| Plasmodium gallinaceum | |
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| Scanning electron micrograph of invading mosquito midgut | |
Scientific classification  | |
| Domain: | Eukaryota |
| Clade: | Diaphoretickes |
| Clade: | SAR |
| Clade: | Alveolata |
| Phylum: | Apicomplexa |
| Class: | Aconoidasida |
| Order: | Haemospororida |
| Family: | Plasmodiidae |
| Genus: | Plasmodium |
| Species: | P. gallinaceum |
| Binomial name | |
| Plasmodium gallinaceum Brumpt, 1935 | |
Plasmodium gallinaceum is a species of the genus Plasmodium (subgenus Haemamoeba ) that causes malaria in poultry. [1]
This species was described by Alexandre Joseph Emile Brumpt (1877–1951) a French professor of parasitology during a trip to Ceylon (now Sri Lanka). [2]
Oocysts must develop inside the vector host. [3] They are not transmissible – if they enter an avian host they will not develop. [3]
Sporozoites are the transmission stage. [3] If they enter an avian host they may infect. [3]
Aedes aegypti is a vector. [4]
P. gallinaceum manipulates A. aegypti to increase its own chances of success. [3] Koella et al., 2002 finds that oocysts in the gut increase the volume of each blood meal. [3] This lowers the chances of disgorgement of the parasites into the final host – chicken (Gallus gallus domesticus) – which is important because oocysts can't infect. [3] This prolongs the average duration of oocyst residence in the vector, increasing their chance of successfully maturing to the transmission stage. [3]
On the other hand sporozoites do the opposite: They decrease the volume of meals, increasing the number of meals taken, shortening the time they must continue to be in the vector, and increasing their chance of being successfully disgorged into a final host. [3] Because this is the transmittable (infectious) stage that is desirable. [3]
This appears to generalize to P. gallinaceum and any combination of mosquito and avian. [3]
Circumsporozoite protein (CSP) is required for host invasion. [4] Warburg et al., 1992 provides a monoclonal antibody against CSP and demonstrates efficacy. [4] The complete inhibition of sporozoite colonization of Aedes aegypti salivary glands they achieved could be due to the antibody itself blocking contact between the sporozoites and the gland surface, however the antibody's binding is inhibited by a particular CSP motif, suggesting antibody efficacy is due to its anti-CSP effect. [4] This 15-amino acid motif is one found by the original Dame et al., 1984 discovery of CSP which contains the 5-length CSP Region I. [4] : 395–396 [5]
Infection produces severe changes in blood plasma composition. [6] Williams 2005 finds large changes in plasma proteins at 8 days post infection. [6] There is a reduction in albumin, α2-globulin, and creatinine. [6] Meanwhile, there is an increase in γ1-globulin, γ2-globulin, total plasma protein, and total plasma enzyme. [6] (The enzyme increase is due to an increase in aspartate aminotransferase, glutamate dehydrogenase, and γ-glutamyltransferase.) [6]
Plasmodium is a genus of unicellular eukaryotes that are obligate parasites of vertebrates and insects. The life cycles of Plasmodium species involve development in a blood-feeding insect host which then injects parasites into a vertebrate host during a blood meal. Parasites grow within a vertebrate body tissue before entering the bloodstream to infect red blood cells. The ensuing destruction of host red blood cells can result in malaria. During this infection, some parasites are picked up by a blood-feeding insect, continuing the life cycle.
Plasmodium falciparum is a unicellular protozoan parasite of humans, and the deadliest species of Plasmodium that causes malaria in humans. The parasite is transmitted through the bite of a female Anopheles mosquito and causes the disease's most dangerous form, falciparum malaria. It is responsible for around 50% of all malaria cases. P. falciparum is therefore regarded as the deadliest parasite in humans. It is also associated with the development of blood cancer and is classified as a Group 2A (probable) carcinogen.
Plasmodium vivax is a protozoal parasite and a human pathogen. This parasite is the most frequent and widely distributed cause of recurring malaria. Although it is less virulent than Plasmodium falciparum, the deadliest of the five human malaria parasites, P. vivax malaria infections can lead to severe disease and death, often due to splenomegaly. P. vivax is carried by the female Anopheles mosquito; the males do not bite.
Plasmodium malariae is a parasitic protozoan that causes malaria in humans. It is one of several species of Plasmodium parasites that infect other organisms as pathogens, also including Plasmodium falciparum and Plasmodium vivax, responsible for most malarial infection. Found worldwide, it causes a so-called "benign malaria", not nearly as dangerous as that produced by P. falciparum or P. vivax. The signs include fevers that recur at approximately three-day intervals – a quartan fever or quartan malaria – longer than the two-day (tertian) intervals of the other malarial parasite.
Plasmodium knowlesi is a parasite that causes malaria in humans and other primates. It is found throughout Southeast Asia, and is the most common cause of human malaria in Malaysia. Like other Plasmodium species, P. knowlesi has a life cycle that requires infection of both a mosquito and a warm-blooded host. While the natural warm-blooded hosts of P. knowlesi are likely various Old World monkeys, humans can be infected by P. knowlesi if they are fed upon by infected mosquitoes. P. knowlesi is a eukaryote in the phylum Apicomplexa, genus Plasmodium, and subgenus Plasmodium. It is most closely related to the human parasite Plasmodium vivax as well as other Plasmodium species that infect non-human primates.
Babesia, also called Nuttallia, is an apicomplexan parasite that infects red blood cells and is transmitted by ticks. Originally discovered by the Romanian bacteriologist Victor Babeș in 1888, over 100 species of Babesia have since been identified.
Plasmodium yoelii is a parasite of the genus Plasmodium subgenus Vinckeia. As in all Plasmodium species, P. yoelii has both vertebrate and insect hosts. The vertebrate hosts for this parasite are mammals.
Malaria vaccines are vaccines that prevent malaria, a mosquito-borne infectious disease which annually affects an estimated 247 million people worldwide and causes 619,000 deaths. The first approved vaccine for malaria is RTS,S, known by the brand name Mosquirix. As of April 2023, the vaccine has been given to 1.5 million children living in areas with moderate-to-high malaria transmission. It requires at least three doses in infants by age 2, and a fourth dose extends the protection for another 1–2 years. The vaccine reduces hospital admissions from severe malaria by around 30%.
Leucocytozoon is a genus of parasitic alveolates belonging to the phylum Apicomplexa.
Avian malaria is a parasitic disease of birds, caused by parasite species belonging to the genera Plasmodium and Hemoproteus. The disease is transmitted by a dipteran vector including mosquitoes in the case of Plasmodium parasites and biting midges for Hemoproteus. The range of symptoms and effects of the parasite on its bird hosts is very wide, from asymptomatic cases to drastic population declines due to the disease, as is the case of the Hawaiian honeycreepers. The diversity of parasites is large, as it is estimated that there are approximately as many parasites as there are species of hosts. As research on human malaria parasites became difficult, Dr. Ross studied avian malaria parasites. Co-speciation and host switching events have contributed to the broad range of hosts that these parasites can infect, causing avian malaria to be a widespread global disease, found everywhere except Antarctica.
Haemoproteus is a genus of alveolates that are parasitic in birds, reptiles, and amphibians. Its name is derived from Greek: haima 'blood' and Proteus, a sea god that had the power to assume various shapes. The name Haemoproteus was first used in the description of H. columbae in the blood of the pigeon Columba livia by Walther Kruse in 1890. This was also the first description of this genus. Two other genera—Halteridium and Simondia—are now considered to be synonyms of Haemoproteus.
Mosquito-borne diseases or mosquito-borne illnesses are diseases caused by bacteria, viruses or parasites transmitted by mosquitoes. Nearly 700 million people get a mosquito-borne illness each year, resulting in over 725,000 deaths.
Hematozoa is a subclass of blood parasites of the Apicomplexa clade. Well known examples include the Plasmodium spp. which cause malaria in humans and Theileria which causes theileriosis in cattle. A large number of species are known to infect birds and are transmitted by insect vectors. The pattern in which Haematozoa infect a host cell depends on the genera of the blood parasite. Plasmodium and Leucozytozoon displace the nucleus of the host cell so that the parasite can take control of the cell where as Hemoproteus completely envelops the nucleus in a host cell.
Apicomplexans, a group of intracellular parasites, have life cycle stages that allow them to survive the wide variety of environments they are exposed to during their complex life cycle. Each stage in the life cycle of an apicomplexan organism is typified by a cellular variety with a distinct morphology and biochemistry.
Polychromophilus is a genus of obligate intracellular eukaryotic parasites that infect bats from every continent except Antarctica. They are transmitted by bat flies, which act as an insect vector as well as the parasite’s site of sporogeny. Polychromophilus follows a fairly typical Haemospororidian lifecycle, with gametocytes and gametes restricted to the bloodstream of the host and meronts infecting organs – most notably the lungs and the liver. The type species is Polychromophilus melanipherus, and was described by Dionisi in 1898.
Ann Bishop was a British biologist from Girton College at the University of Cambridge and a Fellow of the Royal Society, one of the few female Fellows of the Royal Society. She was born in Manchester but stayed at Cambridge for the vast majority of her professional life. Her specialties were protozoology and parasitology; early work with ciliate parasites, including the one responsible for blackhead disease in the domesticated turkey, lay the groundwork for her later research. While working towards her doctorate, Bishop studied parasitic amoebae and examined potential chemotherapies for the treatment of amoebic diseases including amoebic dysentery.
Circumsporozoite protein (CSP) is a secreted protein of the sporozoite stage of the malaria parasite and is the antigenic target of RTS,S and other malaria vaccines. The amino-acid sequence of CSP consists of an immunodominant central repeat region flanked by conserved motifs at the N- and C- termini that are implicated in protein processing as the parasite travels from the mosquito to the mammalian vector. The amino acid sequence of CSP was determined in 1984.
Plasmodium cynomolgi is an apicomplexan parasite that infects mosquitoes and Asian Old World monkeys. In recent years, a number of natural infections of humans have also been documented. This species has been used as a model for human Plasmodium vivax because Plasmodium cynomolgi shares the same life cycle and some important biological features with P. vivax.
Coquillettidia (Coquillettidia) crassipes is a species complex of zoophilic mosquito belonging to the genus Coquillettidia.
Parr Tate was an Irish parasitologist, particularly known for his research on malaria. He spent his entire academic career in Cambridge, England, where he was Reader in Parasitology (1949–68) and head of the Department of Parasitology at the University of Cambridge, director of the Molteno Institute for Research in Parasitology (1953–68), and one of the founding fellows of what is now Wolfson College, Cambridge. He was the editor of the journal Parasitology (1952–68).
Kumnuan, Rapeeporn; Pattaradilokrat, Sittiporn; Chumpolbanchornc, Kamlang (November 2013). "In vivo transmission blocking activities of artesunate on the avian malaria parasite Plasmodium gallinaceum". Veterinary Parasitology . 197 (3–4): 447–454. doi:10.1016/j.vetpar.2013.07.024. PMID 23937960.
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