|  | 
| By-election | Date | Former incumbent | Party | Winner | Party | Cause | 
|---|
| Clitheroe | 13 July 1868 [19 1] | Richard Fort |  | Liberal | Ralph Assheton |  | Conservative | Death | 
| Stamford | 24 June 1868 [19 1] | Viscount Ingestre |  | Conservative | William Unwin Heygate |  | Conservative | Succession to a peerage | 
| Dublin City | 1 June 1868 [19 1] | Benjamin Guinness |  | Conservative | Arthur Guinness |  | Conservative | Resignation | 
| East Worcestershire | 1 June 1868 | Frederick Gough-Calthorpe |  | Liberal | Hon. Charles Lyttelton |  | Liberal | Succession to a peerage | 
| Stamford | 4 May 1868 [19 1] | Viscount Cranborne |  | Conservative | Viscount Ingestre |  | Conservative | Succession to a peerage | 
| East Kent | 2 May 1868 | Brook Bridges |  | Conservative | Edward Leigh Pemberton |  | Conservative | Elevation to the peerage | 
| Stirling Burghs | 30 April 1868 | Laurence Oliphant |  | Liberal | John Ramsay |  | Liberal | Resignation | 
| Bristol | 30 April 1868 | Samuel Morton Peto |  | Liberal | John William Miles |  | Conservative | Resignation | 
| South Lincolnshire | 29 April 1868 [19 1] | John Trollope |  | Conservative | William Earle Welby |  | Conservative | Elevation to the peerage | 
| Radnorshire | 28 April 1868 [19 1] | John Walsh |  | Conservative | Arthur Walsh |  | Conservative | Elevation to the peerage | 
| Leominster | 27 April 1868 [19 1] | Arthur Walsh |  | Conservative | Viscount Mahon |  | Conservative | Resignation to contest Radnorshire | 
| Grantham | 27 April 1868 | William Earle Welby |  | Conservative | Edmund Turnor |  | Conservative | Resignation to contest South Lincolnshire | 
| Cockermouth | 27 April 1868 | John Steel |  | Liberal | Andrew Green Thompson |  | Conservative | Death | 
| Wycombe | 11 April 1868 [19 1] | Charles Carington |  | Liberal | William Carington |  | Liberal | Succession to a peerage | 
| Launceston | 9 April 1868 [19 1] | Alexander Henry Campbell |  | Conservative | Henry Lopes |  | Conservative | Resignation | 
| Coventry | 26 March 1868 | Henry Jackson |  | Liberal | Samuel Carter |  | Liberal | Void election | 
| Huddersfield | 20 March 1868 | Thomas Crosland |  | Liberal | Edward Aldam Leatham |  | Liberal | Death | 
| North Northamptonshire | 7 March 1868 [19 1] | George Ward Hunt |  | Conservative | George Ward Hunt |  | Conservative | Chancellor of the Exchequer  [19 2] | 
| Argyllshire | 3 March 1868 [19 1] | Alexander Struthers Finlay |  | Liberal | Marquess of Lorne |  | Liberal | Resignation | 
| Cambridge University | 24 February 1868 | Charles Jasper Selwyn |  | Conservative | Alexander Beresford Hope |  | Conservative | Resignation (Judge of the Court of Appeal in Chancery) | 
| Stoke-upon-Trent | 20 February 1868 | Alexander Beresford Hope |  | Conservative | George Melly |  | Liberal | Resignation to contest Cambridge University | 
| Helston | 19 February 1868 [19 1] | William Brett |  | Conservative | William Brett |  | Conservative | Solicitor General for England and Wales  [19 2] | 
| Kirkcudbright | 30 January 1868 [19 1] | James Mackie |  | Liberal | Wellwood Herries Maxwell |  | Liberal | Death | 
| Westmorland | 8 January 1868 [19 1] | Henry Lowther |  | Conservative | William Lowther |  | Conservative | Death | 
| Thetford | 2 December 1867 [19 1] | Alexander Baring |  | Conservative | Edward Gordon |  | Conservative | Resignation | 
| South Leicestershire | 30 November 1867 | Charles William Packe |  | Conservative | Thomas Paget |  | Liberal | Death | 
| Manchester | 27 November 1867 | Edward James |  | Liberal | Jacob Bright |  | Liberal | Death | 
| Rutland | 23 November 1867 [19 1] | Gilbert Heathcote |  | Liberal | George Finch |  | Conservative | Succession to a peerage | 
| Bradford | 16 October 1867 | Henry Wickham Wickham |  | Conservative | Matthew William Thompson |  | Liberal | Death | 
| Galway County | 12 September 1867 [19 1] | Lord Dunkellin |  | Liberal | Viscount Burke |  | Liberal | Death | 
| Dublin University | 27 August 1867 [19 1] | Hedges Eyre Chatterton |  | Conservative | Robert Warren |  | Conservative | Resignation (Vice-Chancellor of Ireland) | 
| Stroud | 20 August 1867 | George Poulett Scrope |  | Liberal | Henry Winterbotham |  | Liberal | Resignation | 
| Downpatrick | 5 August 1867 [19 1] | David Stewart Ker |  | Conservative | William Keown |  | Conservative | Resignation | 
| West Gloucestershire | 25 July 1867 | John Rolt |  | Conservative | Edward Arthur Somerset |  | Conservative | Resignation (Lord Justice of Appeal) | 
| Coventry | 23 July 1867 | Morgan Treherne |  | Conservative | Henry Jackson |  | Liberal | Death | 
| Birmingham | 23 July 1867 | William Scholefield |  | Liberal | George Dixon |  | Liberal | Death | 
| Andover | 22 July 1867 [19 1] | John Burgess Karslake |  | Conservative | John Burgess Karslake |  | Conservative | Attorney General for England and Wales  [19 2] | 
| Cambridge University | 22 July 1867 [19 1] | Charles Jasper Selwyn |  | Conservative | Charles Jasper Selwyn |  | Conservative | Solicitor General for England and Wales  [19 2] | 
| North Lancashire | 1 July 1867 [19 1] | John Wilson-Patten |  | Conservative | John Wilson-Patten |  | Conservative | Chancellor of the Duchy of Lancaster  [19 2] | 
| Weymouth and Melcombe Regis | 11 June 1867 [19 1] | Henry Gridley |  | Liberal | Henry Edwards |  | Liberal | Resignation | 
| Sutherland | 27 May 1867 [19 1] | David Dundas |  | Liberal | Lord Ronald Gower |  | Liberal | Resignation | 
| Oxford University | 20 May 1867 [19 1] | Gathorne Hardy |  | Conservative | Gathorne Hardy |  | Conservative | Home Secretary  [19 2] | 
| Middlesex | 15 April 1867 [19 1] | Robert Culling Hanbury |  | Liberal | Henry Labouchère |  | Liberal | Death | 
| Galway Borough | 1 April 1867 [19 1] | Michael Morris |  | Conservative | George Morris |  | Liberal | Resignation (Puisne Judge of the Court of Common Pleas in Ireland) | 
| Dublin University | 30 March 1867 [19 1] | Hedges Eyre Chatterton |  | Conservative | Hedges Eyre Chatterton |  | Conservative | Attorney-General for Ireland  [19 2] | 
| Huntingdonshire | 25 March 1867 [19 1] | Lord Robert Montagu |  | Conservative | Lord Robert Montagu |  | Conservative | Vice-President of the Committee on Education  [19 2] | 
| Tyrone | 21 March 1867 [19 1] | Henry Lowry-Corry |  | Conservative | Henry Lowry-Corry |  | Conservative | First Lord of the Admiralty  [19 2] | 
| North Devon | 18 March 1867 [19 1] | Stafford Northcote |  | Conservative | Stafford Northcote |  | Conservative | Secretary of State for India  [19 2] | 
| Boston | 16 March 1867 [19 1] | Meaburn Staniland |  | Liberal | Thomas Parry |  | Liberal | Resignation | 
| North Shropshire | 14 March 1867 [19 1] | Adelbert Brownlow-Cust |  | Conservative | Viscount Newport |  | Conservative | Succession to a peerage | 
| Droitwich | 13 March 1867 [19 1] | John Pakington |  | Conservative | John Pakington |  | Conservative | Secretary of State for War  [19 2] | 
| South Shropshire | 8 March 1867 [19 1] | Percy Egerton Herbert |  | Conservative | Percy Egerton Herbert |  | Conservative | Treasurer of the Household  [19 2] | 
| North Riding of Yorkshire | 4 March 1867 [19 1] | William Duncombe |  | Conservative | Octavius Duncombe |  | Conservative | Succession to a peerage | 
|
| Cork County | 23 February 1867 [19 1] | George Richard Barry |  | Liberal | Arthur Smith-Barry |  | Conservative | Death | 
| East Suffolk | 20 February 1867 | Sir Edward Kerrison |  | Conservative | Frederick Snowdon Corrance |  | Conservative | Resignation | 
| Colchester | 15 February 1867 | Taverner John Miller |  | Conservative | Edward Karslake |  | Conservative | Resignation (Chief Justice of the Common Pleas) | 
| North Northamptonshire | 13 February 1867 [19 1] | Lord Burghley |  | Conservative | Sackville Stopford |  | Conservative | Succession to a peerage | 
| Galway Borough | 12 February 1867 [19 1] | Michael Morris |  | Conservative | Michael Morris |  | Conservative | Attorney General for Ireland  [19 2] | 
| Dublin University | 12 February 1867 [19 1] | John Edward Walsh |  | Conservative | Hedges Eyre Chatterton |  | Conservative | Resignation (Master of the Rolls in Ireland) | 
| Andover | 11 February 1867 [19 1] | William Henry Humphery |  | Conservative | John Burgess Karslake |  | Conservative | Resignation | 
| Armagh City | 30 January 1867 [19 1] | Stearne Ball Miller |  | Conservative | John Vance |  | Conservative | Resignation (Judge in Bankruptcy in Ireland) | 
| County Waterford | 31 December 1866 | Earl of Tyrone |  | Conservative | Edmond de la Poer |  | Liberal | Succession to a peerage | 
| Guildford | 17 December 1866 | William Bovill |  | Conservative | Richard Garth |  | Conservative | Resignation (Chief Justice of the Common Pleas) | 
| Pembrokeshire | 26 November 1866 [19 1] | George Lort Phillips |  | Conservative | James Bevan Bowen |  | Conservative | Death | 
| Belfast | 22 November 1866 | Hugh Cairns |  | Conservative | Charles Lanyon |  | Conservative | Resignation (Lord Justice of Appeal of England and Wales) | 
| West Gloucestershire | 15 November 1866 [19 1] | John Rolt |  | Conservative | John Rolt |  | Conservative | Attorney General for England and Wales  [19 2] | 
| County Wexford | 15 November 1866 | John George |  | Conservative | Arthur MacMorrough Kavanagh |  | Conservative | Resignation (Judge in Bankruptcy in Ireland) | 
| Tipperary | 22 October 1866 | John Blake Dillon |  | Liberal | Charles William White |  | Liberal | Death | 
| Penryn and Falmouth | 15 October 1866 | Thomas Baring |  | Liberal | Jervoise Smith |  | Liberal | Succession to a peerage | 
| Brecon | 3 October 1866 | Earl of Brecknock |  | Liberal | Howel Gwyn |  | Conservative | Succession to a peerage | 
| North Shropshire | 17 August 1866 [19 1] | Charles Cust |  | Conservative | Adelbert Brownlow-Cust |  | Conservative | Resignation | 
| Caenarvonshire | 14 August 1866 [19 1] | Edward Douglas-Pennant |  | Conservative | George Douglas-Pennant |  | Conservative | Elevation to the peerage | 
| Abingdon | 6 August 1866 [19 1] | Charles Lindsay |  | Conservative | Charles Lindsay |  | Conservative | Groom in Waiting  [19 2] | 
| Galway Borough | 2 August 1866 | Michael Morris |  | Liberal | Michael Morris |  | Conservative | Solicitor General for Ireland  [19 2] | 
| Dublin University | 30 July 1866 [19 1] | James Whiteside |  | Conservative | John Edward Walsh |  | Conservative | Resignation (Lord Chief Justice of Ireland) | 
| Eye | 27 July 1866 [19 1] | Edward Kerrison |  | Conservative | George Barrington |  | Conservative | Resignation to contest East Suffolk | 
| East Suffolk | 25 July 1866 [19 1] | The Lord Henniker |  | Conservative | John Henniker-Major |  | Conservative | Elevation to the peerage | 
| Fitzroy Kelly |  | Conservative | Edward Kerrison |  | Conservative | Resignation (Lord Chief Baron of the Exchequer) | 
| Peeblesshire | 24 July 1866 [19 1] | Graham Graham-Montgomery |  | Conservative | Graham Graham-Montgomery |  | Conservative | Lord Commissioner of the Treasury  [19 2] | 
| Petersfield | 23 July 1866 [19 1] | William Jolliffe |  | Conservative | William Nicholson |  | Liberal | Elevation to the peerage | 
| Hertfordshire | 23 July 1866 [19 1] | Edward Bulwer-Lytton |  | Conservative | Abel Smith |  | Conservative | Elevation to the peerage | 
| Bridgnorth | 21 July 1866 [19 1] | Henry Whitmore |  | Conservative | Henry Whitmore |  | Conservative | Lord Commissioner of the Treasury  [19 2] | 
| Tyrone | 20 July 1866 [19 1] | Lord Claud Hamilton |  | Conservative | Lord Claud Hamilton |  | Conservative | Vice-Chamberlain of the Household  [19 2] | 
| Tyrone | 18 July 1866 [19 1] | Henry Lowry-Corry |  | Conservative | Henry Lowry-Corry |  | Conservative | Vice-President of the Committee of the Council on Education  [19 2] | 
| Cambridgeshire | 17 July 1866 [19 1] | Viscount Royston |  | Conservative | Viscount Royston |  | Conservative | Comptroller of the Household  [19 2] | 
| Antrim | 17 July 1866 [19 1] | George Henry Seymour |  | Conservative | George Henry Seymour |  | Conservative | Third Naval Lord  [19 2] | 
| North Essex | 16 July 1866 [19 1] | Charles Du Cane |  | Conservative | Charles Du Cane |  | Conservative | Civil Lord of the Admiralty  [19 2] | 
| Rutlandshire | 14 July 1866 [19 1] | Gerard Noel |  | Conservative | Gerard Noel |  | Conservative | Lord Commissioner of the Treasury  [19 2] | 
| North Northamptonshire | 14 July 1866 [19 1] | Lord Burghley |  | Conservative | Lord Burghley |  | Conservative | Treasurer of the Household  [19 2] | 
| North Leicestershire | 14 July 1866 [19 1] | Lord John Manners |  | Conservative | Lord John Manners |  | Conservative | First Commissioner of Works  [19 2] | 
| North Devon | 14 July 1866 [19 1] | Stafford Northcote |  | Conservative | Stafford Northcote |  | Conservative | President of the Board of Trade  [19 2] | 
| New Shoreham | 14 July 1866 [19 1] | Stephen Cave |  | Conservative | Stephen Cave |  | Conservative | Paymaster General and Vice-President of the Board of Trade  [19 2] | 
| Belfast | 13 July 1866 [19 1] | Hugh Cairns |  | Conservative | Hugh Cairns |  | Conservative | Attorney General for England and Wales  [19 2] | 
| Buckinghamshire | 13 July 1866 [19 1] | Benjamin Disraeli |  | Conservative | Benjamin Disraeli |  | Conservative | Chancellor of the Exchequer  [19 2] | 
| Oxford University | 12 July 1866 [19 1] | Gathorne Hardy |  | Conservative | Gathorne Hardy |  | Conservative | President of the Poor Law Board  [19 2] | 
| Stamford | 12 July 1866 [19 1] | Viscount Cranborne |  | Conservative | Viscount Cranborne |  | Conservative | Secretary of State for India  [19 2] | 
| Sir John Dalrymple-Hay |  | Conservative | Sir John Dalrymple-Hay |  | Conservative | Fourth Naval Lord  [19 2] | 
| Bridgewater | 12 July 1866 | George Patton |  | Conservative | Philip Vanderbyl |  | Liberal | Lord Advocate  [19 2] | 
| Cambridge University | 11 July 1866 [19 1] | Spencer Horatio Walpole |  | Conservative | Spencer Horatio Walpole |  | Conservative | Home Secretary  [19 2] | 
| King's Lynn | 11 July 1866 [19 1] | Lord Stanley |  | Conservative | Lord Stanley |  | Conservative | Foreign Secretary  [19 2] | 
| Huntingdon | 11 July 1866 [19 1] | Jonathan Peel |  | Conservative | Jonathan Peel |  | Conservative | Secretary of State for War  [19 2] | 
| Guildford | 11 July 1866 | William Bovill |  | Conservative | William Bovill |  | Conservative | Solicitor General for England and Wales  [19 2] | 
| Durham | 11 July 1866 [19 1] | John Mowbray |  | Conservative | John Mowbray |  | Conservative | Judge Advocate General  [19 2] | 
| Droitwich | 11 July 1866 [19 1] | John Pakington |  | Conservative | John Pakington |  | Conservative | First Lord of the Admiralty  [19 2] | 
| Cockermouth | 11 July 1866 [19 1] | Lord Naas |  | Conservative | Lord Naas |  | Conservative | Chief Secretary for Ireland  [19 2] | 
| Hertford | 30 June 1866 [19 1] | Walter Townshend-Farquhar |  | Conservative | Robert Dimsdale |  | Conservative | Death | 
| South Nottinghamshire | 18 June 1866 [19 1] | Lord Stanhope |  | Conservative | Thomas Thoroton-Hildyard |  | Conservative | Succession to a peerage | 
| Bridgewater | 7 June 1866 | Henry Westropp |  | Conservative | George Patton |  | Conservative | Void election | 
| County Waterford | 7 June 1866 [19 1] | John Esmonde |  | Liberal | John Esmonde |  | Liberal | Lord Commissioner of the Treasury  [19 2] | 
| Winchester | 4 June 1866 | John Bonham-Carter |  | Liberal | John Bonham-Carter |  | Liberal | Lord Commissioner of the Treasury  [19 2] | 
| Devonport | 22 May 1866 | William Ferrand |  | Conservative | Lord Eliot |  | Liberal | Void election | 
| John Fleming |  | Conservative | Montague Chambers |  | Liberal | Void election | 
| Kildare | 21 May 1866 [19 1] | Lord Otho FitzGerald |  | Liberal | Lord Otho FitzGerald |  | Liberal | Treasurer of the Household  [19 2] | 
| Aberdeenshire | 15 May 1866 | William Leslie |  | Conservative | William Dingwall Fordyce |  | Liberal | Resignation | 
| Nottingham | 11 May 1866 | Robert Juckes Clifton |  | Liberal | Ralph Bernal Osborne |  | Liberal | Void election | 
| Samuel Morley |  | Liberal | Viscount Amberley |  | Liberal | Void election | 
| Northallerton | 10 May 1866 | Charles Mills |  | Conservative | Egremont Lascelles |  | Conservative | Void election | 
| North Devon | 9 May 1866 [19 1] | Charles Trefusis |  | Conservative | Stafford Northcote |  | Conservative | Succession to a peerage | 
| Windsor | 9 May 1866 [19 1] | Sir Henry Hoare |  | Liberal | Charles Edwards |  | Liberal | Void election | 
| Henry Labouchère |  | Liberal | Roger Eykyn |  | Liberal | Void election | 
| Stamford | 8 May 1866 [19 1] | Stafford Northcote |  | Conservative | Sir John Dalrymple-Hay |  | Conservative | Resignation to Contest North Devon | 
| Sandwich | 8 May 1866 | Lord Clarence Paget |  | Liberal | Charles Capper |  | Conservative | Resignation | 
| Reading | 5 May 1866 [19 1] | George Shaw-Lefevre |  | Liberal | George Shaw-Lefevre |  | Liberal | Civil Lord of the Admiralty  [19 2] | 
| Helston | 1 May 1866 [19 3] | Adolphus William Young |  | Liberal | Robert Campbell |  | Liberal | Void election | 
| Robert Campbell |  | Liberal | William Brett |  | Conservative | By-election result reversed on petition | 
| Cambridge | 24 April 1866 | William Forsyth |  | Conservative | John Eldon Gorst |  | Conservative | Void election | 
| Ripon | 28 March 1866 [19 1] | Lord John Hay |  | Liberal | Lord John Hay |  | Liberal | Fifth Naval Lord  [19 2] | 
| Honiton | 28 March 1866 [19 1] | Frederick Goldsmid |  | Liberal | Julian Goldsmid |  | Liberal | Death | 
| Wigan | 27 March 1866 | James Alexander Lindsay |  | Conservative | Nathaniel Eckersley |  | Conservative | Resignation | 
| Western Worcestershire | 24 March 1866 [19 1] | Frederick Lygon |  | Conservative | William Edward Dowdeswell |  | Conservative | Succession to a peerage | 
| County Louth | 22 March 1866 [19 1] | Chichester Parkinson-Fortescue |  | Liberal | Chichester Parkinson-Fortescue |  | Liberal | Chief Secretary for Ireland  [19 2] | 
| Tewkesbury | 20 March 1866 | William Edward Dowdeswell |  | Conservative | Sir Edmund Lechmere |  | Conservative | Resignation to contest Western Worcestershire | 
| Kerry | 16 March 1866 [19 1] | Henry Arthur Herbert |  | Liberal | Henry Arthur Herbert |  | Liberal | Death | 
| Richmond | 6 March 1866 | John Dundas |  | Liberal | Marmaduke Wyvill |  | Liberal | Death | 
| County Limerick | 1 March 1866 [19 1] | William Monsell |  | Liberal | William Monsell |  | Liberal | Vice-President of the Board of Trade and Paymaster General  [19 2] | 
| North Lancashire | 28 February 1866 [19 1] | Marquess of Hartington |  | Liberal | Marquess of Hartington |  | Liberal | Secretary of State for War  [19 2] | 
| Tiverton | 28 February 1866 | The Viscount Palmerston |  | Liberal | George Denman |  | Liberal | Death | 
| Sunderland | 28 February 1866 | Henry Fenwick |  | Liberal | John Candlish |  | Liberal | Civil Lord of the Admiralty  [19 2] | 
| Brecon | 27 February 1866 [19 1] | John Lloyd Vaughan Watkins |  | Liberal | Earl of Brecknock |  | Liberal | Death | 
| Ripon | 26 February 1866 [19 1] | Sir Charles Wood |  | Liberal | Lord John Hay |  | Liberal | Resignation pending elevation to the peerage | 
| Leominster | 26 February 1866 [19 1] | Gathorne Hardy |  | Conservative | Richard Arkwright |  | Conservative | Double election, chose to sit for Oxford University | 
| City of London | 26 February 1866 [19 1] | George Joachim Goschen |  | Liberal | George Joachim Goschen |  | Liberal | Chancellor of the Duchy of Lancaster  [19 2] | 
|  | 
| By-election | Date | Former incumbent | Party | Winner | Party | Cause | 
|---|
| Devonport | 22 June 1865 | Arthur William Buller |  | Liberal | Thomas Brassey |  | Liberal | Resignation to contest Liskeard | 
| Liskeard | 21 June 1865 [18 1] | Ralph Bernal Osborne |  | Liberal | Arthur William Buller |  | Liberal | Resignation | 
| Coventry | 21 June 1865 [18 1] | Joseph Paxton |  | Liberal | Henry Eaton |  | Conservative | Death | 
| Lambeth | 9 May 1865 [18 1] | William Williams |  | Liberal | James Lawrence |  | Liberal | Death | 
| Clackmannanshire and Kinross-shire | 20 April 1865 [18 1] | William Patrick Adam |  | Liberal | William Patrick Adam |  | Liberal | Lord of the Treasury  [18 2] | 
| Wigtown Burghs | 15 April 1865 [18 1] | William Dunbar |  | Liberal | George Young |  | Liberal | Resignation (Commissioner for Auditing the Public Accounts) | 
| Rochdale | 15 April 1865 | Richard Cobden |  | Liberal | Thomas Bayley Potter |  | Liberal | Death | 
| Louth | 15 April 1865 | Richard Montesquieu Bellew |  | Liberal | Tristram Kennedy |  | Liberal | Resignation (Commissioner of Poor Laws in Ireland) | 
| South Shropshire | 12 April 1865 [18 1] | Viscount Newport |  | Conservative | Percy Egerton Herbert |  | Conservative | Succession to a peerage | 
| Evesham | 4 April 1865 [18 1] | Henry Willoughby |  | Conservative | James Bourne |  | Conservative | Death | 
| North Devon | 1 April 1865 [18 1] | James Wentworth Buller |  | Liberal | Thomas Dyke Acland |  | Liberal | Death | 
| North Wiltshire | 20 March 1865 [18 1] | Thomas H. Sotheron-Estcourt |  | Conservative | Lord Charles Bruce |  | Liberal | Resignation | 
| Tipperary | 24 February 1865 | Daniel O'Donoghue |  | Liberal | Charles Moore |  | Liberal | Resignation to contest Tralee | 
| Lancaster | 20 February 1865 [18 1] | Samuel Gregson |  | Liberal | Henry Schneider |  | Liberal | Death | 
| Truro | 14 February 1865 | Montague Edward Smith |  | Conservative | Frederick Williams |  | Conservative | Resignation (Judge of the Court of Common Pleas) | 
| Tralee | 14 February 1865 | Thomas O'Hagan |  | Liberal | Daniel O'Donoghue |  | Liberal | Resignation (Judge of the Court of Common Pleas in Ireland) | 
| Cork City | 14 February 1865 [18 1] | Francis Lyons |  | Liberal | Nicholas Daniel Murphy |  | Liberal | Resignation | 
| Salford | 13 February 1865 [18 1] | William Nathaniel Massey |  | Liberal | John Cheetham |  | Liberal | Resignation (Council of India) | 
| Buteshire | 6 February 1865 | David Mure |  | Conservative | George Boyle |  | Conservative | Resignation (Senator of the College of Justice) | 
| North Warwickshire | 13 December 1864 [18 1] | Richard Spooner |  | Conservative | William Bromley-Davenport |  | Conservative | Death | 
| West Suffolk | 8 December 1864 [18 1] | Earl Jermyn |  | Conservative | Lord Augustus Hervey |  | Conservative | Succession to a peerage | 
| Carmarthen Boroughs | 31 October 1864 [18 1] | David Morris |  | Liberal | William Morris |  | Liberal | Death | 
| Hastings | 6 October 1864 | Lord Harry George Vane |  | Liberal | George Waldegrave-Leslie |  | Liberal | Succession to a peerage | 
| Exeter | 4 August 1864 | Edward Divett |  | Liberal | Lord Courtenay |  | Conservative | Death | 
| East Gloucestershire | 12 July 1864 [18 1] | Christopher William Codrington |  | Conservative | Michael Hicks Beach |  | Conservative | Death | 
| North Durham | 28 June 1864 [18 1] | Lord Adolphus Vane-Tempest |  | Conservative | Hedworth Williamson |  | Liberal | Death | 
| Gloucester | 25 May 1864 [18 1] | John Joseph Powell |  | Liberal | John Joseph Powell |  | Liberal | Recorder of Wolverhampton  [18 2] | 
| Stockport | 9 May 1864 [18 1] | James Kershaw |  | Liberal | Edward Watkin |  | Liberal | Death | 
| Merthyr Tydfil | 25 April 1864 [18 1] | Henry Austin Bruce |  | Liberal | Henry Austin Bruce |  | Liberal | Vice-President of the Committee on Education  [18 2] | 
| Pontefract | 20 April 1864 [18 1] | Hugh Childers |  | Liberal | Hugh Childers |  | Liberal | Civil Lord of the Admiralty  [18 2] | 
| Fife | 19 April 1864 [18 1] | James Hay Erskine Wemyss |  | Liberal | Robert Anstruther |  | Liberal | Death | 
| Devizes | 18 April 1864 [18 1] | William Addington |  | Conservative | Thomas Bateson |  | Conservative | Succession to a peerage | 
| Lancaster | 13 April 1864 | William James Garnett |  | Conservative | Edward Matthew Fenwick |  | Liberal | Resignation | 
| Oxford | 9 April 1864 [18 1] | Edward Cardwell |  | Liberal | Edward Cardwell |  | Liberal | Secretary of State for the Colonies  [18 2] | 
| County Armagh | 23 March 1864 [18 1] | Maxwell Charles Close |  | Conservative | James Stronge |  | Conservative | Resignation | 
| Hertfordshire | 14 March 1864 | Christopher William Puller |  | Liberal | Henry Surtees |  | Conservative | Death | 
| Dorset | 27 February 1864 [18 1] | Henry Ker Seymer |  | Conservative | John Floyer |  | Conservative | Resignation | 
| Brighton | 16 February 1864 | William Coningham |  | Liberal | Henry Moor |  | Conservative | Resignation | 
| Winchester | 10 February 1864 [18 1] | James Buller East |  | Conservative | Thomas Willis Fleming |  | Conservative | Resignation | 
| Tewkesbury | 9 February 1864 [18 1] | Frederick Lygon |  | Conservative | John Yorke |  | Conservative | Resignation to contest West Worcestershire. | 
| Durham City | 9 February 1864 [18 1] | William Atherton |  | Liberal | John Henderson |  | Liberal | Death | 
| Buckinghamshire | 29 December 1863 | William George Cavendish |  | Liberal | Robert Bateson Harvey |  | Conservative | Succession to a peerage | 
| Andover | 18 November 1863 | William Cubitt |  | Conservative | William Humphery |  | Conservative | Death | 
| Oxford | 7 November 1863 [18 1] | James Haughton Langston |  | Liberal | Charles Neate |  | Liberal | Death | 
| Windsor | 4 November 1863 | George William Hope |  | Conservative | Richard Henry Howard Vyse |  | Conservative | Death | 
| West Worcestershire | 26 October 1863 [18 1] | Viscount Elmley |  | Conservative | Frederick Lygon |  | Conservative | Succession to a peerage | 
| Barnstaple | 20 October 1863 | George Potts |  | Liberal | Thomas Lloyd |  | Liberal | Death | 
| Thomas Lloyd |  | Liberal | Richard Bremridge |  | Conservative | By-election result reversed on petition | 
| Richmond | 17 October 1863 [18 1] | Roundell Palmer |  | Liberal | Roundell Palmer |  | Liberal | Attorney General for England and Wales  [18 2] | 
| Reading | 17 October 1863 [18 1] | Gillery Pigott |  | Liberal | George Shaw-Lefevre |  | Liberal | Resignation (Baron of the Court of the Exchequer) | 
| Plymouth | 17 October 1863 [18 1] | Robert Collier |  | Liberal | Robert Collier |  | Liberal | Solicitor General for England and Wales  [18 2] | 
| Tamworth | 12 October 1863 | Viscount Raynham |  | Liberal | John Peel |  | Conservative | Succession to a peerage | 
| Coventry | 8 October 1863 | Edward Ellice |  | Liberal | Morgan Treherne |  | Conservative | Death | 
| Ludlow | 28 August 1863 | Beriah Botfield |  | Conservative | William Fraser |  | Conservative | Death | 
| Montgomery Boroughs | 20 August 1863 | John Willes-Johnson |  | Conservative | Charles Hanbury-Tracy |  | Liberal | Death | 
| Pontefract | 3 August 1863 [18 1] | Richard Monckton Milnes |  | Liberal | Samuel Waterhouse |  | Conservative | Elevation to the peerage | 
| Clare | 3 August 1863 [18 1] | Francis Macnamara Calcutt |  | Liberal | Colman O'Loghlen |  | Liberal | Death | 
| Berwick-upon-Tweed | 29 June 1863 | Charles William Gordon |  | Conservative | William Walter Cargill |  | Conservative | Death | 
| Lisburn | 26 June 1863 | John Doherty Barbour |  | Liberal | Edward Wingfield Verner |  | Conservative | Void By-election | 
| New Ross | 8 June 1863 | Charles Tottenham (II) |  | Conservative | Charles George Tottenham |  | Conservative | Resignation | 
| Kinsale | 8 June 1863 | John Arnott |  | Liberal | George Conway Colthurst |  | Independent Liberal (Liberal-Conservative) [1] | Resignation | 
| City of London | 2 June 1863 [18 1] | Western Wood |  | Liberal | George Joachim Goschen |  | Liberal | Death | 
| Tralee | 15 May 1863 [18 1] | Daniel O'Connell Jnr |  | Liberal | Thomas O'Hagan |  | Liberal | Resignation | 
| Antrim | 6 May 1863 [18 1] | George Upton |  | Conservative | Edward O'Neill |  | Conservative | Succession to an Irish peerage | 
| Halifax | 28 April 1863 [18 1] | James Stansfeld |  | Liberal | James Stansfeld |  | Liberal | Civil Lord of the Admiralty  [18 2] | 
| Radnor Boroughs | 25 April 1863 [18 1] | George Cornewall Lewis |  | Liberal | Richard Green-Price |  | Liberal | Death | 
| Dublin County | 22 April 1863 [18 1] | James Hans Hamilton |  | Conservative | Ion Hamilton |  | Conservative | Resignation | 
| Thetford | 21 April 1863 | Earl of Euston |  | Liberal | Lord Frederick FitzRoy |  | Liberal | Succession to a peerage | 
| North Lancashire | 24 March 1863 [18 1] | Marquess of Hartington |  | Liberal | Marquess of Hartington |  | Liberal | Civil Lord of the Admiralty  [18 2] | 
| Bandon | 27 February 1863 | William Smyth Bernard |  | Conservative | Henry Boyle Bernard |  | Conservative | Death | 
| Lisburn | 23 February 1863 | Jonathan Joseph Richardson |  | Conservative | John Doherty Barbour |  | Liberal | Resignation | 
| Chichester | 21 February 1863 [18 1] | Humphrey William Freeland |  | Liberal | John Abel Smith |  | Liberal | Resignation | 
| Devizes | 18 February 1863 | John Neilson Gladstone |  | Conservative | William Addington |  | Conservative | Death | 
| West Somerset | 17 February 1863 [18 1] | Charles Moody |  | Conservative | William Gore-Langton |  | Conservative | Resignation | 
| Cambridgeshire | 14 February 1863 [18 1] | Edward Ball |  | Conservative | Lord George Manners |  | Conservative | Resignation | 
| Devonport | 12 February 1863 | Michael Seymour |  | Liberal | William Ferrand |  | Conservative | Resignation | 
| Cambridge | 12 February 1863 | Andrew Steuart |  | Conservative | Francis Powell |  | Conservative | Resignation | 
| Reigate | 6 February 1863 | William John Monson |  | Liberal | Granville William Gresham Leveson-Gower |  | Liberal | Succession to a peerage | 
| Totnes | 20 January 1863 | George Hay |  | Liberal | Alfred Seymour |  | Liberal | Death | 
| East Kent | 5 January 1863 | William Deedes |  | Conservative | Edward Dering |  | Liberal | Death | 
| Andover | 17 December 1862 [18 1] | Henry Beaumont Coles |  | Conservative | William Cubitt |  | Conservative | Death | 
| Totnes | 9 December 1862 | Thomas Mills |  | Liberal | John Pender |  | Liberal | Death | 
| Southampton | 6 December 1862 | Brodie McGhie Willcox |  | Liberal | William Anderson Rose |  | Conservative | Death | 
| Stoke-upon-Trent | 23 September 1862 | John Lewis Ricardo |  | Liberal | Henry Grenfell |  | Liberal | Death | 
| County Carlow | 7 August 1862 [18 1] | William McClintock-Bunbury |  | Conservative | Denis Pack-Beresford |  | Conservative | Resignation | 
| Kirkcaldy Burghs | 25 July 1862 [18 1] | Robert Ferguson |  | Liberal | Roger Sinclair Aytoun |  | Liberal | Resignation | 
| Montgomeryshire | 14 July 1862 | Herbert Watkin Williams-Wynn |  | Conservative | Charles Watkin Williams-Wynn |  | Conservative | Death | 
| Shrewsbury | 2 June 1862 | Robert Aglionby Slaney |  | Liberal | Henry Robertson |  | Liberal | Death | 
| Kidderminster | 27 May 1862 | Alfred Rhodes Bristow |  | Liberal | Luke White |  | Liberal | Resignation | 
| Oldham | 5 May 1862 [18 1] | William Johnson Fox |  | Liberal | John Tomlinson Hibbert |  | Liberal | Resignation | 
| Lambeth | 5 May 1862 | William Roupell |  | Liberal | Frederick Doulton |  | Liberal | Resignation | 
| Preston | 4 April 1862 | Richard Assheton Cross |  | Conservative | Thomas Hesketh |  | Conservative | Resignation | 
| Wycombe | 18 March 1862 | George Dashwood |  | Liberal | John Remington Mills |  | Liberal | Death | 
| North Riding of Yorkshire | 17 March 1862 | Edward Stillingfleet Cayley |  | Liberal | William Morritt |  | Conservative | Death | 
| Longford | 7 March 1862 | Luke White |  | Liberal | Myles William O'Reilly |  | Liberal | Lord of the Treasury  [18 2] | 
| Canterbury | 6 March 1862 | Henry Butler-Johnstone |  | Conservative | Henry Munro-Butler-Johnstone |  | Conservative | Resignation | 
| Wakefield | 28 February 1862 | William Henry Leatham |  | Liberal | John Charles Dalrymple Hay |  | Conservative | Void election | 
| Gloucester | 26 February 1862 | Charles James Monk |  | Liberal | Charles Berkeley |  | Liberal | Void election | 
| William Philip Price |  | Liberal | John Joseph Powell |  | Liberal | Void election | 
| Leicester | 17 February 1862 [18 1] | John Biggs |  | Liberal | Peter Alfred Taylor |  | Liberal | Resignation | 
| Great Grimsby | 14 February 1862 | Lord Worsley |  | Liberal | John Chapman |  | Conservative | Succession to a peerage | 
| Lincoln | 12 February 1862 | George Heneage |  | Liberal | John Bramley-Moore |  | Conservative | Resignation to contest Great Grimsby | 
| New Shoreham | 5 February 1862 [18 1] | Charles Burrell |  | Conservative | Percy Burrell |  | Conservative | Death | 
| Oxfordshire | 3 February 1862 | George Harcourt |  | Liberal | John Fane |  | Conservative | Death | 
| Coleraine | 31 January 1862 [18 1] | John Boyd |  | Conservative | Henry Bruce |  | Conservative | Death | 
| Nottingham | 26 December 1861 | John Mellor |  | Liberal | Robert Juckes Clifton |  | Liberal | Resignation (Justice of the Court of the King's Bench) | 
| East Worcestershire | 20 December 1861 [18 1] | John Hodgetts-Foley |  | Liberal | Harry Vernon |  | Liberal | Death | 
| Finsbury | 17 December 1861 | Thomas Slingsby Duncombe |  | Liberal | William Cox |  | Liberal | Death | 
| Birkenhead | 11 December 1861 | N/A |  | N/A | John Laird |  | Conservative | Birkenhead enfranchised | 
| Carlisle | 26 November 1861 | James Graham |  | Liberal | Edmund Potter |  | Liberal | Death | 
| Lincoln | 9 November 1861 [18 1] | Gervaise Tottenham Waldo Sibthorp |  | Conservative | Charles Seely |  | Liberal | Death | 
| Plymouth | 31 October 1861 | Viscount Valletort |  | Conservative | Walter Morrison |  | Liberal | Succession to a peerage | 
| South Lancashire | 19 August 1861 | N/A |  | N/A | Charles Turner |  | Conservative | South Lancashire granted a third seat | 
| Selkirkshire | 1 August 1861 | Allen Eliott-Lockhart |  | Conservative | Lord Henry Scott |  | Conservative | Resignation | 
| Tamworth | 31 July 1861 [18 1] | Robert Peel |  | Liberal | Robert Peel |  | Liberal | Chief Secretary for Ireland  [18 2] | 
| Morpeth | 31 July 1861 [18 1] | George Grey |  | Liberal | George Grey |  | Liberal | Home Secretary  [18 2] | 
| Oxford | 30 July 1861 [18 1] | Edward Cardwell |  | Liberal | Edward Cardwell |  | Liberal | Chancellor of the Duchy of Lancaster  [18 2] | 
| City of London | 29 July 1861 | Lord John Russell |  | Liberal | Western Wood |  | Liberal | Resignation (elevated to the peerage) | 
| Andover | 29 July 1861 [18 1] | William Cubitt |  | Conservative | Henry Beaumont Coles |  | Conservative | Resignation to contest City of London | 
| Richmond | 9 July 1861 [18 1] | Henry Rich |  | Liberal | Roundell Palmer |  | Liberal | Resignation | 
| Durham City | 8 July 1861 [18 1] | William Atherton |  | Liberal | William Atherton |  | Liberal | Attorney General for England and Wales  [18 2] | 
| Longford | 4 July 1861 [18 1] | Henry White |  | Liberal | Luke White |  | Liberal | Resignation | 
| Wolverhampton | 3 July 1861 | Sir Richard Bethell |  | Liberal | Thomas Matthias Weguelin |  | Liberal | Appointed Lord Chancellor  [18 2] | 
| Southwark | 30 May 1861 | Thomas Lloyd-Mostyn |  | Liberal | Lord Richard Grosvenor |  | Liberal | Death | 
| Montgomery Boroughs | 4 May 1861 [18 1] | David Pugh |  | Conservative | John Willes-Johnson |  | Conservative | Death | 
| Banffshire | 1 May 1861 [18 1] | Lachlan Gordon-Duff |  | Liberal | Robert William Duff |  | Liberal | Resignation | 
| Southwark | 24 April 1861 [18 1] | John Locke |  | Liberal | John Locke |  | Liberal | Recorder of Brighton  [18 2] | 
| Tynemouth and North Shields | 23 April 1861 | Hugh Taylor |  | Conservative | Richard Hodgson |  | Conservative | Resignation | 
| Marylebone | 19 April 1861 | Edwin James |  | Liberal | John Harvey Lewis |  | Liberal | Resignation | 
| Tiverton | 28 March 1861 [18 1] | The Viscount Palmerston |  | Liberal | The Viscount Palmerston |  | Liberal | Lord Warden of the Cinque Ports  [18 2] | 
| Sutherland | 27 March 1861 [18 1] | Marquess of Stafford |  | Liberal | David Dundas |  | Liberal | Succession to a peerage | 
| County Cork | 28 February 1861 | Rickard Deasy |  | Liberal | Nicholas Leader |  | Conservative | Resignation (Baron of the Exchequer in Ireland) | 
| Pembroke Boroughs | 22 February 1861 | Sir John Owen |  | Liberal | Sir Hugh Owen |  | Liberal | Death | 
| South Wiltshire | 14 February 1861 [18 1] | Sidney Herbert |  | Liberal | Frederick Hervey-Bathurst |  | Conservative | Elevation to the peerage | 
| Aberdeenshire | 13 February 1861 | Lord Haddo |  | Liberal | Walter Barttelot |  | Conservative | Succession to a peerage | 
| Bradford | 11 February 1861 [18 1] | Titus Salt |  | Liberal | William Edward Forster |  | Liberal | Resignation | 
| Bolton | 11 February 1861 [18 1] | Joseph Crook |  | Liberal | Thomas Barnes |  | Liberal | Resignation | 
| Leicester | 7 February 1861 | Joseph William Noble |  | Liberal | William Unwin Heygate |  | Conservative | Death | 
| Pembrokeshire | 19 January 1861 | Viscount Emlyn |  | Conservative | George Lort Phillips |  | Conservative | Succession to a peerage | 
| West Sussex | 27 December 1860 [18 1] | Earl of March |  | Conservative | Walter Barttelot |  | Conservative | Succession to a peerage | 
| Ripon | 22 December 1860 | John Ashley Warre |  | Liberal | Reginald Vyner |  | Liberal | Death | 
| South Nottinghamshire | 18 December 1860 [18 1] | Viscount Newark |  | Conservative | Lord Stanhope |  | Conservative | Succession to a peerage | 
| Southwark | 12 December 1860 | Charles Napier |  | Liberal | Austen Henry Layard |  | Liberal | Death | 
| Newcastle-upon-Tyne | 7 December 1860 | George Ridley |  | Liberal | Somerset Beaumont |  | Liberal | Resignation (Inclosure Commissioner) | 
| Wick Burghs | 1 December 1860 [18 1] | Samuel Laing |  | Liberal | Viscount Bury |  | Liberal | Resignation (Council of India) | 
| Reading | 21 November 1860 | Francis Pigott |  | Liberal | Gillery Pigott |  | Liberal | Resignation (Lieutenant Governor of the Isle of Man) | 
| Dartmouth | 3 November 1860 | John Dunn |  | Conservative | John Hardy |  | Conservative | Death | 
| Boston | 30 October 1860 | Herbert Ingram |  | Liberal | John Malcolm |  | Conservative | Death | 
| Honiton | 22 October 1860 [18 1] | Joseph Locke |  | Liberal | George Moffatt |  | Liberal | Death | 
| Ludlow | 4 September 1860 [18 1] | Percy Egerton Herbert |  | Conservative | George Windsor-Clive |  | Conservative | Resignation | 
| West Cumberland | 27 August 1860 [18 1] | Henry Wyndham |  | Conservative | Percy Wyndham |  | Conservative | Death | 
| Sligo Borough | 9 August 1860 | John Arthur Wynne |  | Conservative | Francis Macdonogh |  | Conservative | Resignation | 
| Stafford | 3 August 1860 | John Ayshford Wise |  | Liberal | Thomas Sidney |  | Liberal | Resignation | 
| Donegal | 17 July 1860 [18 1] | Edmund Hayes |  | Conservative | Viscount Hamilton |  | Conservative | Death | 
| Brighton | 16 July 1860 | George Brooke-Pechell |  | Liberal | James White |  | Liberal | Death | 
| Belfast | 15 June 1860 [18 1] | Richard Davison |  | Conservative | Samuel Gibson Getty |  | Conservative | Resignation | 
| Lymington | 24 May 1860 | Sir John Rivett-Carnac |  | Conservative | Lord George Gordon-Lennox |  | Conservative | Resignation | 
| Berkshire | 2 May 1860 [18 1] | Leicester Viney Vernon |  | Conservative | Richard Benyon |  | Conservative | Death | 
| Harwich | 24 April 1860 [18 1] | William Campbell |  | Liberal | Richard Rowley |  | Conservative | Succession to a peerage | 
| Clare | 13 April 1860 | Luke White |  | Liberal | Francis Macnamara Calcutt |  | Liberal | Void election | 
| Londonderry City | 2 April 1860 | Robert Ferguson |  | Liberal | William McCormick |  | Conservative | Death | 
| Norwich | 28 March 1860 [18 1] | Viscount Bury |  | Liberal | William Russell |  | Liberal | Void election | 
| Henry William Schneider |  | Liberal | Edward Warner |  | Liberal | Void election | 
| Roscommon | 26 March 1860 [18 1] | Thomas William Goff |  | Conservative | Charles Owen O'Conor |  | Liberal | Void election | 
| Worcester | 12 March 1860 [18 1] | William Laslett |  | Liberal | Richard Padmore |  | Liberal | Resignation | 
| West Surrey | 10 March 1860 [18 1] | Henry Drummond |  | Conservative | George Cubitt |  | Conservative | Death | 
| County Cork | 5 March 1860 | Rickard Deasy |  | Liberal | Rickard Deasy |  | Liberal | Attorney General for Ireland  [18 2] | 
| Ennis | 20 February 1860 [18 1] | John FitzGerald |  | Liberal | William Stacpoole |  | Liberal | Resignation (Judge of the Court of the Queen's Bench in Ireland) | 
| Hertford | 13 February 1860 [18 1] | William Cowper |  | Liberal | William Cowper |  | Liberal | First Commissioner of Works  [18 2] | 
| Gateshead | 13 February 1860 [18 1] | William Hutt |  | Liberal | William Hutt |  | Liberal | Vice-President of the Board of Trade and Paymaster General  [18 2] | 
| Forfarshire | 1 February 1860 [18 1] | Viscount Duncan |  | Liberal | Charles Carnegie |  | Liberal | Succession to a peerage | 
| Scarborough | 1 February 1860 | William Denison |  | Liberal | John Dent Dent |  | Liberal | Succession to a peerage | 
| Pontefract | 31 January 1860 | William Overend |  | Conservative | Hugh Childers |  | Liberal | Resignation (arbitrator recommended resignation after contested election) | 
| Beverly | 31 January 1860 [18 1] | Ralph Walters |  | Liberal | James Walker |  | Conservative | Void election | 
| Lewes | 16 January 1860 [18 1] | Henry Fitzroy |  | Liberal | John Blencowe |  | Liberal | Death | 
| Reading | 11 January 1860 | Henry Singer Keating |  | Liberal | Francis Goldsmid |  | Liberal | Resignation (Justice of the Court of Common Pleas) | 
| Liskeard | 9 January 1860 [18 1] | William Atherton |  | Liberal | William Atherton |  | Liberal | Solicitor General for England and Wales  [18 2] | 
| Whitby | 23 November 1859 | Robert Stephenson |  | Conservative | Harry Stephen Thompson |  | Liberal | Death | 
| Ayrshire | 31 October 1859 | Lord Patrick Crichton-Stuart |  | Liberal | James Fergusson |  | Conservative | Death | 
| South Shropshire | 14 September 1859 [18 1] | Robert Windsor-Clive |  | Conservative | Baldwin Leighton |  | Conservative | Death | 
| Kingston upon Hull | 20 August 1859 | Joseph Hoare |  | Conservative | Joseph Somes |  | Conservative | Void election | 
| Berwick-upon-Tweed | 20 August 1859 | Ralph Anstruther Earle |  | Conservative | Dudley Marjoribanks |  | Liberal | Resignation (in exchange for withdrawal of election petition) | 
| Liskeard | 18 August 1859 [18 1] | Ralph Grey |  | Liberal | Ralph Bernal Osborne |  | Liberal | Resignation | 
| Hertford | 18 August 1859 | William Cowper |  | Liberal | William Cowper |  | Liberal | Vice-President of the Board of Trade and Paymaster General  [18 2] | 
| Devonport | 17 August 1859 | James Wilson |  | Liberal | Arthur William Buller |  | Liberal | Resignation | 
| Bodmin | 13 August 1859 [18 1] | William Michell |  | Conservative | James Wyld |  | Liberal | Resignation (in exchange for withdrawal of election petition) | 
| Taunton | 9 August 1859 | Henry Labouchere |  | Liberal | George Cavendish-Bentinck |  | Conservative | Resignation (Elevation to the peerage) | 
| Devonport | 9 August 1859 | Thomas Erskine Perry |  | Liberal | Michael Seymour |  | Liberal | Resignation (Council of India) | 
| Dartmouth | 8 August 1859 [18 1] | Edward Wyndham Harrington Schenley |  | Liberal | John Dunn |  | Conservative | Void election | 
| Wicklow | 18 July 1859 [18 1] | Lord Proby |  | Liberal | Lord Proby |  | Liberal | Comptroller of the Household  [18 2] | 
| Wolverhampton | 9 July 1859 [18 1] | Charles Pelham Villiers |  | Liberal | Charles Pelham Villiers |  | Liberal | President of the Poor Law Board  [18 2] | 
| Ashton-under-Lyne | 9 July 1859 [18 1] | Thomas Milner Gibson |  | Liberal | Thomas Milner Gibson |  | Liberal | President of the Board of Trade  [18 2] | 
| Marylebone | 7 July 1859 | Benjamin Hall |  | Liberal | Edmond Roche |  | Liberal | Elevation to the peerage | 
| West Gloucestershire | 7 July 1859 [18 1] | Robert Kingscote |  | Liberal | Robert Kingscote |  | Liberal | Groom in Waiting  [18 2] | 
| Lichfield | 6 July 1859 [18 1] | Lord Alfred Paget |  | Liberal | Lord Alfred Paget |  | Liberal | Chief Equerry and Clerk Marshal  [18 2] | 
| Northampton | 5 July 1859 [18 1] | Robert Vernon Smith |  | Liberal | The Lord Henley |  | Liberal | Elevation to the peerage | 
| Kerry | 5 July 1859 [18 1] | Viscount Castlerosse |  | Liberal | Viscount Castlerosse |  | Liberal | Vice-Chamberlain of the Household  [18 2]  [18 3] | 
| County Cork | 5 July 1859 [18 1] | Rickard Deasy |  | Liberal | Rickard Deasy |  | Liberal | Solicitor General for Ireland  [18 2] | 
| Oxford University | 1 July 1859 | William Ewart Gladstone |  | Peelite | William Ewart Gladstone |  | Liberal | Chancellor of the Exchequer  [18 2] | 
| Monmouthshire | 1 July 1859 [18 1] | Edward Arthur Somerset |  | Conservative | Poulett Somerset |  | Conservative | Resignation | 
| Clonmel | 1 July 1859 [18 1] | John Bagwell |  | Liberal | John Bagwell |  | Liberal | Lord Commissioner of the Treasury  [18 2] | 
| Ennis | 29 June 1859 [18 1] | John FitzGerald |  | Liberal | John FitzGerald |  | Liberal | Attorney General for Ireland  [18 2] | 
| Cork | 29 June 1859 [18 1] | William Trant Fagan |  | Liberal | Francis Lyons |  | Liberal | Death | 
| South Wiltshire | 29 June 1859 [18 1] | Sidney Herbert |  | Liberal | Sidney Herbert |  | Liberal | Secretary of State for War and Secretary at War  [18 2] | 
| Edinburgh | 28 June 1859 [18 1] | James Moncreiff |  | Liberal | James Moncreiff |  | Liberal | Lord Advocate  [18 2] | 
| Sandwich | 28 June 1859 | Edward Knatchbull-Hugessen |  | Liberal | Edward Knatchbull-Hugessen |  | Liberal | Lord Commissioner of the Treasury  [18 2] | 
| Norwich | 28 June 1859 | Viscount Bury |  | Liberal | Viscount Bury |  | Liberal | Treasurer of the Household  [18 2]  [18 4] | 
| Newcastle upon Tyne | 28 June 1859 | Thomas Emerson Headlam |  | Liberal | Thomas Emerson Headlam |  | Liberal | Judge Advocate General  [18 2] | 
| Halifax | 28 June 1859 [18 1] | Charles Wood |  | Liberal | Charles Wood |  | Liberal | Secretary of State for India  [18 2] | 
| Bedford | 28 June 1859 | Samuel Whitbread |  | Liberal | Samuel Whitbread |  | Liberal | Civil Lord of the Admiralty  [18 2] | 
| Wigtown Burghs | 27 June 1859 [18 1] | William Dunbar |  | Liberal | William Dunbar |  | Liberal | Lord Commissioner of the Treasury  [18 2] | 
| Radnor Boroughs | 27 June 1859 [18 1] | George Cornewall Lewis |  | Liberal | George Cornewall Lewis |  | Liberal | Home Secretary  [18 2] | 
| Wolverhampton | 27 June 1859 [18 1] | Richard Bethell |  | Liberal | Richard Bethell |  | Liberal | Attorney General for England and Wales  [18 2] | 
| Tiverton | 27 June 1859 [18 1] | The Viscount Palmerston |  | Liberal | The Viscount Palmerston |  | Liberal | Prime Minister and First Lord of the Treasury  [18 2] | 
| Reading | 27 June 1859 [18 1] | Henry Singer Keating |  | Liberal | Henry Singer Keating |  | Liberal | Solicitor General for England and Wales  [18 2] | 
| Oxford | 27 June 1859 [18 1] | Edward Cardwell |  | Liberal | Edward Cardwell |  | Liberal | Chief Secretary for Ireland  [18 2] | 
| Morpeth | 27 June 1859 [18 1] | George Grey |  | Liberal | George Grey |  | Liberal | Chancellor of the Duchy of Lancaster  [18 2] | 
| Lewes | 27 June 1859 [18 1] | Henry Fitzroy |  | Liberal | Henry Fitzroy |  | Liberal | First Commissioner of Works  [18 2] | 
| Devonport | 27 June 1859 [18 1] | James Wilson |  | Liberal | James Wilson |  | Liberal | Vice-President of the Board of Trade and Paymaster General  [18 2] | 
| Calne | 27 June 1859 [18 1] | Robert Lowe |  | Liberal | Robert Lowe |  | Liberal | Vice-President of the Committee of the Council on Education  [18 2] | 
| Ashton-under-Lyne | 27 June 1859 [18 1] | Thomas Milner Gibson |  | Liberal | Thomas Milner Gibson |  | Liberal | President of the Poor Law Board  [18 2] | 
| City of London | 27 June 1859 [18 1] | Lord John Russell |  | Liberal | Lord John Russell |  | Liberal | Foreign Secretary  [18 2] | 
|  | 
| By-election | Date | Former incumbent | Party | Winner | Party | Cause | 
|---|
| Harwich | 18 March 1859 | John Bagshaw |  | Whig | Henry Jervis-White-Jervis |  | Conservative | Resignation | 
| Stirlingshire | 14 March 1859 [17 1] | Peter Blackburn |  | Conservative | Peter Blackburn |  | Conservative | Junior Lord of the Treasury  [17 2] | 
| North Northumberland | 10 March 1859 [17 1] | Lord Lovaine |  | Conservative | Lord Lovaine |  | Conservative | Vice-President of the Board of Trade and Paymaster General  [17 2] | 
| West Sussex | 9 March 1859 [17 1] | Earl of March |  | Conservative | Earl of March |  | Conservative | President of the Poor Law Board  [17 2] | 
| North Wiltshire | 8 March 1859 [17 1] | Thomas H. Sotheron-Estcourt |  | Conservative | Thomas H. Sotheron-Estcourt |  | Conservative | Home Secretary  [17 2] | 
| Tewkesbury | 8 March 1859 | Frederick Lygon |  | Conservative | Frederick Lygon |  | Conservative | Civil Lord of the Admiralty  [17 2] | 
| Bury St. Edmunds | 7 March 1859 [17 1] | Earl Jermyn |  | Conservative | Lord Alfred Hervey |  | Conservative | Succession to a peerage | 
| Midhurst | 3 March 1859 [17 1] | Samuel Warren |  | Conservative | John Hardy |  | Conservative | Resignation | 
| Marylebone | 25 February 1859 | Viscount Ebrington |  | Whig | Edwin James |  | Whig | Resignation and elevation to the House of Lords through a Writ of acceleration | 
| East Worcestershire | 24 February 1859 | George Rushout |  | Conservative | Frederick Gough-Calthorpe |  | Whig | Succession to a peerage | 
| West Riding of Yorkshire | 21 February 1859 [17 1] | Viscount Goderich |  | Whig | John Ramsden |  | Whig | Succession to a peerage | 
| Enniskillen | 21 February 1859 | James Whiteside |  | Conservative | John Lowry Cole |  | Conservative | Resignation in order to contest Dublin University | 
| Greenwich | 16 February 1859 | John Townsend |  | Whig | David Salomons |  | Whig | Resignation | 
| Hythe | 15 February 1859 [17 1] | John Ramsden |  | Whig | Mayer Amschel de Rothschild |  | Whig | Resignation in order to contest the West Riding of Yorkshire | 
| Oxford University | 12 February 1859 [17 1] | William Ewart Gladstone |  | Peelite | William Ewart Gladstone |  | Peelite | Resignation (Lord High Commissioner of the Ionian Islands) | 
| Galway Borough | 11 February 1859 [17 1] | Anthony O'Flaherty |  | Whig | John Orrell Lever |  | Conservative | Void election | 
| Dublin University | 11 February 1859 [17 1] | George Alexander Hamilton |  | Conservative | James Whiteside |  | Conservative | Resignation | 
| Banbury | 9 February 1859 | Henry William Tancred |  | Whig | Bernhard Samuelson |  | Whig | Resignation | 
| Linlithgowshire | 5 February 1859 [17 1] | George Dundas |  | Conservative | Charles Baillie |  | Conservative | Resignation (Lieutenant Governor of Prince Edward Island) | 
| Boston | 3 February 1859 [17 1] | William Henry Adams |  | Conservative | William Henry Adams |  | Conservative | Recorder of Derby  [17 2] | 
| Breconshire | 28 December 1858 [17 1] | Joseph Bailey |  | Conservative | Godfrey Morgan |  | Conservative | Death | 
| Herefordshire | 18 December 1858 [17 1] | Thomas William Booker-Blakemore |  | Conservative | Lord Montagu Graham |  | Conservative | Death | 
| Manchester | 17 November 1858 [17 1] | John Potter |  | Whig | Thomas Bazley |  | Whig | Death | 
| Reigate | 23 October 1858 | Henry Rawlinson |  | Whig | William Monson |  | Whig | Resignation (Council of India) | 
| Leominster | 22 October 1858 [17 1] | John Willoughby |  | Conservative | Charles Bateman-Hanbury |  | Conservative | Resignation (Council of India) | 
| Guildford | 22 October 1858 | Ross Donnelly Mangles |  | Whig | Guildford Onslow |  | Whig | Resignation (Council of India) | 
| North Cheshire | 7 August 1858 [17 1] | William Egerton |  | Conservative | Wilbraham Egerton |  | Conservative | Resignation | 
| South Devon | 6 August 1858 [17 1] | John Yarde-Buller |  | Conservative | Samuel Trehawke Kekewich |  | Conservative | Resignation and elevation to the peerage | 
| Stamford | 17 July 1858 [17 1] | John Inglis |  | Conservative | Stafford Northcote |  | Conservative | Resignation (Lord Justice Clerk) | 
| West Cornwall | 5 July 1858 [17 1] | Michael Williams |  | Whig | John St Aubyn |  | Whig | Death | 
| East Norfolk | 1 July 1858 | Edward Buxton |  | Whig | Wenman Coke |  | Whig | Death | 
| Hertfordshire | 8 June 1858 [17 1] | Edward Bulwer-Lytton |  | Conservative | Edward Bulwer-Lytton |  | Conservative | Secretary of State for the Colonies  [17 2] | 
| King's Lynn | 5 June 1858 [17 1] | Lord Stanley |  | Conservative | Lord Stanley |  | Conservative | President of the Board of Control  [17 2] | 
| Limerick City | 21 May 1858 [17 1] | George Gavin |  | Whig | James Spaight |  | Conservative | Void By-Election | 
| Leitrim | 17 May 1858 [17 1] | Hugh Lyons-Montgomery |  | Conservative | William Ormsby-Gore |  | Conservative | Resignation | 
| Dublin University | 27 March 1858 | Joseph Napier |  | Conservative | Anthony Lefroy |  | Conservative | Resignation (Lord Chancellor of Ireland) | 
| City Durham | 17 March 1858 [17 1] | John Mowbray |  | Conservative | John Mowbray |  | Conservative | Judge Advocate General  [17 2] | 
| Tyrone | 11 March 1858 [17 1] | Lord Claud Hamilton |  | Conservative | Lord Claud Hamilton |  | Conservative | Treasurer of the Household  [17 2] | 
| North Northumberland | 11 March 1858 [17 1] | Lord Lovaine |  | Conservative | Lord Lovaine |  | Conservative | Civil Lord of the Admiralty  [17 2] | 
| County Dublin | 11 March 1858 [17 1] | Thomas Edward Taylor |  | Conservative | Thomas Edward Taylor |  | Conservative | Junior Lord of the Treasury  [17 2] | 
| South Shropshire | 9 March 1858 [17 1] | Viscount Newport |  | Conservative | Viscount Newport |  | Conservative | Vice-Chamberlain of the Household  [17 2] | 
| Enniskillen | 9 March 1858 [17 1] | James Whiteside |  | Conservative | James Whiteside |  | Conservative | Attorney-General for Ireland  [17 2] | 
| North Staffordshire | 8 March 1858 [17 1] | Charles Adderley |  | Conservative | Charles Adderley |  | Conservative | Vice-President of the Committee of the Council on Education and President of the Board of Health  [17 2] | 
| North Leicestershire | 8 March 1858 [17 1] | Lord John Manners |  | Conservative | Lord John Manners |  | Conservative | First Commissioner of Works  [17 2] | 
| Buckinghamshire | 8 March 1858 [17 1] | Benjamin Disraeli |  | Conservative | Benjamin Disraeli |  | Conservative | Chancellor of the Exchequer  [17 2] | 
| East Suffolk | 6 March 1858 [17 1] | Fitzroy Kelly |  | Conservative | Fitzroy Kelly |  | Conservative | Attorney General for England and Wales  [17 2] | 
| Oxfordshire | 6 March 1858 [17 1] | Joseph Warner Henley |  | Conservative | Joseph Warner Henley |  | Conservative | President of the Board of Trade  [17 2] | 
| Chichester | 6 March 1858 [17 1] | Lord Henry Lennox |  | Conservative | Lord Henry Lennox |  | Conservative | Junior Lord of the Treasury  [17 2] | 
| North Wiltshire | 5 March 1858 [17 1] | Thomas H. Sotheron-Estcourt |  | Conservative | Thomas H. Sotheron-Estcourt |  | Conservative | President of the Poor Law Board  [17 2] | 
| Belfast | 5 March 1858 [17 1] | Hugh Cairns |  | Conservative | Hugh Cairns |  | Conservative | Solicitor General for England and Wales  [17 2] | 
| King's Lynn | 4 March 1858 [17 1] | Lord Stanley |  | Conservative | Lord Stanley |  | Conservative | Secretary of State for the Colonies  [17 2] | 
| Huntingdon | 4 March 1858 [17 1] | Jonathan Peel |  | Conservative | Jonathan Peel |  | Conservative | Secretary of State for War and Secretary at War  [17 2] | 
| Cambridge University | 4 March 1858 [17 1] | Spencer Horatio Walpole |  | Conservative | Spencer Horatio Walpole |  | Conservative | Home Secretary  [17 2] | 
| Wenlock | 3 March 1858 [17 1] | George Weld-Forester |  | Conservative | George Weld-Forester |  | Conservative | Comptroller of the Household  [17 2] | 
| Stamford | 3 March 1858 [17 1] | Sir Frederic Thesiger |  | Conservative | John Inglis |  | Conservative | Appointed Lord Chancellor  [17 2] | 
| Droitwich | 3 March 1858 [17 1] | Sir John Pakington |  | Conservative | Sir John Pakington |  | Conservative | First Lord of the Admiralty  [17 2] | 
| Cockermouth | 3 March 1858 [17 1] | Lord Naas |  | Conservative | Lord Naas |  | Conservative | Chief Secretary for Ireland  [17 2] | 
| Bridgnorth | 3 March 1858 [17 1] | Henry Whitmore |  | Conservative | Henry Whitmore |  | Conservative | Junior Lord of the Treasury  [17 2] | 
| Wicklow | 25 February 1858 [17 1] | Viscount Milton |  | Whig | Lord Proby |  | Whig | Succession to a peerage | 
| South Northamptonshire | 20 February 1858 | Viscount Althorp |  | Whig | Henry Cartwright |  | Conservative | Succession to a peerage | 
| Limerick City | 15 February 1858 | James O'Brien |  | Whig | George Gavin |  | Whig | Resignation (Justice of the Court of Queen's Bench in Ireland) | 
| Reigate | 6 February 1858 | William Hackblock |  | Independent Whig [2]  [3] | Henry Rawlinson |  | Whig | Death | 
| Mayo | 30 December 1857 [17 1] | George Henry Moore |  | Independent Irish | Lord John Browne |  | Whig | Void election | 
| Buckinghamshire | 28 December 1857 | Charles Compton Cavendish |  | Whig | William George Cavendish |  | Whig | Resignation and elevation to the peerage | 
| Elgin Burghs | 19 December 1857 [17 1] | George Skene Duff |  | Whig | M. E. Grant Duff |  | Whig | Resignation | 
| Whitehaven | 17 December 1857 [17 1] | Robert Charles Hildyard |  | Conservative | George Lyall |  | Conservative | Death | 
| North Northamptonshire | 16 December 1857 | Augustus Stafford |  | Conservative | George Ward Hunt |  | Conservative | Death | 
| Scarborough | 14 December 1857 | Earl of Mulgrave |  | Whig | John Dent Dent |  | Whig | Resignation | 
| Ashton-under-Lyne | 14 December 1857 | Charles Hindley |  | Whig | Thomas Milner Gibson |  | Whig | Death | 
| Paisley | 11 December 1857 | Archibald Hastie |  | Whig | Humphrey Crum-Ewing |  | Whig | Death | 
| East Kent | 10 December 1857 [17 1] | Sir Edward Dering |  | Whig | William Deedes |  | Conservative | Resignation | 
| Thetford | 9 December 1857 [17 1] | Francis Baring |  | Conservative | Alexander Baring |  | Conservative | Resignation | 
| Harwich | 9 December 1857 | George Drought Warburton |  | Independent Whig [4]  [5] | Robert John Bagshaw |  | Whig | Death | 
| Oldham | 19 October 1857 [17 1] | James Platt |  | Whig | William Johnson Fox |  | Whig | Death | 
| Tavistock | 4 September 1857 | George Henry Charles Byng |  | Whig | Lord Arthur Russell |  | Whig | Resignation to contest Middlesex | 
| Middlesex | 3 September 1857 [17 1] | Lord Robert Grosvenor |  | Whig | George Henry Charles Byng |  | Whig | Elevation to the peerage | 
| Beverley | 11 August 1857 | Edward Auchmuty Glover |  | Whig | Henry Edwards |  | Conservative | Void election | 
| Great Yarmouth | 10 August 1857 [17 1] | William McCullagh Torrens |  | Independent Whig [6]  [7]  [8] | Adolphus William Young |  | Whig | Void election | 
| Edward Watkin |  | Whig | John Mellor |  | Whig | Void election | 
| Birmingham | 10 August 1857 [17 1] | George Frederic Muntz |  | Whig | John Bright |  | Whig | Death | 
| Falkirk Burghs | 8 August 1857 [17 1] | James Merry |  | Whig | John Glencairn Carter Hamilton |  | Whig | Void election | 
| City of London | 28 July 1857 [17 1] | Lionel de Rothschild |  | Whig | Lionel de Rothschild |  | Whig | Seeks re-election following the rejection of the Jewish Disabilities Bill | 
| Woodstock | 24 July 1857 [17 1] | Marquess of Blandford |  | Conservative | Lord Alfred Spencer-Churchill |  | Conservative | Succession to a peerage | 
| Oxford | 21 July 1857 | Charles Neate |  | Whig | Edward Cardwell |  | Peelite | Void election | 
| Banffshire | 30 June 1857 [17 1] | The Earl Fife |  | Whig | Lachlan Gordon-Duff |  | Whig | Resignation | 
| Carmarthenshire | 12 June 1857 [17 1] | David Arthur Saunders Davies |  | Conservative | David Pugh |  | Conservative | Death | 
| Kerry | 9 June 1857 [17 1] | Henry Arthur Herbert |  | Whig | Henry Arthur Herbert |  | Whig | Chief Secretary for Ireland  [17 2] | 
| Leeds | 5 June 1857 | Robert Hall |  | Conservative | George Skirrow Beecroft |  | Conservative | Death | 
| Reading | 2 June 1857 [17 1] | Henry Singer Keating |  | Whig | Henry Singer Keating |  | Whig | Solicitor General for England and Wales  [17 2] | 
| Penryn and Falmouth | 27 May 1857 [17 1] | Thomas George Baring |  | Whig | Thomas George Baring |  | Whig | Civil Lord of the Admiralty  [17 2] | 
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