Inositol-1,3,4-trisphosphate 5/6-kinase

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inositol-1,3,4-trisphosphate 5/6-kinase
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EC no. 2.7.1.159
CAS no. 288307-53-9
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inositol-1,3,4-trisphosphate 5/6-kinase (EC 2.7.1.159, Ins(1,3,4)P3 5/6-kinase, inositol trisphosphate 5/6-kinase) is an enzyme with systematic name ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase. [1] [2] [3] This enzyme catalyses the following chemical reaction

(1) ATP + 1D-myo-inositol 1,3,4-trisphosphate ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
(2) ATP + 1D-myo-inositol 1,3,4-trisphosphate ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate

In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6).

Related Research Articles

The enzyme glycerophosphoinositol inositolphosphodiesterase (EC 3.1.4.43) is an enzyme that catalyzes the chemical reaction

The enzyme inositol-1,4-bisphosphate 1-phosphatase (EC 3.1.3.57) catalyzes the reaction

The enzyme multiple inositol-polyphosphate phosphatase (EC 3.1.3.62) catalyzes the reaction

The enzyme phosphatidylinositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) that catalyzes the reaction

<span class="mw-page-title-main">1-phosphatidylinositol 4-kinase</span> Class of enzymes

In enzymology, a 1-phosphatidylinositol 4-kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a 1-phosphatidylinositol-5-phosphate 4-kinase is an enzyme that catalyzes the chemical reaction

In enzymology, a diphosphoinositol-pentakisphosphate kinase is an enzyme that catalyzes the chemical reaction

In enzymology, an inositol 3-kinase is an enzyme that catalyzes the chemical reaction

In enzymology, an inositol-pentakisphosphate 2-kinase is an enzyme that catalyzes the chemical reaction

In enzymology, an inositol-tetrakisphosphate 1-kinase is an enzyme that catalyzes the chemical reaction

In enzymology, an inositol-tetrakisphosphate 5-kinase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Inositol-trisphosphate 3-kinase</span> Class of enzymes

Inositol (1,4,5) trisphosphate 3-kinase (EC 2.7.1.127), abbreviated here as ITP3K, is an enzyme that facilitates a phospho-group transfer from adenosine triphosphate to 1D-myo-inositol 1,4,5-trisphosphate. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase. ITP3K catalyzes the transfer of the gamma-phosphate from ATP to the 3-position of inositol 1,4,5-trisphosphate to form inositol 1,3,4,5-tetrakisphosphate. ITP3K is highly specific for the 1,4,5-isomer of IP3, and it exclusively phosphorylates the 3-OH position, producing Ins(1,3,4,5)P4, also known as inositol tetrakisphosphate or IP4.

In enzymology, a phosphatidylinositol-4,5-bisphosphate 3-kinase is an enzyme that catalyzes the chemical reaction:

<span class="mw-page-title-main">ITPK1</span> Protein-coding gene in the species Homo sapiens

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.

Bisphosphate may refer to:

Inositol-polyphosphate multikinase is an enzyme with systematic name ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase. This enzyme catalyses the following chemical reaction

Inositol-hexakisphosphate kinase is an enzyme with systematic name ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase. This enzyme catalyses the following chemical reaction

The enzyme Inositol-polyphosphate 5-phosphatase (EC 3.1.3.56, systematic name 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase; other names type I inositol-polyphosphate phosphatase, inositol trisphosphate phosphomonoesterase, InsP3/Ins(1,3,4,5)P4 5-phosphatase, inosine triphosphatase, D-myo-inositol 1,4,5-triphosphate 5-phosphatase, D-myo-inositol 1,4,5-trisphosphate 5-phosphatase, L-myo-inositol 1,4,5-trisphosphate-monoesterase, inositol phosphate 5-phosphomonoesterase, inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase, Ins(1,4,5)P3 5-phosphataseD-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase, inositol 1,4,5-trisphosphate phosphatase, inositol polyphosphate-5-phosphatase, myo-inositol-1,4,5-trisphosphate 5-phosphatase, inositol-1,4,5-trisphosphate 5-phosphatase) catalyses the following reaction

Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78, phosphatidylinositol-4,5-bisphosphate 4-phosphatase I, phosphatidylinositol-4,5-bisphosphate 4-phosphatase II, type I PtdIns-4,5-P2 4-Ptase, type II PtdIns-4,5-P2 4-Ptase, IpgD, PtdIns-4,5-P2 4-phosphatase type I, PtdIns-4,5-P2 4-phosphatase type II, type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase, type 1 4-phosphatase) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase. This enzyme catalyses the following chemical reaction

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase, that has two isoforms: SHIP1 and SHIP2 (INPPL1).

References

  1. ↑ Wilson MP, Majerus PW (May 1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme". The Journal of Biological Chemistry. 271 (20): 11904–10. doi: 10.1074/jbc.271.20.11904 . PMID   8662638.
  2. ↑ Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW (January 2005). "The pathway for the production of inositol hexakisphosphate in human cells". The Journal of Biological Chemistry. 280 (3): 1911–20. doi: 10.1074/jbc.M411528200 . PMID   15531582.
  3. ↑ Miller GJ, Wilson MP, Majerus PW, Hurley JH (April 2005). "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase". Molecular Cell. 18 (2): 201–12. doi: 10.1016/j.molcel.2005.03.016 . PMID   15837423.
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