Glucuronate-1-phosphate uridylyltransferase

Last updated
glucuronate-1-phosphate uridylyltransferase
Identifiers
EC no. 2.7.7.44
CAS no. 52228-05-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, a glucuronate-1-phosphate uridylyltransferase (EC 2.7.7.44) is an enzyme that catalyzes the chemical reaction

UTP + 1-phospho-alpha-D-glucuronate diphosphate + UDP-glucuronate

Thus, the two substrates of this enzyme are UTP and 1-phospho-alpha-D-glucuronate, whereas its two products are diphosphate and UDP-glucuronate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:1-phospho-alpha-D-glucuronate uridylyltransferase. Other names in common use include UDP-glucuronate pyrophosphorylase, UDP-D-glucuronic acid pyrophosphorylase, UDP-glucuronic acid pyrophosphorylase, and uridine diphosphoglucuronic pyrophosphorylase. This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.

Related Research Articles

<span class="mw-page-title-main">Uridine triphosphate</span> Chemical compound

Uridine-5′-triphosphate (UTP) is a pyrimidine nucleoside triphosphate, consisting of the organic base uracil linked to the 1′ carbon of the ribose sugar, and esterified with tri-phosphoric acid at the 5′ position. Its main role is as substrate for the synthesis of RNA during transcription. UTP is the precursor for the production of CTP via CTP synthetase. UTP can be biosynthesized from UDP by Nucleoside Diphosphate Kinase after using the phosphate group from ATP. UDP + ATP ⇌ UTP + ADP; both UTP and ATP are energetically equal.

<span class="mw-page-title-main">Uridine diphosphate</span> Chemical compound

Uridine diphosphate, abbreviated UDP, is a nucleotide diphosphate. It is an ester of pyrophosphoric acid with the nucleoside uridine. UDP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase uracil.

<span class="mw-page-title-main">Uridine diphosphate glucose</span> Chemical compound

Uridine diphosphate glucose is a nucleotide sugar. It is involved in glycosyltransferase reactions in metabolism.

<span class="mw-page-title-main">UTP—glucose-1-phosphate uridylyltransferase</span> Class of enzymes

UTP—glucose-1-phosphate uridylyltransferase also known as glucose-1-phosphate uridylyltransferase is an enzyme involved in carbohydrate metabolism. It synthesizes UDP-glucose from glucose-1-phosphate and UTP; i.e.,

In enzymology, an UDP-arabinose 4-epimerase is an enzyme that catalyzes the chemical reaction

In enzymology, an UDP-glucuronate 4-epimerase is an enzyme that catalyzes the chemical reaction

In enzymology, an UDP-glucuronate 5'-epimerase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">UDP-glucuronate decarboxylase</span> Class of enzymes

The enzyme UDP-glucuronate decarboxylase (EC 4.1.1.35) catalyzes the chemical reaction

In enzymology, a dioxotetrahydropyrimidine phosphoribosyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase</span>

In enzymology, a galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Nicotinate-nucleotide diphosphorylase (carboxylating)</span>

In enzymology, a nicotinate-nucleotide diphosphorylase (carboxylating) (EC 2.4.2.19) is an enzyme that catalyzes the chemical reaction

In enzymology, a xanthine phosphoribosyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a glucuronokinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">UDP-N-acetylglucosamine diphosphorylase</span> Class of enzymes

In enzymology, an UDP-N-acetylglucosamine diphosphorylase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">UTP—hexose-1-phosphate uridylyltransferase</span> Class of enzymes

In enzymology, an UTP—hexose-1-phosphate uridylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an UTP-monosaccharide-1-phosphate uridylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an UTP—xylose-1-phosphate uridylyltransferase is an enzyme that catalyzes the chemical reaction

David Sidney Feingold was an American biochemist.

UDP-N-acetylgalactosamine diphosphorylase is an enzyme with systematic name UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase. This enzyme catalyses the following chemical reaction

UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase is an enzyme with systematic name 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate 2-epimerase. This enzyme catalyses the following chemical reaction

References