| Lord Lieutenant | From | Until |
|---|
| Robert Radclyffe, 1st Earl of Sussex | 1537 | 1542 |
| Edward Stanley, 3rd Earl of Derby | 1552 | 1572 |
| Henry Stanley, 4th Earl of Derby | 1572 | 25 September 1593 |
| vacant |
William Stanley, 6th Earl of Derby jointly with James Stanley, Lord Strange | 21 December 1607 12 December 1626 | 1642 1642 |
| Interregnum 1649–1660 |
| Charles Stanley, 8th Earl of Derby | 30 July 1660 | 21 December 1672 |
| John Egerton, 2nd Earl of Bridgewater | 24 January 1673 | 11 May 1676 |
| William Stanley, 9th Earl of Derby | 11 May 1676 | 13 September 1687 |
| Caryll Molyneux, 3rd Viscount Molyneux | 13 September 1687 | 25 October 1688 |
| William Stanley, 9th Earl of Derby | 25 October 1688 | 13 May 1689 |
| Charles Gerard, 2nd Earl of Macclesfield | 13 May 1689 | 5 November 1701 |
| Richard Savage, 4th Earl Rivers | 15 January 1702 | 18 June 1702 |
| William Stanley, 9th Earl of Derby | 18 June 1702 | 5 November 1702 |
| James Stanley, 10th Earl of Derby | 19 December 1702 | 29 November 1710 |
| James Hamilton, 4th Duke of Hamilton | 29 November 1710 | 15 November 1712 |
| vacant 1712–1714 |
| James Stanley, 10th Earl of Derby | 19 August 1714 | 1 February 1736 |
| vacant 1733–1742 |
| Edward Stanley, 11th Earl of Derby | 13 March 1742 | 22 July 1757 |
| James Stanley, Lord Strange | 22 July 1757 | 1 June 1771 |
| Edward Stanley, 11th Earl of Derby | 22 July 1771 | 22 February 1776 |
| Edward Smith-Stanley, 12th Earl of Derby | 14 March 1776 | 21 October 1834 |
| Edward Smith-Stanley, 13th Earl of Derby | 15 November 1834 | 30 June 1851 |
| Charles Molyneux, 3rd Earl of Sefton | 3 September 1851 | 2 August 1855 |
| Francis Egerton, 1st Earl of Ellesmere | 15 October 1855 | 18 February 1857 |
| William Cavendish, 2nd Earl of Burlington | 28 March 1857 | 20 February 1858 |
| William Molyneux, 4th Earl of Sefton | 20 February 1858 | 27 June 1897 |
| Frederick Stanley, 16th Earl of Derby | 30 July 1897 | 14 June 1908 |
| Ughtred Kay-Shuttleworth, 1st Baron Shuttleworth | 14 July 1908 | 29 March 1928 |
| Edward Stanley, 17th Earl of Derby | 29 March 1928 | 4 February 1948 |
| Arthur Peel, 2nd Earl Peel | 19 April 1948 | 22 January 1951 |
| Edward Stanley, 18th Earl of Derby | 22 January 1951 | 13 September 1968 |
| Hervey Rhodes, Baron Rhodes | 13 September 1968 | 13 August 1971 |
| Ralph Assheton, 1st Baron Clitheroe | 13 August 1971 | March 1976 |
| Sir Simon Towneley | March 1976 | 13 January 1997 |
| Charles Kay-Shuttleworth, 5th Baron Shuttleworth | 13 January 1997 [2] | 2 August 2023 |
| Amanda Parker | 2 August 2023 [3] | present |