Hermann Emil Fischer

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Hermann Emil Fischer

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Hermann Emil Fischer
BornHermann Emil Louis Fischer
(1852-10-09)9 October 1852
Euskirchen, Rhine Province
Died 15 July 1919(1919-07-15) (aged 66)
Berlin, Germany
Nationality Germany
Alma mater University of Bonn
University of Strasbourg
Known for Study of sugars & purines
Awards
Scientific career
Fields Chemistry
Institutions University of Munich (1875–81)
University of Erlangen (1881–88)
University of Würzburg (1888–92)
University of Berlin (1892–1919)
Doctoral advisor Adolf von Baeyer [ citation needed ]
Doctoral students Alfred Stock
Otto Diels
Otto Ruff
Walter A. Jacobs
Ludwig Knorr
Oskar Piloty
Julius Tafel

Hermann Emil Louis Fischer FRS FRSE FCS (9 October 1852 – 15 July 1919) was a German chemist and 1902 recipient of the Nobel Prize in Chemistry. He discovered the Fischer esterification. He also developed the Fischer projection, a symbolic way of drawing asymmetric carbon atoms. He never used his first given name, and was known throughout his life simply as Emil Fischer. [2] [3] [4] [5]

Fellow of the Royal Society of Edinburgh Award granted by the Royal Society of Edinburgh

Fellowship of the Royal Society of Edinburgh (FRSE) is an award granted to individuals that the Royal Society of Edinburgh, Scotland, judges to be "eminently distinguished in their subject". This society had, in itself received a royal charter in 1783, allowing for its expansion.

Chemist scientist trained in the study of chemistry

A chemist is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe the properties they study in terms of quantities, with detail on the level of molecules and their component atoms. Chemists carefully measure substance proportions, reaction rates, and other chemical properties. The word 'chemist' is also used to address Pharmacists in Commonwealth English.

Nobel Prize in Chemistry One of the five Nobel Prizes established in 1895 by Alfred Nobel

The Nobel Prize in Chemistry is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for outstanding contributions in chemistry, physics, literature, peace, and physiology or medicine. This award is administered by the Nobel Foundation, and awarded by Royal Swedish Academy of Sciences on proposal of the Nobel Committee for Chemistry which consists of five members elected by Academy. The award is presented in Stockholm at an annual ceremony on December 10, the anniversary of Nobel's death.

Contents

Early years

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Fischer was born in Euskirchen, near Cologne, the son of Laurenz Fischer, a businessman, and his wife Julie Poensgen. After graduating he wished to study natural sciences, but his father compelled him to work in the family business until determining that his son was unsuitable. Fischer then attended the University of Bonn in 1871, but switched to the University of Strasbourg in 1872. [6] He earned his doctorate in 1874 under Adolf von Baeyer [6] with his study of phthalein and was appointed to a position at the university.

Euskirchen Place in North Rhine-Westphalia, Germany

Euskirchen is a town in North Rhine-Westphalia, Germany, capital of the district Euskirchen. While Euskirchen resembles a modern shopping town, it also has a history dating back over 700 years, having been granted town status in 1302. As of December 2007, it had a population of 55,446.

Cologne Place in North Rhine-Westphalia, Germany

Cologne is the largest city of Germany's most populous federal state of North Rhine-Westphalia, and its 1 million+ (2016) inhabitants make it the fourth most populous city in Germany after Berlin, Hamburg, and Munich. The largest city on the Rhine, it is also the most populous city both of the Rhine-Ruhr Metropolitan Region, which is Germany's largest and one of Europe's major metropolitan areas, and of the Rhineland. Centred on the left bank of the Rhine, Cologne is about 45 kilometres (28 mi) southeast of North Rhine-Westphalia's capital of Düsseldorf and 25 kilometres (16 mi) northwest of Bonn. It is the largest city in the Central Franconian and Ripuarian dialect areas.

Natural science branch of science about the natural world

Natural science is a branch of science concerned with the description, prediction, and understanding of natural phenomena, based on empirical evidence from observation and experimentation. Mechanisms such as peer review and repeatability of findings are used to try to ensure the validity of scientific advances.

Research

Fischer is noted for his work on sugars: among other work, the organic synthesis of (+) glucose [7] and purines (including the first synthesis of caffeine).

Organic synthesis is a special branch of chemical synthesis and is concerned with the intentional construction of organic compounds. Organic molecules are often more complex than inorganic compounds, and their synthesis has developed into one of the most important branches of organic chemistry. There are several main areas of research within the general area of organic synthesis: total synthesis, semisynthesis, and methodology.

Caffeine A central nervous system stimulant

Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class. It is the world's most widely consumed psychoactive drug. Unlike many other psychoactive substances, it is legal and unregulated in nearly all parts of the world. There are several known mechanisms of action to explain the effects of caffeine. The most prominent is that it reversibly blocks the action of adenosine on its receptor and consequently prevents the onset of drowsiness induced by adenosine. Caffeine also stimulates certain portions of the autonomic nervous system.

Fischer was also instrumental in the discovery of barbiturates, a class of sedative drugs used for insomnia, epilepsy, anxiety, and anesthesia. Along with the physician Josef von Mering, he helped to launch the first barbiturate sedative, barbital, in 1904. [8]

Barbital chemical compound

Barbital, marketed under the brand names Veronal for the pure acid and Medinal for the sodium salt, was the first commercially available barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s. The chemical names for barbital are diethylmalonyl urea or diethylbarbituric acid; hence, the sodium salt is known also as sodium diethylbarbiturate.

Honours, awards, and legacy

Monument to Hermann Emil Fischer in Berlin Hermann Emil Fischer berlin.jpg
Monument to Hermann Emil Fischer in Berlin

In 1897 he put forward the idea to create the International Atomic Weights Commission. Fischer was elected a Foreign Member of the Royal Society (ForMemRS) in 1899. [1]

Commission on Isotopic Abundances and Atomic Weights organization

The Commission on Isotopic Abundances and Atomic Weights (CIAAW) is an international scientific committee of the International Union of Pure and Applied Chemistry (IUPAC) under its Division of Inorganic Chemistry. Since 1899, it is entrusted with periodic critical evaluation of atomic weights of chemical elements and other cognate data, such as the isotopic composition of elements. The biennial CIAAW Standard Atomic Weights are accepted as the authoritative source in science and appear worldwide on the periodic table wall charts.

Many names of chemical reactions and concepts are named after him:

The Fischer indole synthesis is a chemical reaction that produces the aromatic heterocycle indole from a (substituted) phenylhydrazine and an aldehyde or ketone under acidic conditions. The reaction was discovered in 1883 by Emil Fischer. Today antimigraine drugs of the triptan class are often synthesized by this method.

Fischer projection

The Fischer projection, devised by Emil Fischer in 1891, is a two-dimensional representation of a three-dimensional organic molecule by projection. Fischer projections were originally proposed for the depiction of carbohydrates and used by chemists, particularly in organic chemistry and biochemistry. The use of Fischer projections in non-carbohydrates is discouraged, as such drawings are ambiguous when confused with other types of drawing.

Fischer oxazole synthesis

The Fischer oxazole synthesis is a chemical synthesis of an oxazole from a cyanohydrin and an aldehyde in the presence of anhydrous hydrochloric acid. This method was discovered by Emil Fischer in 1896. The cyanohydrin itself is derived from a separate aldehyde. The reactants of the oxazole synthesis itself, the cyanohydrin of an aldehyde and the other aldehyde itself, are usually present in equimolar amounts. Both reactants usually have an aromatic group, which appear at specific positions on the resulting heterocycle.

(Fischer–Tropsch process is named after Franz Emil Fischer a chemist who was no relation, head of the Max Planck Institute for Coal Research in Muelheim.)

Related Research Articles

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References

  1. 1 2 "Fellows of the Royal Society". London: Royal Society. Archived from the original on 2015-03-16.
  2. Horst Kunz (2002). "Emil Fischer – Unequalled Classicist, Master of Organic Chemistry Research, and Inspired Trailblazer of Biological Chemistry". Angewandte Chemie International Edition. 41 (23): 4439–4451. doi:10.1002/1521-3773(20021202)41:23<4439::AID-ANIE4439>3.0.CO;2-6. PMID   12458504.
  3. Lichtenthaler, F. W. (1992). "Emil Fischers Beweis der Konfiguration von Zuckern: eine Würdigung nach hundert Jahren". Angewandte Chemie. 104 (12): 1577–1593. doi:10.1002/ange.19921041204.
  4. Forster, Martin Onslow (1 January 1920). "Emil Fischer memorial lecture". Journal of the Chemical Society, Transactions. 117: 1157–1201. doi:10.1039/CT9201701157.
  5. Biography Biography of Fischer from Nobelprize.org website
  6. 1 2 Eduard, Farber (1970–80). "Fischer, Emil Hermann". Dictionary of Scientific Biography . 5. New York: Charles Scribner's Sons. pp. 1–5. ISBN   978-0-684-10114-9.
  7. Fischer, Emil (1890). "Synthese des Traubenzuckers". Berichte der deutschen chemischen Gesellschaft. 23: 799–805. doi:10.1002/cber.189002301126.
  8. López-Muñoz; et al. "The History of Barbiturates". PMC   2424120 Lock-green.svg.