This is a list of airlines operating with an air operator's certificate granted by the Federal Office of Civil Aviation of Switzerland.
| Airline | AOC no. | Photo | IATA | ICAO | Callsign | Hub airport(s) | Notes | 
|---|---|---|---|---|---|---|---|
| Chair Airlines | CH.AOC.1052 |   | GM | GSW | EIGER | Zurich Airport | |
| EasyJet Switzerland | CH.AOC.1018 |   | DS | EZS | TOPSWISS | Geneva International Airport EuroAirport Basel Mulhouse Freiburg | Operates flights on behalf of EasyJet plc (U2) | 
| Edelweiss Air | CH.AOC.1007 |   | WK | EDW | EDELWEISS | Zurich Airport | |
| Helvetic Airways | CH.AOC.1033 |   | 2L | OAW | HELVETIC | Zurich Airport | Operates scheduled flights on behalf of Swiss International Air Lines (LX) | 
| Swiss International Air Lines | CH.AOC.1006 |   | LX | SWR | SWISS | Zurich Airport Geneva Airport | Flag carrier of Switzerland | 
| Airline | AOC no. | Photo | IATA | ICAO | Callsign | Hub airport(s) | Notes | 
|---|---|---|---|---|---|---|---|
| Air Glaciers | CH.AOC.1502 |   | AGV | AIR GLACIERS | |||
| Air Zermatt | CH.MG.3007 |   | AZF | AIR ZERMATT | |||
| Albinati Aeronautics | CH.AOC.1036 |   | |||||
| Cat Aviation | CH.AOC.1004 |   | |||||
| Dasnair | CH.AOC.1035 |   | |||||
| ExecuJet Europe | CH.AOC.1020 |   | EuroAirport Basel Mulhouse Freiburg | ||||
| Gama Aviation | CH.AOC.1051 |   | Geneva Airport | ||||
| Heliswiss | CH.MG.3034 |   | HSI | HELISWISS | Bern Airport | ||
| Jet Aviation | CH.AOC.1010 |   | PP | PJS | JETAVIATION | Zurich Airport, Teterboro Airport | |
| JU Air | CH.AOC.1013 |   | Dübendorf Air Base | ||||
| Lions Air | CH.AOC.1501 |   | LEU | LIONSAIR | |||
| Nomad Aviation | CH.AOC.1046 |   | |||||
| Premium Jet | CH.AOC.1011 |   | |||||
| Rabbit-Air | CH.AOC.1026 |   | |||||
| Swiss Air-Rescue | CH.AOC.1015 |   | Zurich Airport | ||||
| TAG Aviation | CH.AOC.1001 |   | Geneva Airport | ||||
| Zimex Aviation | CH.AOC.1025 |   | C4 | IMX | ZIMEX | Zurich Airport |