Girentuximab

Last updated
Girentuximab
Monoclonal antibody
Type Whole antibody
Source Chimeric
Target CA-IX
Clinical data
Trade names Rencarex
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
Chemical and physical data
Formula C6460H10006N1718O2018S48
Molar mass 145566.00 g·mol−1
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Girentuximab (trade name Rencarex) is a chimeric IgG1 monoclonal antibody to carbonic anhydrase IX (CAIX). [1] CAIX is expressed on the surface of most renal cancer cells and is hypothesized to be on the surface of other tumor cells. It is investigational agent in clinical trials for renal cell carcinoma. [2] Its development was suspended as a "naked" or unconjugated antibody during phase III trials due to efficacy. [3] [4]

Girentuximab was originally developed by Wilex AG, Germany. It was granted fast track status and orphan drug designation by the FDA for renal cancer. [5] In January 2017, Telix Pharmaceuticals Limited, an Australian biotechnology company, announced that it had in-licensed Girentuximab for use as a radioimmunoconjugate. [6]

It triggers antibody-dependent cell-mediated cytotoxicity (ADCC). When it binds to its antigen (carbonic anhydrase IX), it activates natural killer cells by binding to a receptor on the NK cells. [7]

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References

  1. "Statement On A Nonproprietary Name Adopted By The USAN Council: Girentuximab" (PDF). American Medical Association.
  2. Bedke J, Stenzl A (2013). "Immunotherapeutic strategies for the treatment of renal cell carcinoma: where are we now?". Expert Review of Anticancer Therapy. 13 (12): 1399–408. doi:10.1586/14737140.2013.856761. PMID   24215158. S2CID   30585644.
  3. "A Randomized, Double Blind Phase III Study to Evaluate Adjuvant cG250 Treatment Versus Placebo in Patients with Clear Cell RCC and High Risk of Recurrence (ARISER)". 31 October 2018.
  4. "Cyclacel's cancer drug isn't working in Phase III, but that won't stop the trial". Fierce Biotech. 16 December 2014.
  5. adisinsight.springer.com/drugs/800006571
  6. "WILEX signs antibody license agreement with Telix Pharmaceuticals Limited | WILEX AG". www.wilex.de (in German). Archived from the original on 2017-09-18. Retrieved 2017-09-18.
  7. "Girentuximab (Rencarex) for renal cell carcinoma". Archived from the original on 2016-03-06. Retrieved 2016-03-04.