LY-2365109

Last updated
LY-2365109
LY-2365109.svg
Names
IUPAC name
2-[2-[4-(1,3-Benzodioxol-5-yl)-2-tert-butylphenoxy]ethyl-methylamino]acetic acid
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
PubChem CID
  • InChI=1S/C22H27NO5/c1-22(2,3)17-11-15(16-6-8-19-20(12-16)28-14-27-19)5-7-18(17)26-10-9-23(4)13-21(24)25/h5-8,11-12H,9-10,13-14H2,1-4H3,(H,24,25)
    Key: FKPLJWGRBCQLTL-UHFFFAOYSA-N
  • CC(C)(C)C1=C(C=CC(=C1)C2=CC3=C(C=C2)OCO3)OCCN(C)CC(=O)O
Properties
C22H27NO5
Molar mass 385.460 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

LY-2365109 is a glycine reuptake inhibitor. It is able to inhibit the type 1 glycine transporter. [1] This inhibition increases extracellular levels of glycine. LY-2365109 has been shown to increase the seizure threshold in mice, meaning that this drug has potential as an anticonvulsant. [2]

References

  1. ↑ Zhang, Jichun; Wu, Jin; Toyohara, Jun; Fujita, Yuko; Chen, Hongxian; Hashimoto, Kenji (2011). "Pharmacological characterization of [³H]CHIBA-3007 binding to glycine transporter 1 in the rat brain". PLOS ONE. 6 (6) e21322. Bibcode:2011PLoSO...621322Z. doi: 10.1371/journal.pone.0021322 . ISSN   1932-6203. PMC   3121759 . PMID   21731704.
  2. ↑ Shen, Hai-Ying; van Vliet, Erwin A.; Bright, Kerry-Ann; Hanthorn, Marissa; Lytle, Nikki K.; Gorter, Jan; Aronica, Eleonora; Boison, Detlev (December 2015). "Glycine transporter 1 is a target for the treatment of epilepsy". Neuropharmacology. 99: 554–565. doi:10.1016/j.neuropharm.2015.08.031. ISSN   1873-7064. PMC   4655139 . PMID   26302655.


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