Hepatitis C virus nonstructural protein 3

Last updated

HCV genome.png
HCV genome
Identifiers
Organism Hepacivirus hominis
SymbolNS3
Entrez 951475
RefSeq (Prot) NP_803144.1
UniProt Q91RS4
Other data
Chromosome Genomic: 0 - 0 Mb
Search for
Structures Swiss-model
Domains InterPro

Nonstructural protein 3 (NS3), also known as p-70, is a viral nonstructural protein that is the 70 kDa cleavage product of the hepatitis C virus polyprotein. It acts as a serine protease. [1] [2] The C-terminal two-thirds of the protein also acts as a helicase and nucleoside triphosphatase. [3] The first (N-terminal) 180 amino acids of NS3 have an additional role as cofactor domains for the NS2 protein. [4]

See also

References

  1. ↑ Hijikata M, Mizushima H, Tanji Y, Komoda Y, Hirowatari Y, Akagi T, et al. (November 1993). "Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus". Proceedings of the National Academy of Sciences of the United States of America. 90 (22): 10773–10777. Bibcode:1993PNAS...9010773H. doi: 10.1073/pnas.90.22.10773 . PMC   47860 . PMID   7504283.
  2. ↑ Raney KD, Sharma SD, Moustafa IM, Cameron CE (July 2010). "Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target". The Journal of Biological Chemistry. 285 (30): 22725–22731. doi: 10.1074/jbc.R110.125294 . PMC   2906261 . PMID   20457607.
  3. ↑ Zhang C, Cai Z, Kim YC, Kumar R, Yuan F, Shi PY, et al. (July 2005). "Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase". Journal of Virology. 79 (14): 8687–8697. doi:10.1128/jvi.79.14.8687-8697.2005. PMC   1168731 . PMID   15994762.
  4. ↑ Schregel V, Jacobi S, Penin F, Tautz N (March 2009). "Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3". Proceedings of the National Academy of Sciences of the United States of America. 106 (13): 5342–5347. Bibcode:2009PNAS..106.5342S. doi: 10.1073/pnas.0810950106 . PMC   2663979 . PMID   19282477.
  5. ↑ "NS3/4A Protease Inhibitors - DrugBank".
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