Bartholin's gland

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Bartholin's gland
Skenes gland.jpg
Female genital organs with Bartholin's gland opening circled
Details
Precursor Urogenital sinus
Artery External pudendal artery [1]
Nerve Ilioinguinal nerve [1]
Lymph Superficial inguinal lymph nodes
Identifiers
Latin glandula vestibularis major
MeSH D001472
TA98 A09.2.01.016
TA2 3563
FMA 9598
Anatomical terminology

The Bartholin's glands (named after Caspar Bartholin the Younger; also called Bartholin glands or greater vestibular glands) are two pea-sized compound alveolar glands [2] located slightly posterior and to the left and right of the opening of the vagina. [3] They secrete mucus to lubricate the vagina. [3]

Contents

They are homologous to bulbourethral glands in males. However, while Bartholin's glands are located in the superficial perineal pouch in females, bulbourethral glands are located in the deep perineal pouch in males. Their duct length is 1.5 to 2.0 cm and they open into navicular fossa. [2] The ducts are paired and they open on the surface of the vulva. [3]

Structure

The embryological origin of the Bartholin's glands is derived from the urogenital sinus; therefore, the innervation and blood supply are via the pudendal nerve and external pudendal artery, respectively. The superficial inguinal lymph nodes and pelvic nodes provide lymphatic drainage. [4]

These glands are pea-sized (0.5–1.0 cm) and are lined with columnar epithelium. The duct length is 1.5–2 cm and is lined with squamous epithelium. These are located just beneath the fascia and their ducts drain into the vestibular mucosa. These mucoid alkaline secreting glands are arranged as lobules consisting of alveoli lined by cuboidal or columnar epithelium. Their efferent ducts are composed of transitional epithelium, which merges into squamous epithelium as it enters the distal vagina. The more proximal portions of the ductal system are lined by transitional epithelium and may be lined by columnar epithelium before arborization into glandular secretory elements. [5]

These glands lie on the perineal membrane and beneath the bulbospongiosus muscle at the tail end of the vestibular bulb deep to the posterior labia majora. The intimate relation between the enormously vascular tissue of the vestibular bulb and the Bartholin's glands is responsible for the risk of hemorrhage associated with the removal of this latter structure. [6]

The openings of the Bartholin's glands are located on the posterior margin of the introitus bilaterally in a groove between the hymen and the labium minus at the 4:00 and 8:00 o'clock positions. The glands duct opening is seen on the posterolateral aspect of the vestibule 3 to 4 mm outside the hymen or hymenal caruncles lateral to the hymenal ring. [7]

History

De ovariis mulierum et generationis historia epistola anatomica, 1678 Bartholin - De ovariis mulierum et generationis historia epistola anatomica, 1678 - 3036572.tif
De ovariis mulierum et generationis historia epistola anatomica, 1678

Bartholin's glands were first described in 1677 by the 17th-century Danish anatomist Caspar Bartholin the Younger (1655–1738). [8] [9] Earlier he jointly discovered the glands in cows with Joseph Guichard Duverney (1648-1730), a French anatomist. [10] Some sources mistakenly ascribe their discovery to his grandfather, theologian and anatomist Caspar Bartholin the Elder (1585–1629). [11]

Function

Bartholin's glands secrete mucus to provide vaginal lubrication during sexual arousal. [9] [12] [13] The fluid may slightly moisten the labial opening of the vagina, serving to make contact with this sensitive area more comfortable. [14] Fluid from the Bartholin's glands is combined with other vaginal secretions as a "lubrication fluid" in the amount of about 6 grams per day, and contains high potassium and low sodium concentrations relative to blood plasma, with a slightly acidic pH of 4.7. [15]

Clinical pathology

It is possible for the Bartholin's glands to become blocked and inflamed resulting in pain. [14] This is known as bartholinitis or a Bartholin's cyst. [9] [16] [17] A Bartholin's cyst in turn can become infected and form an abscess. Adenocarcinoma of the gland is rare and benign tumors and hyperplasia are even more rare. [18] Bartholin gland carcinoma [19] is a rare malignancy that occurs in 1% of vulvar cancers. This may be due to the presence of three different types of epithelial tissue. [8] Inflammation of the Skene's glands and Bartholin glands may appear similar to cystocele. [20]

Other animals

The major vestibular glands are found in many mammals such as cats, cows, and some sheep. [21] [22]

See also

Related Research Articles

<span class="mw-page-title-main">Vagina</span> Part of the female reproductive tract

In mammals and other animals, the vagina is the elastic, muscular reproductive organ of the female genital tract. In humans, it extends from the vulval vestibule to the cervix. The vaginal introitus is normally partly covered by a thin layer of mucosal tissue called the hymen. The vagina allows for copulation and birth. It also channels menstrual flow, which occurs in humans and closely related primates as part of the menstrual cycle.

<span class="mw-page-title-main">Skene's gland</span> Glands located on the anterior wall of the vagina

In female human anatomy, Skene's glands or the Skene glands are two glands located towards the lower end of the urethra. The glands are surrounded by tissue that swells with blood during sexual arousal, and secrete a fluid, carried by the Skene's ducts to openings near the urethral meatus, particularly during orgasm.

<span class="mw-page-title-main">Bulbourethral gland</span> Gland in males to help with sperm health

The bulbourethral glands or Cowper's glands are two small exocrine and accessory glands in the reproductive system of many male mammals. They are homologous to Bartholin's glands in females. The bulbourethral glands are responsible for producing a pre-ejaculate fluid called Cowper's fluid, which is secreted during sexual arousal, neutralizing the acidity of the urethra in preparation for the passage of sperm cells. The paired glands are found adjacent to the urethra just below the prostate, seen best by screening (medicine) MRI as a tool in preventative healthcare in males. Screening MRI may be performed when there is a positive prostate-specific antigen on basic laboratory tests. Prostate cancer is the second-most common cause of cancer-related mortality in males in the USA.

<span class="mw-page-title-main">Cyst</span> Closed sac growth on the body

A cyst is a closed sac, having a distinct envelope and division compared with the nearby tissue. Hence, it is a cluster of cells that have grouped together to form a sac ; however, the distinguishing aspect of a cyst is that the cells forming the "shell" of such a sac are distinctly abnormal when compared with all surrounding cells for that given location. A cyst may contain air, fluids, or semi-solid material. A collection of pus is called an abscess, not a cyst. Once formed, a cyst may resolve on its own. When a cyst fails to resolve, it may need to be removed surgically, but that would depend upon its type and location.

<span class="mw-page-title-main">Bartholin's cyst</span> Medical condition

A Bartholin's cyst occurs when a Bartholin's gland within the labia becomes blocked. Small cysts may result in minimal or no symptoms. Larger cysts may result in swelling on one side of the vaginal opening, as well as pain during sex or walking. If the cyst becomes infected, an abscess can occur, which is typically red and very painful. If there are no symptoms, no treatment is needed. Bartholin's cysts affect about 2% of women at some point in their life. They most commonly occur during childbearing years.

<span class="mw-page-title-main">Female reproductive system</span> Reproductive system of female humans

The human female reproductive system is made up of the internal and external sex organs that function in the reproduction of new offspring. The reproductive system is immature at birth and develops at puberty to be able to release matured ova from the ovaries, facilitate their fertilization, and create a protective environment for the developing fetus during pregnancy. The female reproductive tract is made of several connected internal sex organs—the vagina, uterus, and fallopian tubes—and is prone to infections. The vagina allows for sexual intercourse, and is connected to the uterus at the cervix. The uterus accommodates the embryo by developing the uterine lining.

<span class="mw-page-title-main">Cystocele</span> Protrusion of the bladder into the vagina

The cystocele, also known as a prolapsed bladder, is a medical condition in which a woman's bladder bulges into her vagina. Some may have no symptoms. Others may have trouble starting urination, urinary incontinence, or frequent urination. Complications may include recurrent urinary tract infections and urinary retention. Cystocele and a prolapsed urethra often occur together and is called a cystourethrocele. Cystocele can negatively affect quality of life.

<span class="mw-page-title-main">Lactiferous duct</span> Structure carrying milk to the nipple

Lactiferous ducts are ducts that converge and form a branched system connecting the nipple to the lobules of the mammary gland. When lactogenesis occurs, under the influence of hormones, the milk is moved to the nipple by the action of smooth muscle contractions along the ductal system to the tip of the nipple. They are also referred to as galactophores, galactophorous ducts, mammary ducts, mamillary ducts or milk ducts.

<span class="mw-page-title-main">Vulval vestibule</span> Part of the vulva that contains the openings

The vulval vestibule is the part of the vulva between the labia minora. At the innermost part are the vaginal introitus and urinary meatus. The Bartholin's and Skene's glands each have two openings to the vestibule on the inside. The outer edge, marked by a coloration difference in the tissues, is called Hart's line, named after David Berry Hart.

<span class="mw-page-title-main">Perineal membrane</span> Anatomical term

The perineal membrane is an anatomical term for a fibrous membrane in the perineum. The term "inferior fascia of urogenital diaphragm", used in older texts, is considered equivalent to the perineal membrane.

<span class="mw-page-title-main">Urogenital triangle</span> Anterior part of the perineum

The urogenital triangle is the anterior part of the perineum. In female mammals, it contains the vulva, while in male mammals, it contains the penis and scrotum.

<span class="mw-page-title-main">Nabothian cyst</span> Mucus filled cyst on the surface of the cervix

A nabothian cyst is a mucus-filled cyst on the surface of the cervix. They are most often caused when stratified squamous epithelium of the ectocervix grows over the simple columnar epithelium of the endocervix. This tissue growth can block the cervical crypts, trapping cervical mucus inside the crypts.

<span class="mw-page-title-main">Vulva</span> External genitalia of the female mammal

In mammals, the vulva comprises mostly external, visible structures of the female genitalia leading away from the interior parts of the female reproductive tract, starting at the vaginal opening. For humans, it includes the mons pubis, labia majora, labia minora, clitoris, vestibule, urinary meatus, vaginal introitus, hymen, and openings of the vestibular glands. The folds of the outer and inner labia provide a double layer of protection for the vagina. Pelvic floor muscles support the structures of the vulva. Other muscles of the urogenital triangle also give support.

<span class="mw-page-title-main">Male accessory gland</span> Sexual gland in males

Male accessory glands (MAG) are the seminal vesicles, prostate gland, and the bulbourethral glands. These glands are found only in mammals. In insects, male accessory glands produce products that mix with the sperm to protect and preserve them, including seminal fluid proteins. Some insecticides can induce an increase in the protein content of the male accessory glands of certain types of insects. This has the unintended effect of increasing the number of offspring they produce.

Vaginal adenosis is a benign abnormality in the vagina, commonly thought to be caused by intrauterine and neonatal exposure of diethylstilbestrol and other progestogens and nonsteroidal estrogens, however it has also been observed in otherwise healthy women and has been considered at times idiopathic or congenital. Postpubertal lesions have also been observed to grow de novo. It has a rather common incidence, of about 10% of adult women.

A vestibulectomy is a gynecological surgical procedure that can be used to treat vulvar pain, specifically in cases of provoked vestibulodynia. Vestibulodynia is a chronic pain syndrome that is a subtype of localized vulvodynia where chronic pain and irritation is present in the vulval vestibule, which is near the entrance of the vagina. Vestibulectomy may be partial or complete.

The Pelvic Organ Prolapse Quantifications System (POP-Q) is a system for assessing the degree of prolapse of pelvic organs to help standardize diagnosing, comparing, documenting, and sharing of clinical findings. This assessment is the most frequently used among research publications related to pelvic organ prolapse.

Vaginal rugae are structures of the vagina that are transverse ridges formed out of the supporting tissues and vaginal epithelium in females. Some conditions can cause the disappearance of vaginal rugae and are usually associated with childbirth and prolapse of pelvic structures. The rugae contribute to the resiliency and elasticity of the vagina and its ability to distend and return to its previous state. These structures not only allow expansions and an increase in surface area of the vaginal epithelium, they provide the space necessary for the vaginal microbiota. The shape and structure of the rugae are supported and maintained by the lamina propria of the vagina and the anterior and posterior rugae.

<span class="mw-page-title-main">Vaginal cysts</span> Benign growths of the vaginal epithelium

Vaginal cysts are uncommon benign cysts that develop in the vaginal wall. The type of epithelial tissue lining a cyst is used to classify these growths. They can be congenital. They can present in childhood and adulthood. The most common type is the squamous inclusion cyst. It develops within vaginal tissue present at the site of an episiotomy or other vaginal surgical sites. In most instances they do not cause symptoms and present with few or no complications. A vaginal cyst can develop on the surface of the vaginal epithelium or in deeper layers. Often, they are found by the woman herself and as an incidental finding during a routine pelvic examination. Vaginal cysts can mimic other structures that protrude from the vagina such as a rectocele and cystocele. Some cysts can be distinguished visually but most will need a biopsy to determine the type. Vaginal cysts can vary in size and can grow as large as 7 cm. Other cysts can be present on the vaginal wall though mostly these can be differentiated. Vaginal cysts can often be palpated (felt) by a clinician. Vaginal cysts are one type of vaginal mass, others include cancers and tumors. The prevalence of vaginal cysts is uncertain since many go unreported but it is estimated that 1 out of 200 women have a vaginal cyst. Vaginal cysts may initially be discovered during pregnancy and childbirth. These are then treated to provide an unobstructed delivery of the infant. Growths that originate from the urethra and other tissue can present as cysts of the vagina.

Vulvar tumors are those neoplasms of the vulva. Vulvar and vaginal neoplasms make up a small percentage (3%) of female genital cancers. They can be benign or malignant. Vulvar neoplasms are divided into cystic or solid lesions and other mixed types. Vulvar cancers are those malignant neoplasms that originate from vulvar epithelium, while vulvar sarcomas develop from non-epithelial cells such as bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Epithelial and mesenchymal tissue are the origin of vulvar tumors.

References

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