Monoclonal antibody | |
---|---|
Type | ? |
Source | Humanized (from mouse) |
Target | RSPO3 |
Clinical data | |
Other names | OMP-131R10 |
ATC code |
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Identifiers | |
CAS Number | |
ChemSpider |
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UNII | |
KEGG | |
Chemical and physical data | |
Formula | C6456H9954N1714O2048S46 |
Molar mass | 145825.36 g·mol−1 |
Rosmantuzumab (INN; [1] development code OMP-131R10) is a humanized monoclonal antibody designed for the treatment of cancer. [2] [3] [4]
This drug was developed by OncoMed Pharmaceuticals. [5]
Tyrosine-protein kinase transmembrane receptor ROR2, also known as neurotrophic tyrosine kinase, receptor-related 2, is a protein that in humans is encoded by the ROR2 gene located on position 9 of the long arm of chromosome 9. This protein is responsible for aspects of bone and cartilage growth. It is involved in Robinow syndrome and autosomal dominant brachydactyly type B. ROR2 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family.
Frizzled-3(Fz-3) is a protein that in humans is encoded by the FZD3 gene.
Frizzled-10(Fz-10) is a protein that in humans is encoded by the FZD10 gene. Fz-10 has also been designated as CD350.
Secreted frizzled-related protein 1, also known as SFRP1, is a protein which in humans is encoded by the SFRP1 gene.
Protein Wnt-5a is a protein that in humans is encoded by the WNT5A gene.
Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.
Protein Wnt-11 is a protein that in humans is encoded by the WNT11 gene.
Protein Wnt-2b is a protein that in humans is encoded by the WNT2B gene.
Protein Wnt-9a is a protein that in humans is encoded by the WNT9A gene.
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Protein Wnt-5b is a protein that in humans is encoded by the WNT5B gene.
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Protein Wnt-8b is a protein that in humans is encoded by the WNT8B gene.
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Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene.
PDZ domain-containing protein GIPC3 is a protein that in humans is encoded by the GIPC3 gene. GIPC3 is a member of the GIPC gene family that also includes GIPC1 and GIPC2. The encoded protein, GIPC3, features a centrally located PDZ domain, which is flanked on each side by a single GIPC-homology domain.
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Seviteronel is an experimental cancer medication which is under development by Viamet Pharmaceuticals and Innocrin Pharmaceuticals for the treatment of prostate cancer and breast cancer. It is a nonsteroidal CYP17A1 inhibitor and works by inhibiting the production of androgens and estrogens in the body. As of July 2017, seviteronel is in phase II clinical trials for both prostate cancer and breast cancer. In January 2016, it was designated fast-track status by the United States Food and Drug Administration for prostate cancer. In April 2017, seviteronel received fast-track designation for breast cancer as well.
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Prickle planar cell polarity protein 2 is a protein that in humans is encoded by the PRICKLE2 gene.