Albinism in humans

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Albinism
Other namesAchromia, achromasia, achromatosis
Albinisitic man portrait.jpg
Young African boy with albinism
Pronunciation
  • albino ( UK: /ælˈbiːnoʊ/ , [1] or US: /ælˈbaɪnoʊ/ ) [2]
Specialty Dermatology

Albinism is a congenital condition characterized in humans by the partial or complete absence of pigment in the skin, hair and eyes. Albinism is associated with a number of vision defects, such as photophobia, nystagmus, and amblyopia. Lack of skin pigmentation makes for more susceptibility to sunburn and skin cancers. In rare cases such as Chédiak–Higashi syndrome, albinism may be associated with deficiencies in the transportation of melanin granules. This also affects essential granules present in immune cells, leading to increased susceptibility to infection. [3]

Contents

Albinism results from inheritance of recessive gene alleles and is known to affect all vertebrates, including humans. It is due to absence or defect of tyrosinase, a copper-containing enzyme involved in the production of melanin. Unlike humans, other animals have multiple pigments and for these, albinism is considered to be a hereditary condition characterised by the absence of melanin in particular, in the eyes, skin, hair, scales, feathers or cuticle. [4] While an organism with complete absence of melanin is called an albino, an organism with only a diminished amount of melanin is described as leucistic or albinoid. [5] The term is from the Latin albus, "white".

Signs and symptoms

Girl with albinism from Papua New Guinea Albinistic girl papua new guinea.jpg
Girl with albinism from Papua New Guinea

There are two principal types of albinism: oculocutaneous, affecting the eyes, skin and hair, and ocular affecting the eyes only.

There are different types of oculocutaneous albinism depending on which gene has undergone mutation. With some there is no pigment at all. The other end of the spectrum of albinism is "a form of albinism called rufous oculocutaneous albinism, which usually affects dark-skinned people". [6]

According to the National Organization for Albinism and Hypopigmentation, "With ocular albinism, the color of the iris of the eye may vary from blue to green or even brown, and sometimes darkens with age. However, when an optometrist or ophthalmologist examines the eye by shining a light from the side of the eye, the light shines back through the iris since very little pigment is present." [7]

Because individuals with albinism have skin that entirely lacks the dark pigment melanin, which helps protect the skin from the sun's ultraviolet radiation, their skin can burn more easily from overexposure. [8]

The human eye normally produces enough pigment to color the iris blue, green or brown and lend opacity to the eye. In photographs, those with albinism are more likely to demonstrate "red eye", due to the red of the retina being visible through the iris. Lack of pigment in the eyes also results in problems with vision, both related and unrelated to photosensitivity. [9]

Those with albinism are generally as healthy as the rest of the population (but see related disorders below), with growth and development occurring as normal, and albinism by itself does not cause mortality, [10] although the lack of pigment blocking ultraviolet radiation increases the risk of melanomas (skin cancers) and other problems. [11]

Visual problems

Malian Mandinka singer Salif Keita with albinism Mali Salif Keita2 400.jpg
Malian Mandinka singer Salif Keita with albinism

Development of the optical system is highly dependent on the presence of melanin. For this reason, the reduction or absence of this pigment in people with albinism may lead to:

Eye conditions common in albinism include:

The improper development of the retinal pigment epithelium (RPE), which in normal eyes absorbs most of the reflected sunlight, further increases glare due to light scattering within the eye. [13] The resulting sensitivity (photophobia) generally leads to discomfort in bright light, but this can be reduced by the use of sunglasses or brimmed hats. [14]

Genetics

Family with albinism, showing inheritance Gould Pyle 73.jpg
Family with albinism, showing inheritance

Oculocutaneous albinism is generally the result of the biological inheritance of genetically recessive alleles (genes) passed from both parents of an individual such as OCA1 and OCA2. A mutation in the human TRP-1 gene may result in the deregulation of melanocyte tyrosinase enzymes, a change that is hypothesized to promote brown versus black melanin synthesis, resulting in a third oculocutaneous albinism (OCA) genotype, "OCA3". [15] Some rare forms are inherited from only one parent. There are other genetic mutations which are proven to be associated with albinism. All alterations, however, lead to changes in melanin production in the body. [10] [16]

The chance of offspring with albinism resulting from the pairing of an organism with albinism and one without albinism is low. However, because organisms (including humans) can be carriers of genes for albinism without exhibiting any traits, albinistic offspring can be produced by two non-albinistic parents. Albinism usually occurs with equal frequency in both sexes. [10] An exception to this is ocular albinism, which it is passed on to offspring through X-linked inheritance. Thus, ocular albinism occurs more frequently in males as they have a single X and Y chromosome, unlike females, whose genetics are characterized by two X chromosomes. [17]

There are two different forms of albinism: a partial lack of the melanin is known as hypomelanism, or hypomelanosis, and the total absence of melanin is known as amelanism or amelanosis. [18]

Enzyme

The enzyme defect responsible for OCA1-type albinism is tyrosine 3-monooxygenase (tyrosinase), which synthesizes melanin from the amino acid tyrosine. [19]

Evolutionary theories

It is suggested that the early genus Homo (humans in the broader sense) started to evolve in East Africa around 3 million years ago. [20] The dramatic phenotypic change from the ape-like Australopithecus to early Homo is hypothesized to have involved the extreme loss of body hair – except for areas most exposed to UV radiation, such as the head – to allow for more efficient thermoregulation in the early hunter-gatherers. The skin that would have been exposed upon general body hair loss in these early proto-humans would have most likely been non-pigmented, reflecting the pale skin underlying the hair of our chimpanzee relatives. A positive advantage would have been conferred to early hominids inhabiting the African continent that were capable of producing darker skin – those who first expressed the eumelanin-producing MC1R allele – which protected them from harmful epithelium-damaging ultraviolet rays. Over time, the advantage conferred to those with darker skin may have led to the prevalence of darker skin on the continent. The positive advantage, however, would have had to be strong enough so as to produce a significantly higher reproductive fitness in those who produced more melanin. The cause of a selective pressure strong enough to cause this shift is an area of much debate. Some hypotheses include the existence of significantly lower reproductive fitness in people with less melanin due to lethal skin cancer, lethal kidney disease due to excess vitamin D formation in the skin of people with less melanin, or simply natural selection due to mate preference and sexual selection. [20]

When comparing the prevalence of albinism in Africa to its prevalence in other parts of the world, such as Europe and the United States, the potential evolutionary effects of skin cancer as a selective force due to its effect on these populations may not be insignificant. [20] It would follow, then, that there would be stronger selective forces acting on albino individuals in Africa than on albinos in Europe and the US. [21] In two separate studies in Nigeria, very few people with albinism appear to survive to old age. One study found that 89% of people diagnosed with albinism are between 0 and 30 years of age, while the other found that 77% of albinos were under the age of 20. [21]

However, it has also been theorized that albinism may have been able to spread in some Native American communities, because albino males were culturally revered and assumed as having divine origins. The very high incidence of albinism among the Hopi tribe has been frequently attributed to the privileged status of albino males in Hopi society, who were not required to perform physical work outdoors, shielding them from the harmful effects of UV radiation. This privileged status of albino males in Hopi society allowed them to reproduce with large numbers of non-albino women, spreading the genes that are associated with albinism. [22] [23]

Diagnosis

Genetic testing can confirm albinism and what variety it is, but offers no medical benefits, except in the case of non-OCA disorders. Such disorders cause other medical problems in conjunction with albinism, and may be treatable. Genetic tests are currently available for parents who want to find out if they are carriers of ty-neg albinism. Diagnosis of albinism involves carefully examining a person's eyes, skin and hairs. Genealogical analysis can also help.

Albinism can also be a feature of several syndromes: [24]

Management

Since there is no cure for albinism, it is managed through lifestyle adjustments. People with albinism need to take care not to get sunburnt and should have regular healthy skin checks by a dermatologist.[ citation needed ]

For the most part, treatment of the eye conditions consists of visual rehabilitation. Surgery is possible on the extra-ocular muscles to decrease strabismus. [8] Nystagmus-damping surgery can also be performed, to reduce the "shaking" of the eyes back and forth. [25] The effectiveness of all these procedures varies greatly and depends on individual circumstances.[ citation needed ]

Glasses (often with tinted lenses), low vision aids, large-print materials, and bright angled reading lights can help individuals with albinism. Some people with albinism do well using bifocals (with a strong reading lens), prescription reading glasses, hand-held devices such as magnifiers or monoculars or wearable devices like eSight and Brainport. [14] [26]

The condition may lead to abnormal development of the optic nerve and sunlight may damage the retina of the eye as the iris cannot filter out excess light due to a lack of pigmentation. Photophobia may be ameliorated by the use of sunglasses which filter out ultraviolet light. [27] Some use bioptics, glasses which have small telescopes mounted on, in, or behind their regular lenses, so that they can look through either the regular lens or the telescope. Newer designs of bioptics use smaller light-weight lenses. Some US states allow the use of bioptic telescopes for driving motor vehicles.[ citation needed ] (See also NOAH bulletin "Low Vision Aids".)

There are a number of national support groups across the globe which come under the umbrella of the World Albinism Alliance. [28]

Epidemiology

Albinism affects people of all ethnic backgrounds; its frequency worldwide is estimated to be approximately one in 17,000. Prevalence of the different forms of albinism varies considerably by population, and is highest overall in people of sub-Saharan African descent. [29] Today, the prevalence of albinism in sub-Saharan Africa is around 1 in 5,000, while in Europe and the US it is around 1 in 20,000 of the European derived population. [30] [20] Rates as high as 1 in 1,000 have been reported for some populations in Zimbabwe and other parts of Southern Africa. [21]

Certain ethnic groups and populations in isolated areas exhibit heightened susceptibility to albinism, presumably due to genetic factors. These include notably the Native American Kuna, Zuni and Hopi nations (respectively of Panama, New Mexico and Arizona); Japan, in which one particular form of albinism is unusually common (OCA 4); [31] and Ukerewe Island, the population of which shows a very high incidence of albinism. [32]

Society and culture

Special status of albinos in Native American culture

The man seated left is a Zuni with albinism. The Zuni people and other indigenous tribes of the American Southwest have a very high incidence of albinism. Curbsites of the Zuni Pueblos Albino and Zuni Indians New Mexico 1873 - NARA - 519774 (R-2).jpg
The man seated left is a Zuni with albinism. The Zuni people and other indigenous tribes of the American Southwest have a very high incidence of albinism.

In some Native American and South Pacific cultures, people with albinism have been traditionally revered, because they were considered heavenly beings associated with the sky. [34] [35] Among various indigenous tribes in South America, albinos were able to live luxurious lives due to their divine status. [36] This special status was applied mainly to male albinos. [37] It has been theorized that the very high level of albinism among some Native American tribes can be attributed to sexual privileges given to male albinos, which allowed them to reproduce with large numbers of non-albino women in their tribes, leading to the spread of genes that are associated with albinism. [34]

Persecution of people with albinism

Humans with albinism often face social and cultural challenges (even threats), as the condition is often a source of ridicule, discrimination, or even fear and violence. It is especially socially stigmatised in many African societies. A study conducted in Nigeria on albino children stated that "they experienced alienation, avoided social interactions and were less emotionally stable. Furthermore, affected individuals were less likely to complete schooling, find employment, and find partners". [38] Many cultures around the world have developed beliefs regarding people with albinism.[ citation needed ]

In African countries such as Tanzania [39] and Burundi, [40] [41] there has been an unprecedented rise in witchcraft-related killings of people with albinism in recent years, because their body parts are used in potions sold by witch doctors. [42] Numerous authenticated incidents have occurred in Africa during the 21st century. [43] [44] [45] [46] For example, in Tanzania, in September 2009, three men were convicted of killing a 14-year-old albino boy and severing his legs in order to sell them for witchcraft purposes. [47] Again in Tanzania and Burundi in 2010, the murder and dismemberment of a kidnapped albino child was reported from the courts, [40] as part of a continuing problem. The US-based National Geographic Society estimated that in Tanzania a complete set of albino body parts is worth US$75,000. [48] [49]

Another harmful and false belief is that sex with an albinistic woman will cure a man of HIV. This has led, for example in Zimbabwe, to rapes (and subsequent HIV infection). [50]

Famous people with albinism include historical figures such as Oxford don William Archibald Spooner; actor-comedian Victor Varnado; musicians such as Johnny and Edgar Winter, Salif Keita, Winston "Yellowman" Foster, Brother Ali, Sivuca, Hermeto Pascoal, Willie "Piano Red" Perryman, Kalash Criminel; actor-rapper Krondon, and fashion models Connie Chiu, Ryan "La Burnt" Byrne and Shaun Ross. Emperor Seinei of Japan is thought to have albinism because he was said to have been born with white hair.[ citation needed ]

International Albinism Awareness Day

International Albinism Awareness Day was established after a motion was accepted on 18 December 2014 by the United Nations General Assembly, proclaiming that 13 June would be known as International Albinism Awareness Day as of 2015. [51] This was followed by a mandate created by the United Nations Human Rights Council that appointed Ms. Ikponwosa Ero, who is from Nigeria, as the first Independent Expert on the enjoyment of human rights by persons with albinism. [52]

See also

Related Research Articles

<span class="mw-page-title-main">Human skin color</span>

Human skin color ranges from the darkest brown to the lightest hues. Differences in skin color among individuals is caused by variation in pigmentation, which is the result of genetics, exposure to the sun, disorders, or some combination thereof. Differences across populations evolved through natural selection or sexual selection, because of social norms and differences in environment, as well as regulations of the biochemical effects of ultraviolet radiation penetrating the skin.

<span class="mw-page-title-main">Melanin</span> Group of natural pigments found in most organisms

Melanin is a family of biomolecules organized as oligomers or polymers, which among other functions provide the pigments of many organisms. Melanin pigments are produced in a specialized group of cells known as melanocytes.

<span class="mw-page-title-main">Melanocyte</span> Melanin-producing cells of the skin

Melanocytes are melanin-producing neural crest-derived cells located in the bottom layer of the skin's epidermis, the middle layer of the eye, the inner ear, vaginal epithelium, meninges, bones, and heart found in many mammals and birds. Melanin is a dark pigment primarily responsible for skin color. Once synthesized, melanin is contained in special organelles called melanosomes which can be transported to nearby keratinocytes to induce pigmentation. Thus darker skin tones have more melanosomes present than lighter skin tones. Functionally, melanin serves as protection against UV radiation. Melanocytes also have a role in the immune system.

<span class="mw-page-title-main">Tiger eye</span> Color of horses eyes

Tiger eye or goat eye is a gene causing diluted eye color in horses. There are two variants, Tiger-eye 1 (TE1) and Tiger-eye 2 (TE2), which are both recessive. Horses displaying tiger eye typically have a yellow, orange, or amber iris. Tiger eye has only been found in Puerto Rican Paso Fino horses. Horses of related breeds were tested, and none were found to have either tiger eye allele. No obvious link between eye shade and coat color was seen, making this the first studied gene in horses to affect eye color but not coat color. Tiger eye does not appear to affect vision, and there were no signs of reduced pigment on the retina or retinal pigment epithelium.

<span class="mw-page-title-main">Eye color</span> Polygenic phenotypic characteristic

Eye color is a polygenic phenotypic trait determined by two factors: the pigmentation of the eye's iris and the frequency-dependence of the scattering of light by the turbid medium in the stroma of the iris.

<span class="mw-page-title-main">Hypopigmentation</span> Area of skin becoming lighter than the baseline skin color

Hypopigmentation is characterized specifically as an area of skin becoming lighter than the baseline skin color, but not completely devoid of pigment. This is not to be confused with depigmentation, which is characterized as the absence of all pigment. It is caused by melanocyte or melanin depletion, or a decrease in the amino acid tyrosine, which is used by melanocytes to make melanin. Some common genetic causes include mutations in the tyrosinase gene or OCA2 gene. As melanin pigments tend to be in the skin, eye, and hair, these are the commonly affected areas in those with hypopigmentation.

<span class="mw-page-title-main">Tyrosinase</span> Enzyme for controlling the production of melanin

Tyrosinase is an oxidase that is the rate-limiting enzyme for controlling the production of melanin. The enzyme is mainly involved in two distinct reactions of melanin synthesis otherwise known as the Raper–Mason pathway. Firstly, the hydroxylation of a monophenol and secondly, the conversion of an o-diphenol to the corresponding o-quinone. o-Quinone undergoes several reactions to eventually form melanin. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation. It is found inside melanosomes which are synthesized in the skin melanocytes. In humans, the tyrosinase enzyme is encoded by the TYR gene.

<span class="mw-page-title-main">Leucism</span> Partial loss of pigmentation in an animal

Leucism is a wide variety of conditions that result in partial loss of pigmentation in an animal—causing white, pale, or patchy coloration of the skin, hair, feathers, scales, or cuticles, but not the eyes. It is occasionally spelled leukism. Some genetic conditions that result in a "leucistic" appearance include piebaldism, Waardenburg syndrome, vitiligo, Chédiak–Higashi syndrome, flavism, isabellinism, xanthochromism, axanthism, amelanism, and melanophilin mutations. Pale patches of skin, feathers, or fur can also result from injury.

<span class="mw-page-title-main">Hermansky–Pudlak syndrome</span> Medical condition

Heřmanský–Pudlák syndrome is an extremely rare autosomal recessive disorder which results in oculocutaneous albinism, bleeding problems due to a platelet abnormality, and storage of an abnormal fat-protein compound. It is thought to affect around 1 in 500,000 people worldwide, with a significantly higher occurrence in Puerto Ricans, with a prevalence of 1 in 1800. Many of the clinical research studies on the disease have been conducted in Puerto Rico.

Oculocutaneous albinism is a form of albinism involving the eyes, the skin, and the hair. Overall, an estimated 1 in 20,000 people worldwide are born with oculocutaneous albinism. OCA is caused by mutations in several genes that control the synthesis of melanin within the melanocytes. Seven types of oculocutaneous albinism have been described, all caused by a disruption of melanin synthesis and all autosomal recessive disorders. Oculocutaneous albinism is also found in non-human animals.

<span class="mw-page-title-main">Piebaldism</span> Medical condition

Piebaldism refers to the absence of mature melanin-forming cells (melanocytes) in certain areas of the skin and hair. It is a rare autosomal dominant disorder of melanocyte development. Common characteristics include a congenital white forelock, scattered normal pigmented and hypopigmented macules and a triangular shaped depigmented patch on the forehead. There is nevertheless great variation in the degree and pattern of presentation, even within affected families. In some cases, piebaldism occurs together with severe developmental problems, as in Waardenburg syndrome and Hirschsprung's disease.

<span class="mw-page-title-main">White horse</span> Horse coat color

A white horse is born predominantly white and stays white throughout its life. A white horse has mostly pink skin under its hair coat, and may have brown, blue, or hazel eyes. "True white" horses, especially those that carry one of the dominant white (W) genes, are rare. Most horses that are commonly referred to as "white" are actually "gray" horses whose hair coats are completely white. Gray horses may be born of any color and their hairs gradually turn white as time goes by and take on a white appearance. Nearly all gray horses have dark skin, except under any white markings present at birth. Skin color is the most common method for an observer to distinguish between mature white and gray horses.

<span class="mw-page-title-main">P protein</span> Protein-coding gene in humans

P protein, also known as melanocyte-specific transporter protein or pink-eyed dilution protein homolog, is a protein that in humans is encoded by the oculocutaneous albinism II (OCA2) gene. The P protein is believed to be an integral membrane protein involved in small molecule transport, specifically of tyrosine—a precursor of melanin. Certain mutations in OCA2 result in type 2 oculocutaneous albinism. OCA2 encodes the human homologue of the mouse p gene.

<span class="mw-page-title-main">Membrane-associated transporter protein</span> Protein

Membrane-associated transporter protein (MATP), also known as solute carrier family 45 member 2 (SLC45A2) or melanoma antigen AIM1, is a protein that in humans is encoded by the SLC45A2 gene.

Oculocutaneous albinism type I or type 1A is form of the autosomal recessive condition oculocutaneous albinism that is caused by a dysfunction in the gene for tyrosinase.

<span class="mw-page-title-main">Ocular albinism type 1</span> Most common type of ocular albinism

Ocular albinism type 1(OA1) is the most common type of ocular albinism, with a prevalence rate of 1:50,000. It is an inheritable classical Mendelian type X-linked recessive disorder wherein the retinal pigment epithelium lacks pigment while hair and skin appear normal. Since it is usually an X-linked disorder, it occurs mostly in males, while females are carriers unless they are homozygous. About 60 missense and nonsense mutations, insertions, and deletions have been identified in Oa1. Mutations in OA1 have been linked to defective glycosylation and thus improper intracellular transportation.

<span class="mw-page-title-main">Acromelanism</span> Coloration of animal coat/fur

Acromelanism is a genetic condition that results in pigmentation being affected by temperature. It results in point coloration where the extremities of an animal are a different colour to the rest of the body. It is commonly known for the coloration of Siamese and related breeds of cat, but can be found in many other species including dogs, rabbits, rats, mice, guinea pigs, minks, and gerbils. It is a specific type of point coloration.

<span class="mw-page-title-main">Amelanism</span> Pigmentation abnormality

Amelanism is a pigmentation abnormality characterized by the lack of pigments called melanins, commonly associated with a genetic loss of tyrosinase function. Amelanism can affect fish, amphibians, reptiles, birds, and mammals including humans. The appearance of an amelanistic animal depends on the remaining non-melanin pigments. The opposite of amelanism is melanism, a higher percentage of melanin.

<span class="mw-page-title-main">Albinism</span> Disorder causing lack of pigmentation

Albinism is the congenital absence of melanin in an animal or plant resulting in white hair, feathers, scales and skin and reddish pink or blue eyes. Individuals with the condition are referred to as albinos.

Ocular albinism late onset sensorineural deafness (OASD) is a rare, X-linked recessive disease characterized by intense visual impairments, reduced retinal pigments, translucent pale-blue irises and moderately severe hearing loss from adolescence to middle-age. It is a subtype of Ocular Albinism (OA) that is linked to Ocular albinism type I (OA1). OA1 is the most common form of ocular albinism, affecting at least 1/60,000 males.

References

  1. ↑ "albino". Random House Dictionary. 2017. Retrieved 10 November 2017– via Dictionary.Reference.com.
  2. ↑ "American Pronunciation of albino". Macmillan Dictionary. 2017. Retrieved 10 November 2017.
  3. ↑ Kaplan, J.; De Domenico, I.; Ward, D. M. (2008). "Chediak-Higashi syndrome". Current Opinion in Hematology. 15 (1): 22–29. doi:10.1097/MOH.0b013e3282f2bcce. PMID   18043242. S2CID   43243529.
  4. ↑ "Albinism". Encyclopædia Britannica. Retrieved 27 January 2015.
  5. ↑ Tietz, W. (1963). "A Syndrome of Deaf-Mutism Associated with Albinism Showing Dominant Autosomal Inheritance". American Journal of Human Genetics. 15 (3): 259–264. PMC   1932384 . PMID   13985019.
  6. ↑ "oculocutaneous albinism". Genetics Home Reference. Bethesda, Maryland: U.S. National Library of Medicine, National Institutes of Health. October 2015. Retrieved 10 November 2017. This tertiary source reuses information from other sources but does not name them.
  7. ↑ "Information Bulletin – Ocular Albinism". National Organization for Albinism and Hypopigmentation. Archived from the original on 12 March 2017. Retrieved 11 March 2017.
  8. 1 2 3 4 5 6 7 Chen, Harold (2006). Atlas of genetic diagnosis and counseling. Totowa, New Jersey: Humana Press. pp. 37–40. ISBN   9781588296818 . Retrieved 22 July 2010.
  9. ↑ Khanna, Pragya (30 December 2013). Essentials of Genetics. I. K. International. ISBN   9789380026343.
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  11. ↑ Richter, Roxane; Flowers, Thomas; Bongmba, Elias (2017). Witchcraft as a Social Diagnosis: Traditional Ghanaian Beliefs and Global Health. Lexington Books. ISBN   9781498523196.
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  13. ↑ Sowka, Joseph W.; Gurwood, Andrew S.; Kabat, Allan G. (15 April 2009). "Albinism" (PDF). The Handbook of Ocular Disease Management: Supplement to Review of Optometry (11th ed.). New York: Jobson Medical Information. pp. 63A–65A. Archived (PDF) from the original on 24 August 2015. Retrieved 10 November 2017– via ReviewOfOptometry.com.
  14. 1 2 King, Richard; Summers, C. Gail; Haefemeyer, James W.; LeRoy, Bonnie (2004). "Facts About Albinism". Albinism.Med.UMN.edu. University of Minnesota. Archived from the original on 25 January 2009. Retrieved 10 November 2017.
  15. ↑ Boissy, R. E.; Zhao, H.; Oetting, W. S.; Austin, L. M.; Wildenberg, S. C.; Boissy, Y. L.; Zhao, Y.; Sturm, R. A.; Hearing, V. J.; King, R. A.; Nordlund, J. J. (1996). "Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: A new subtype of albinism classified as "OCA3"". American Journal of Human Genetics. 58 (6): 1145–1156. PMC   1915069 . PMID   8651291.
  16. ↑ Online Mendelian Inheritance in Man, at Johns Hopkins University (see also Mendelian Inheritance in Man for more information about this source).
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  20. 1 2 3 4 Greaves, M. (2014). "Was skin cancer a selective force for black pigmentation in early hominin evolution?". Proceedings of the Royal Society B: Biological Sciences. 281 (1781): 20132955. doi:10.1098/rspb.2013.2955. PMC   3953838 . PMID   24573849.
  21. 1 2 3 Hong, E. S.; Zeeb, H.; Repacholi, M. H. (2006). "Albinism in Africa as a public health issue". BMC Public Health. 6: 212. doi: 10.1186/1471-2458-6-212 . PMC   1584235 . PMID   16916463.
  22. ↑ Hedrick, Philip W. (2005). Genetics of Populations. Jones & Bartlett Learning. pp. 2, 186. ISBN   9780763747725. An often-cited example of pleiotropic effects of viability and male-mating success in humans is for albinism in Hopi Indians, a small tribe in northern Arizona.
  23. ↑ Shuttleworth, Russell P. (2000). The Pursuit of Sexual Intimacy for Men with Cerebral Palsy. University of California, San Francisco. p. 74. The apparent reason for this phenomenon is that albino Hopi men developed a sexual advantage over non-albino men.
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  25. ↑ Lee, J. (May 2002). "Surgical management of nystagmus". Journal of the Royal Society of Medicine. 95 (5): 238–241. doi:10.1177/014107680209500506. PMC   1279676 . PMID   11983764.
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  27. ↑ "Albinism causes". News-Medical.net. 20 March 2018. Retrieved 27 July 2018.
  28. ↑ Anon (7 January 2015). "World Albinism Alliance". WAA. Archived from the original on 27 July 2018. Retrieved 27 July 2018.
  29. ↑ Gronskov, K.; Ek, J.; Brondum-Nielsen, K. (2 November 2007). "Oculocutaneous albinism". Orphanet Journal of Rare Diseases. 2: 43. doi: 10.1186/1750-1172-2-43 . PMC   2211462 . PMID   17980020.
  30. ↑ "About Albinism and Hypopigmentation". Albinism.org. National Organization for Albinism and Hypopigmentation. 15 December 2020.
  31. ↑ "Entry - #606574 - Albinism, Oculocutaneous, Type IV; OCA4 - OMIM". omim.org. Retrieved 5 March 2023.
  32. ↑ "Ukerewe Albino Society". Southern Africa's Children. 2009. Archived from the original on 24 December 2012. Retrieved 21 July 2010.
  33. ↑ Yi, Z.; Garrison, N.; Cohen-Barak, O.; Karafet, T. M.; King, R. A.; Erickson, R. P.; Hammer, M. F.; Brilliant, M. H. (January 2003). "A 122.5-kilobase deletion of the P gene underlies the high prevalence of oculocutaneous albinism type 2 in the Navajo population". American Journal of Human Genetics. 72 (1): 62–72. doi:10.1086/345380. PMC   420013 . PMID   12469324.
  34. 1 2 Hedrick, Philip W. (June 2003). "Hopi Indians, cultural selection, and albinism". American Journal of Physical Anthropology. 121 (2): 151–156. doi:10.1002/ajpa.10180. ISSN   0002-9483. PMID   12740958.
  35. ↑ Lester, Paul Martin (2003). Visual Communication: Images with Messages. Thomson/Wadsworth. p. 17. ISBN   9780534562441.
  36. ↑ Kromberg, Jennifer; Manga, Prashiela (2 January 2018). Albinism in Africa: Historical, Geographic, Medical, Genetic, and Psychosocial Aspects. Academic Press. p. 58. ISBN   9780128133170.
  37. ↑ Nagle, James J. (1984). Heredity and Human Affairs. Times Mirror/Mosby. p. 291. ISBN   9780801636264. Albino men in particular have been socially accepted in the dark-skinned Hopi society.
  38. ↑ Magna, P. (January 2014). "Biology and genetics of Oculocutaneous albinism and vitiligo-common pigmentation disorders in Southern Africa". South African Medical Journal. 103 (1): 984–988. doi:10.7196/samj.7046 (inactive 1 November 2024). PMID   24300644.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
  39. ↑ "Living in fear: Tanzania's albinos". BBC News . British Broadcasting Corporation. 21 July 2008. Retrieved 27 February 2010.
  40. 1 2 "Burundi albino boy 'dismembered'". BBC News. 24 October 2010.
  41. ↑ "Burundian albino murders denied". BBC News. 19 May 2009. Retrieved 27 February 2010.
  42. ↑ Vogel, Franck (August 2010). "Zeru, Zeru: Being Albino in Tanzania". Visura Magazine. No. 10. Westford, Vermont: Foto Visura. Retrieved 10 November 2017.
  43. ↑ "Man 'tried to sell' albino wife". BBC News. 13 November 2008. Retrieved 27 February 2010.
  44. ↑ "Tanzania albinos targeted again". BBC News. 27 July 2008. Retrieved 27 February 2010.
  45. ↑ Ntetema, Vicky (24 July 2008). "In hiding for exposing Tanzania witchdoctors". BBC News. Retrieved 27 February 2010.
  46. ↑ "Mothers hacked in albino attacks". BBC News. 14 November 2008. Retrieved 27 February 2010.
  47. ↑ "Death for Tanzania albino killers". BBC News. 23 September 2009. Retrieved 27 February 2010.
  48. ↑ Ingber, Sasha; Martin, Jacquelyn (27 January 2013). "Pictures: Inside the Lives of Albinos in Tanzania". National Geographic News. Washington DC: National Geographic Society. Archived from the original on 27 January 2013. Retrieved 10 November 2017.
  49. ↑ Tanzanians with albinism targeted for witchcraft. UNICEF. 30 April 2015. Archived from the original on 23 November 2021. Retrieved 22 February 2017– via YouTube.
  50. ↑ Machipisa, Lewis (25 November 2002). "The Last Minority Group to Find a Voice". IPSNews.net. Inter Press Service News Agency. Archived from the original on 21 January 2009. Retrieved 30 January 2010.
  51. ↑ "International Albinism Awareness Day".
  52. ↑ "Independent Expert on the enjoyment of human rights by persons with albinism". OHCHR.org. Geneva: Office of the High Commissioner for Human Rights, United Nations.
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