Genetic history of Central Africa

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The genetic history of Central Africa encompasses the genetic history of the people of Central Africa. The Sahara served as a trans-regional passageway and place of dwelling for people in Africa during various humid phases [1] [2] [3] and periods throughout the history of Africa. [4] [5]

Contents

Archaic Human DNA

Archaic traits found in human fossils of West Africa (e.g., Iho Eleru fossils, which dates to 13,000 BP) and Central Africa (e.g., Ishango fossils, which dates between 25,000 BP and 20,000 BP) may have developed as a result of admixture between archaic humans and modern humans or may be evidence of late-persisting early modern humans. [6] While Denisovan and Neanderthal ancestry in non-Africans outside of Africa are more certain, archaic human ancestry in Africans is less certain and is too early to be established with certainty. [6]

Ancient DNA

In 4000 BP (or even earlier during the Mesolithic), there may have been a population that traversed from Africa (e.g., West Africa or West-Central Africa), through the Strait of Gibraltar, into the Iberian peninsula, where admixing between Africans and Iberians (e.g., of northern Portugal, of southern Spain) occurred. Based on a small trace presence of sub-Saharan African components in select samples from Iberia, and the discovery of a mitogenome L2a1 found in one individual, while all others belonged to European mitochondrial haplogroups. [7]

Cameroon

West African hunter-gatherers, in the region of western Central Africa (e.g., Shum Laka, Cameroon), particularly between 8000 BP and 3000 BP, were found to be related to modern Central African hunter-gatherers (e.g., Baka, Bakola, Biaka, Bedzan). [8]

Democratic Republic of Congo

At Kindoki, in the Democratic Republic of Congo, there were three individuals, dated to the protohistoric period (230 BP, 150 BP, 230 BP); one carried haplogroups E1b1a1a1d1a2 (E-CTS99, E-CTS99) and L1c3a1b, another carried haplogroup E (E-M96, E-PF1620), and the last carried haplogroups R1b1 (R-P25 1, R-M415) and L0a1b1a1. [9] [10]

At Ngongo Mbata, in the Democratic Republic of Congo, an individual, dated to the protohistoric period (220 BP), carried haplogroup L1c3a. [9] [10]

At Matangai Turu Northwest, in the Democratic Republic of Congo, an individual, dated to the Iron Age (750 BP), carried an undetermined haplogroup(s). [9] [10]

Y-Chromosomal DNA

Haplogroup R-V88 may have originated in western Central Africa (e.g., Equatorial Guinea), and, in the middle of the Holocene, arrived in North Africa through population migration. [11]

Mitochondrial DNA

In 150,000 BP, Africans (e.g., Central Africans, East Africans) bearing haplogroup L1 diverged. [12] Between 75,000 BP and 60,000 BP, Africans bearing haplogroup L3 emerged in East Africa and eventually migrated into and became present in modern West Africans, Central Africans, and non-Africans. [12] Amid the Holocene, including the Holocene Climate Optimum in 8000 BP, Africans bearing haplogroup L2 spread within West Africa and Africans bearing haplogroup L3 spread within East Africa. [12] As the largest migration since the Out of Africa migration, migration from Sub-Saharan Africa toward the North Africa occurred, by West Africans, Central Africans, and East Africans, resulting in migrations into Europe and Asia; consequently, Sub-Saharan African mitochondrial DNA was introduced into Europe and Asia. [12]

Mitochondrial haplogroup L1c is strongly associated with pygmies, especially with Bambenga groups. [13] L1c prevalence was variously reported as: 100% in Ba-Kola, 97% in Aka (Ba-Benzélé), and 77% in Biaka, [14] 100% of the Bedzan (Tikar), 97% and 100% in the Baka people of Gabon and Cameroon, respectively, [15] 97% in Bakoya (97%), and 82% in Ba-Bongo. [13] Mitochondrial haplogroups L2a and L0a are prevalent among the Bambuti. [13] [16]

Autosomal DNA

Genetically, African pygmies have some key difference between them and Bantu peoples. [17] [18]

Medical DNA

Evidence suggests that, when compared to other Sub-Saharan African populations, African pygmy populations display unusually low levels of expression of the genes encoding for human growth hormone and its receptor associated with low serum levels of insulin-like growth factor-1 and short stature. [19]

The genomes of Africans commonly found to undergo adaptation are regulatory DNA, and many cases of adaptation found among Africans relate to diet, physiology, and evolutionary pressures from pathogens. [20] Throughout Sub-Saharan Africa, genetic adaptation (e.g., rs334 mutation, Duffy blood group, increased rates of G6PD deficiency, sickle cell disease) to malaria has been found among Sub-Saharan Africans, which may have initially developed in 7300 BP. [20] Sub-Saharan Africans have more than 90% of the Duffy-null genotype. [21] In the rainforests of Central Africa, genetic adaptation for non-height-related factors (e.g., immune traits, reproduction, thyroid function) and short stature (e.g., EHB1 and PRDM5 – bone synthesis; OBSCN and COX10 – muscular development; HESX1 and ASB14 – pituitary gland’s growth hormone production/secretion) has been found among rainforest hunter-gatherers. [20]

Related Research Articles

Haplogroup E-V38, also known as E1b1a-V38, is a human Y-chromosome DNA haplogroup. E-V38 is primarily distributed in sub-Saharan Africa. E-V38 has two basal branches, E-M329 and E-M2. E-M329 is a subclade mostly found in East Africa. E-M2 is the predominant subclade in West Africa, Central Africa, Southern Africa, and the region of African Great Lakes; it also occurs at moderate frequencies in some parts of North Africa, West Asia, and Southern Europe.

<span class="mw-page-title-main">African admixture in Europe</span>

African admixture in Europe refers to the presence of human genotypes attributable to periods of human population dispersals out of Africa in the genetic history of Europe. For example, certain Y-DNA and mtDNA lineages are thought to have spread from Northeastern Africa to the Near East during the later Pleistocene, and from there to Europe with the Neolithic Revolution.

<span class="mw-page-title-main">Mechta-Afalou</span> Prehistoric North African population

Mechta-Afalou, also known as Mechtoid or Paleo-Berber, are a population that inhabited parts of North Africa during the late Paleolithic and Mesolithic. They are associated with the Iberomaurusian archaeological culture.

<span class="mw-page-title-main">Iberomaurusian</span> Archaeological culture in the Middle East

The Iberomaurusian is a backed bladelet lithic industry found near the coasts of Morocco, Algeria, and Tunisia. It is also known from a single major site in Libya, the Haua Fteah, where the industry is locally known as the Eastern Oranian. The Iberomaurusian seems to have appeared around the time of the Last Glacial Maximum (LGM), somewhere between c. 25,000 and 23,000 cal BP. It would have lasted until the early Holocene c. 11,000 cal BP.

The genetic history of North Africa encompasses the genetic history of the people of North Africa. The most important source of gene flow to North Africa was from the Middle East, although the Sahara desert to the south and the Mediterranean Sea to the North were also important barriers to gene flow from sub-Saharan Africa and parts of Europe in prehistory. However, North Africa is connected to Western Asia via the Isthmus of Suez and the Sinai peninsula, while at the Straits of Gibraltar, North Africa and Europe are separated by only 15 km (9 mi), similarly Malta, Sicily, Canary Islands, and Crete are close to the coasts of North Africa.

<span class="mw-page-title-main">African Pygmies</span> Group of ethnicities native to Central Africa

The African Pygmies are a group of ethnicities native to Central Africa, mostly the Congo Basin, traditionally subsisting on a forager and hunter-gatherer lifestyle. They are divided into three roughly geographic groups:

<span class="mw-page-title-main">Genetic history of Egypt</span>

The genetic history of Egypt reflects its geographical location at the crossroads of several major biocultural areas: North Africa, the Sahara, the Middle East, the Mediterranean and sub-Saharan Africa.

<span class="mw-page-title-main">Haplogroup E-M2</span> Human Y-chromosome DNA haplogroup

Haplogroup E-M2, also known as E1b1a1-M2, is a human Y-chromosome DNA haplogroup. E-M2 is primarily distributed within sub-Saharan Africa. More specifically, E-M2 is the predominant subclade in West Africa, Central Africa, Southern Africa, and the region of the African Great Lakes; it also occurs at low to moderate frequencies in North Africa, and at low frequencies in the Middle East. E-M2 has several subclades, but many of these subhaplogroups are included in either E-L485 or E-U175. E-M2 is especially common among indigenous Africans who speak Niger-Congo languages, and was spread to Southern Africa and East Africa through the Bantu expansion.

<span class="mw-page-title-main">Genetic history of Africa</span>

The genetic history of Africa is composed of the overall genetic history of African populations in Africa, including the regional genetic histories of North Africa, West Africa, East Africa, Central Africa, and Southern Africa, as well as the recent origin of modern humans in Africa. The Sahara served as a trans-regional passageway and place of dwelling for people in Africa during various humid phases and periods throughout the history of Africa.

<span class="mw-page-title-main">History of Central Africa</span>

The history of Central Africa has been divided into its prehistory, its ancient history, the major polities flourishing, the colonial period, and the post-colonial period, in which the current nations were formed. Central Africa is the central region of Africa, bordered by North Africa, West Africa, East Africa, Southern Africa, the Atlantic Ocean, and the Sahara Desert. Colonial boundaries are reflected in the modern boundaries between contemporary Central African states, cutting across ethnic and cultural lines, often dividing single ethnic groups between two or more states.

<span class="mw-page-title-main">History of Southern Africa</span> History of Southern African region

The history of Southern Africa has been divided into its prehistory, its ancient history, the major polities flourishing, the colonial period, and the post-colonial period, in which the current nations were formed. Southern Africa is bordered by Central Africa, East Africa, the Atlantic Ocean, the Indian Ocean, and the Sahara Desert. Colonial boundaries are reflected in the modern boundaries between contemporary Southern African states, cutting across ethnic and cultural lines, often dividing single ethnic groups between two or more states.

<span class="mw-page-title-main">West African hunter-gatherers</span> West African hunter-gatherers

West African hunter-gatherers, West African foragers, or West African pygmies dwelled in western Central Africa earlier than 32,000 BP and dwelled in West Africa between 16,000 BP and 12,000 BP until as late as 1000 BP or some period of time after 1500 CE. West African hunter-gatherers are archaeologically associated with the West African Microlithic Technocomplex. Despite its significance in the prehistory of West Africa, the peopling of various parts of Western Africa from the Sub-Saharan regions of coastal West Africa and the forests of western Central Africa often goes overlooked.

<span class="mw-page-title-main">Genetic history of the African diaspora</span>

The genetic history of the African diaspora is composed of the overall genetic history of the African diaspora, within regions outside of Africa, such as North America, Central America, the Caribbean, South America, Europe, Asia, and Australia; this includes the genetic histories of African Americans, Afro-Canadians, Afro-Caribbeans, Afro-Latinos, Afro-Europeans, Afro-Asians, and African Australians.

<span class="mw-page-title-main">Population history of West Africa</span> West African population history

The population history of West Africa is composed of West African populations that were considerably mobile and interacted with one another throughout the history of West Africa. Acheulean tool-using archaic humans may have dwelled throughout West Africa since at least between 780,000 BP and 126,000 BP. During the Pleistocene, Middle Stone Age peoples, who dwelled throughout West Africa between MIS 4 and MIS 2, were gradually replaced by incoming Late Stone Age peoples, who migrated into West Africa as an increase in humid conditions resulted in the subsequent expansion of the West African forest. West African hunter-gatherers occupied western Central Africa earlier than 32,000 BP, dwelled throughout coastal West Africa by 12,000 BP, and migrated northward between 12,000 BP and 8000 BP as far as Mali, Burkina Faso, and Mauritania.

<span class="mw-page-title-main">Prehistoric Central Africa</span> Prehistory of the Central African subregion of the African continent

The prehistory of Central Africa spans from the earliest human presence in the region until the emergence of the Iron Age in Central Africa. By at least 2,000,000 BP, Central Africa was occupied by early hominins. West African hunter-gatherers occupied western Central Africa earlier than 32,000 BP, dwelled throughout coastal West Africa by 12,000 BP, and migrated northward between 12,000 BP and 8000 BP as far as Mali, Burkina Faso, and Mauritania. Prehistoric West Africans may have diverged into distinct ancestral groups of modern West Africans and Bantu-speaking peoples in Cameroon, and, subsequently, around 5000 BP, the Bantu-speaking peoples migrated into other parts of Sub-Saharan Africa.

<span class="mw-page-title-main">Prehistoric East Africa</span> Prehistory of the East African subregion of the African continent

The prehistory of East Africa spans from the earliest human presence in the region until the emergence of the Iron Age in East Africa. Between 1,600,000 BP and 1,500,000 BP, the Homo ergaster known as Nariokotome Boy resided near Nariokotome River, Kenya. Modern humans, who left behind remains, resided at Omo Kibish in 233,000 BP. Afro-Asiatic speakers and Nilo-Saharan speakers expanded in East Africa, resulting in transformation of food systems of East Africa. Prehistoric West Africans may have diverged into distinct ancestral groups of modern West Africans and Bantu-speaking peoples in Cameroon, and, subsequently, around 5000 BP, the Bantu-speaking peoples migrated into other parts of Sub-Saharan Africa.

<span class="mw-page-title-main">Prehistoric Southern Africa</span> Prehistory of the Southern African subregion of the African continent

The prehistory of Southern Africa spans from the earliest human presence in the region until the emergence of the Iron Age in Southern Africa. In 1,000,000 BP, hominins controlled fire at Wonderwerk Cave, South Africa. Ancestors of the Khoisan may have expanded from East Africa or Central Africa into Southern Africa before 150,000 BP, possibly as early as before 260,000 BP. Prehistoric West Africans may have diverged into distinct ancestral groups of modern West Africans and Bantu-speaking peoples in Cameroon, and, subsequently, around 5000 BP, the Bantu-speaking peoples migrated into other parts of Sub-Saharan Africa.

The genetic history of West Africa encompasses the genetic history of the people of West Africa. The Sahara served as a trans-regional passageway and place of dwelling for people in Africa during various humid phases and periods throughout the history of Africa.

The genetic history of Eastern Africa encompasses the genetic history of the people of Eastern Africa. The Sahara served as a trans-regional passageway and place of dwelling for people in Africa during various humid phases and periods throughout the history of Africa.

The genetic history of Southern Africa encompasses the genetic history of the people of Southern Africa. The Sahara served as a trans-regional passageway and place of dwelling for people in Africa during various humid phases and periods throughout the history of Africa.

References

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  2. ↑ Drake, Nick; Breeze, Paul (2016). "Climate Change and Modern Human Occupation of the Sahara from MIS 6-2". Africa from MIS 6-2. Vertebrate Paleobiology and Paleoanthropology. Africa from MIS 6-2. pp. 103–122. doi:10.1007/978-94-017-7520-5_6. ISBN   978-94-017-7519-9. S2CID   131383927.
  3. ↑ El-Shenawy, Mohammed I.; et al. (2018). "Speleothem evidence for the greening of the Sahara and its implications for the early human dispersal out of sub-Saharan Africa". Quaternary Science Reviews. 188: 67–76. Bibcode:2018QSRv..188...67E. doi:10.1016/j.quascirev.2018.03.016. S2CID   134694090.
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  19. ↑ Bozzola M, Travaglino P, Marziliano N, Meazza C, Pagani S, Grasso M, et al. (November 2009). "The shortness of Pygmies is associated with severe under-expression of the growth hormone receptor". Molecular Genetics and Metabolism. 98 (3): 310–313. doi:10.1016/j.ymgme.2009.05.009. PMID   19541519.
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  21. ↑ Wonkam, Ambroise; Adeyemo, Adebowale (March 8, 2023). "Leveraging our common African origins to understand human evolution and health" (PDF). Cell Genomics. 3 (3): 100278. doi:10.1016/j.xgen.2023.100278. PMC   10025516 . PMID   36950382. S2CID   257458855.
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