| 2021 President's Cup II | |
|---|---|
| Date | 19–25 July 2021 |
| Edition | 16th |
| Surface | Hard |
| Location | Nur-Sultan, Kazakhstan |
| Champions | |
| Singles | |
 Andrey Kuznetsov | |
| Doubles | |
 Hsu Yu-hsiou /  Benjamin Lock | |
The 2021 President's Cup II was a professional tennis tournament played on outdoor hard courts. It was the sixteenth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Nur-Sultan, Kazakhstan between 19 and 25 July 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| RUS | |||
 UKR | Sergiy Stakhovsky | 226 | 2 |
 GBR | Jay Clarke | 243 | 3 |
 FRA | Hugo Grenier | 253 | 4 |
 CAN | Peter Polansky | 254 | 5 |
 NED | Jesper de Jong | 263 | 6 |
| TPE | Tseng Chun-hsin | 265 | 7 |
| TPE | Wu Tung-lin | 268 | 8 |
The following players received wildcards into the singles main draw:
Grigoriy Lomakin Dostanbek Tashbulatov Beibit Zhukayev The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Andrey Kuznetsov def. 
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