Great cerebral vein | |
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Details | |
Drains from | Cerebrum |
Source | Internal cerebral veins |
Drains to | Straight sinus |
Artery | Cerebral arteries |
Identifiers | |
Latin | vena magna cerebri |
TA98 | A12.3.06.027 |
TA2 | 4922 |
FMA | 50993 |
Anatomical terminology |
The great cerebral vein is one of the large blood vessels in the skull draining the cerebrum of the brain. It is also known as the vein of Galen, named for its discoverer, the Greek physician Galen.
The great cerebral vein is one of the deep cerebral veins. Other deep cerebral veins are the internal cerebral veins, formed by the union of the superior thalamostriate vein and the superior choroid vein at the interventricular foramina. The internal cerebral veins can be seen on the superior surfaces of the caudate nuclei and thalami just under the corpus callosum. [1] The veins at the anterior poles of the thalami merge posterior to the pineal gland to form the great cerebral vein. [1] Most of the blood in the deep cerebral veins collects into the great cerebral vein. [2] This comes from the inferior side of the posterior end of the corpus callosum and empties ie similarities, there are also differences between these two types of veins in the brain. The superficial veins at the dorsal parts of the hemispheres run upward and medially and empty into the large superior sagittal sinus in the upper margin of the falx cerebri. The superior sagittal sinus divides into two parts called the transverse sinuses where the falx cerebri meets the tentorium cerebelli. [3] The sigmoid sinus, which continues the transverse sinus, empties into the jugular vein at the jugular foramen. The internal jugular vein leaves the skull and travels downward to the neck. [3]
The length of the great cerebral vein of Galen varies from 0.15 to 4.2 cm (mean 0.93 cm). [4]
The veins of the brain have very thin walls and contain no valves. They emerge in the brain and lie in the subarachnoid space. They pierce the arachnoid mater and the meningeal layer in the dura and drain into the cranial dural venous sinuses. [3]
Most conditions associated with the great cerebral vein are due to congenital defects. Vein of Galen aneurysmal malformations (VGAM) are the most common form of symptomatic cerebrovascular malformation in neonates and infants. [5] The presence and locations of angiomas are very variable and do not follow any predictable pattern. [6] The congenital malformation develops during weeks 6-11 of fetal development as a persistent embryonic prosencephalic vein of Markowski; thus, VGAM is actually a misnomer. The vein of Markowski actually drains into the vein of Galen. A falcine sinus lies within the falx cerebri and connects the vein of Galen and superior sagittal sinus; it is normally present during fetal development and involutes after birth, but its presence after birth is associated with a vein of Galen malformation and other vascular anomalies. [7]
Absence of the great cerebral vein is a congenital disorder. The deep cerebral veins of the brain normally drain through the great cerebral vein. In its absence, the veins from the diencephalon and the basal ganglia drain laterally into the transverse sinus instead of conjoining in the midline through the Galenic drainage system. [8] Absence of the great cerebral vein is quite rare. It is detected in infancy and most patients die in the neonatal period or in early infancy.
Thrombosis of the great cerebral vein is a form of stroke due to a blood clot in the vein. It affects just 3 to 8% of patients, predominantly women. [9] Patients may present with consciousness problems, headaches, nausea, visual defects, fatigue, disturbance of eye movements and pupillary reflexes, or coma. [9] Thrombosis of the cerebral vein is often deadly but can be survived. Risk factors include oral contraceptives, pregnancy, and the postpartum period. [9]
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Veins are blood vessels in the circulatory system of humans and most other animals that carry blood towards the heart. Most veins carry deoxygenated blood from the tissues back to the heart; exceptions are those of the pulmonary and fetal circulations which carry oxygenated blood to the heart. In the systemic circulation, arteries carry oxygenated blood away from the heart, and veins return deoxygenated blood to the heart, in the deep veins.
The dura mater, is the outermost of the three meningeal membranes. The dura mater has two layers, an outer periosteal layer closely adhered to the neurocranium, and an inner meningeal layer known as the dural border cell layer. The two dural layers are for the most part fused together forming a thick fibrous tissue membrane that covers the brain and the vertebrae of the spinal column. But the layers are separated at the dural venous sinuses to allow blood to drain from the brain. The dura covers the arachnoid mater and the pia mater the other two meninges in protecting the central nervous system.
Cerebral circulation is the movement of blood through a network of cerebral arteries and veins supplying the brain. The rate of cerebral blood flow in an adult human is typically 750 milliliters per minute, or about 15% of cardiac output. Arteries deliver oxygenated blood, glucose and other nutrients to the brain. Veins carry "used or spent" blood back to the heart, to remove carbon dioxide, lactic acid, and other metabolic products. The neurovascular unit regulates cerebral blood flow so that activated neurons can be supplied with energy in the right amount and at the right time. Because the brain would quickly suffer damage from any stoppage in blood supply, the cerebral circulatory system has safeguards including autoregulation of the blood vessels. The failure of these safeguards may result in a stroke. The volume of blood in circulation is called the cerebral blood flow. Sudden intense accelerations change the gravitational forces perceived by bodies and can severely impair cerebral circulation and normal functions to the point of becoming serious life-threatening conditions.
The falx cerebri is a large, crescent-shaped fold of dura mater that descends vertically into the longitudinal fissure to separate the cerebral hemispheres. It supports the dural sinuses that provide venous and CSF drainage from the brain. It is attached to the crista galli anteriorly, and blends with the tentorium cerebelli posteriorly.
The cavernous sinus within the human head is one of the dural venous sinuses creating a cavity called the lateral sellar compartment bordered by the temporal bone of the skull and the sphenoid bone, lateral to the sella turcica.
The dural venous sinuses are venous sinuses (channels) found between the periosteal and meningeal layers of dura mater in the brain. They receive blood from the cerebral veins, and cerebrospinal fluid (CSF) from the subarachnoid space via arachnoid granulations. They mainly empty into the internal jugular vein. Cranial venous sinuses communicate with veins outside the skull through emissary veins. These communications help to keep the pressure of blood in the sinuses constant.
The confluence of sinuses, torcular Herophili, or torcula is the connecting point of the superior sagittal sinus, straight sinus, and occipital sinus. It is below the internal occipital protuberance of the skull. It drains venous blood from the brain into the transverse sinuses. It may be affected by arteriovenous fistulas, a thrombus, major trauma, or surgical damage, and may be imaged with many radiology techniques.
The straight sinus, also known as tentorial sinus or the sinus rectus, is an area within the skull beneath the brain. It receives blood from the inferior sagittal sinus and the great cerebral vein, and drains into the confluence of sinuses.
The superior sagittal sinus, within the human head, is an unpaired dural venous sinus lying along the attached margin of the falx cerebri. It allows blood to drain from the lateral aspects of anterior cerebral hemispheres to the confluence of sinuses. Cerebrospinal fluid drains through arachnoid granulations into the superior sagittal sinus and is returned to venous circulation.
The inferior sagittal sinus, within the human head, is an area beneath the brain which allows blood to drain outwards posteriorly from the center of the head. It drains to the straight sinus, which connects to the transverse sinuses. See diagram : labeled in the brain as "SIN. SAGITTALIS INF.".
A dural arteriovenous fistula (DAVF) or malformation is an abnormal direct connection (fistula) between a meningeal artery and a meningeal vein or dural venous sinus.
The transverse sinuses, within the human head, are two areas beneath the brain which allow blood to drain from the back of the head. They run laterally in a groove along the interior surface of the occipital bone. They drain from the confluence of sinuses to the sigmoid sinuses, which ultimately connect to the internal jugular vein. See diagram : labeled under the brain as "SIN. TRANS.".
The occipital vein is a vein of the scalp. It originates from a plexus around the external occipital protuberance and superior nuchal line to the back part of the vertex of the skull. It usually drains into the internal jugular vein, but may also drain into the posterior auricular vein. It drains part of the scalp.
The internal cerebral veins are two veins included in the group of deep cerebral veins that drain the deep parts of the hemispheres; each internal cerebral vein is formed near the interventricular foramina by the union of the superior thalamostriate vein and the superior choroid vein.
The cerebellar veins are veins which drain the cerebellum. They consist of the superior cerebellar veins and the inferior cerebellar veins. The superior cerebellar veins drain to the straight sinus and the internal cerebral veins. The inferior cerebellar veins drain to the transverse sinus, the superior petrosal sinus, and the occipital sinus.
Cerebral venous sinus thrombosis (CVST), cerebral venous and sinus thrombosis or cerebral venous thrombosis (CVT), is the presence of a blood clot in the dural venous sinuses, the cerebral veins, or both. Symptoms may include severe headache, visual symptoms, any of the symptoms of stroke such as weakness of the face and limbs on one side of the body, and seizures, which occur in around 40% of patients.
Vein of Galen aneurysmal malformations(VGAMs) and Vein of Galen aneurysmal dilations (VGADs) are the most frequent arteriovenous malformations in infants and fetuses. A VGAM consists of a tangled mass of dilated vessels supplied by an enlarged artery. The malformation increases greatly in size with age, although the mechanism of the increase is unknown. Dilation of the great cerebral vein of Galen is a secondary result of the force of arterial blood either directly from an artery via an arteriovenous fistula or by way of a tributary vein that receives the blood directly from an artery. There is usually a venous anomaly downstream from the draining vein that, together with the high blood flow into the great cerebral vein of Galen causes its dilation. The right sided cardiac chambers and pulmonary arteries also develop mild to severe dilation.
A falcine sinus is a venous channel that lies within the falx cerebri connecting the vein of Galen and the posterior part of superior sagittal sinus. It is normally present during fetal development and involutes after birth. The presence of a falcine sinus has been associated with a vein of Galen malformation and other vascular anomalies. The persistence of a falcine sinus after the neonatal period was previously thought to be rare, but has recently been described to be present in up to 5% of all people, appearings in approximately 2.1% of CT examinations of adult patients. Some authors have studied the plexus rather than the sinus, a rare form of the venous pathway between the layers of the cerebral falx, which connects the superior sagittal sinus with the inferior sagittal sinus and the straight sinus.
The empty delta sign is a radiologic sign seen on brain imaging which is associated with cerebral venous sinus thrombosis. It is usually seen on magnetic resonance imaging (MRI) or computed tomography (CT) scans with contrast. It is seen as dural wall enhancement in the absence of intra-sinus enhancement. This is due to the presence of a blood clot in the dural venous sinuses. The dural venous sinuses drain blood from the brain to the internal jugular veins, which in turn drains blood to the heart. It has been proposed that the empty delta sign occurs in dural venous thromboses due to contrast material filling the dural venous collateral circulation immediately surrounding the dura whilst being unable to fill the intra-dural sinus space due to the presence of a blood clot. The superior sagittal sinus is most commonly affected, but the radiologic sign may also be seen in the transverse sinuses.
Cranial venous outflow obstruction, also referred to as impaired cranial venous outflow, impaired cerebral venous outflow, cerebral venous impairment is a vascular disorder that involves the impairment of venous drainage from the cerebral veins of the human brain.