(deoxy)nucleoside-phosphate kinase

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(deoxy)nucleoside-phosphate kinase
Identifiers
EC no. 2.7.4.13
CAS no. 37278-20-9
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MetaCyc metabolic pathway
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In enzymology, a (deoxy)nucleoside-phosphate kinase (EC 2.7.4.13) is an enzyme that catalyzes the chemical reaction

ATP + deoxynucleoside phosphate ADP + deoxynucleoside diphosphate

Thus, the two substrates of this enzyme are ATP and deoxynucleoside phosphate, whereas its two products are ADP and deoxynucleoside diphosphate. [1]

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:deoxynucleoside-phosphate phosphotransferase. Other names in common use include deoxynucleoside monophosphate kinase, deoxyribonucleoside monophosphokinase, and deoxynucleoside-5'-monophosphate kinase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1DEK and 1DEL.

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References

  1. ↑ BESSMAN MJ, HERRIOTT ST, ORR MJ (1965). "The Enzymology of Virus-Infected Bacteria. Vi. Purification and Properties of the Deoxynucleotide Kinase Induced by Bacteriophage T5". J. Biol. Chem. 240: 439–45. doi: 10.1016/S0021-9258(18)97668-4 . PMID   14253449.


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