Cantuzumab mertansine

Cantuzumab mertansine

Monoclonal antibody
Type	Whole antibody
Source	Humanized (from mouse)
Target	MUC1
Clinical data
ATC code	none
Identifiers
CAS Number	400010-39-1  N
ChemSpider	none
UNII	7Z7EUX7R6M
NY  (what is this?)    (verify)

Cantuzumab mertansine (SB-408075; huC242-DM1) is an antibody-drug conjugate investigated to treat colorectal cancer and other types of cancer. ^[1] It is a humanized monoclonal antibody, cantuzumab (huC242) linked to a cytotoxic agent, mertansine (DM1). ^[2] It was developed by ImmunoGen.

Mechanism

After the huC242 mab binds to the external domain of CanAg, the cantuzumab mertansine-CanAg complex is internalized, and the DM1 molecules are released intracellularly by cleavage of the DM1-huC242 disulfide bonds. ^[3]

Clinical trials

Three phase I clinical studies had reported results by 2003. ^[4] By 2005, clinical development had been suspended. ^[5]

See also

• Cantuzumab ravtansine

References

1. Statement On A Nonproprietary Name Adopted By The Usan Council - Cantuzumab mertansine, American Medical Association. Archived 2011-06-04 at the Wayback Machine
2. Rodon J, Garrison M, Hammond LA, de Bono J, Smith L, Forero L, et al. (October 2008). "Cantuzumab mertansine in a three-times a week schedule: a phase I and pharmacokinetic study". Cancer Chemotherapy and Pharmacology. 62 (5): 911–9. doi:10.1007/s00280-007-0672-8. PMID   18301896. S2CID   5829870.
3. Helft PR, Schilsky RL, Hoke FJ, Williams D, Kindler HL, Sprague E, et al. (July 2004). "A phase I study of cantuzumab mertansine administered as a single intravenous infusion once weekly in patients with advanced solid tumors". Clinical Cancer Research. 10 (13): 4363–8. doi:10.1158/1078-0432.CCR-04-0088. PMID   15240523.
4. Smith SV (December 2004). "Technology evaluation: cantuzumab mertansine, ImmunoGen". Current Opinion in Molecular Therapeutics. 6 (6): 666–74. PMID   15663331.
5. "Cantuzumab mertansine". Springer Nature Switzerland AG.