Cantuzumab ravtansine

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Cantuzumab ravtansine
Ravtansine ADCs.svg
Monoclonal antibody
Type Whole antibody
Source Humanized (from mouse)
Target MUC1
Clinical data
ATC code
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Identifiers
CAS Number
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UNII
KEGG
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Cantuzumab ravtansine (huC242-SPDB-DM4) is an antibody-drug conjugate designed for the treatment of cancers. The humanized monoclonal antibody cantuzumab (huC242) is linked to a cytotoxic agent, ravtansine (DM4). [1] It uses a more hindered disulfide linkage than cantuzumab mertansine. [2]

See also

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References

  1. World Health Organization (2011). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 105" (PDF). WHO Drug Information. 25 (2). Archived from the original (PDF) on April 1, 2012.
  2. Goldmacher VS, Singh R, Chittenden T, Kovtun Y (2013). "Linker technology and impact of linker design on ADC properties.". In Phillips GL (ed.). Antibody-Drug Conjugates and Immunotoxins: From Pre-Clinical Development to Therapeutic Applications. New York: Springer. pp. 117–135 (131). ISBN   978-1-4614-5456-4.