March 2–3 – The Great Slave Auction, the largest single sale of slaves in U.S. history, with more than 400 people sold, takes place near Savannah, Georgia.
April 20 –Daniel E. Sickles, a New York Congressman, is acquitted of the murder of Philip Barton Key on grounds of temporary insanity.[1] The case marked the first successful use of the "temporary insanity" legal defense.[2]
June 8 – The discovery of the Comstock Lode in the western Utah Territory (present-day Nevada) sets off a rush of prospectors to the area.
June 15 – The so-called Pig War border dispute between the Americans and the British on the San Juan Islands begins with the shooting of the namesake pig; the episode is resolved in October without human bloodshed.
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