April 19 – Actress-playwright Mae West is sentenced to ten days incarceration for "corrupting the morals of youth" for her comedy-drama Sex after 375 performances on Broadway.
April 22–May 5 – The Great Mississippi Flood of 1927 affects 700,000 people in the greatest national disaster in U.S. history at this time.
May 14 – The University of Chicago's local collegiate organization, Phi Sigma, becomes incorporated under the laws of the State of Illinois as Eta Sigma Phi, the National Honorary Classical Fraternity.
August 23 – After six years of appeals, as protests rage in capital cities around the world, Nicola Sacco and Bartolomeo Vanzetti are electrocuted at midnight in Charlestown, Massachusetts.
August 26 – Paul Redfern leaves Brunswick, Georgia, flying his Stinson DetroiterPort of Brunswick to attempt a solo non-stop flight to Rio de Janeiro, Brazil. He later crashes in the Venezuela jungle (the crash site is never located).
September 18 – The Columbia Phonographic Broadcasting System (later known as CBS) is formed and goes on the air with 47 radio stations.
September 29 – 79 are killed and 550 are injured when a tornado strikes the St. Louis, Missouri area; it is the second-costliest and at least 24th-deadliest tornado in U.S. history.
November 3–4 – Floods devastating Vermont incur the "worst natural disaster in the state's history".[2]
November 4
Frank Heath and his horse Gypsy Queen return to Washington, D.C., having completed a 2-year journey of 11,356 miles to all 48 states.
The 7.3 MwLompoc earthquake affected the central coast of California with a maximum Mercalli intensity of VIII (Severe), causing a tsunami and moderate damage.
November 10 – Unexplained explosions occur in Canton, Ohio.
December 15 – Marion Parker, 12, is kidnapped in Los Angeles. Her dismembered body is found on December 19, prompting the largest manhunt to date on the West Coast for her killer, William Edward Hickman, who is arrested on December 22 in Oregon.
December 27 – Kern and Hammerstein's musical play Show Boat, based on Edna Ferber's novel, opens on Broadway and goes on to become the first great classic of the American musical theatre.
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