Amnesic shellfish poisoning

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Amnesic shellfish poisoning (ASP) is an illness caused by consumption of shellfish that contain the marine biotoxin called domoic acid. [1] In mammals, including humans, domoic acid acts as a neurotoxin, causing permanent short-term memory loss, brain damage, and death in severe cases.

Contents

This toxin is produced naturally by marine diatoms belonging to the genus Pseudo-nitzschia and the species Nitzschia navis-varingica . [2] When accumulated in high concentrations by shellfish during filter feeding, domoic acid can then be passed on to birds, marine mammals, and humans by consumption of the contaminated shellfish. [3] [4] [5] [6] [7] [8] [9] [10]

Although human illness due to domoic acid has only been associated with shellfish, the toxin can bioaccumulate in many marine organisms that consume phytoplankton, such as anchovies and sardines. Intoxication by domoic acid in nonhuman organisms is frequently referred to as domoic acid poisoning.

Symptoms and treatment

In the brain, domoic acid especially damages the hippocampus and amygdaloid nucleus. [1] It damages the neurons by activating AMPA and kainate receptors, causing an influx of calcium. Although calcium flowing into cells is a normal event, the uncontrolled increase of calcium causes the cell to degenerate. [11] [12]

Discovery

ASP was first discovered in humans late in 1987, when a serious outbreak of food poisoning occurred in eastern Canada. [1] [13] Three elderly patients died and other victims suffered long-term neurological problems. Because the victims suffered from memory loss, the term "amnesic" shellfish poisoning is used. [14]

Epidemiologists from Health Canada quickly linked the illnesses to restaurant meals of cultured mussels harvested from one area in Prince Edward Island, a place never before affected by toxic algae. Mouse bioassays on aqueous extracts of the suspect mussels caused death with some unusual neurotoxic symptoms very different from those of paralytic shellfish poisoning toxins and other known toxins. On December 12, 1987, a team of scientists was assembled at the National Research Council of Canada laboratory in Halifax, Nova Scotia. Integrating bioassay-directed fractionation with chemical analysis, the team identified the toxin on the afternoon of December 16, only four days after the start of the concerted investigation. [15] [16]

Possible animal effects

On June 22, 2006, a California brown pelican, possibly under the influence of domoic acid, flew through the windshield of a car on the Pacific Coast Highway. The phycotoxin is found in the local coastal waters. [17]

According to the Channel Islands Marine and Wildlife Institute,

It is generally accepted that the incidence of problems associated with toxic algae is increasing. Possible reasons to explain this increase include natural mechanisms of species dispersal (currents and tides) to a host of human-related phenomena such as nutrient enrichment (agricultural run-off), climate shifts, or transport of algae species via ship ballast water. [18]

Domoic acid poisoning may have caused an August 18, 1961, invasion of thousands of frantic seabirds in Capitola and Santa Cruz, California. [19] Director Alfred Hitchcock heard about this invasion while working on his adaptation of the Daphne du Maurier novelette "The Birds" for his feature film The Birds (1963), and asked the Santa Cruz Sentinel for any further news copy as "research for his new thriller."

See also

Related Research Articles

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<span class="mw-page-title-main">Domoic acid</span> Chemical compound

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<span class="mw-page-title-main">Cyanotoxin</span> Toxin produced by cyanobacteria

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<i>Pseudo-nitzschia</i> Genus of marine planktonic diatoms

Pseudo-nitzschia is a marine planktonic diatom genus that accounts for 4.4% of pennate diatoms found worldwide. Some species are capable of producing the neurotoxin domoic acid (DA), which is responsible for the neurological disorder in humans known as amnesic shellfish poisoning (ASP). Currently, 58 species are known, 28 of which have been shown to produce DA. It was originally hypothesized that only dinoflagellates could produce harmful algal toxins, but a deadly bloom of Pseudo-nitzschia occurred in 1987 in the bays of Prince Edward Island, Canada, and led to an outbreak of ASP. Over 100 people were affected by this outbreak after consuming contaminated mussels; three people died. Since this event, no additional deaths have been attributed to ASP, though the prevalence of toxic diatoms and DA has increased worldwide. This anomaly is likely due to increased awareness of harmful algal blooms (HABs) and their implications for human and ecosystem health.

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References

  1. 1 2 3 Clark, R. F.; Williams, S. R.; Nordt, S. P.; Manoguerra, A. S. (1999). "A Review of Selected Seafood Poisonings". Undersea and Hyperbaric Medicine. 26 (3): 175–184. PMID   10485519. Archived from the original on 2011-08-11. Retrieved 2008-08-13.{{cite journal}}: CS1 maint: unfit URL (link)
  2. ↑ "IOC-UNESCO Taxonomic Reference List of Harmful Micro Algae (HABs)". Archived from the original on 2016-09-17. Retrieved 2012-05-17.Nitzschia navis-varingica
  3. ↑ Bates, S. S.; Trainer, V. L. (2006). "The Ecology of Harmful Diatoms". In Granéli, E.; Turner, J. (eds.). Ecology of Harmful Algae. Ecological Studies. Vol. 189. Heidelberg: Springer-Verlag. pp. 81–93. doi:10.1007/978-3-540-32210-8_7. ISBN   978-3-540-74009-4.
  4. ↑ Bejarano, A. C.; van Dola, F. M.; Gulland, F. M.; Rowles, T. K.; Schwacke, L. H. (2008). "Production and Toxicity of the Marine Biotoxin Domoic Acid and its Effects on Wildlife: A Review" (PDF). Human and Ecological Risk Assessment. 14 (3): 544–567. doi:10.1080/10807030802074220. S2CID   51778319. Archived from the original (PDF) on 2016-06-29. Retrieved 2012-05-17.
  5. ↑ Trainer, V. L.; Hickey, B. M.; Bates, S. S. (2008). "Toxic Diatoms". In Walsh, P. J.; Smith, S. L.; Fleming, L. E.; Solo-Gabriele, H.; Gerwick, W. H. (eds.). Oceans and Human Health: Risks and Remedies from the Sea. New York: Elsevier Science. pp. 219–237. ISBN   978-0-12-372584-4.
  6. ↑ Lefebvre, K. A.; Robertson, A. (2010). "Domoic Acid and Human Exposure Risks: A Review". Toxicon. 56 (2): 218–230. doi:10.1016/j.toxicon.2009.05.034. PMID   19505488.
  7. ↑ Bargu, S.; Smith, E.; Ozhan, K. (2011). "Toxic Diatom Pseudo-nitzschia and its Primary Consumers (Vectors)". In Seckbach, J.; Kociolek, P. (eds.). The Diatom World. Springer. pp. 493–512. ISBN   978-9400713260.
  8. ↑ Bargu, S.; Goldstein, T.; Roberts, K.; Li, C.; Gulland, F. (2012). "Pseudo-nitzschia Blooms, Domoic Acid, and Related California Sea Lion Strandings in Monterey Bay, California". Marine Mammal Science. 28 (2): 237–253. doi:10.1111/j.1748-7692.2011.00480.x.
  9. ↑ Lelong, A.; Hégaret, H.; Soudant, P.; Bates, S. S. (2012). "Pseudo-nitzschia (Bacillariophyceae) Species, Domoic Acid and Amnesic Shellfish Poisoning: Revisiting Previous Paradigms". Phycologia. 51 (2): 168–216. doi:10.2216/11-37.1. S2CID   55094773.
  10. ↑ Trainer, V. L.; Bates, S. S.; Lundholm, N.; Thessen, A. E.; Cochlan, W. P.; Adams, N. G.; Trick, C. G. (2012). "Pseudo-nitzschia Physiological Ecology, Phylogeny, Toxicity, Monitoring and Impacts on Ecosystem Health". Harmful Algae. 14: 271–300. doi:10.1016/j.hal.2011.10.025. hdl: 1912/5118 .
  11. ↑ Ramsdell, J. S. (2007). "The Molecular and Integrative Basis to Domoic Acid Toxicity". In Botana, L. (ed.). Phycotoxins: Chemistry and Biochemistry. Cambridge, MA: Wiley-Blackwell. pp. 223–250. doi:10.1002/9780470277874.ch13. ISBN   978-0-8138-2700-1.
  12. ↑ Pulido, O. M. (2008). "Domoic Acid Toxicologic Pathology: A Review" (PDF). Marine Drugs. 6 (2): 180–219. doi: 10.3390/md20080010 . PMC   2525487 . PMID   18728725.
  13. ↑ Bates, S. S.; et al. (1989). "Pennate diatom Nitzschia pungens as the primary source of domoic acid, a toxin in shellfish from eastern Prince Edward Island, Canada". Canadian Journal of Fisheries and Aquatic Sciences. 46 (7): 1203–1215. doi:10.1139/f89-156.
  14. ↑ Todd, E. C. D. (1993). "Domoic Acid and Amnesic Shellfish Poisoning: A Review". Journal of Food Protection. 56 (1): 69–83. doi: 10.4315/0362-028X-56.1.69 . PMID   31084045. Archived from the original on 2020-09-21. Retrieved 2012-07-10.
  15. ↑ Quilliam M. A.; Wright J. L. C. (1989). "The Amnesic Shellfish Poisoning Mystery". Analytical Chemistry. 61 (18): 1053A–1060A. doi:10.1021/ac00193a002. PMID   2802153. S2CID   40176293.
  16. ↑ Bird, C. J.; Boyd, R. K.; Brewer, D.; Craft, C. A.; de Freitas, A. S. W.; Dyer, E. W.; Embree, D. J.; Falk, M.; Flack, M. G.; Foxall, R. A.; Gillis, C.; Greenwell, M.; Hardstaff, W. R.; Jamieson, W. D.; Laycock, M. V.; LeBlanc, P.; Lewis, N. I.; McCulloch, A. W.; McCully, G. K.; McInerney-Northcott, M.; McInnes, A. G.; McLachlan, J. L.; Odense, P.; O'Neil, D.; Pathak, V.; Quilliam, M. A.; Ragan, M. A.; Seto, P. F.; Sim, P. G.; Tappen, D.; Thibault, P.; Walter, J. A.; Wright, J. L. C.; Backman, A. M.; Taylor, A. M.; Dewar, D.; Gilgan, M.; Richard, D. J. A. (1988). Identification of domoic acid as the toxic agent responsible for the P.E.I. contaminated mussel incident: a summary of work conducted at the Atlantic Research Laboratory of the National Research Council, Halifax, between 13 Dec. 1987 and 11 Jan. 1988 (Report). doi:10.4224/23000874.
  17. ↑ "Possibly drunk pelican hits windshield". NBC News . 24 June 2006. Archived from the original on 2017-03-16.
  18. ↑ Domic Acid Information and History Archived May 13, 2009, at the Wayback Machine
  19. ↑ Bargu, S.; Silver, M. W.; Ohman, M. D.; Benitez-Nelson, C. R.; Garrison, D. L. (2012). "Mystery behind Hitchcock's Birds". Nature Geoscience. 5 (1): 2–3. Bibcode:2012NatGe...5....2B. doi: 10.1038/ngeo1360 .
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