Pol (HIV)

The Gag-Pol region containing the protease gene flanked by p6 at the N-terminus and reverse transcriptase at the C-terminus.

Pol (DNA polymerase) refers to a gene in retroviruses, or the protein produced by that gene. Products of pol include: ^{[1] [2]}

• Reverse transcriptase (RT), which transcribes the viral RNA into double-stranded DNA.
• Integrase, which integrates the DNA produced by RT into the host cell's genome.
• Protease, an enzyme that cuts proteins into segments. HIV's gag and pol genes do not encode their proteins in their final form but as larger polyproteins that the HIV protease cleaves into separate functional units.

See also

• Gag/pol translational readthrough site

References

1. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2012). Biological Agents. Lyon, France: IARC. pp. 216–218. ISBN   978-92-832-1319-2.
2. "Lentivirus". ViralZone. Swiss Institute of Bioinformatics. Retrieved 3 April 2025.

External links

• Gene+Products,+pol at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• pol+Gene+Products,+Human+Immunodeficiency+Virus at the U.S. National Library of Medicine Medical Subject Headings (MeSH)