In primates, and specifically in humans, the labia majora (sg.: labium majus), also known as the outer lips or outer labia, are two prominent longitudinal skin folds that extend downward and backward from the mons pubis to the perineum. [1] Together with the labia minora, they form the labia of the vulva.
The labia majora are homologous to the male scrotum. [2]
Labia majora is the Latin plural for big ("major") lips. The Latin term labium/labia is used in anatomy for a number of usually paired parallel structures, but in English, it is mostly applied to two pairs of parts of the vulva—labia majora and labia minora. Traditionally, to avoid confusion with other lip-like structures of the body, the vulvar labia were termed by anatomists in Latin as labia majora (or minora) pudendi.
Embryologically, they develop from labioscrotal folds. [3]
The labia majora after puberty may become of a darker color than the skin outside them and grow pubic hair on their external surface.
The main function of the labia majora is to cover and protect the other parts of the vulva. [4] The labia majora contain the labia minora, interlabial sulci, clitoral hood, clitoral glans, frenulum clitoridis, the Hart's Line, and the vulval vestibule, where the external openings of the urethra and the vagina are located. Each labium majus has two surfaces, an outer, pigmented and covered with strong, pubic hair; and an inner, smooth and beset with large sebaceous follicles. The labia majora are covered with squamous epithelium. Between the two, there is a considerable quantity of areolar tissue and fat, besides vessels, nerves, and glands. Below the skin of the labia majora, there is a tissue called the dartos muliebris, which gives them a wrinkled appearance. [5]
The labia majora constitute the lateral boundaries of the pudendal cleft. The pudendal cleft, also known as the vulvar cleft or cleft of Venus (rima vulvae or rima pudendi in Latin), [6] is a vertical fissure between the labia majora starting at the basal point of the mons pubis. After puberty, the clitoral hood and the labia minora can protrude into the pudendal cleft to a variable degree. [7]
The labia majora are thicker in front, and form the anterior labial commissure where they meet below the mons pubis. Posteriorly, they are not really joined, but appear to become lost in the neighboring integument, ending close to, and nearly parallel to, each other. Together with the connecting skin between them, they form another commissure, the posterior labial commissure, which is also the posterior boundary of the vulva. The interval between the posterior commissure and the anus, from 2.5 to 3 cm in length, constitutes the perineum. [8] The anterior region of the perineum is known as the urogenital triangle, which separates it from the anal region. Between the labia majora and the inner thighs are the labiocrural folds. Between the labia majora and labia minora are the interlabial sulci. Labia majora atrophy after menopause.
While the labia majora is present in all female primates, many have them until adulthood or become inconspicuous around that period. [9] Primates besides humans that always have visible labia majora are bonobos, strepsirrhines, tarsiers, cebid monkeys, and gibbons. [10] [11] [12]
In non-primate female mammals, the labia majora are absent since the labioscrotal swellings have disappeared as a fetus. [13] Because of this, the pudendal cleft refers to the slit between the small labia in those mammals. [14]
The fat pad of the labia majora can be used as a graft, often as a so-called "Martius labial fat pad graft", and can be used, for example, in urethrolysis. [15]
The labia minora, also known as the inner labia, inner lips, or nymphae, are two flaps of skin that are part of the primate vulva, extending outwards from the vaginal and urethral openings to encompass the vestibule. The labia minora are situated between the labia majora and together form the labia. They vary widely in size, color and shape from individual to individual.
The perineum in placental mammals is the space between the anus and the genitals. The human perineum is between the anus and scrotum in the male or between the anus and vulva in the female. The perineum is the region of the body between the pubic symphysis and the coccyx, including the perineal body and surrounding structures. The perineal raphe is visible and pronounced to varying degrees. The perineum is an erogenous zone. This area is also known as the taint or gooch in American slang; it is further known as the chad or grundle in British slang.
In human anatomy, and in mammals in general, the mons pubis or pubic mound is a rounded mass of fatty tissue found over the pubic symphysis of the pubic bones.
The labia are the major externally visible portions of the vulva. In humans and other primates, there are two pairs of labia: the labia majora are large and thick folds of skin that cover the vulva's other parts while the labia minora are the inner folds of skin between the outer labia that surround and protect the urethral and vaginal openings.
Vulvitis is inflammation of the vulva, the external female mammalian genitalia that include the labia majora, labia minora, clitoris, and introitus. It may co-occur as vulvovaginitis with vaginitis, inflammation of the vagina, and may have infectious or non-infectious causes. The warm and moist conditions of the vulva make it easily affected. Vulvitis is prone to occur in any female especially those who have certain sensitivities, infections, allergies, or diseases that make them likely to have vulvitis. Postmenopausal women and prepubescent girls are more prone to be affected by it, as compared to women in their menstruation period. It is so because they have low estrogen levels which makes their vulvar tissue thin and dry. Women having diabetes are also prone to be affected by vulvitis due to the high sugar content in their cells, increasing their vulnerability. Vulvitis is not a disease, it is just an inflammation caused by an infection, allergy or injury. Vulvitis may also be symptom of any sexually transmitted infection or a fungal infection.
Labiaplasty is a plastic surgery procedure for creating or altering the labia minora and the labia majora, the folds of skin of the human vulva. It is a type of vulvoplasty. There are two main categories of women seeking cosmetic genital surgery: those with conditions such as intersex, and those with no underlying condition who experience physical discomfort or wish to alter the appearance of their vulvas because they believe they do not fall within a normal range.
The vulval vestibule is the part of the vulva between the labia minora. On the inside, the urinary meatus and the vaginal introitus open to the vestibule, while the outer edge is marked by Hart's line, named after David Berry Hart.
The perineal nerve is a nerve of the pelvis. It arises from the pudendal nerve in the pudendal canal. It gives superficial branches to the skin, and a deep branch to muscles. It supplies the skin and muscles of the perineum. Its latency is tested with electrodes.
The membranous layer of the superficial fascia of the perineum is the deeper layer of the superficial perineal fascia. It is thin, aponeurotic in structure, and of considerable strength, serving to bind down the muscles of the root of the penis. Colles' fascia emerges from the perineal membrane, which divides the base of the penis from the prostate. Colles' fascia emerges from the inferior side of the perineal membrane and continues along the ventral (inferior) penis without covering the scrotum. It separates the skin and subcutaneous fat from the superficial perineal pouch.
The labioscrotal swellings are paired structures in the mammalian embryo that represent the final stage of development of the caudal end of the external genitals before sexual differentiation. In humans, the two swellings merge:
A commissure is the location at which two objects abut or are joined. The term is used especially in the fields of anatomy and biology.
The posterior scrotal branches are two in number, medial and lateral. They are branches of the perineal nerve, which is itself a branch of the pudendal nerve. The pudendal nerve arises from spinal roots S2 through S4, travels through the pudendal canal on the fascia of the obturator internus muscle, and gives off the perineal nerve in the perineum. The major branch of the perineal nerve is the posterior scrotal/posterior labial.
The deep external pudendal artery is one of the pudendal arteries that is more deeply seated than the superficial external pudendal artery, passes medially across the pectineus and the adductor longus muscles; it is covered by the fascia lata, which it pierces at the medial side of the thigh, and is distributed, in the male, to the integument of the scrotum and perineum, in the female to the labia majora; its branches anastomose with the scrotal or labial branches of the perineal artery.
The urogenital triangle is the anterior part of the perineum. In female mammals, it contains the vulva, while in male mammals, it contains the penis and scrotum.
The posterior labial nerves are branches of the pudendal nerve. They supply the female labia majora.
The development of the reproductive system is the part of embryonic growth that results in the sex organs and contributes to sexual differentiation. Due to its large overlap with development of the urinary system, the two systems are typically described together as the genitourinary system.
Clitoral hood reduction, also termed clitoral hoodectomy, clitoral unhooding, clitoridotomy, or (partial) hoodectomy, is a plastic surgery procedure for reducing the size and the area of the clitoral hood in order to further expose the glans of the clitoris.
In mammals, the vulva consists of the external female genitalia. For humans, it includes the mons pubis, labia majora, labia minora, clitoris, vestibule, urinary meatus, vaginal introitus, hymen, and openings of the vestibular glands. The vulva includes the entrance to the vagina, which leads to the uterus, and provides a double layer of protection for this by the folds of the outer and inner labia. Pelvic floor muscles support the structures of the vulva. Other muscles of the urogenital triangle also give support.
Labial fusion is a medical condition of the vulva where the labia minora become fused together. It is generally a pediatric condition.
Crohn's disease (CD) of the vulva is a rare extra intestinal condition, with granulomatous cutaneous lesions affecting the female genitalia. Lesions connected to the affected gut via a healthy tissue are referred to as metastatic lesions.