February 28 – The Baltimore and Ohio Railroad is incorporated, becoming the first railroad in America offering commercial transportation of both people and freight.
March 12 – In Brown v. Maryland, the United States Supreme Court ruled that imported goods in their original package are under federal jurisdiction and thus not subject to state regulation.
July 4 –Madawaska declares independence from the United States, as part of a border dispute between British North America and the United States, so that it can be annexed by Maine.
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