Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It then travels down the axon terminating in the posterior pituitary, and is released from vesicles into the circulation in response to extracellular fluid hypertonicity (hyperosmolality). AVP has two primary functions. First, it increases the amount of solute-free water reabsorbed back into the circulation from the filtrate in the kidney tubules of the nephrons. Second, AVP constricts arterioles, which increases peripheral vascular resistance and raises arterial blood pressure.
Oxytocin is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. Present in animals since early stages of evolution, in humans it plays roles in behavior that include social bonding, reproduction, childbirth, and the period after childbirth. Oxytocin is released into the bloodstream as a hormone in response to sexual activity and during labour. It is also available in pharmaceutical form. In either form, oxytocin stimulates uterine contractions to speed up the process of childbirth. In its natural form, it also plays a role in maternal bonding and milk production. Production and secretion of oxytocin is controlled by a positive feedback mechanism, where its initial release stimulates production and release of further oxytocin. For example, when oxytocin is released during a contraction of the uterus at the start of childbirth, this stimulates production and release of more oxytocin and an increase in the intensity and frequency of contractions. This process compounds in intensity and frequency and continues until the triggering activity ceases. A similar process takes place during lactation and during sexual activity.
Voles are small rodents that are relatives of lemmings and hamsters, but with a stouter body; a longer, hairy tail; a slightly rounder head; smaller eyes and ears; and differently formed molars. They are sometimes known as meadow mice or field mice in North America.
The eastern meadow vole, sometimes called the field mouse or meadow mouse, is a North American vole found in eastern Canada and the United States. Its range extends farther south along the Atlantic coast.
Animal sexual behaviour takes many different forms, including within the same species. Common mating or reproductively motivated systems include monogamy, polygyny, polyandry, polygamy and promiscuity. Other sexual behaviour may be reproductively motivated or non-reproductively motivated.
In biology, a pair bond is the strong affinity that develops in some species between a mating pair, often leading to the production and rearing of young and potentially a lifelong bond. Pair-bonding is a term coined in the 1940s that is frequently used in sociobiology and evolutionary biology circles. The term often implies either a lifelong socially monogamous relationship or a stage of mating interaction in socially monogamous species. It is sometimes used in reference to human relationships.
Vasopressin receptor 1A (V1AR), or arginine vasopressin receptor 1A is one of the three major receptor types for vasopressin, and is present throughout the brain, as well as in the periphery in the liver, kidney, and vasculature.
Monogamous pairing in animals refers to the natural history of mating systems in which species pair bond to raise offspring. This is associated, usually implicitly, with sexual monogamy.
Social connection is the experience of feeling close and connected to others. It involves feeling loved, cared for, and valued, and forms the basis of interpersonal relationships.
"Connection is the energy that exists between people when they feel seen, heard and valued; when they can give and receive without judgement; and when they derive sustenance and strength from the relationship." —Brené Brown, Professor of social work at the University of Houston
The montane vole is a species of vole native to the western United States and Canada.
C. Sue Carter is an American biologist and behavioral neurobiologist. She is an internationally recognized expert in behavioral neuroendocrinology. In 2014 she was appointed Director of The Kinsey Institute and Rudy Professor of Biology at Indiana University. Carter was the first person to identify the physiological mechanisms responsible for social monogamy.
Monogamy is a relationship of two individuals in which they form an exclusive intimate partnership. Having only one partner at any one time, whether that be for life or whether that be serial monogamy, contrasts with various forms of non-monogamy. More generally, the term is used to describe the behavioral ecology and sexual selection of animal mating systems, referring to the state of having only one mate at any one given time. In a human cultural context, monogamy typically refers to the custom of two individuals, regardless of orientation, committing to a sexually exclusive relationship.
Thomas Roland Insel is an American neuroscientist, psychiatrist, entrepreneur, and author who led the National Institute of Mental Health (NIMH) from 2002 until November 2015. Prior to becoming Director of NIMH, he was the founding Director of the Center for Behavioral Neuroscience at Emory University in Atlanta, Georgia. He is best known for research on oxytocin and vasopressin, two peptide hormones implicated in complex social behaviors, such as parental care and attachment. He announced on Sept. 15, 2015, that he was resigning as the director of the NIMH to join the Life Science division of Google X. On May 8, 2017, CNBC reported that he had left Verily Life Sciences. Insel is a Co-founder with Richard Klausner and Paul Dagum of a digital mental health company named "Mindstrong," a Bay-area startup. He has also co-founded Humanest Care, NeuraWell Therapeutics, and MindSite News and is a member of the scientific advisory board for Compass Pathways, a company that is developing the psychedelic drug psilocybin to treat depression and other mental health disorders. His book, Healing: Our Path from Mental Illness to Mental Health was published by Penguin Random House in February, 2022.
The Bruce effect, or pregnancy block, is the tendency for female rodents to terminate their pregnancies following exposure to the scent of an unfamiliar male. The effect was first noted in 1959 by Hilda M. Bruce, and has primarily been studied in laboratory mice. In mice, pregnancy can only be terminated prior to embryo implantation, but other species will interrupt even a late-term pregnancy.
Social monogamy in mammals is defined as sexually mature adult organisms living in pairs. While there are many definitions of social monogamy, this social organization can be found in invertebrates, reptiles and amphibians, fish, birds, mammals, and humans.
Even though intimacy has been broadly defined in terms of romantic love and sexual desire, the neuroanatomy of intimacy needs further explanation in order to fully understand their neurological functions in different components within intimate relationships, which are romantic love, lust, attachment, and rejection in love. Also, known functions of the neuroanatomy involved can be applied to observations seen in people who are experiencing any of the stages in intimacy. Research analysis of these systems provide insight on the biological basis of intimacy, but the neurological aspect must be considered as well in areas that require special attention to mitigate issues in intimacy, such as violence against a beloved partner or problems with social bonding.
Endocrinology of parenting has been the subject of considerable study with focus both on human females and males and on females and males of other mammalian species. Parenting as an adaptive problem in mammals involves specific endocrine signals that were naturally selected to respond to infant cues and environmental inputs. Infants across species produce a number of cues to inform caregivers of their needs. These include visual cues, like facial characteristics, or in some species smiling, auditory cues, such as vocalizations, olfactory cues, and tactile stimulation. A commonly mentioned hormone in parenting is oxytocin, however many other hormones relay key information that results in variations in behavior. These include estrogen, progesterone, prolactin, cortisol, and testosterone. While hormones are not necessary for the expression of maternal behavior, they may influence it.
Larry James Young was an American psychiatrist who was the William P. Timmie Professor of Psychiatry and Behavioral Sciences at the Emory University School of Medicine. He was head of the Division of Behavioral Neuroscience and Psychiatric Disorders at Emory National Primate Research Center. Young studied how genetic, cellular and neurobiological mechanisms regulate complex social behavior, including social cognition and social bonding. His research focuses heavily on the roles of the neuropeptides oxytocin and vasopressin in regulating the neural processing of social signals and social attachment.
Angela J. Grippo is an American neuroscientist and health psychologist known for her research on stress, mood disorders, and cardiovascular disease. She is an associate professor of psychology at Northern Illinois University.
Zoe R. Donaldson is an American neuroscientist and assistant professor at the University of Colorado Boulder. Donaldson explores the neurobiological and genetic mechanisms of social bonding and social behavior in rodents. Her work will help to elucidate how variations in genetics and circuit activity across the population predispose certain individuals to mental illness. Donaldson is a pioneer in the use of the monogamous prairie voles to study social behaviors and has been developing novel genetic tools, since her graduate work at Emory University, to study voles in the lab to better understand the neural circuits underlying pair bonding.
