–32. doi: 10.1074/jbc.272.22.14029 . PMID 9162022.

Wajant H, Henkler F, Scheurich P (Jun 2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cellular Signalling. 13 (6): 389–400. doi:10.1016/S0898-6568(01)00160-7. PMID 11384837.
Bradley JR, Pober JS (Oct 2001). "Tumor necrosis factor receptor-associated factors (TRAFs)". Oncogene. 20 (44): 6482–91. doi: 10.1038/sj.onc.1204788 . PMID 11607847.
Nakano H, Oshima H, Chung W, Williams-Abbott L, Ware CF, Yagita H, Okumura K (Jun 1996). "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor". The Journal of Biological Chemistry. 271 (25): 14661–4. doi: 10.1074/jbc.271.25.14661 . PMID 8663299.
Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J (Sep 1996). "TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling". Proceedings of the National Academy of Sciences of the United States of America. 93 (18): 9437–42. Bibcode:1996PNAS...93.9437I. doi: 10.1073/pnas.93.18.9437 . PMC 38446 . PMID 8790348.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T (Jan 1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". The Journal of Biological Chemistry. 272 (4): 2042–5. doi: 10.1074/jbc.272.4.2042 . PMID 8999898.
Hsu H, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle WJ (May 1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". The Journal of Biological Chemistry. 272 (21): 13471–4. doi: 10.1074/jbc.272.21.13471 . PMID 9153189.
Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". The Journal of Biological Chemistry. 272 (22): 14029–32. doi: 10.1074/jbc.272.22.14029 . PMID 9162022.
Nakano H, Shindo M, Yamada K, Yoshida MC, Santee SM, Ware CF, Jenkins NA, Gilbert DJ, Yagita H, Copeland NC, Okumura K (May 1997). "Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32". Genomics. 42 (1): 26–32. doi:10.1006/geno.1997.4697. PMID 9177772.
Song HY, Régnier CH, Kirschning CJ, Goeddel DV, Rothe M (Sep 1997). "Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2". Proceedings of the National Academy of Sciences of the United States of America. 94 (18): 9792–6. Bibcode:1997PNAS...94.9792S. doi: 10.1073/pnas.94.18.9792 . PMC 23270 . PMID 9275204.
Kawamata S, Hori T, Imura A, Takaori-Kondo A, Uchiyama T (Mar 1998). "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation". The Journal of Biological Chemistry. 273 (10): 5808–14. doi: 10.1074/jbc.273.10.5808 . PMID 9488716.
Mizushima S, Fujita M, Ishida T, Azuma S, Kato K, Hirai M, Otsuka M, Yamamoto T, Inoue J (Jan 1998). "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)". Gene. 207 (2): 135–40. doi:10.1016/S0378-1119(97)00616-1. PMID 9511754.
Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware CF, Malinin NL, Wallach D, Yagita H, Okumura K (May 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". The Journal of Biological Chemistry. 273 (21): 13353–8. doi: 10.1074/jbc.273.21.13353 . PMID 9582383.
McCarthy JV, Ni J, Dixit VM (Jul 1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". The Journal of Biological Chemistry. 273 (27): 16968–75. doi: 10.1074/jbc.273.27.16968 . PMID 9642260.
Pullen SS, Miller HG, Everdeen DS, Dang TT, Crute JJ, Kehry MR (Aug 1998). "CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization". Biochemistry. 37 (34): 11836–45. doi:10.1021/bi981067q. PMID 9718306.
Wong BR, Josien R, Lee SY, Vologodskaia M, Steinman RM, Choi Y (Oct 1998). "The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor". The Journal of Biological Chemistry. 273 (43): 28355–9. doi: 10.1074/jbc.273.43.28355 . PMID 9774460.
Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (Sep 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Molecular Cell. 2 (3): 389–95. doi: 10.1016/S1097-2765(00)80283-X . PMID 9774977.
Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J (Feb 1999). "Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1234–9. Bibcode:1999PNAS...96.1234T. doi: 10.1073/pnas.96.4.1234 . PMC 15446 . PMID 9990007.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000082512 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026637 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9126477-5] Tang XX, Pleasure DE, Ikegaki N (Apr 1997). "cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors". Genomics. 41 (1): 17–24. doi: 10.1006/geno.1997.4615 . PMID 9126477.

[entrez-6] "Entrez Gene: TRAF5 TNF receptor-associated factor 5".

[pmid9774977-7] Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (Sep 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Molecular Cell. 2 (3): 389–95. doi: 10.1016/s1097-2765(00)80283-x . PMID 9774977.

[pmid10523862-8] Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR (Oct 1999). "Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)". Oncogene. 18 (42): 5814–20. doi:10.1038/sj.onc.1202975. PMID 10523862. S2CID 12132452.

[pmid9488716-9] Kawamata S, Hori T, Imura A, Takaori-Kondo A, Uchiyama T (Mar 1998). "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation". The Journal of Biological Chemistry. 273 (10): 5808–14. doi: 10.1074/jbc.273.10.5808 . PMID 9488716.

[pmid8999898-10] Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T (Jan 1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". The Journal of Biological Chemistry. 272 (4): 2042–5. doi: 10.1074/jbc.272.4.2042 . PMID 8999898.

[pmid9990007-11] Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J (Feb 1999). "Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1234–9. Bibcode:1999PNAS...96.1234T. doi: 10.1073/pnas.96.4.1234 . PMC 15446 . PMID 9990007.

[pmid8790348-12] Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J (Sep 1996). "TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling". Proceedings of the National Academy of Sciences of the United States of America. 93 (18): 9437–42. Bibcode:1996PNAS...93.9437I. doi: 10.1073/pnas.93.18.9437 . PMC 38446 . PMID 8790348.

[pmid9685412-13] Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB (Aug 1998). "Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase". The Journal of Biological Chemistry. 273 (32): 20551–5. doi: 10.1074/jbc.273.32.20551 . PMID 9685412.

[pmid10075662-14] Darnay BG, Ni J, Moore PA, Aggarwal BB (Mar 1999). "Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif". The Journal of Biological Chemistry. 274 (12): 7724–31. doi: 10.1074/jbc.274.12.7724 . PMID 10075662.

[pmid9852070-15] Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC (Dec 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". The Journal of Biological Chemistry. 273 (51): 34120–7. doi: 10.1074/jbc.273.51.34120 . PMID 9852070.

[pmid10880535-16] Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H (Jul 2000). "TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation". The Journal of Experimental Medicine. 192 (1): 137–43. doi:10.1084/jem.192.1.137. PMC 1887716 . PMID 10880535.

[pmid9153189-17] Hsu H, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle WJ (May 1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". The Journal of Biological Chemistry. 272 (21): 13471–4. doi: 10.1074/jbc.272.21.13471 . PMID 9153189.

[pmid9162022-18] Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A (May 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". The Journal of Biological Chemistry. 272 (22): 14029–32. doi: 10.1074/jbc.272.22.14029 . PMID 9162022.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

TRAF5

Contents

Function

Interactions

Related Research Articles

References

Further reading