Ventricle (heart)

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Ventricle
CG Heart.gif
Computer generated animation of cut section of the human heart showing both ventricles.
Details
Identifiers
Latin ventriculus cordis
MeSH D006352
TA98 A12.1.00.012
FMA 7100
Anatomical terminology

A ventricle is one of two large chambers located toward the bottom of the heart that collect and expel blood towards the peripheral beds within the body and lungs. The blood pumped by a ventricle is supplied by an atrium, an adjacent chamber in the upper heart that is smaller than a ventricle. Interventricular means between the ventricles (for example the interventricular septum), while intraventricular means within one ventricle (for example an intraventricular block).

Contents

In a four-chambered heart, such as that in humans, there are two ventricles that operate in a double circulatory system: the right ventricle pumps blood into the pulmonary circulation to the lungs, and the left ventricle pumps blood into the systemic circulation through the aorta.

Structure

Heart section showing ventricles and ventricular septum Gray498.png
Heart section showing ventricles and ventricular septum

Ventricles have thicker walls than atria and generate higher blood pressures. The physiological load on the ventricles requiring pumping of blood throughout the body and lungs is much greater than the pressure generated by the atria to fill the ventricles. Further, the left ventricle has thicker walls than the right because it needs to pump blood to most of the body while the right ventricle fills only the lungs.[ citation needed ] [1]

On the inner walls of the ventricles are irregular muscular columns called trabeculae carneae which cover all of the inner ventricular surfaces except that of the conus arteriosus, in the right ventricle. There are three types of these muscles. The third type, the papillary muscles, give origin at their apices to the chordae tendinae which attach to the cusps of the tricuspid valve and to the mitral valve.

The mass of the left ventricle, as estimated by magnetic resonance imaging, averages 143 g ± 38.4 g, with a range of 87–224 g. [2]

The right ventricle is equal in size to the left ventricle[ citation needed ] and contains roughly 85 millilitres (3 imp fl oz; 3 US fl oz) in the adult. Its upper front surface is circled and convex, and forms much of the sternocostal surface of the heart. Its under surface is flattened, forming part of the diaphragmatic surface of the heart that rests upon the diaphragm.

Its posterior wall is formed by the ventricular septum, which bulges into the right ventricle, so that a transverse section of the cavity presents a semilunar outline. Its upper and left angle forms a conical pouch, the conus arteriosus, from which the pulmonary artery arises. A tendinous band, called the tendon of the conus arteriosus, extends upward from the right atrioventricular fibrous ring and connects the posterior surface of the conus arteriosus to the aorta.[ citation needed ]

Shape

The left ventricle is longer and more conical in shape than the right, and on transverse section its concavity presents an oval or nearly circular outline. It forms a small part of the sternocostal surface and a considerable part of the diaphragmatic surface of the heart; it also forms the apex of the heart. The left ventricle is thicker and more muscular than the right ventricle because it pumps blood at a higher pressure.

The right ventricle is triangular in shape and extends from the tricuspid valve in the right atrium to near the apex of the heart. Its wall is thickest at the apex and thins towards its base at the atrium. When viewed via cross section however, the right ventricle seems to be crescent shaped. [3] [4] The right ventricle is made of two components: the sinus and the conus. The Sinus is the inflow which flows away from the tricuspid valve. [5] Three bands made from muscle, separate the right ventricle: the parietal, the septal, and the moderator band. [5] The moderator band connects from the base of the anterior papillary muscle to the ventricular septum. [4] [6]

Development

By young adulthood, the walls of the left ventricle have thickened from three to six times greater than that of the right ventricle. This reflects the typical five times greater pressure workload this chamber performs while accepting blood returning from the pulmonary veins at ~80mmHg pressure (equivalent to around 11 kPa) and pushing it forward to the typical ~120mmHg pressure (around 16.3 kPa) in the aorta during each heartbeat. (The pressures stated are resting values and stated as relative to surrounding atmospheric which is the typical "0" reference pressure used in medicine.)

Function

During systole, the ventricles contract, pumping blood through the body. During diastole, the ventricles relax and fill with blood again.

The left ventricle receives oxygenated blood from the left atrium via the mitral valve and pumps it through the aorta via the aortic valve, into the systemic circulation. The left ventricular muscle must relax and contract quickly and be able to increase or lower its pumping capacity under the control of the nervous system. In the diastolic phase, it has to relax very quickly after each contraction so as to quickly fill with the oxygenated blood flowing from the pulmonary veins. Likewise in the systolic phase, the left ventricle must contract rapidly and forcibly to pump this blood into the aorta, overcoming the much higher aortic pressure. The extra pressure exerted is also needed to stretch the aorta and other arteries to accommodate the increase in blood volume.

The right ventricle receives deoxygenated blood from the right atrium via the tricuspid valve and pumps it into the pulmonary artery via the pulmonary valve, into the pulmonary circulation.

Pumping volume

The typical healthy adult heart pumping volume is ~5 liters/min, resting. Maximum capacity pumping volume extends from ~25 liters/min for non-athletes to as high as ~45 liters/min for Olympic level athletes.

Volumes

In cardiology, the performance of the ventricles are measured with several volumetric parameters, including end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (Ef).

Wiggers diagram of various events of a cardiac cycle, showing left ventricular volume as a red trace. Wiggers Diagram.svg
Wiggers diagram of various events of a cardiac cycle, showing left ventricular volume as a red trace.
Ventricular volumes
MeasureRight ventricleLeft ventricle
End-diastolic volume 144 mL (± 23 mL) [7] 142 mL (± 21 mL) [8]
End-diastolic volume / body surface area (mL/m2)78 mL/m2 (± 11 mL/m2) [7] 78 mL/m2 (± 8.8 mL/m2) [8]
End-systolic volume 50 mL (± 14 mL) [7] 47 mL (± 10 mL) [8]
End-systolic volume / body surface area (mL/m2)27 mL/m2 (± 7 mL/m2) [7] 26 mL/m2 (± 5.1 mL/m2) [8]
Stroke volume 94 mL (± 15 mL) [7] 95 mL (± 14 mL) [8]
Stroke volume / body surface area (mL/m2)51 mL/m2 (± 7 mL/m2) [7] 52 mL/m2 (± 6.2 mL/m2) [8]
Ejection fraction 66% (± 6%) [7] 67% (± 4.6%) [8]
Heart rate 60–100 bpm [9] 60–100 bpm [9]
Cardiac output 4.0–8.0 L/minute [10] 4.0–8.0 L/minute [10]

Pressures

Partial Wiggers diagram. Red = aortic pressure Blue = left ventricular pressure Yellow = left atrial pressure. Wiggers.png
Partial Wiggers diagram.

Red = aortic pressure
Blue = left ventricular pressure
Yellow = left atrial pressure.
SiteNormal
pressure range
(in mmHg) [11]
Central venous pressure 3–8
Right ventricular pressure systolic15–30
diastolic3–8
Pulmonary artery pressure systolic15–30
diastolic4–12
Pulmonary vein/

Pulmonary capillary wedge pressure

2–15
Left ventricular pressure systolic100–140
diastolic3–12

Ventricular pressure is a measure of blood pressure within the ventricles of the heart. [12]

Left

During most of the cardiac cycle, ventricular pressure is less than the pressure in the aorta, but during systole, the ventricular pressure rapidly increases, and the two pressures become equal to each other (represented by the junction of the blue and red lines on the diagram on this page), the aortic valve opens, and blood is pumped to the body.

Elevated left ventricular end-diastolic pressure has been described as a risk factor in cardiac surgery. [13]

Noninvasive approximations have been described. [14]

An elevated pressure difference between the aortic pressure and the left ventricular pressure may be indicative of aortic stenosis. [15]

Right ventricular pressure demonstrates a different pressure-volume loop than left ventricular pressure. [16]

Dimensions

The heart and its performance are also commonly measured in terms of dimensions, which in this case means one-dimensional distances, usually measured in millimeters. This is not as informative as volumes but may be much easier to estimate with (e.g., M-Mode echocardiography [17] or with sonomicrometry, which is mostly used for animal model research). Optimally, it is specified with which plane the distance is measured in, e.g. the dimension of the longitudinal plane. [18]

DimensionAbbreviationDefinitionNormally
End-diastolic dimensionEDDThe diameter across a ventricle at the end of diastole, if not else specified then usually referring to the transverse [19] (left-to-right) internal (luminal) distance, excluding thickness of walls, although it can also be measured as the external distance.
Left ventricular end-diastolic dimension
LVEDD or sometimes LVDDThe end-diastolic dimension of the left ventricle.48 mm, [20]
Range 36 – 56 mm [21]
Right ventricular end-diastolic dimension
RVEDD or sometimes RVDDThe end-diastolic dimension of the right ventricle.Range 10 – 26 mm [21]
End-systolic dimensionESDESD is similar to the end-diastolic dimension, but is measured at the end of systole (after the ventricles have pumped out blood) rather than at the end of diastole.
Left ventricular end-systolic dimension
LVESD or sometimes LVSDThe end-systolic dimension of the left ventricle.Range 20 – 40 mm [21]
Right ventricular end-systolic dimension
RVESD or sometimes RVSDThe end-systolic dimension of the right ventricle.Range 10 – 26 mm [21]
Interventricular septal end diastolic dimensionIVSdThe thickness of the interventricular septum.8.3 mm, [20]
Range 7 – 11 mm [21]
Left ventricular end diastolic posterior wall dimensionLVPWdThe thickness of the posterior left ventricular wall.8.3 mm, [20]
Range 7 – 11 mm [21]
Mean left ventricular myocardial thicknessMean LVMTAverage thickness of the left ventricle, with numbers given as 95% prediction interval for the short axis images at the mid-cavity level [22] Women: 4 - 8 mm [22]
Men: 5 - 9 mm [22]
Mean right ventricular myocardial thicknessMean RVMTAverage thickness of the right ventricle, with numbers given as 95% prediction interval. [23] 4 - 7 mm [23]
Left ventricular end systolic dimensionAs above but measured during systole. This measurement is not commonly used clinically.16  mm [24]
Left atrial dimensionLARange 24 – 40 mm [21]

Fractional shortening (FS) is the fraction of any diastolic dimension that is lost in systole. When referring to endocardial luminal distances, it is EDD minus ESD divided by EDD (times 100 when measured in percentage). [25] Normal values may differ somewhat dependent on which anatomical plane is used to measure the distances. Normal range is 25–45%, Mild is 20–25%, Moderate is 15–20%, and Severe is <15%. [26] Cardiology Diagnostic Tests Midwall fractional shortening may also be used to measure diastolic/systolic changes for inter-ventricular septal dimensions [27] and posterior wall dimensions. However, both endocardial and midwall fractional shortening are dependent on myocardial wall thickness, and thereby dependent on long-axis function. [28] By comparison, a measure of short-axis function termed epicardial volume change (EVC) is independent of myocardial wall thickness and represents isolated short-axis function. [28]

Clinical significance

An arrhythmia is an irregular heartbeat that can occur in the ventricles or atria. Normally the heartbeat is initiated in the SA node of the atrium but initiation can also occur in the Purkinje fibres of the ventricles, giving rise to premature ventricular contractions, also called ventricular extra beats. When these beats become grouped the condition is known as ventricular tachycardia.[ citation needed ]

Another form of arrhythmia is that of the ventricular escape beat. This can happen as a compensatory mechanism when there is a problem in the conduction system from the SA node.[ citation needed ]

The most severe form of arrhythmia is ventricular fibrillation which is the most common cause of cardiac arrest and subsequent sudden death.

See also

Related Research Articles

<span class="mw-page-title-main">Heart</span> Organ found inside most animals

The heart is a muscular organ in most animals. This organ pumps blood through the blood vessels of the circulatory system. The pumped blood carries oxygen and nutrients to the body, while carrying metabolic waste such as carbon dioxide to the lungs. In humans, the heart is approximately the size of a closed fist and is located between the lungs, in the middle compartment of the chest, called the mediastinum.

<span class="mw-page-title-main">Coronary circulation</span> Circulation of blood in the blood vessels of the heart muscle (myocardium)

Coronary circulation is the circulation of blood in the arteries and veins that supply the heart muscle (myocardium). Coronary arteries supply oxygenated blood to the heart muscle. Cardiac veins then drain away the blood after it has been deoxygenated. Because the rest of the body, and most especially the brain, needs a steady supply of oxygenated blood that is free of all but the slightest interruptions, the heart is required to function continuously. Therefore its circulation is of major importance not only to its own tissues but to the entire body and even the level of consciousness of the brain from moment to moment. Interruptions of coronary circulation quickly cause heart attacks, in which the heart muscle is damaged by oxygen starvation. Such interruptions are usually caused by coronary ischemia linked to coronary artery disease, and sometimes to embolism from other causes like obstruction in blood flow through vessels.

<span class="mw-page-title-main">Heart valve</span> A flap of tissue that prevent backflow of blood around the heart

A heart valve is a biological one-way valve that allows blood to flow in one direction through the chambers of the heart. Four valves are usually present in a mammalian heart and together they determine the pathway of blood flow through the heart. A heart valve opens or closes according to differential blood pressure on each side.

<span class="mw-page-title-main">Heart murmur</span> Medical condition

Heart murmurs are unique heart sounds produced when blood flows across a heart valve or blood vessel. This occurs when turbulent blood flow creates a sound loud enough to hear with a stethoscope. Turbulent blood flow is not smooth. The sound differs from normal heart sounds by their characteristics. For example, heart murmurs may have a distinct pitch, duration and timing. The major way health care providers examine the heart on physical exam is heart auscultation; another clinical technique is palpation, which can detect by touch when such turbulence causes the vibrations called cardiac thrill. A murmur is a sign found during the cardiac exam. Murmurs are of various types and are important in the detection of cardiac and valvular pathologies.

<span class="mw-page-title-main">Systole</span> Part of the cardiac cycle when a heart chamber contracts

Systole is the part of the cardiac cycle during which some chambers of the heart contract after refilling with blood.

<span class="mw-page-title-main">Afterload</span> Pressure in the wall of the left ventricle during ejection

Afterload is the pressure that the heart must work against to eject blood during systole. Afterload is proportional to the average arterial pressure. As aortic and pulmonary pressures increase, the afterload increases on the left and right ventricles respectively. Afterload changes to adapt to the continually changing demands on an animal's cardiovascular system. Afterload is proportional to mean systolic blood pressure and is measured in millimeters of mercury.

<span class="mw-page-title-main">Diastole</span> Part of the cardiac cycle

Diastole is the relaxed phase of the cardiac cycle when the chambers of the heart are refilling with blood. The contrasting phase is systole when the heart chambers are contracting. Atrial diastole is the relaxing of the atria, and ventricular diastole the relaxing of the ventricles.

<span class="mw-page-title-main">Aortic regurgitation</span> Medical condition

Aortic regurgitation (AR), also known as aortic insufficiency (AI), is the leaking of the aortic valve of the heart that causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle. As a consequence, the cardiac muscle is forced to work harder than normal.

<span class="mw-page-title-main">Ventricular septal defect</span> Medical condition

A ventricular septal defect (VSD) is a defect in the ventricular septum, the wall dividing the left and right ventricles of the heart. The extent of the opening may vary from pin size to complete absence of the ventricular septum, creating one common ventricle. The ventricular septum consists of an inferior muscular and superior membranous portion and is extensively innervated with conducting cardiomyocytes.

<span class="mw-page-title-main">Mitral regurgitation</span> Form of valvular heart disease

Mitral regurgitation (MR), also known as mitral insufficiency or mitral incompetence, is a form of valvular heart disease in which the mitral valve is insufficient and does not close properly when the heart pumps out blood. It is the abnormal leaking of blood backwards – regurgitation from the left ventricle, through the mitral valve, into the left atrium, when the left ventricle contracts. Mitral regurgitation is the most common form of valvular heart disease.

A transthoracic echocardiogram (TTE) is the most common type of echocardiogram, which is a still or moving image of the internal parts of the heart using ultrasound. In this case, the probe is placed on the chest or abdomen of the subject to get various views of the heart. It is used as a non-invasive assessment of the overall health of the heart, including a patient's heart valves and degree of heart muscle contraction. The images are displayed on a monitor for real-time viewing and then recorded.

<span class="mw-page-title-main">Cardiac cycle</span> Performance of the human heart

The cardiac cycle is the performance of the human heart from the beginning of one heartbeat to the beginning of the next. It consists of two periods: one during which the heart muscle relaxes and refills with blood, called diastole, following a period of robust contraction and pumping of blood, called systole. After emptying, the heart relaxes and expands to receive another influx of blood returning from the lungs and other systems of the body, before again contracting to pump blood to the lungs and those systems.

<span class="mw-page-title-main">Valvular heart disease</span> Disease in the valves of the heart

Valvular heart disease is any cardiovascular disease process involving one or more of the four valves of the heart. These conditions occur largely as a consequence of aging, but may also be the result of congenital (inborn) abnormalities or specific disease or physiologic processes including rheumatic heart disease and pregnancy.

<span class="mw-page-title-main">Right ventricular hypertrophy</span> Medical condition

Right ventricular hypertrophy (RVH) is a condition defined by an abnormal enlargement of the cardiac muscle surrounding the right ventricle. The right ventricle is one of the four chambers of the heart. It is located towards the lower-end of the heart and it receives blood from the right atrium and pumps blood into the lungs.

The following outline is provided as an overview of and topical guide to cardiology, the branch of medicine dealing with disorders of the human heart. The field includes medical diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular heart disease and electrophysiology. Physicians who specialize in cardiology are called cardiologists.

The E/A ratio is a marker of the function of the left ventricle of the heart. It represents the ratio of peak velocity blood flow from left ventricular relaxation in early diastole to peak velocity flow in late diastole caused by atrial contraction. It is calculated using Doppler echocardiography, an ultrasound-based cardiac imaging modality. Abnormalities in the E/A ratio suggest that the left ventricle, which pumps blood into the systemic circulation, cannot fill with blood properly in the period between contractions. This phenomenon is referred to as diastolic dysfunction and can eventually lead to the symptoms of heart failure.

Cardiac physiology or heart function is the study of healthy, unimpaired function of the heart: involving blood flow; myocardium structure; the electrical conduction system of the heart; the cardiac cycle and cardiac output and how these interact and depend on one another.

A plot of a system's pressure versus volume has long been used to measure the work done by the system and its efficiency. This analysis can be applied to heat engines and pumps, including the heart. A considerable amount of information on cardiac performance can be determined from the pressure vs. volume plot. A number of methods have been determined for measuring PV-loop values experimentally.

The heart is a muscular organ situated in the mediastinum. It consists of four chambers, four valves, two main arteries, and the conduction system. The left and right sides of the heart have different functions: the right side receives de-oxygenated blood through the superior and inferior venae cavae and pumps blood to the lungs through the pulmonary artery, and the left side receives saturated blood from the lungs.

References

  1. ↑ "How your Heart works?". HealthyWa.
  2. ↑ Schlosser T, Pagonidis K, Herborn CU, Hunold P, Waltering KU, Lauenstein TC, Barkhausen J (March 2005). "Assessment of left ventricular parameters using 16-MDCT and new software for endocardial and epicardial border delineation". AJR. American Journal of Roentgenology. 184 (3): 765–73. doi:10.2214/ajr.184.3.01840765. PMID   15728595.
  3. ↑ Leng J. Right ventricle. In: Weyman AE, ed. Principle andpractice of echocardiography. Philadelphia: Lippincott Williams& Wilkins, 1994:901–21
  4. 1 2 Haddad F, Couture P, Tousignant C, Denault AY. The right ventricle in cardiac surgery, a perioperative perspective: I. Anatomy, physiology, and assessment. Anesth Analg. 2009;108(2):407-21. doi:10.1213/ane.0b013e31818f8623.
  5. 1 2 Haddad F, Couture P, Tousignant C, Denault AY. The right ventricle in cardiac surgery, a perioperative perspective: I. Anatomy, physiology, and assessment. Anesth Analg. 2009;108(2):407-21. doi:10.1213/ane.0b013e31818f8623.
  6. ↑ Farb A, Burke AP, Virmani R. Anatomy and pathology of theright ventricle (including acquired tricuspid and pulmonicvalve disease). Cardiol Clin 1992;10:1–21
  7. 1 2 3 4 5 6 7 Maceira AM, Prasad SK, Khan M, Pennell DJ (December 2006). "Reference right ventricular systolic and diastolic function normalized to age, gender and body surface area from steady-state free precession cardiovascular magnetic resonance" (PDF). European Heart Journal. 27 (23): 2879–88. doi:10.1093/eurheartj/ehl336. PMID   17088316.
  8. 1 2 3 4 5 6 7 Maceira A (2006). "Normalized Left Ventricular Systolic and Diastolic Function by Steady State Free Precession Cardiovascular Magnetic Resonance". Journal of Cardiovascular Magnetic Resonance. 8: 417–426. doi:10.1080/10976640600572889.(subscription required)
  9. 1 2 Normal ranges for heart rate are among the narrowest limits between bradycardia and tachycardia. See the Bradycardia and Tachycardia articles for more detailed limits.
  10. 1 2 "Normal Hemodynamic Parameters – Adult" (PDF). Edwards Lifesciences LLC. 2009.
  11. ↑ Table 30-1 in: Goers TA, Klingensmith ME, Chen LE, Glasgow SC (2008). The Washington Manual of Surgery. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. ISBN   978-0-7817-7447-5.
  12. ↑ Ventricular+pressure at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  13. ↑ Salem R, Denault AY, Couture P, Bélisle S, Fortier A, Guertin MC, Carrier M, Martineau R (September 2006). "Left ventricular end-diastolic pressure is a predictor of mortality in cardiac surgery independently of left ventricular ejection fraction". British Journal of Anaesthesia. 97 (3): 292–7. doi: 10.1093/bja/ael140 . PMID   16835254.
  14. ↑ Brenner JI, Baker KR, Berman MA (October 1980). "Prediction of left ventricular pressure in infants with aortic stenosis". British Heart Journal. 44 (4): 406–10. doi:10.1136/hrt.44.4.406. PMC   482419 . PMID   7426202.
  15. ↑ "Aortic Stenosis: Overview – eMedicine Emergency Medicine" . Retrieved 2009-02-28.
  16. ↑ Redington AN, Gray HH, Hodson ME, Rigby ML, Oldershaw PJ (January 1988). "Characterisation of the normal right ventricular pressure-volume relation by biplane angiography and simultaneous micromanometer pressure measurements". British Heart Journal. 59 (1): 23–30. doi:10.1136/hrt.59.1.23. PMC   1277068 . PMID   3342146.
  17. ↑ van Dam I, van Zwieten G, Vogel JA, Meijler FL (1980). "Left ventricular (diastolic) dimensions and relaxation in patients with atrial fibrillation". European Heart Journal. Suppl A: 149–56. doi:10.1093/eurheartj/1.suppl_1.149. PMID   7274225.
  18. ↑ Kurita A (2008). "Longitudinal fractional shortening and its relation to diastolic cardiac function". Journal of Medical Ultrasonics. 35 (3): 113–118. doi:10.1007/s10396-008-0176-0. PMID   27278833. S2CID   22506795.
  19. ↑ Grimsgaard S, Bønaa KH, Hansen JB, Myhre ES (July 1998). "Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans". The American Journal of Clinical Nutrition. 68 (1): 52–9. doi: 10.1093/ajcn/68.1.52 . PMID   9665096.
  20. 1 2 3 Basavarajaiah S, Wilson M, Naghavi R, Whyte G, Turner M, Sharma S (November 2007). "Physiological upper limits of left ventricular dimensions in highly trained junior tennis players". British Journal of Sports Medicine. 41 (11): 784–8. doi:10.1136/bjsm.2006.033993. PMC   2465269 . PMID   17957014.
  21. 1 2 3 4 5 6 7 Page 41 in: O'Connor, Simon (2009). Examination Medicine (The Examination). Edinburgh: Churchill Livingstone. ISBN   978-0-7295-3911-1.
  22. 1 2 3 Kawel, Nadine; Turkbey, Evrim B.; Carr, J. Jeffrey; Eng, John; Gomes, Antoinette S.; Hundley, W. Gregory; Johnson, Craig; Masri, Sofia C.; Prince, Martin R.; van der Geest, Rob J.; Lima, João A.C.; Bluemke, David A. (2012). "Normal Left Ventricular Myocardial Thickness for Middle-Aged and Older Subjects With Steady-State Free Precession Cardiac Magnetic Resonance". Circulation: Cardiovascular Imaging. 5 (4): 500–508. doi: 10.1161/CIRCIMAGING.112.973560 . ISSN   1941-9651. PMC   3412148 . PMID   22705587.
  23. 1 2 Karna, S.K.; Rohit, M.K.; Wanchu, A. (2015). "Right ventricular thickness as predictor of global myocardial performance in systemic sclerosis: A Doppler tissue imaging study". Indian Heart Journal. 67 (6): 521–528. doi: 10.1016/j.ihj.2015.06.021 . ISSN   0019-4832. PMC   4699958 . PMID   26702679.
  24. ↑ Lang, Roberto M. (1985). "Adverse Cardiac Effects of Acute Alcohol Ingestion in Young Adults". Annals of Internal Medicine. 102 (6): 742–747. doi:10.7326/0003-4819-102-6-742. ISSN   0003-4819. PMID   3994186.
  25. ↑ chfpatients.com > Fractional Shortening (FS) Retrieved on April 7, 2010
  26. ↑ "Left ventricle size – Echocardiography in ICU". Stanford.edu. 2009-06-23. Retrieved 2018-09-21.
  27. ↑ de Simone G, Devereux RB, Roman MJ, Ganau A, Saba PS, Alderman MH, Laragh JH (May 1994). "Assessment of left ventricular function by the midwall fractional shortening/end-systolic stress relation in human hypertension". Journal of the American College of Cardiology. 23 (6): 1444–51. doi: 10.1016/0735-1097(94)90390-5 . PMID   8176105.
  28. 1 2 Ugander M, Carlsson M, Arheden H (February 2010). "Short-axis epicardial volume change is a measure of cardiac left ventricular short-axis function, which is independent of myocardial wall thickness". American Journal of Physiology. Heart and Circulatory Physiology. 298 (2): H530-5. doi:10.1152/ajpheart.00153.2009. PMID   19933422.
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