Rosmantuzumab

Last updated
Rosmantuzumab
Monoclonal antibody
Type ?
Source Humanized (from mouse)
Target RSPO3
Clinical data
Other namesOMP-131R10
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
Formula C6456H9954N1714O2048S46
Molar mass 145825.36 g·mol−1

Rosmantuzumab (INN; [1] development code OMP-131R10) is a humanized monoclonal antibody designed for the treatment of cancer. [2] [3] [4]

This drug was developed by OncoMed Pharmaceuticals. [5]

Related Research Articles

<span class="mw-page-title-main">ROR2</span> Protein

Tyrosine-protein kinase transmembrane receptor ROR2, also known as neurotrophic tyrosine kinase, receptor-related 2, is a protein that in humans is encoded by the ROR2 gene located on position 9 of the long arm of chromosome 9. This protein is responsible for aspects of bone and cartilage growth. It is involved in Robinow syndrome and autosomal dominant brachydactyly type B. ROR2 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family.

<span class="mw-page-title-main">Frizzled-3</span> Protein-coding gene in the species Homo sapiens

Frizzled-3(Fz-3) is a protein that in humans is encoded by the FZD3 gene.

<span class="mw-page-title-main">Frizzled-10</span> Protein-coding gene in the species Homo sapiens

Frizzled-10(Fz-10) is a protein that in humans is encoded by the FZD10 gene. Fz-10 has also been designated as CD350.

<span class="mw-page-title-main">Secreted frizzled-related protein 1</span> Protein-coding gene in the species Homo sapiens

Secreted frizzled-related protein 1, also known as SFRP1, is a protein which in humans is encoded by the SFRP1 gene.

<span class="mw-page-title-main">Protein Wnt-5a</span> Protein-coding gene in the species Homo sapiens

Protein Wnt-5a is a protein that in humans is encoded by the WNT5A gene.

<span class="mw-page-title-main">WNT3</span> Protein and coding gene in humans

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.

<span class="mw-page-title-main">WNT11</span> Protein-coding gene in the species Homo sapiens

Protein Wnt-11 is a protein that in humans is encoded by the WNT11 gene.

<span class="mw-page-title-main">WNT2B</span> Protein-coding gene in the species Homo sapiens

Protein Wnt-2b is a protein that in humans is encoded by the WNT2B gene.

<span class="mw-page-title-main">WNT9A</span> Protein-coding gene in the species Homo sapiens

Protein Wnt-9a is a protein that in humans is encoded by the WNT9A gene.

<span class="mw-page-title-main">PTK7</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein kinase-like 7 also known as colon carcinoma kinase 4 (CCK4) is a receptor tyrosine kinase that in humans is encoded by the PTK7 gene.

<span class="mw-page-title-main">WNT5B</span> Protein-coding gene in the species Homo sapiens

Protein Wnt-5b is a protein that in humans is encoded by the WNT5B gene.

<span class="mw-page-title-main">SEMA6A</span> Protein-coding gene in the species Homo sapiens

Semaphorin-6A is a protein that in humans is encoded by the SEMA6A gene.

<span class="mw-page-title-main">WNT8B</span> Protein-coding gene in humans

Protein Wnt-8b is a protein that in humans is encoded by the WNT8B gene.

<span class="mw-page-title-main">WNT2</span> Protein-coding gene in the species Homo sapiens

Wingless-type MMTV integration site family, member 2, also known as WNT2, is a human gene.

<span class="mw-page-title-main">FAT4</span> Protein-coding gene in the species Homo sapiens

Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene.

<span class="mw-page-title-main">GIPC3</span> Protein-coding gene in the species Homo sapiens

PDZ domain-containing protein GIPC3 is a protein that in humans is encoded by the GIPC3 gene. GIPC3 is a member of the GIPC gene family that also includes GIPC1 and GIPC2. The encoded protein, GIPC3, features a centrally located PDZ domain, which is flanked on each side by a single GIPC-homology domain.

Vantictumab is a human IgG2 monoclonal antibody designed for the treatment of cancer.

<span class="mw-page-title-main">Seviteronel</span> Chemical compound

Seviteronel is an experimental cancer medication which is under development by Viamet Pharmaceuticals and Innocrin Pharmaceuticals for the treatment of prostate cancer and breast cancer. It is a nonsteroidal CYP17A1 inhibitor and works by inhibiting the production of androgens and estrogens in the body. As of July 2017, seviteronel is in phase II clinical trials for both prostate cancer and breast cancer. In January 2016, it was designated fast-track status by the United States Food and Drug Administration for prostate cancer. In April 2017, seviteronel received fast-track designation for breast cancer as well.

<span class="mw-page-title-main">PRICKLE1</span> Protein-coding gene in the species Homo sapiens

Prickle planar cell polarity protein 1 is a protein that in humans is encoded by the PRICKLE1 gene.

<span class="mw-page-title-main">Prickle planar cell polarity protein 2</span> Protein-coding gene in the species Homo sapiens

Prickle planar cell polarity protein 2 is a protein that in humans is encoded by the PRICKLE2 gene.

References

  1. World Health Organization (2016). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 115" (PDF). WHO Drug Information. 30 (2).
  2. Katoh M (August 2018). "Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review)". Int. J. Mol. Med. 42 (2): 713–725. doi:10.3892/ijmm.2018.3689. PMC   6034925 . PMID   29786110.
  3. Katoh M (November 2017). "Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)". Int. J. Oncol. 51 (5): 1357–1369. doi:10.3892/ijo.2017.4129. PMC   5642388 . PMID   29048660.
  4. Katoh M, Katoh M (September 2017). "Molecular genetics and targeted therapy of WNT-related human diseases (Review)". Int. J. Mol. Med. 40 (3): 587–606. doi:10.3892/ijmm.2017.3071. PMC   5547940 . PMID   28731148.
  5. Statement On A Nonproprietary Name Adopted By The USAN Council - Rosmantuzumab, American Medical Association.