CDC6

Last updated
CDC6
PDB 2cch EBI.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CDC6 , CDC18L, HsCDC18, Hscell division cycle 6, MGORS5
External IDs OMIM: 602627; MGI: 1345150; HomoloGene: 68172; GeneCards: CDC6; OMA:CDC6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

990

23834

Ensembl

ENSG00000094804

ENSMUSG00000017499

UniProt

Q99741

O89033

RefSeq (mRNA)

NM_001254

NM_001025779
NM_011799
NM_001362735

RefSeq (protein)

NP_001245

NP_001020950
NP_035929
NP_001349664

Location (UCSC) Chr 17: 40.29 – 40.3 Mb Chr 11: 98.8 – 98.81 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene. [5] [6]

Contents

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in the cell nucleus during cell cycle phase G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during the cell cycle is regulated through its phosphorylation by cyclin-dependent kinases. Transcription of this protein was reported to be regulated in response to mitogenic signals through a transcriptional control mechanism involving E2F proteins. [7]

Interactions

CDC6 has been shown to interact with ORC1L, [6] [8] ORC2L, [8] [9] Cyclin A2, [6] [10] PPP2R3B, [11] MCM3, [9] [12] PPP2R3A, [13] MCM7 [8] [12] and PSKH1. [10]

See also

Related Research Articles

E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as repressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells. E2Fs as TFs bind to the TTTCCCGC consensus binding site in the target promoter sequence.

<span class="mw-page-title-main">MCM6</span>

DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication.

<span class="mw-page-title-main">Proliferating cell nuclear antigen</span> Mammalian protein found in Homo sapiens

Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics.

Cyclin A is a member of the cyclin family, a group of proteins that function in regulating progression through the cell cycle. The stages that a cell passes through that culminate in its division and replication are collectively known as the cell cycle Since the successful division and replication of a cell is essential for its survival, the cell cycle is tightly regulated by several components to ensure the efficient and error-free progression through the cell cycle. One such regulatory component is cyclin A which plays a role in the regulation of two different cell cycle stages.

<span class="mw-page-title-main">E2F1</span> Protein-coding gene in the species Homo sapiens

Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.

<span class="mw-page-title-main">CDC25A</span> Protein-coding gene in humans

M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.

<span class="mw-page-title-main">MCM7</span> Protein-coding gene in the species Homo sapiens

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.

<span class="mw-page-title-main">MCM3</span> Protein-coding gene in the species Homo sapiens

DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.

<span class="mw-page-title-main">Cyclin E1</span> Protein-coding gene in the species Homo sapiens

G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.

<span class="mw-page-title-main">Cyclin A1</span> Protein-coding gene in the species Homo sapiens

Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene.

<span class="mw-page-title-main">E2F3</span> Protein-coding gene in the species Homo sapiens

Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.

<span class="mw-page-title-main">E2F2</span> Protein-coding gene in the species Homo sapiens

Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.

<span class="mw-page-title-main">MCM4</span> Protein-coding gene in the species Homo sapiens

DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.

<span class="mw-page-title-main">Cyclin A2</span> Protein-coding gene in the species Homo sapiens

Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene. It is one of the two types of cyclin A: cyclin A1 is expressed during meiosis and embryogenesis while cyclin A2 is expressed in the mitotic division of somatic cells.

<span class="mw-page-title-main">DNA replication factor CDT1</span> Protein found in humans

CDT1 is a protein that in humans is encoded by the CDT1 gene. It is a licensing factor that functions to limit DNA from replicating more than once per cell cycle.

<span class="mw-page-title-main">ORC2</span> Protein-coding gene in the species Homo sapiens

Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.

<span class="mw-page-title-main">DMAP1</span> Protein-coding gene in the species Homo sapiens

DNA methyltransferase 1-associated protein 1 is an enzyme that in humans is encoded by the DMAP1 gene.

<span class="mw-page-title-main">Cell division cycle 7-related protein kinase</span> Protein found in humans

Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. The gene CDC7 appears to be conserved throughout eukaryotic evolution; this means that most eukaryotic cells have the Cdc7 kinase protein.

<span class="mw-page-title-main">GPSM2</span> Protein-coding gene in the species Homo sapiens

G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.

<span class="mw-page-title-main">ORC1</span> Protein-coding gene in the species Homo sapiens

Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. It is closely related to CDC6, and both are the same protein in archaea.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000094804 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017499 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Williams RS, Shohet RV, Stillman B (February 1997). "A human protein related to yeast Cdc6p". Proc Natl Acad Sci U S A. 94 (1): 142–7. Bibcode:1997PNAS...94..142S. doi: 10.1073/pnas.94.1.142 . PMC   19260 . PMID   8990175.
  6. 1 2 3 Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A (May 1998). "Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase". Mol Cell Biol. 18 (5): 2758–67. doi:10.1128/mcb.18.5.2758. PMC   110655 . PMID   9566895.
  7. ↑ "Entrez Gene: CDC6 cell division cycle 6 homolog (S. cerevisiae)".
  8. 1 2 3 Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1). England: 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN   0022-2836. PMID   12614612.
  9. 1 2 Méndez, J; Stillman B (November 2000). "Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis". Mol. Cell. Biol. 20 (22). UNITED STATES: 8602–12. doi:10.1128/MCB.20.22.8602-8612.2000. ISSN   0270-7306. PMC   102165 . PMID   11046155.
  10. 1 2 Petersen, B O; Lukas J; Sørensen C S; Bartek J; Helin K (January 1999). "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization". EMBO J. 18 (2). ENGLAND: 396–410. doi:10.1093/emboj/18.2.396. ISSN   0261-4189. PMC   1171134 . PMID   9889196.
  11. ↑ Yan, Z; Fedorov S A; Mumby M C; Williams R S (February 2000). "PR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells". Mol. Cell. Biol. 20 (3). UNITED STATES: 1021–9. doi:10.1128/MCB.20.3.1021-1029.2000. ISSN   0270-7306. PMC   85219 . PMID   10629059.
  12. 1 2 Fujita, M; Yamada C; Goto H; Yokoyama N; Kuzushima K; Inagaki M; Tsurumi T (September 1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. 274 (36). UNITED STATES: 25927–32. doi: 10.1074/jbc.274.36.25927 . ISSN   0021-9258. PMID   10464337.
  13. ↑ Davis, Anthony J; Yan Zhen; Martinez Bobbie; Mumby Marc C (June 2008). "Protein Phosphatase 2A Is Targeted to Cell Division Control Protein 6 by a Calcium-binding Regulatory Subunit". J. Biol. Chem. 283 (23). United States: 16104–14. doi: 10.1074/jbc.M710313200 . ISSN   0021-9258. PMC   2414307 . PMID   18397887.

Further reading

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