Cribriform plate

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Cribriform plate
Cribriform plate Close-up view.png
Superior view of the central part of the anterior cranial fossa. CG: crista galli; CF: cribriform plate
Olfactory system.svg
Details
Part of Ethmoid bone of the human skull
System Skeletal
Identifiers
Latin lamina cribrosa ossis ethmoidalis
TA98 A02.1.07.002
TA2 722
FMA 52890
Anatomical terms of bone

In mammalian anatomy, the cribriform plate (Latin for lit. sieve-shaped), horizontal lamina or lamina cribrosa is part of the ethmoid bone. It is received into the ethmoidal notch of the frontal bone and roofs in the nasal cavities. It supports the olfactory bulb, and is perforated by olfactory foramina for the passage of the olfactory nerves to the roof of the nasal cavity to convey smell to the brain. The foramina at the medial part of the groove allow the passage of the nerves to the upper part of the nasal septum while the foramina at the lateral part transmit the nerves to the superior nasal concha.

Contents

A fractured cribriform plate can result in olfactory dysfunction, septal hematoma, cerebrospinal fluid rhinorrhoea (CSF rhinorrhoea), and possibly infection which can lead to meningitis. CSF rhinorrhoea (clear fluid leaking from the nose) is very serious and considered a medical emergency. Aging can cause the openings in the cribriform plate to close, pinching olfactory nerve fibers. A reduction in olfactory receptors, loss of blood flow, and thick nasal mucus can also cause an impaired sense of smell. [1]

Structure

The cribriform plate is part of the ethmoid bone, which has a low density, and is spongy. [2] It is narrow, with deep grooves supporting the olfactory bulb.

Its anterior border, short and thick, articulates with the frontal bone. It has two small projecting alae (wings), which are received into corresponding depressions in the frontal bone to complete the foramen cecum.

Its sides are smooth, and sometimes bulging due to the presence of a small air sinus in the interior.

The crista galli projects upwards from the middle line of the cribriform plate. The long thin posterior border of the crista galli serves for the attachment of the falx cerebri. On either side of the crista galli, the cribriform plate is narrow and deeply grooved. At the front part of the cribriform plate, on either side of the crista galli, is a small fissure that is occupied by a process of dura mater.

Lateral to this fissure is a notch or foramen which transmits the nasociliary nerve; from this notch a groove extends backward to the anterior ethmoidal foramen.

Development

The cribriform plate is formed from the fetal age to the end of the first year, completing ossification. Deriving from the nasal capsule, formation begins specifically during the 5th week of gestation. Ossification begins at its most anterior part and proceeds in a posterior manner. The position also shifts from vertical during the 1st postnatal month to horizontal at the age of 6 months.

Keros classification

From left to right, Keros type I, II, and III. Keros types CT Coronal.jpg
From left to right, Keros type I, II, and III.

The Keros classification is a method of classifying the depth of the olfactory fossa.

The depth of the olfactory fossa is determined by the height of the lateral lamella of the cribriform plate. Keros in 1962, classified the depth into three categories. [3]

Function

The cribriform plate is perforated by olfactory foramina, which allow for the passage of the olfactory nerves to the roof of the nasal cavity. [4] This conveys information from smell receptors to the brain. The foramina at the medial part of the groove allow the passage of the nerves to the upper part of the nasal septum while the foramina at the lateral part transmit the nerves to the superior nasal concha.

Clinical significance

A fractured cribriform plate (anterior skull trauma) can result in leaking of cerebrospinal fluid into the nose and loss of sense of smell. The tiny apertures of the plate transmitting the olfactory nerve become the route of ascent for a pathogen, Naegleria fowleri . This amoeba tends to destroy the olfactory bulb and the adjacent inferior surface of the frontal lobe of the brain. This surface initially becomes the site of proliferation of the trophozoites of Naegleria fowleri and their subsequent spread to the rest of the brain and CSF. Because of its initial involvement and trophozoite presence in early phases of Naegleria fowleri infection, flushing of this region with saline using a device, to obtain Naegleria fowleri for diagnostic PCR and microscopic viewing, has been proposed for patients affected by naegleriasis, by (Baig AM., et al.) in a recent publication. [5] Researchers have suggested the same route to administer drugs at an early phase of infection by using a "Transcribrial Device" [6] that has been proposed to kill this pathogen at the place of its maximum proliferation. In 2017 the inventor of this device suggested that after slight modifications this method could be effective in delivery of stem cells to the brain as well. [7] A recent Australian study has shown that the bacterium causing the tropical disease melioidosis, Burkholderia pseudomallei , can also invade the brain via the olfactory nerve within 24 h by traversing the cribriform plate. [8]

Etymology

The cribriform plate is named after its resemblance to a sieve (from Latin cribrum, "sieve" + -form). [2] It is also known as the horizontal lamina, and the lamina cribrosa.

Other animals

The cribriform plate is found in every mammal that has been studied. [9] It serves the same function of allowing passage of the olfactory nerves. [9]

Additional images

Related Research Articles

<span class="mw-page-title-main">Cranial nerves</span> Nerves that emerge directly from the brain and the brainstem

Cranial nerves are the nerves that emerge directly from the brain, of which there are conventionally considered twelve pairs. Cranial nerves relay information between the brain and parts of the body, primarily to and from regions of the head and neck, including the special senses of vision, taste, smell, and hearing.

<span class="mw-page-title-main">Olfactory nerve</span> Cranial nerve I, for smelling

The olfactory nerve, also known as the first cranial nerve, cranial nerve I, or simply CN I, is a cranial nerve that contains sensory nerve fibers relating to the sense of smell.

Articles related to anatomy include:

<span class="mw-page-title-main">Ethmoid bone</span> Bone of the facial skeleton

The ethmoid bone is an unpaired bone in the skull that separates the nasal cavity from the brain. It is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that make up the orbit of the eye.

<span class="mw-page-title-main">Sphenoid bone</span> Bone of the neurocranium

The sphenoid bone is an unpaired bone of the neurocranium. It is situated in the middle of the skull towards the front, in front of the basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended.

<span class="mw-page-title-main">Naegleriasis</span> Rare and usually fatal brain infection by a protist

Naegleriasis, also known as primary amoebic meningoencephalitis (PAM), is an almost invariably fatal infection of the brain by the free-living unicellular eukaryote Naegleria fowleri. Symptoms are meningitis-like and include headache, fever, nausea, vomiting, a stiff neck, confusion, hallucinations and seizures. Symptoms progress rapidly over around five days, and death usually results within one to two weeks of symptoms.

<span class="mw-page-title-main">Orbit (anatomy)</span> Cavity or socket of the skull in which the eye and its appendages are situated

In anatomy, the orbit is the cavity or socket/hole of the skull in which the eye and its appendages are situated. "Orbit" can refer to the bony socket, or it can also be used to imply the contents. In the adult human, the volume of the orbit is about 28 millilitres, of which the eye occupies 6.5 ml. The orbital contents comprise the eye, the orbital and retrobulbar fascia, extraocular muscles, cranial nerves II, III, IV, V, and VI, blood vessels, fat, the lacrimal gland with its sac and duct, the eyelids, medial and lateral palpebral ligaments, cheek ligaments, the suspensory ligament, septum, ciliary ganglion and short ciliary nerves.

<span class="mw-page-title-main">Falx cerebri</span> Anatomical structure of the brain

The falx cerebri is a large, crescent-shaped fold of dura mater that descends vertically into the longitudinal fissure to separate the cerebral hemispheres. It supports the dural sinuses that provide venous and CSF drainage from the brain. It is attached to the crista galli anteriorly, and blends with the tentorium cerebelli posteriorly.

<span class="mw-page-title-main">Crista galli</span> Upper part of the ethmoid bone of the skull

The crista galli is a wedge-shaped, vertical, midline upward continuation of the perpendicular plate of the ethmoid bone of the skull, projecting above the cribriform plate into the cranial cavity. It serves as an attachment for the membranes surrounding the brain.

<span class="mw-page-title-main">Ethmoidal labyrinth</span>

The ethmoidal labyrinth or lateral mass of the ethmoid bone consists of a number of thin-walled cellular cavities, the ethmoid air cells, arranged in three groups, anterior, middle, and posterior, and interposed between two vertical plates of bone; the lateral plate forms part of the orbit, the medial plate forms part of the nasal cavity. In the disarticulated bone many of these cells are opened into, but when the bones are articulated, they are closed in at every part, except where they open into the nasal cavity.

<span class="mw-page-title-main">Perpendicular plate of ethmoid bone</span>

The perpendicular plate of the ethmoid bone is a thin, flattened lamina, polygonal in form, which descends from the under surface of the cribriform plate, and assists in forming the septum of the nose; it is generally deflected a little to one or other side. The anterior border articulates with the spine of the frontal bone and the crest of the nasal bones.

<span class="mw-page-title-main">Anterior ethmoidal artery</span>

The anterior ethmoidal artery is a branch of the ophthalmic artery in the orbit. It exits the orbit through the anterior ethmoidal foramen alongside the anterior ethmoidal nerve. It contributes blood supply to the ethmoid sinuses, frontal sinuses, the dura mater, lateral nasal wall, and nasal septum. It issues a meningeal branch, and nasal branches.

<span class="mw-page-title-main">Anterior ethmoidal foramen</span> Opening in the ethmoid bone in the skull

The anterior ethmoidal foramen is a small opening in the ethmoid bone in the skull.

<span class="mw-page-title-main">Anterior ethmoidal nerve</span> Nerve of the nose

The anterior ethmoidal nerve is a nerve of the head. It is a branch of the nasociliary nerve (itself a branch of the ophthalmic nerve (V1)). It arises in the orbit, and enters first the cranial cavity and then the nasal cavity. It provides sensory innervation to part of the meninges, parts of the nasal cavity, and part of the skin of the nose.

<span class="mw-page-title-main">Petrous part of the temporal bone</span> Feature at the base of the human skull

The petrous part of the temporal bone is pyramid-shaped and is wedged in at the base of the skull between the sphenoid and occipital bones. Directed medially, forward, and a little upward, it presents a base, an apex, three surfaces, and three angles, and houses in its interior the components of the inner ear. The petrous portion is among the most basal elements of the skull and forms part of the endocranium. Petrous comes from the Latin word petrosus, meaning "stone-like, hard". It is one of the densest bones in the body. In other mammals, it is a separate bone, the petrosal bone.

<span class="mw-page-title-main">Anterior cranial fossa</span>

The anterior cranial fossa is a depression in the floor of the cranial base which houses the projecting frontal lobes of the brain. It is formed by the orbital plates of the frontal, the cribriform plate of the ethmoid, and the small wings and front part of the body of the sphenoid; it is limited behind by the posterior borders of the small wings of the sphenoid and by the anterior margin of the chiasmatic groove. The lesser wings of the sphenoid separate the anterior and middle fossae.

<span class="mw-page-title-main">Body of sphenoid bone</span>

The body of the sphenoid bone, more or less cubical in shape, is hollowed out in its interior to form two large cavities, the sphenoidal sinuses, which are separated from each other by a septum.

<span class="mw-page-title-main">Base of skull</span> Inferior area of the skull, composed of the endocranium and lower parts of the skull roof

The base of skull, also known as the cranial base or the cranial floor, is the most inferior area of the skull. It is composed of the endocranium and the lower parts of the calvaria.

<span class="mw-page-title-main">Outline of human anatomy</span> Overview of and topical guide to human anatomy

The following outline is provided as an overview of and topical guide to human anatomy:

<span class="mw-page-title-main">Olfactory foramina</span> Grouping of holes located on the cribriform plate

The olfactory foramina, also known as the cribriform foramina, is the grouping of holes located on the cribriform plate. The cribriform plate forms the roof of the nasal cavity, and the olfactory foramina are in the two depressions lateral to the median blade of the cribriform plate called the crista galli. There is a pair of olfactory bulbs of the brain that rest in these two depressions. These holes that make up the olfactory foramina allow passage for about 20 bundles of nerve fibers that make up the olfactory nerve, also known as Cranial Nerve I (CNI), from the nasal cavity to meet with the olfactory bulbs. Therefore, the olfactory foramina are necessary for the human sense of smell. These foramina vary in size and number with age.

References

PD-icon.svgThis article incorporates text in the public domain from page 153 of the 20th edition of Gray's Anatomy (1918)

  1. Marjorie Calvert, Dr. Ronald DeVere, MD (2010). "Why Can't I Smell (ch.3)". Navigating Smell and Taste Disorders. Demos Medical Publishing. ISBN   9781932603965.{{cite book}}: CS1 maint: multiple names: authors list (link)
  2. 1 2 White, Tim D.; Folkens, Pieter A. (2005-01-01). "7 - SKULL". The Human Bone Manual. Academic Press. pp. 75–126. ISBN   978-0-12-088467-4.
  3. "Keros classification of olfactory fossa".
  4. Barral, Jean-Pierre; Crobier, Alain (2009-01-01). "4: Cranial nerves as they emerge from the skull". Manual Therapy for the Cranial Nerves. Churchill Livingstone. pp. 19–23. ISBN   978-0-7020-3100-7.
  5. Abdul Mannan Baig, Naveed Ahmed Khan, (2014). Tackling infection owing to brain-eating amoeba. Acta Tropica 11/2014; doi : 10.1016/j.actatropica.2014.11.004
  6. Abdul Mannan Baig, Naveed Ahmed Khan (2014), Novel chemotherapeutic strategies in the management of naegleriasis due to Naegleria fowleri. CNS Neurosciences & Therapeutics (2014). 01/2014; doi : 10.1111/cns.12225
  7. Abdul Mannan Baig. Emerging Insights for Better Delivery of Chemicals and Stem Cells to the Brain ACS Chemical Neuroscience 2017 8 (6), 1119-1121 DOI: 10.1021/acschemneuro.7b00106
  8. St John, JA; Ekberg, JA; Dando, SJ; Meedeniya, AC; Horton, RE; Batzloff, M; Owen, SJ; Holt, S; Peak, IR; Ulett, GC; Mackay-Sim, A; Beacham, IR (Apr 2014). "Burkholderia pseudomallei penetrates the brain via destruction of the olfactory and trigeminal nerves: implications for the pathogenesis of neurological melioidosis". mBio. 5 (2): e00025. doi:10.1128/mBio.00025-14. PMC   3993850 . PMID   24736221.
  9. 1 2 Bird, Deborah Jean; Van Valkenburgh, Blaire (2017). The cribriform plate: Evolution of mammalian olfaction written in bone. UCLA (Thesis) via eScholarship.