Haplogroup R1b

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Haplogroup R1b
Haplogrupo R1b (ADN-Y).png
Possible time of originProbably soon after R1, possibly between 18,000-14,000 BC [1]
Possible place of origin Western Asia, North Eurasia or Eastern Europe [2]
Ancestor R1
Descendants
  • R1b1a (L754, PF6269, YSC0000022)
  • R1b2 (PH155)
Defining mutationsM343

Haplogroup R1b (R-M343), previously known as Hg1 and Eu18, is a human Y-chromosome haplogroup.

Contents

It is the most frequently occurring paternal lineage in Western Europe, as well as some parts of Russia (e.g. the Bashkirs) and across the Sahel in Central Africa, namely: Cameroon, Chad, Guinea, Mauritania, Mali, Niger, Nigeria and Senegal (concentrated in parts of Chad with concentration in the Hausa Tribe and among the Chadic-speaking ethnic groups of Cameroon).

The clade is also present at lower frequencies throughout Eastern Europe, Western Asia, Central Asia as well as parts of North Africa, South Asia and Central Asia.

R1b has two primary branches: R1b1-L754 and R1b2-PH155. R1b1-L754 has two major subclades: R1b1a1b-M269, which predominates in Western Europe, and R1b1b-V88, which is today common in parts of Central Africa. The other branch, R1b2-PH155, is so rare and widely dispersed that it is difficult to draw any conclusions about its origins. It has been found in Bahrain, India, Nepal, Bhutan, Ladakh, Tajikistan, Turkey, and Western China.

According to ancient DNA studies, most R1a and R1b lineages would have expanded from the Pontic Steppe along with the Indo-European languages. [2] [3] [4] [5] [6]

Origin and dispersal

Genetic studies performed since 2015 have revealed that the Yamna culture, thought to have spoken some stage of Proto-Indo-European, carried R1b-L23. Map Corded Ware culture-en.svg
Genetic studies performed since 2015 have revealed that the Yamna culture, thought to have spoken some stage of Proto-Indo-European, carried R1b-L23.

The age of R1 was estimated by Tatiana Karafet et al. (2008) at between 12,500 and 25,700 BP, and most probably occurred about 18,500 years ago. [7] Since the earliest known example has been dated at circa 14,000 BP, and belongs to R1b1 (R-L754), [1] R1b must have arisen relatively soon after the emergence of R1.

Early human remains found to carry R1b include:

R1b is a subclade within the "macro-haplogroup" K (M9), the most common group of human male lines outside of Africa. K is believed to have originated in Asia (as is the case with an even earlier ancestral haplogroup, F (F-M89). Karafet T. et al. (2014) suggested that a "rapid diversification process of K-M526 likely occurred in Southeast Asia, with subsequent westward expansions of the ancestors of haplogroups R and Q". [29] However the oldest example of R* has been found in an Ancient North Eurasian sample from Siberia (Mal'ta boy, 24,000 years ago), and its precursor P1 has been found in another Ancient North Eurasian sample from northern Siberia (Yana RHS) dating from c. 31,600 years ago. [30]

Three genetic studies in 2015 gave support to the Kurgan hypothesis of Marija Gimbutas regarding the Proto-Indo-European homeland. According to those studies, haplogroups R1b-M269 and R1a, now the most common in Europe (R1a is also common in South Asia) would have expanded from the West Eurasian Steppe, along with the Indo-European languages; they also detected an autosomal component present in modern Europeans which was not present in Neolithic Europeans, which would have been introduced with paternal lineages R1b and R1a, as well as Indo-European languages. [2] [3] [4]

Map of Indo-European migrations from c. 4000 to 1000 BC according to the Kurgan model. The magenta area corresponds to the assumed urheimat (Samara culture, Sredny Stog culture). IE expansion.png
Map of Indo-European migrations from c. 4000 to 1000 BC according to the Kurgan model. The magenta area corresponds to the assumed urheimat (Samara culture, Sredny Stog culture).

Analysis of ancient Y-DNA from the remains from early Neolithic Central and North European Linear Pottery culture settlements have not yet found males belonging to haplogroup R1b-M269. [31] [32] Olalde et al. (2017) trace the spread of haplogroup R1b-M269 in western Europe, particularly Britain, to the spread of the Beaker culture, with a sudden appearance of many R1b-M269 haplogroups in Western Europe ca. 5000–4500 years BP during the early Bronze Age. [33]

Structure

External phylogeny of R1b

The broader haplogroup R (M207) is a primary subclade of haplogroup P1 (M45) itself a primary branch of P (P295), which is also known as haplogroup K2b2. R-M207 is therefore a secondary branch of K2b (P331), and a direct descendant of K2 (M526).

There was "an initial rapid diversification" of K-M526, according to Karafet et al. (2014), which "likely occurred in Southeast Asia, with subsequent westward expansions of the ancestors of haplogroups R and Q".

Phylogeny within K2b

Internal structure of R1b

Names such as R1b, R1b1 and so on are phylogenetic (i.e. "family tree") names which make clear their place within the branching of haplogroups, or the phylogenetic tree. An alternative way of naming the same haplogroups and subclades refers to their defining SNP mutations: for example, R-M343 is equivalent to R1b. [34] Phylogenetic names change with new discoveries and SNP-based names are consequently reclassified within the phylogenetic tree. In some cases, an SNP is found to be unreliable as a defining mutation and an SNP-based name is removed completely. For example, before 2005, R1b was synonymous with R-P25, which was later reclassified as R1b1; in 2016, R-P25 was removed completely as a defining SNP, due to a significant rate of back-mutation. [35] (Below is the basic outline of R1b according to the ISOGG Tree as it stood on January 30, 2017. [36] )

Basic phylogenetic tree for R1b
 M343/PF6242 

R-M343* (R1b*). No cases have been reported.

 L278 
PH155

R-PH155 (R1b2) has been found in individuals from Albania, Bahrain, Bhutan, China, Germany, India, Italy, Singapore, Tajikistan, Turkey, the UK, and the USA.

L754/PF6269/YSC0000022
V88

R-V88 (R1b1b): the most common forms of R1b found among males native to Sub-Saharan Africa, also found rarely elsewhere.

L389/PF6531
 V1636

R-V1636 (R1b1a2) is rare, but has been found in China, [37] [38] Bulgaria, Belarus, Southern Finland, Turkey, Iraq, Lebanon, Kuwait, Qatar, Saudi Arabia, Russia (including a Tomsk Tatar), Italy (including one from the Province of Salerno), Puerto Rico, the Dominican Republic, Canada, Germany, Valais, Israel, and Armenia. [39] [40]

 P297/PF6398 
 M73 

Subclades of R-M73 (R1b1a1a) are rare overall, with most cases being observed in the Caucasus, Siberia, Central Asia, and Mongolia.

 M269/PF6517 

Subclades of R-M269 (R1b1a1b; previously R1b1a1a2) are now extremely common throughout Western Europe, but are also found at lower levels in many other parts of Western Eurasia and the Mediterranean.

Geographical distribution

R1b* (R-M343*)

No confirmed cases of R1b* (R-M343*) – that is R1b (xR1b1, R1b2), also known as R-M343 (xL754, PH155) – have been reported in peer-reviewed literature.

R-M343 (xM73, M269, V88)

In early research, because R-M269, R-M73 and R-V88 are by far the most common forms of R1b, examples of R1b (xM73, xM269) were sometimes assumed to signify basal examples of "R1b*". [35] However, while the paragroup R-M343 (xM73, M269, V88) is rare, it does not preclude membership of rare and/or subsequently-discovered, relatively basal subclades of R1b, such as R-L278* (R1b*), R-L389* (R1b1a*), R-P297* (R1b1a1*), R-V1636 (R1b1a2) or R-PH155 (R1b2).

The population believed to have the highest proportion of R-M343 (xM73, M269, V88) are the Kurds of southeastern Kazakhstan with 13%. [41] However, more recently, a large study of Y-chromosome variation in Iran, revealed R-M343 (xV88, M73, M269) as high as 4.3% among Iranian sub-populations. [42]

It remains a possibility that some, or even most of these cases, may be R-L278* (R1b*), R-L389* (R1b1a*), R-P297* (R1b1a1*), R-V1636 (R1b1a2), R-PH155 (R1b2), R1b* (R-M343*), R1a* (R-M420*), an otherwise undocumented branch of R1 (R-M173), and/or back-mutations of a marker, from a positive to a negative ancestral state, [43] and hence constitute undocumented subclades of R1b.

A compilation of previous studies regarding the distribution of R1b can be found in Cruciani et al. (2010). [44] It is summarised in the table following. (Cruciani did not include some studies suggesting even higher frequencies of R1b1a1b [R-M269] in some parts of Western Europe.)

Distribution of R-V88, R-M73 and M269
ContinentRegionSample
size
Total R1bR-P25
(unreliable
marker for
R1b1*)
R-V88
(R1b1b)
R-M269
(R1b1a1a2)
R-M73
(R1b1a1a1)
AfricaNorthern Africa6915.9%0.0%5.2%0.7%0.0%
AfricaCentral Sahel Region46123.0%0.0%23.0%0.0%0.0%
AfricaWestern Africa1230.0%0.0%0.0%0.0%0.0%
AfricaEastern Africa4420.0%0.0%0.0%0.0%0.0%
AfricaSouthern Africa1050.0%0.0%0.0%0.0%0.0%
EuropeWestern Europeans46557.8%0.0%0.0%57.8%0.0%
EuropeNorth-west Europeans4355.8%0.0%0.0%55.8%0.0%
EuropeCentral Europeans7742.9%0.0%0.0%42.9%0.0%
EuropeNorth Eastern Europeans741.4%0.0%0.0%1.4%0.0%
EuropeRussians606.7%0.0%0.0%6.7%0.0%
EuropeEastern Europeans14920.8%0.0%0.0%20.8%0.0%
EuropeSouth-east Europeans51013.1%0.0%0.2%12.9%0.0%
AsiaWest Asians3285.8%0.0%0.3%5.5%0.0%
AsiaSouth Asians2884.8%0.0%0.0%1.7%3.1%
AsiaSouth-east Asians100.0%0.0%0.0%0.0%0.0%
AsiaNorth-east Asians300.0%0.0%0.0%0.0%0.0%
AsiaEast Asians1560.6%0.0%0.0%0.6%0.0%
Total5326

R1b (R-L278)

R-L278 among modern men falls into the R-L754 and R-PH155 subclades, though it is possible some very rare R-L278* may exist as not all examples have been tested for both branches. Examples may also exist in ancient DNA, though due to poor quality it is often impossible to tell whether or not the ancients carried the mutations that define subclades.

Some examples described in older articles, for example two found in Turkey, [34] are now thought to be mostly in the more recently discovered sub-clade R1b1b (R-V88). Most examples of R1b therefore fall into subclades R1b1b (R-V88) or R1b1a (R-P297). Cruciani et al. in the large 2010 study found 3 cases amongst 1173 Italians, 1 out of 328 West Asians and 1 out of 156 East Asians. [44] Varzari found 3 cases in Ukraine, in a study of 322 people from the DniesterCarpathian Mountains region, who were P25 positive, but M269 negative. [45] Cases from older studies are mainly from Africa, the Middle East or Mediterranean, and are discussed below as probable cases of R1b1b (R-V88).

R1b1 (R-L754)

R-L754 contains the vast majority of R1b. The only known example of R-L754* (xL389, V88) is also the earliest known individual to carry R1b: "Villabruna 1", who lived circa 14,000 years BP (north east Italy). Villabruna 1 belonged to the Epigravettian culture.

R1b1a (R-L389)

R-L389, also known as R1b1a (L388/PF6468, L389/PF6531), contains the very common subclade R-P297 and the rare subclade R-V1636. It is unknown whether all previously reported R-L389* (xP297) belong to R-V1636 or not.

R1b1a1 (R-P297)

The SNP marker P297 was recognised in 2008 as ancestral to the significant subclades M73 and M269, combining them into one cluster. [7] This had been given the phylogenetic name R1b1a1a (and, previously, R1b1a).

A majority of Eurasian R1b falls within this subclade, representing a very large modern population. Although P297 itself has not yet been much tested for, the same population has been relatively well studied in terms of other markers. Therefore, the branching within this clade can be explained in relatively high detail below.

R1b1a1a (R-M73)

Malyarchuk et al. (2011) found R-M73 in 13.2% (5/38) of Shors, 11.4% (5/44) of Teleuts, 3.3% (2/60) of Kalmyks, 3.1% (2/64) of Khakassians, 1.9% (2/108) of Tuvinians, and 1.1% (1/89) of Altaians. [46] The Kalmyks, Tuvinians, and Altaian belong to a Y-STR cluster marked by DYS390=19, DYS389=14-16 (or 14–15 in the case of the Altaian individual), and DYS385=13-13.

Dulik et al. (2012) found R-M73 in 35.3% (6/17) of a sample of the Kumandin of the Altai Republic in Russia. [47] Three of these six Kumandins share an identical 15-loci Y-STR haplotype, and another two differ only at the DYS458 locus, having DYS458=18 instead of DYS458=17. This pair of Kumandin R-M73 haplotypes resembles the haplotypes of two Kalmyks, two Tuvinians, and one Altaian whose Y-DNA has been analyzed by Malyarchuk et al. (2011). The remaining R-M73 Kumandin has a Y-STR haplotype that is starkly different from the haplotypes of the other R-M73 Kumandins, resembling instead the haplotypes of five Shors, five Teleuts, and two Khakassians. [46]

While early research into R-M73 claimed that it was significantly represented among the Hazara of Afghanistan and the Bashkirs of the Ural Mountains, this has apparently been overturned. For example, supporting material from a 2010 study by Behar et al. suggested that Sengupta et al. (2006) might have misidentified Hazara individuals, who instead belonged to "PQR2" as opposed to "R(xR1a)." [48] [41] [49] However, the assignment of these Hazaras' Y-DNA to the "PQR2" category by Behar et al. (2010) is probably ascribable to the habit that was popular for a while of labeling R-M269 as "R1b" or "R(xR1a)," with any members of R-M343 (xM269) being placed in a polyphyletic, catch-all "R*" or "P" category. Myres et al. (2011), Di Cristofaro et al. (2013), and Lippold et al. (2014) all agree that the Y-DNA of 32% (8/25) of the HGDP sample of Pakistani Hazara should belong to haplogroup R-M478/M73. [41] [50] [51] Likewise, most Bashkir males have been found to belong to U-152 (R1b1a1a2a1a2b) and some, mostly from southeastern Bashkortostan, belonged to Haplogroup Q-M25 (Q1a1b) rather than R1b; contra this, Myres et al. (2011) found a high frequency of R-M73 among their sample of Bashkirs from southeast Bashkortostan (77/329 = 23.4% R1b-M73), in agreement with the earlier study of Bashkirs. [41] Besides the high frequency of R-M73 in southeastern Bashkirs, Myres et al. also reported finding R-M73 in the following samples: 10.3% (14/136) of Balkars from the northwest Caucasus, 9.4% (8/85) of the HGDP samples from northern Pakistan (these are the aforementioned Pakistani Hazaras), 5.8% (4/69) of Karachays from the northwest Caucasus, 2.6% (1/39) of Tatars from Bashkortostan, 1.9% (1/54) of Bashkirs from southwest Bashkortostan, 1.5% (1/67) of Megrels from the south Caucasus, 1.4% (1/70) of Bashkirs from north Bashkortostan, 1.3% (1/80) of Tatars from Kazan, 1.1% (1/89) of a sample from Cappadocia, Turkey, 0.7% (1/141) of Kabardians from the northwest Caucasus, 0.6% (3/522) of a pool of samples from Turkey, and 0.38% (1/263) of Russians from Central Russia. [41]

Besides the aforementioned Pakistani Hazaras, Di Cristofaro et al. (2013) found R-M478/M73 in 11.1% (2/18) of Mongols from central Mongolia, 5.0% (1/20) of Kyrgyz from southwest Kyrgyzstan, 4.3% (1/23) of Mongols from southeast Mongolia, 4.3% (4/94) of Uzbeks from Jawzjan, Afghanistan, 3.7% (1/27) of Iranians from Gilan, 2.5% (1/40) of Kyrgyz from central Kyrgyzstan, 2.1% (2/97) of Mongols from northwest Mongolia, and 1.4% (1/74) of Turkmens from Jawzjan, Afghanistan. [50] The Mongols as well as the individual from southwest Kyrgyzstan, the individual from Gilan, and one of the Uzbeks from Jawzjan belong to the same Y-STR haplotype cluster as five of six Kumandin members of R-M73 studied by Dulik et al. (2012). This cluster's most distinctive Y-STR value is DYS390=19. [41]

Karafet et al. (2018) found R-M73 in 37.5% (15/40) of a sample of Teleuts from Bekovo, Kemerovo oblast, 4.5% (3/66) of a sample of Uyghurs from Xinjiang Uyghur Autonomous Region, 3.4% (1/29) of a sample of Kazakhs from Kazakhstan, 2.3% (3/129) of a sample of Selkups, 2.3% (1/44) of a sample of Turkmens from Turkmenistan, and 0.7% (1/136) of a sample of Iranians from Iran. [52] Four of these individuals (one of the Teleuts, one of the Uyghurs, the Kazakh, and the Iranian) appear to belong to the aforementioned cluster marked by DYS390=19 (the Kumandin-Mongol R-M73 cluster); the Teleut and the Uyghur also share the modal values at the DYS385 and the DYS389 loci. The Iranian differs from the modal for this cluster by having 13-16 (or 13–29) at DYS389 instead of 14-16 (or 14–30). The Kazakh differs from the modal by having 13–14 at DYS385 instead of 13-13. The other fourteen Teleuts and the three Selkups appear to belong to the Teleut-Shor-Khakassian R-M73 cluster from the data set of Malyarchuk et al. (2011); this cluster has the modal values of DYS390=22 (but 21 in the case of two Teleuts and one Khakassian), DYS385=13-16, and DYS389=13-17 (or 13–30, but 14–31 in the case of one Selkup).

A Kazakhstani paper published in 2017 found haplogroup R1b-M478 Y-DNA in 3.17% (41/1294) of a sample of Kazakhs from Kazakhstan, with this haplogroup being observed with greater than average frequency among members of the Qypshaq (12/29 = 41.4%), Ysty (6/57 = 10.5%), Qongyrat (8/95 = 8.4%), Oshaqty (2/29 = 6.9%), Kerey (1/28 = 3.6%), and Jetyru (3/86 = 3.5%) tribes. [53] A Chinese paper published in 2018 found haplogroup R1b-M478 Y-DNA in 9.2% (7/76) of a sample of Dolan Uyghurs from Horiqol township, Awat County, Xinjiang. [54]

R1b1a1b (R-M269)

R-M269, or R1b1a1b (as of 2018) amongst other names, [55] is now the most common Y-DNA lineage in European males. It is carried by an estimated 110 million males in Europe. [56]

Projected spatial frequency distribution within Europe of haplogroup R-M269. Geographical distribution of haplogroup frequency of hgR1b1b2.png
Projected spatial frequency distribution within Europe of haplogroup R-M269.

R-M269 has received significant scientific and popular interest due to its possible connection to the Indo-European expansion in Europe. Specifically the R-Z2103 subclade has been found to be prevalent in ancient DNA associated with the Yamna culture. [2] All seven individuals in one were determined to belong to the R1b-M269 subclade. [2]

Older research, published before researchers could study the DNA of ancient remains, proposed that R-M269 likely originated in Western Asia and was present in Europe by the Neolithic period. [36] [41] [57] [58] But results based on actual ancient DNA noticed that there was a dearth of R-M269 in Europe before the Bronze Age, [2] and the distribution of subclades within Europe is substantially due to the various migrations of the Bronze and Iron Age. Likewise, the oldest samples classified as belonging to R-M269, have been found in Eastern Europe and Pontic-Caspian steppe, not Western Asia. Western European populations are divided between the R-P312/S116 and R-U106/S21 subclades of R-M412 (R-L51).

Distribution of R-M269 in Europe increases in frequency from east to west. It peaks at the national level in Wales at a rate of 92%, at 82% in Ireland, 70% in Scotland, 68% in Spain, 60% in France (76% in Normandy), about 60% in Portugal, [41] 50% in Germany, 50% in the Netherlands, 47% in Italy, [59] 45% in Eastern England and 42% in Iceland. R-M269 reaches levels as high as 95% in parts of Ireland. It has also been found at lower frequencies throughout central Eurasia, [60] but with relatively high frequency among the Bashkirs of the Perm region (84.0%). [61] This marker is present in China and India at frequencies of less than one percent. In North Africa and adjoining islands, while R-V88 (R1b1b) is more strongly represented, R-M269 appears to have been present since antiquity. R-M269 has been found, for instance, at a rate of ~44% among remains dating from the 11th to 13th centuries at Punta Azul, in the Canary Islands. These remains have been linked to the Bimbache (or Bimape), a subgroup of the Guanche. [62] In living males, it peaks in parts of North Africa, especially Algeria, at a rate of 10%. [63] In Sub-Saharan Africa, R-M269 appears to peak in Namibia, at a rate of 8% among Herero males. [64] In western Asia, R-M269 has been reported in 40% of Armenian males and over 35% in Turkmen males. [65] [66] (The table below lists in more detail the frequencies of M269 in regions in Asia, Europe, and Africa.)

Apart from basal R-M269* which has not diverged, there are (as of 2017) two primary branches of R-M269:

R-L23 (Z2105/Z2103; a.k.a. R1b1a1b1) has been reported among the peoples of the Idel-Ural (by Trofimova et al. 2015): 21 out of 58 (36.2%) of Burzyansky District Bashkirs, 11 out of 52 (21.2%) of Udmurts, 4 out of 50 (8%) of Komi, 4 out of 59 (6.8%) of Mordvins, 2 out of 53 (3.8%) of Besermyan and 1 out of 43 (2.3%) of Chuvash were R1b-L23. [67]

Subclades within the paragroup R-M269(xL23) – that is, R-M269* and/or R-PF7558 – appear to be found at their highest frequency in the central Balkans, especially Kosovo with 7.9%, North Macedonia 5.1% and Serbia 4.4%. [41] Unlike most other areas with significant percentages of R-L23, Kosovo, Poland and the Bashkirs of south-east Bashkortostan are notable in having a high percentage of R-L23 (xM412) – at rates of 11.4% (Kosovo), 2.4% (Poland) and 2.4% south-east Bashkortostan. [41] (This Bashkir population is also notable for its high level of R-M73 (R1b1a1a1), at 23.4%. [41] ) Five individuals out of 110 tested in the Ararat Valley of Armenia belonged to R-M269(xL23) and 36 to R-L23*, with none belonging to known subclades of L23. [68]

In 2009, DNA extracted from the femur bones of 6 skeletons in an early-medieval burial place in Ergolding (Bavaria, Germany) dated to around AD 670 yielded the following results: 4 were found to be haplogroup R1b with the closest matches in modern populations of Germany, Ireland and the USA while 2 were in Haplogroup G2a. [69]

The following gives a summary of most of the studies which specifically tested for M269, showing its distribution (as a percentage of total population) in Europe, North Africa, the Middle East and Central Asia as far as China and Nepal.

The phylogeny of R-M269 according to ISOGG 2017:

M269/PF6517

R-M269* (R1b1a1b*)

L23/PF6534/S141

R-L23* (R1b1a1b1*)

L51/M412/PF6536/S167

R-L51*/R-M412* (R1b1a1b1a*)

L151/PF6542

R-L151* (R1b1a1b1a1a*)

M405/U106/S21

R-U106/R-M405/R-S21 (R1b1a1b1a1a1)

P312/PF6547/S116

R-P312 (R1b1a1b1a1a2)

AM01876/S1194

R-S1194 (R1b1a1b1a1a3)

A8051

R-A8051 (R1b1a1b1a1a4)

PF7589/Z2118

R-PF7589 (R1b1a1b1a2)

CTS1078/Z2103

R-Z2103 (R1b1a1b1b)

PF7558

R-PF7558 (R1b1a1b2)

R1b1b (R-V88)

R1b1b (PF6279/V88; previously R1b1a2) is defined by the presence of SNP marker V88, the discovery of which was announced in 2010 by Cruciani et al. [44] Apart from individuals in southern Europe and Western Asia, the majority of R-V88 was found in the Sahel, especially among populations speaking Afroasiatic languages of the Chadic branch.

Based on a detailed phylogenic analysis, D'Atanasio et al. (2018) proposed that R1b-V88 originated in Europe about 12,000 years ago and crossed to North Africa between 8000 and 7000 years ago, during the 'Green Sahara' period. R1b-V1589, the main subclade within R1b-V88, underwent a further expansion around 5500 years ago, likely in the Lake Chad Basin region, from which some lines recrossed the Sahara to North Africa. [70]

Marcus et al. (2020) provide strong evidence for this proposed model of North to South trans-Saharan movement: The earliest basal R1b-V88 haplogroups are found in several Eastern European Hunter Gatherers close to 11,000 years ago. The haplogroup then seemingly spread with the expansion of Neolithic farmers, who established agriculture in the Western Mediterranean by around 7500 BP. R1b-V88 haplogroups were identified in ancient Neolithic individuals in Germany, central Italy, Iberia, and, at a particularly high frequency, in Sardinia. A part of the branch leading to present-day African haplogroups (V2197) was already derived in Neolithic European individuals from Spain and Sardinia, providing further support for a North to South trans-Saharan movement. [71] [72] [73] European autosomal ancestry, mtDNA haplogroups, and lactase persistence alleles have also been identified in African populations that carry R1b-V88 at a high frequency, such as the Fulani and Toubou. [74] [75] [76] [77] The presence of European Neolithic farmers in Africa is further attested by samples from Morocco dating from c. 5400 BC onwards. [78] [79]

Studies in 2005–08 reported "R1b*" at high levels in Jordan, Egypt and Sudan. [80] [64] [81] [note 1] Subsequent research by Myres et al. (2011) indicates that the samples concerned most likely belong to the subclade R-V88. According to Myres et al. (2011), this may be explained by a back-migration from Asia into Africa by R1b-carrying people. [41] [note 2]

Contrary to other studies, Shriner & Rotimi (2018) associated the introduction of R1b into Chad with the more recent movements of Baggara Arabs. [82]

Distribution of R1b in Africa
RegionPopulationCountryLanguageSample
size
Total
%
R1b1b
(R-V88)
R1b1a1b
(R-M269)
R1b1b*
(R-V88*)
R1b1b2a2a1
(R-V69)
N AfricaCompositeMoroccoAA3380.0%0.3%0.6%0.3%0.0%
N AfricaMozabite BerbersAlgeriaAA/Berber673.0%3.0%0.0%3.0%0.0%
N AfricaNorthern EgyptiansEgyptAA/Semitic496.1%4.1%2.0%4.1%0.0%
N AfricaBerbers from SiwaEgyptAA/Berber9328.0%26.9%1.1%23.7%3.2%
N AfricaBahariaEgyptAA/Semitic417.3%4.9%2.4%0.0%4.9%
N AfricaGurna OasisEgyptAA/Semitic340.0%0.0%0.0%0.0%0.0%
N AfricaSouthern EgyptiansEgyptAA/Semitic695.8%5.8%0.0%2.9%2.9%
C AfricaSonghaiNigerNS/Songhai100.0%0.0%0.0%0.0%0.0%
C AfricaFulbeNigerNC/Atlantic714.3%14.3%0.0%14.3%0.0%
C AfricaTuaregNigerAA/Berber224.5%4.5%0.0%4.5%0.0%
C AfricaNgambaiChadNS/Sudanic119.1%9.1%0.0%9.1%0.0%
C AfricaHausaNigeria (North)AA/Chadic1020.0%20.0%0.0%20.0%0.0%
C AfricaFulbeNigeria (North)NC/Atlantic320.0%0.0%0.0%0.0%0.0%
C AfricaYorubaNigeria (South)NC/Defoid214.8%4.8%0.0%4.8%0.0%
C AfricaOuldemeCameroon (Nth)AA/Chadic2295.5%95.5%0.0%95.5%0.0%
C AfricaMadaCameroon (Nth)AA/Chadic1782.4%82.4%0.0%76.5%5.9%
C AfricaMafaCameroon (Nth)AA/Chadic887.5%87.5%0.0%25.0%62.5%
C AfricaGuizigaCameroon (Nth)AA/Chadic977.8%77.8%0.0%22.2%55.6%
C AfricaDabaCameroon (Nth)AA/Chadic1942.1%42.1%0.0%36.8%5.3%
C AfricaGuidarCameroon (Nth)AA/Chadic966.7%66.7%0.0%22.2%44.4%
C AfricaMassaCameroon (Nth)AA/Chadic728.6%28.6%0.0%14.3%14.3%
C AfricaOther ChadicCameroon (Nth)AA/Chadic475.0%75.0%0.0%25.0%50.0%
C AfricaShuwa ArabsCameroon (Nth)AA/Semitic540.0%40.0%0.0%40.0%0.0%
C AfricaKanuriCameroon (Nth)NS/Saharan714.3%14.3%0.0%14.3%0.0%
C AfricaFulbeCameroon (Nth)NC/Atlantic1811.1%11.1%0.0%5.6%5.6%
C AfricaMoundangCameroon (Nth)NC/Adamawa2166.7%66.7%0.0%14.3%52.4%
C AfricaFaliCameroon (Nth)NC/Adamawa4820.8%20.8%0.0%10.4%10.4%
C AfricaTaliCameroon (Nth)NC/Adamawa229.1%9.1%0.0%4.5%4.5%
C AfricaMboumCameroon (Nth)NC/Adamawa90.0%0.0%0.0%0.0%0.0%
C AfricaCompositeCameroon (Sth)NC/Bantu900.0%1.1%0.0%1.1%0.0%
C AfricaBiaka PygmiesCARNC/Bantu330.0%0.0%0.0%0.0%0.0%
W AfricaComposite1230.0%0.0%0.0%0.0%0.0%
E AfricaComposite4420.0%0.0%0.0%0.0%0.0%
S AfricaComposite1050.0%0.0%0.0%0.0%0.0%
Total1822
V88
undefined

R-V88* (R1b1b*)

M18

R-M18 (R1b1b1)

V35

R-V35 (R1b1b2a1)

V69

R-V69 (R1b1b2a2a1)

Two branches of R-V88, R-M18 and R-V35, are found almost exclusively on the island of Sardinia.

As can be seen in the above data table, R-V88 is found in northern Cameroon in west central Africa at a very high frequency, where it is considered to be caused by a pre-Islamic movement of people from Eurasia. [64] [83]

R1b1b1 (R-M18)

R1b1b1 is a sub-clade of R-V88, which is defined by the presence of SNP marker M18. [7] It has been found only at low frequencies in samples from Sardinia [60] [84] and Lebanon. [85]

R1b2 (R-PH155)

R1b2 is extremely rare and defined by the presence of PH155. [36] Living males carrying subclades of R-PH155 have been found in Bahrain, Bhutan, Ladakh, Tajikistan, Turkey, Xinjiang, and Yunnan. ISOGG (2022) cites two primary branches: R-M335 (R1b2a) and R-PH200 (R1b2b).

The defining SNP of R1b2a, M335, was first documented in 2004, when an example was discovered in Turkey, though it was classified at that time as R1b4. [34] Other examples of R-M335 have been reported in a sample of Hui from Yunnan, China [86] and in a sample of people from Ladakh, India. [87]

Health

Studies have shown that haplogroup R1b could have a protective effect on the immune system. [90] However, later studies have confirmed that the Y-chromosome has a very limited effect on coronary artery disease (CAD), for example, and that the previously purported link between Y-chromosome haplogroups and health is far from established scientifically. [91]

See also

Notes

  1. Flores et al. (2005) found that 20 out of all 146 men tested (13.7%) – including 20 out of 45 men tested from the Dead Sea area of Jordan – were positive for M173 (R1), and negative for both the R1a markers SRY10831.2 and M17, as well as P25 (which was later discovered to be an unreliable marker for R1b1). Myres et al. (2011) [41] indicates that they are mostly R-V88 (later known as R1b1b). Wood et al. (2005) also reported two Egyptian cases of R1* (R-M173*) that were negative for SRY10831 (R1a1) and the unreliable R1b1 marker P25, out of a sample of 1,122 males from African countries, including 92 from Egypt. Hassan et al. (2008) found an equally surprising 14 out of 26 (54%) of Sudanese Fula people who were M173+ and P25-.
  2. Myres et al. (2011): "The detection of V88 in Iran, Palestine and especially the Dead Sea, Jordan (Supplementary Table S4) provides an insight into the back to Africa migration route.

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References

  1. 1 2 3 Fu Q, Posth C, Hajdinjak M, Petr M, Mallick S, Fernandes D, et al. (June 2016). "The genetic history of Ice Age Europe". Nature. 534 (7606): 200–5. Bibcode:2016Natur.534..200F. doi:10.1038/nature17993. hdl:10211.3/198594. PMC   4943878 . PMID   27135931.
  2. 1 2 3 4 5 6 Haak et al. 2015.
  3. 1 2 Allentoft ME, Sikora M, Sjögren KG, Rasmussen S, Rasmussen M, Stenderup J, et al. (June 2015). "Population genomics of Bronze Age Eurasia". Nature. 522 (7555): 167–72. Bibcode:2015Natur.522..167A. doi:10.1038/nature14507. PMID   26062507. S2CID   4399103.
  4. 1 2 Mathieson I, Lazaridis I, Rohland N, Mallick S, Patterson N, Roodenberg SA, et al. (2015). "Eight thousand years of natural selection in Europe". bioRxiv: 016477. doi:10.1101/016477. S2CID   7866359.
  5. Cassidy LM, Martiniano R, Murphy EM, Teasdale MD, Mallory J, Hartwell B, Bradley DG (January 2016). "Neolithic and Bronze Age migration to Ireland and establishment of the insular Atlantic genome". Proceedings of the National Academy of Sciences of the United States of America. 113 (2): 368–73. Bibcode:2016PNAS..113..368C. doi: 10.1073/pnas.1518445113 . PMC   4720318 . PMID   26712024.
  6. Martiniano R, Cassidy LM, Ó'Maoldúin R, McLaughlin R, Silva NM, Manco L, et al. (July 2017). "The population genomics of archaeological transition in west Iberia: Investigation of ancient substructure using imputation and haplotype-based methods". PLOS Genetics. 13 (7): e1006852. doi: 10.1371/journal.pgen.1006852 . PMC   5531429 . PMID   28749934.
  7. 1 2 3 Karafet TM, Mendez FL, Meilerman MB, Underhill PA, Zegura SL, Hammer MF (May 2008). "New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree". Genome Research. 18 (5): 830–8. doi:10.1101/gr.7172008. PMC   2336805 . PMID   18385274.
  8. Mathieson 2018, Supplementary Table 1, Row 467.
  9. Mathieson 2018, Supplementary Table 1, Rows 251-272.
  10. 1 2 Jones 2017.
  11. Mathieson 2018, Supplementary Table 1, Rows 205-245.
  12. Mathieson 2018, Supplementary Table 1.
  13. Mathieson 2018, pp. 2–3.
  14. González-Fortes et al. 2017, pp. 8–9.
  15. González-Fortes et al. 2017, p. 4, Table 1, OC1_Meso.
  16. Sánchez-Quinto et al. 2019, Extended Dataset 1.3, OC1.
  17. Mathieson 2018, Supplementary Table 1, Row 298, I4666.
  18. Mathieson 2018, Supplementary Table 1, Row 153, I0124.
  19. Mathieson 2018, Supplementary Table 1, Row 375, I0122.
  20. Haak et al. 2015, Supplementary Information, pp. 26-27.
  21. Haak et al. 2015, Extended Data Table 2, I0410.
  22. Haak et al. 2015, Supplementary Information, pp. 44-45.
  23. Mathieson 2018, Supplementary Table 1, I0410.
  24. Mathieson 2018, Supplementary Table 1, Row 73, I2430.
  25. Marcus et al. 2020, Supplementary Data 1, A Master Table, Row 25, MA89.
  26. Mathieson 2018, Supplementary Table 1, Row 128, I0559.
  27. de Barros Damgaard P, Martiniano R, Kamm J, Moreno-Mayar JV, Kroonen G, Peyrot M, et al. (June 2018). "The first horse herders and the impact of early Bronze Age steppe expansions into Asia". Science. 360 (6396): eaar7711. doi:10.1126/science.aar7711. PMC   6748862 . PMID   29743352.
  28. Haak et al. 2015, p. 5.
  29. Karafet TM, Mendez FL, Sudoyo H, Lansing JS, Hammer MF (March 2015). "Improved phylogenetic resolution and rapid diversification of Y-chromosome haplogroup K-M526 in Southeast Asia". European Journal of Human Genetics. 23 (3): 369–73. doi:10.1038/ejhg.2014.106. PMC   4326703 . PMID   24896152.
  30. Sikora, Martin; Pitulko, Vladimir V.; Sousa, Vitor C.; Allentoft, Morten E.; Vinner, Lasse; Rasmussen, Simon; Margaryan, Ashot; de Barros Damgaard, Peter; de la Fuente, Constanza; Renaud, Gabriel; Yang, Melinda A.; Fu, Qiaomei; Dupanloup, Isabelle; Giampoudakis, Konstantinos; Nogués-Bravo, David (June 2019). "The population history of northeastern Siberia since the Pleistocene". Nature. 570 (7760): 182–188. Bibcode:2019Natur.570..182S. doi:10.1038/s41586-019-1279-z. hdl: 1887/3198847 . ISSN   1476-4687. PMID   31168093. S2CID   174809069.
  31. Lacan M, Keyser C, Ricaut FX, Brucato N, Duranthon F, Guilaine J, et al. (June 2011). "Ancient DNA reveals male diffusion through the Neolithic Mediterranean route". Proceedings of the National Academy of Sciences of the United States of America. 108 (24): 9788–91. Bibcode:2011PNAS..108.9788L. doi: 10.1073/pnas.1100723108 . PMC   3116412 . PMID   21628562.
  32. Haak W, Balanovsky O, Sanchez JJ, Koshel S, Zaporozhchenko V, Adler CJ, et al. (November 2010). Penny D (ed.). "Ancient DNA from European early neolithic farmers reveals their near eastern affinities". PLOS Biology. 8 (11): e1000536. doi: 10.1371/journal.pbio.1000536 . PMC   2976717 . PMID   21085689.
  33. Olalde I, Brace S, Allentoft ME, Armit I, Kristiansen K, Booth T, et al. (March 2018). "The Beaker phenomenon and the genomic transformation of northwest Europe". Nature. 555 (7695): 190–196. Bibcode:2018Natur.555..190O. doi:10.1038/nature25738. PMC   5973796 . PMID   29466337.
  34. 1 2 3 Cinnioğlu C, King R, Kivisild T, Kalfoğlu E, Atasoy S, Cavalleri GL, et al. (January 2004). "Excavating Y-chromosome haplotype strata in Anatolia". Human Genetics. 114 (2): 127–48. doi:10.1007/s00439-003-1031-4. PMID   14586639. S2CID   10763736.
  35. 1 2 "ISOGG 2016 Y-DNA Haplogroup R". isogg.org.
  36. 1 2 3 "ISOGG 2017 Y-DNA Haplogroup R". isogg.org.
  37. YFull YTree v10.00.00
  38. Phylogenetic tree of haplogroup R-V1636 at 23mofang
  39. Haplogroup R on the Y-DNA Haplotree at FTDNA
  40. "R-V1636 YTree". www.yfull.com.
  41. 1 2 3 4 5 6 7 8 9 10 11 12 13 Myres NM, Rootsi S, Lin AA, Järve M, King RJ, Kutuev I, et al. (January 2011). "A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western Europe". European Journal of Human Genetics. 19 (1): 95–101. doi:10.1038/ejhg.2010.146. PMC   3039512 . PMID   20736979.
  42. Grugni V, Battaglia V, Hooshiar Kashani B, Parolo S, Al-Zahery N, Achilli A, et al. (July 18, 2012). "Ancient migratory events in the Middle East: new clues from the Y-chromosome variation of modern Iranians". PLOS ONE. 7 (7): e41252. Bibcode:2012PLoSO...741252G. doi: 10.1371/journal.pone.0041252 . PMC   3399854 . PMID   22815981.
  43. Adams SM, King TE, Bosch E, Jobling MA (May 2006). "The case of the unreliable SNP: recurrent back-mutation of Y-chromosomal marker P25 through gene conversion". Forensic Science International. 159 (1): 14–20. doi:10.1016/j.forsciint.2005.06.003. hdl: 2381/443 . PMID   16026953.
  44. 1 2 3 Cruciani F, Trombetta B, Sellitto D, Massaia A, Destro-Bisol G, Watson E, et al. (July 2010). "Human Y chromosome haplogroup R-V88: a paternal genetic record of early mid Holocene trans-Saharan connections and the spread of Chadic languages". European Journal of Human Genetics. 18 (7): 800–7. doi:10.1038/ejhg.2009.231. PMC   2987365 . PMID   20051990.
  45. Varzari A (2006). Population History of the Dniester-Carpathians: evidence from Alu insertion and Y-chromosome polymorphisms (Thesis). Ludwig-Maximilians-Universität München. doi:10.5282/edoc.5868.
  46. 1 2 Malyarchuk B, Derenko M, Denisova G, Maksimov A, Wozniak M, Grzybowski T, et al. (August 2011). "Ancient links between Siberians and Native Americans revealed by subtyping the Y chromosome haplogroup Q1a". Journal of Human Genetics. 56 (8): 583–8. doi: 10.1038/jhg.2011.64 . PMID   21677663. S2CID   12015336.
  47. Dulik MC, Zhadanov SI, Osipova LP, Askapuli A, Gau L, Gokcumen O, et al. (February 2012). "Mitochondrial DNA and Y chromosome variation provides evidence for a recent common ancestry between Native Americans and Indigenous Altaians". American Journal of Human Genetics. 90 (2): 229–46. doi:10.1016/j.ajhg.2011.12.014. PMC   3276666 . PMID   22281367.
  48. Behar DM, Yunusbayev B, Metspalu M, Metspalu E, Rosset S, Parik J, et al. (July 2010). "The genome-wide structure of the Jewish people". Nature. 466 (7303): 238–42. Bibcode:2010Natur.466..238B. doi:10.1038/nature09103. PMID   20531471. S2CID   4307824.
  49. Sengupta S, Zhivotovsky LA, King R, Mehdi SQ, Edmonds CA, Chow CE, et al. (February 2006). "Polarity and temporality of high-resolution y-chromosome distributions in India identify both indigenous and exogenous expansions and reveal minor genetic influence of Central Asian pastoralists". American Journal of Human Genetics. 78 (2): 202–21. doi:10.1086/499411. PMC   1380230 . PMID   16400607.
  50. 1 2 Di Cristofaro J, Pennarun E, Mazières S, Myres NM, Lin AA, Temori SA, et al. (2013). "Afghan Hindu Kush: where Eurasian sub-continent gene flows converge". PLOS ONE. 8 (10): e76748. Bibcode:2013PLoSO...876748D. doi: 10.1371/journal.pone.0076748 . PMC   3799995 . PMID   24204668.
  51. Lippold S, Xu H, Ko A, Li M, Renaud G, Butthof A, et al. (2014). "Human paternal and maternal demographic histories: insights from high-resolution Y chromosome and mtDNA sequences". Investigative Genetics. 5: 13. doi: 10.1186/2041-2223-5-13 . PMC   4174254 . PMID   25254093.
  52. Karafet TM, Osipova LP, Savina OV, Hallmark B, Hammer MF (November 2018). "Siberian genetic diversity reveals complex origins of the Samoyedic-speaking populations". American Journal of Human Biology. 30 (6): e23194. doi:10.1002/ajhb.23194. PMID   30408262. S2CID   53238849.
  53. Ashirbekov EE, Botbaev DM, Belkozhaev AM, Abayldaev AO, Neupokoeva AS, Mukhataev JE, et al. (2017). "Распределение гаплогрупп И-хромосомы казахов Южно-Казахстанской, Жамбылской и Алматинской областей" [Distribution of Y-Chromosome Haplogroups of the Kazakh from the South Kazakhstan, Zhambyl, and Almaty Regions](PDF). Reports of the National Academy of Sciences of the Republic of Kazakhstan (in Russian). 6 (316): 85–95. Archived from the original (PDF) on 2021-09-23. Retrieved 2021-11-20.
  54. Shuhu LI, Yilihamu NI, Bake RA, Bupatima AB, Matyusup DO (2018). "A study of genetic diversity of three isolated populations in Xinjiang using Y-SNP". Acta Anthropologica Sinica. 37 (1): 146–56. doi:10.16359/j.cnki.cn11-1963/q.2017.0067.
  55. R1b1a1b (R-M269) was previously R1b1a1a2. From 2003 to 2005, what is now R1b1a1b was designated R1b3. From 2005 to 2008, it was R1b1c. From 2008 to 2011, it was R1b1b2. From 2011 to 2018, it was R1b1a1a2.
  56. 1 2 Balaresque P, Bowden GR, Adams SM, Leung HY, King TE, Rosser ZH, et al. (January 2010). Penny D (ed.). "A predominantly neolithic origin for European paternal lineages". PLOS Biology. 8 (1): e1000285. doi: 10.1371/journal.pbio.1000285 . PMC   2799514 . PMID   20087410.
  57. Arredi B, Poloni ES, Tyler-Smith C (2007). "The peopling of Europe". In Crawford MH (ed.). Anthropological genetics: theory, methods and applications. Cambridge, UK: Cambridge University Press. p. 394. ISBN   978-0-521-54697-3.
  58. Cruciani F, Trombetta B, Antonelli C, Pascone R, Valesini G, Scalzi V, et al. (June 2011). "Strong intra- and inter-continental differentiation revealed by Y chromosome SNPs M269, U106 and U152". Forensic Science International. Genetics. 5 (3): e49-52. doi:10.1016/j.fsigen.2010.07.006. hdl:11573/226727. PMID   20732840.
  59. Grugni, Viola; Raveane, Alessandro; Mattioli, Francesca; Battaglia, Vincenza; Sala, Cinzia; Toniolo, Daniela; Ferretti, Luca; Gardella, Rita; Achilli, Alessandro; Olivieri, Anna; Torroni, Antonio; Passarino, Giuseppe; Semino, Ornella (February 2018). "Reconstructing the genetic history of Italians: new insights from a male (Y-chromosome) perspective". Annals of Human Biology. 45 (1): 44–56. doi:10.1080/03014460.2017.1409801. ISSN   1464-5033. PMID   29382284. S2CID   43501209.
  60. 1 2 Underhill PA, Shen P, Lin AA, Jin L, Passarino G, Yang WH, et al. (November 2000). "Y chromosome sequence variation and the history of human populations". Nature Genetics. 26 (3): 358–361. doi:10.1038/81685. PMID   11062480. S2CID   12893406.
  61. Lobov AS (2009). Structure of the Gene Pool of Bashkir Subpopulations (PDF) (Ph.D. thesis) (in Russian). Institute of Biochemistry and Genetics of the Ufa Scientific Center of the Russian Academy of Sciences. Archived from the original (PDF) on 2011-08-16.
  62. Ordóñez AC, Fregel R, Trujillo-Mederos A, Hervella M, de-la-Rúa C, Arnay-de-la-Rosa M (2017). "Genetic studies on the prehispanic population buried in Punta Azul cave (El Hierro, Canary Islands)". Journal of Archaeological Science. 78: 20–28. Bibcode:2017JArSc..78...20O. doi:10.1016/j.jas.2016.11.004.
  63. Robino C, Crobu F, Di Gaetano C, Bekada A, Benhamamouch S, Cerutti N, et al. (May 2008). "Analysis of Y-chromosomal SNP haplogroups and STR haplotypes in an Algerian population sample". International Journal of Legal Medicine. 122 (3): 251–5. doi:10.1007/s00414-007-0203-5. PMID   17909833. S2CID   11556974.
  64. 1 2 3 Wood ET, Stover DA, Ehret C, Destro-Bisol G, Spedini G, McLeod H, et al. (July 2005). "Contrasting patterns of Y chromosome and mtDNA variation in Africa: evidence for sex-biased demographic processes". European Journal of Human Genetics. 13 (7): 867–76. doi: 10.1038/sj.ejhg.5201408 . PMID   15856073. S2CID   20279122.
  65. Yepiskoposian L, Khudoyan A, Harutyunian A (2006). "Genetic Testing of Language Replacement Hypothesis in Southwest Asia". Iran and the Caucasus. 10 (2): 191–208. doi:10.1163/157338406780345899. JSTOR   4030922. S2CID   162345193.
  66. Maciamo Hay. "Haplogrouop R1b (Y-DNA)". Eupedia.
  67. Vadimovna TN (February 2015). Изменчивость Митохондриальной ДНК и Y-Хромосомы в Популяциях Волго-Уральского Региона [Mitochondrial DNA variation and the Y-chromosome in the population of the Volga-Ural Region](PDF) (Biological Sciences thesis) (in Russian). Archived from the original (PDF) on 2017-04-02.
  68. Herrera KJ, Lowery RK, Hadden L, Calderon S, Chiou C, Yepiskoposyan L, et al. (March 2012). "Neolithic patrilineal signals indicate that the Armenian plateau was repopulated by agriculturalists". European Journal of Human Genetics. 20 (3): 313–20. doi:10.1038/ejhg.2011.192. PMC   3286660 . PMID   22085901.
  69. Vanek D, Saskova L, Koch H (June 2009). "Kinship and Y-chromosome analysis of 7th century human remains: novel DNA extraction and typing procedure for ancient material". Croatian Medical Journal. 3. 50 (3): 286–95. doi:10.3325/cmj.2009.50.286. PMC   2702742 . PMID   19480023.
  70. D'Atanasio E, Trombetta B, Bonito M, Finocchio A, Di Vito G, Seghizzi M, et al. (February 2018). "The peopling of the last Green Sahara revealed by high-coverage resequencing of trans-Saharan patrilineages". Genome Biology. 19 (1): 20. doi: 10.1186/s13059-018-1393-5 . PMC   5809971 . PMID   29433568.
  71. Marcus JH, Posth C, Ringbauer H, Lai L, Skeates R, Sidore C, et al. (February 2020). "Genetic history from the Middle Neolithic to present on the Mediterranean island of Sardinia". Nature Communications. 11 (1): 939. Bibcode:2020NatCo..11..939M. doi:10.1038/s41467-020-14523-6. PMC   7039977 . PMID   32094358.
  72. Grugni, Viola; et al. (2019). "Y-chromosome and Surname Analyses for Reconstructing Past Population Structures: The Sardinian Population as a Test Case". International Journal of Molecular Sciences. 20 (5763): 5763. doi: 10.3390/ijms20225763 . PMC   6888588 . PMID   31744094.
  73. Allentoft, M.E. (2024). "Population genomics of post-glacial western Eurasia". Nature. 625 (7994): Supplementary Information, p.48. Bibcode:2024Natur.625..301A. doi:10.1038/s41586-023-06865-0. PMC   10781627 . PMID   38200295.
  74. Haber, Marc; Mezzavilla, Massimo; Bergström, Anders; Prado-Martinez, Javier; Hallast, Pille; Saif-Ali, Riyadh; Al-Habori, Molham; Dedoussis, George; Zeggini, Eleftheria; Blue-Smith, Jason; Wells, R. Spencer; Xue, Yali; Zalloua, Pierre A.; Tyler-Smith, Chris (December 2016). "Chad Genetic Diversity Reveals an African History Marked by Multiple Holocene Eurasian Migrations" (PDF). The American Journal of Human Genetics. 99 (6): 1316–1324. doi:10.1016/j.ajhg.2016.10.012. PMC   5142112 . PMID   27889059. S2CID   38169172.
  75. Kulichova, Iva; et al. (2017). "Internal diversification of non-Sub-Saharan haplogroups in Sahelian populations and the spread of pastoralism beyond the Sahara". American Journal of Biological Anthropology. 164 (2): 424–434. doi:10.1002/ajpa.23285. PMID   28736914.
  76. Grugni, Viola; et al. (2019). "Y-chromosome and Surname Analyses for Reconstructing Past Population Structures: The Sardinian Population as a Test Case". International Journal of Molecular Sciences. 20 (5763): 5763. doi: 10.3390/ijms20225763 . PMC   6888588 . PMID   31744094.
  77. Vicente, Mario; et al. (2019). "Population history and genetic adaptation of the Fulani nomads: inferences from genome-wide data and the lactase persistence trait". BMC Genomics. 20: 915. doi: 10.1186/s12864-019-6296-7 . PMC   6888939 . PMID   31791255.
  78. Simões, L.G.; et al. (2023). "Northwest African Neolithic initiated by migrants from Iberia and Levant". Nature. 618 (7965): 550–556. Bibcode:2023Natur.618..550S. doi:10.1038/s41586-023-06166-6. PMC   10266975 . PMID   37286608.
  79. Fregel, Rosa; Méndez, Fernando L.; Bokbot, Youssef; Martín-Socas, Dimas; Camalich-Massieu, María D.; Santana, Jonathan; Morales, Jacob; Ávila-Arcos, María C.; Underhill, Peter A.; Shapiro, Beth; Wojcik, Genevieve; Rasmussen, Morten; Soares, André E. R.; Kapp, Joshua; Sockell, Alexandra (2018-06-26). "Ancient genomes from North Africa evidence prehistoric migrations to the Maghreb from both the Levant and Europe". Proceedings of the National Academy of Sciences. 115 (26): 6774–6779. doi:10.1073/pnas.1800851115. ISSN   0027-8424. PMC   6042094 . PMID   29895688.
  80. Flores C, Maca-Meyer N, Larruga JM, Cabrera VM, Karadsheh N, Gonzalez AM (2005). "Isolates in a corridor of migrations: a high-resolution analysis of Y-chromosome variation in Jordan". Journal of Human Genetics. 50 (9): 435–441. doi: 10.1007/s10038-005-0274-4 . PMID   16142507. S2CID   6490283.
  81. Hassan HY, Underhill PA, Cavalli-Sforza LL, Ibrahim ME (November 2008). "Y-chromosome variation among Sudanese: restricted gene flow, concordance with language, geography, and history". American Journal of Physical Anthropology. 137 (3): 316–323. doi:10.1002/ajpa.20876. PMID   18618658. 13/32
  82. Shriner, Daniel; Rotimi, Charles N. (December 2018). "Genetic History of Chad". American Journal of Physical Anthropology. 167 (4): 804–812. doi:10.1002/ajpa.23711. ISSN   0002-9483. PMC   6240361 . PMID   30259956.
  83. Cruciani F, Santolamazza P, Shen P, Macaulay V, Moral P, Olckers A, et al. (May 2002). "A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypes". American Journal of Human Genetics. 70 (5): 1197–214. doi:10.1086/340257. PMC   447595 . PMID   11910562., pp. 13–14
  84. Contu D, Morelli L, Santoni F, Foster JW, Francalacci P, Cucca F (January 2008). "Y-chromosome based evidence for pre-neolithic origin of the genetically homogeneous but diverse Sardinian population: inference for association scans". PLOS ONE. 3 (1): e1430. Bibcode:2008PLoSO...3.1430C. doi: 10.1371/journal.pone.0001430 . PMC   2174525 . PMID   18183308.
  85. Zalloua PA, Xue Y, Khalife J, Makhoul N, Debiane L, Platt DE, et al. (April 2008). "Y-chromosomal diversity in Lebanon is structured by recent historical events". American Journal of Human Genetics. 82 (4): 873–882. doi:10.1016/j.ajhg.2008.01.020. PMC   2427286 . PMID   18374297.
  86. Zhong H, Shi H, Qi XB, Duan ZY, Tan PP, Jin L, et al. (January 2011). "Extended Y chromosome investigation suggests postglacial migrations of modern humans into East Asia via the northern route". Molecular Biology and Evolution. 28 (1): 717–27. doi: 10.1093/molbev/msq247 . PMID   20837606.
  87. Rowold DJ, Perez Benedico D, Garcia-Bertrand R, Chennakrishnaiah S, Alfonso-Sanchez MA, Gayden T, Herrera RJ (March 2016). "Ladakh, India: the land of high passes and genetic heterogeneity reveals a confluence of migrations". European Journal of Human Genetics. 24 (3): 442–9. doi:10.1038/ejhg.2015.80. PMC   4755386 . PMID   25966630.
  88. "About R1a and R1b from Ural epic story. Artem Lukichev (c)". Archived from the original on 2021-12-15 via www.youtube.com.
  89. Coble MD, Loreille OM, Wadhams MJ, Edson SM, Maynard K, Meyer CE, et al. (2009). "Mystery solved: the identification of the two missing Romanov children using DNA analysis". PLOS ONE. 4 (3): e4838. Bibcode:2009PLoSO...4.4838C. doi: 10.1371/journal.pone.0004838 . PMC   2652717 . PMID   19277206.
  90. Maan AA, Eales J, Akbarov A, Rowland J, Xu X, Jobling MA, et al. (November 2017). "The Y chromosome: a blueprint for men's health?". European Journal of Human Genetics. 25 (11): 1181–1188. doi:10.1038/ejhg.2017.128. PMC   5643963 . PMID   28853720.
  91. Timmers P, Wilson JF (July 2022). "Limited Effect of Y Chromosome Variation on Coronary Artery Disease and Mortality in UK Biobank—Brief Report". Arteriosclerosis, Thrombosis, and Vascular Biology. 42 (9): 1198–1206. doi:10.1161/ATVBAHA.122.317664. PMC   9394501 . PMID   35861954.

Bibliography