Mannose-1-phosphate guanylyltransferase (GDP)

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mannose-1-phosphate guanylyltransferase (GDP)
Identifiers
EC no. 2.7.7.22
CAS no. 9026-31-7
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In enzymology, a mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) is an enzyme that catalyzes the chemical reaction

GDP + alpha-D-mannose 1-phosphate phosphate + GDP-mannose

Thus, the two substrates of this enzyme are GDP and alpha-D-mannose 1-phosphate, whereas its two products are phosphate and GDP-mannose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GDP:alpha-D-mannose-1-phosphate guanylyltransferase. This enzyme participates in fructose and mannose metabolism.

Other common names

Related Research Articles

Guanylyl transferases are enzymes that transfer a guanosine mono phosphate group, usually from GTP to another molecule, releasing pyrophosphate. Many eukaryotic guanylyl transferases are capping enzymes that catalyze the formation of the 5' cap in the co-transcriptional modification of messenger RNA. Because the 5' end of the RNA molecule ends in a phosphate group, the bond formed between the RNA and the GTP molecule is an unusual 5'-5' triphosphate linkage, instead of the 3'-5' linkages between the other nucleotides that form an RNA strand. In capping enzymes, a highly conserved lysine residue serves as the catalytic residue that forms a covalent enzyme-GMP complex.

<span class="mw-page-title-main">Colitose</span> Chemical compound

Colitose is a mannose-derived 3,6-dideoxysugar produced by certain bacteria. It is a constituent of the lipopolysaccharide. It is the enantiomer of abequose.

In enzymology, a GDP-6-deoxy-D-talose 4-dehydrogenase (EC 1.1.1.135) is an enzyme that catalyzes the chemical reaction

In enzymology, a GDP-mannose 3,5-epimerase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">GDP-mannose 4,6-dehydratase</span>

The enzyme GDP-mannose 4,6-dehydratase (EC 4.2.1.47) catalyzes the chemical reaction

<span class="mw-page-title-main">Guanosine diphosphate mannose</span> Chemical compound

Guanosine diphosphate mannose or GDP-mannose is a nucleotide sugar that is a substrate for glycosyltransferase reactions in metabolism. This compound is a substrate for enzymes called mannosyltransferases.

In enzymology, an alpha,alpha-trehalose-phosphate synthase (GDP-forming) is an enzyme that catalyzes the chemical reaction

In enzymology, a dolichyl-phosphate beta-D-mannosyltransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Adenosylcobinamide-phosphate guanylyltransferase</span> Class of enzymes

In enzymology, an adenosylcobinamide-phosphate guanylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an aldose-1-phosphate adenylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an aldose-1-phosphate nucleotidyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a fucose-1-phosphate guanylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a glucose-1-phosphate guanylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a mannose-1-phosphate guanylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a phosphomannan mannosephosphotransferase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">UDP-N-acetylglucosamine diphosphorylase</span> Class of enzymes

In enzymology, an UDP-N-acetylglucosamine diphosphorylase is an enzyme that catalyzes the chemical reaction

GDP-L-galactose phosphorylase is an enzyme with systematic name GDP:alpha-L-galactose 1-phosphate guanylyltransferase. This enzyme catalyses the following chemical reaction

D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase is an enzyme with systematic name GTP:D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase. This enzyme catalyses the following chemical reaction

GDP-D-glucose phosphorylase is an enzyme with systematic name GDP:alpha-D-glucose 1-phosphate guanylyltransferase. This enzyme catalyses the following chemical reaction

References


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