sphingosine cholinephosphotransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.7.8.10 | ||||||||
CAS no. | 9027-12-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a sphingosine cholinephosphotransferase (EC 2.7.8.10) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are CDP-choline and sphingosine, whereas its two products are CMP and sphingosyl-phosphocholine.
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-choline:sphingosine cholinephosphotransferase. Other names in common use include CDP-choline-sphingosine cholinephosphotransferase, phosphorylcholine-sphingosine transferase, cytidine diphosphocholine-sphingosine cholinephosphotransferase, and sphingosine choline phosphotransferase. This enzyme participates in sphingolipid metabolism.
Choline is a cation with the chemical formula [(CH3)3NCH2CH2OH]+. Choline forms various salts, for example choline chloride and choline bitartrate.
Citicoline (INN), also known as cytidine diphosphate-choline (CDP-Choline) or cytidine 5'-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline, a common biochemical process in cell membranes. Citicoline is naturally occurring in the cells of human and animal tissue, in particular the organs.
In the field of enzymology, a glycerophospholipid arachidonoyl-transferase (CoA-independent) is an enzyme that catalyzes the chemical reaction:
In enzymology, a beta-galactoside alpha-2,6-sialyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a 1-alkenyl-2-acylglycerol choline phosphotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a CDP-diacylglycerol—inositol 3-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a CDP-diacylglycerol—serine O-phosphatidyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a CDP-glycerol glycerophosphotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a CDP-ribitol ribitolphosphotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a ceramide cholinephosphotransferase is an enzyme that catalyzes the chemical reaction
Choline kinase is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis. This reaction involves the transfer of a phosphate group from adenosine triphosphate (ATP) to choline in order to form phosphocholine.
Choline-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a cytidylate kinase is an enzyme that catalyzes the chemical reaction
In enzymology, a diacylglycerol cholinephosphotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, an ethanolaminephosphotransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a phosphatidylcholine synthase is an enzyme that catalyzes the chemical reaction
In enzymology, a serine-phosphoethanolamine synthase is an enzyme that catalyzes the chemical reaction
Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.53, Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase, ADPRibase-Mn) is an enzyme with systematic name CDP-choline phosphohydrolase. This enzyme catalyses the following chemical reaction
The CDP-choline pathway, first identified by Eugene P. Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules. The CDP-choline pathway represents one half of what is known as the Kennedy pathway. The other half is the CDP-ethanolamine pathway which is responsible for the biosynthesis of the phospholipid phosphatidylethanolamine (PE).