ethanolaminephosphotransferase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 2.7.8.1 | ||||||||
CAS no. | 9026-19-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
In enzymology, an ethanolaminephosphotransferase (EC 2.7.8.1) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are CDP-ethanolamine and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylethanolamine.
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase. Other names in common use include EPT, diacylglycerol ethanolaminephosphotransferase, CDPethanolamine diglyceride phosphotransferase, and phosphorylethanolamine-glyceride transferase. This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.
Glycerophospholipids or phosphoglycerides are glycerol-based phospholipids. They are the main component of biological membranes. Two major classes are known: those for bacteria and eukaryotes and a separate family for archaea.
Phosphatidylethanolamine (PE) is a class of phospholipids found in biological membranes. They are synthesized by the addition of cytidine diphosphate-ethanolamine to diglycerides, releasing cytidine monophosphate. S-Adenosyl methionine can subsequently methylate the amine of phosphatidylethanolamines to yield phosphatidylcholines.
In enzymology, a CDP-diacylglycerol diphosphatase (EC 3.6.1.26) is an enzyme that catalyzes the chemical reaction
The enzyme phosphatidate phosphatase (PAP, EC 3.1.3.4) is a key regulatory enzyme in lipid metabolism, catalyzing the conversion of phosphatidate to diacylglycerol:
In enzymology, an acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a CDP-acylglycerol O-arachidonoyltransferase was an enzyme construed to catalyze the chemical reaction
In enzymology, a diacylglycerol-sterol O-acyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a phospholipid:diacylglycerol acyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a CDP-diacylglycerol—inositol 3-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a CDP-diacylglycerol—serine O-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a ceramide cholinephosphotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a diacylglycerol cholinephosphotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, an ethanolamine-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction
Phosphatidate cytidylyltransferase (CDS) is the enzyme that catalyzes the synthesis of CDP-diacylglycerol from cytidine triphosphate and phosphatidate.
In enzymology, a phosphatidylcholine synthase is an enzyme that catalyzes the chemical reaction
In enzymology, a serine-phosphoethanolamine synthase is an enzyme that catalyzes the chemical reaction
In enzymology, a sphingosine cholinephosphotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a ceramide phosphoethanolamine synthase is an enzyme that catalyzes the chemical reaction
The CDP-choline pathway, first identified by Eugene P. Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules. The CDP-choline pathway represents one half of what is known as the Kennedy pathway. The other half is the CDP-ethanolamine pathway which is responsible for the biosynthesis of the phospholipid phosphatidylethanolamine (PE).