February 3 – The National Deaf Mute College (later renamed Gallaudet University) is established in Washington, D.C., becoming the first school for the advanced education of the deaf.
May 1 –Stephen Adams, U.S. Senator from Mississippi from 1852 to 1857 (born 1807)
May 26 –James Bell, U.S. Senator from New Hampshire from 1855 to 1857 (born 1804)
June 19 –Alexander Twilight, educator and minister, first African-American known to have earned a bachelor's degree from an American college or university (Middlebury College, 1823) (born 1795)
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