Hepatitis C virus nonstructural protein 3

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HCV genome

Nonstructural protein 3 (NS3), also known as p-70, is a viral nonstructural protein that is the 70 kDa cleavage product of the hepatitis C virus polyprotein. It acts as a serine protease. [1] [2] The C-terminal two-thirds of the protein also acts as a helicase and nucleoside triphosphatase. [3] The first (N-terminal) 180 amino acids of NS3 have an additional role as cofactor domains for the NS2 protein. [4]

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References

  1. ↑ Hijikata, M.; et al. (1993). "Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus". Proc. Natl. Acad. Sci. USA. 90 (22): 10773–10777. Bibcode:1993PNAS...9010773H. doi: 10.1073/pnas.90.22.10773 . PMC   47860 . PMID   7504283.
  2. ↑ Raney, Kevin D.; Sharma, Suresh D.; Moustafa, Ibrahim M.; Cameron, Craig E. (2010). "Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target". Journal of Biological Chemistry. 285 (30): 22725–22731. doi: 10.1074/jbc.R110.125294 . PMC   2906261 . PMID   20457607.
  3. ↑ Zhang, C.; Cai, Z.; Kim, Y.-C.; Kumar, R.; Yuan, F.; Shi, P.-Y.; Kao, C.; Luo, G. (July 2005). "Stimulation of Hepatitis C Virus (HCV) Nonstructural Protein 3 (NS3) Helicase Activity by the NS3 Protease Domain and by HCV RNA-Dependent RNA Polymerase". J. Virol. 79 (14): 8687–8697. doi:10.1128/jvi.79.14.8687-8697.2005. PMC   1168731 . PMID   15994762.
  4. ↑ Schregel, V; Jacobi, S; Penin, F; Tautz, N (2009). "Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3". Proc Natl Acad Sci U S A. 106 (13): 5342–7. Bibcode:2009PNAS..106.5342S. doi: 10.1073/pnas.0810950106 . PMC   2663979 . PMID   19282477.
  5. ↑ "NS3/4A Protease Inhibitors - DrugBank".


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