D-glycero-beta-D-manno-heptose-7-phosphate kinase

Last updated
D-glycero-beta-D-manno-heptose-7-phosphate kinase
Identifiers
EC no. 2.7.1.167
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Search
PMC articles
PubMed articles
NCBI proteins

D-glycero-beta-D-manno-heptose-7-phosphate kinase (EC 2.7.1.167, heptose 7-phosphate kinase, D-beta-D-heptose 7-phosphotransferase, D-beta-D-heptose-7-phosphate kinase, HldE1 heptokinase, glycero-manno-heptose 7-phosphate kinase, D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase, hldE (gene), rfaE (gene)) is an enzyme with systematic name ATP:D-glycero-beta-D-manno-heptose 7-phosphate 1-phosphotransferase. [1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction

D-glycero-beta-D-manno-heptose 7-phosphate + ATP D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP

The bifunctional protein hldE includes D-glycero-beta-D-manno-heptose-7-phosphate kinase and D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC 2.7.7.70).

References

  1. ↑ McArthur F, Andersson CE, Loutet S, Mowbray SL, Valvano MA (August 2005). "Functional analysis of the glycero-manno-heptose 7-phosphate kinase domain from the bifunctional HldE protein, which is involved in ADP-L-glycero-D-manno-heptose biosynthesis". Journal of Bacteriology. 187 (15): 5292–300. doi:10.1128/jb.187.15.5292-5300.2005. PMC   1196024 . PMID   16030223.
  2. ↑ Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P (January 2002). "Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli". Journal of Bacteriology. 184 (2): 363–9. doi:10.1128/jb.184.2.363-369.2002. PMC   139585 . PMID   11751812.
  3. ↑ Valvano MA, Messner P, Kosma P (July 2002). "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides". Microbiology. 148 (Pt 7): 1979–89. doi: 10.1099/00221287-148-7-1979 . PMID   12101286.
  4. ↑ Jin UH, Chung TW, Lee YC, Ha SD, Kim CH (October 2001). "Molecular cloning and functional expression of the rfaE gene required for lipopolysaccharide biosynthesis in Salmonella typhimurium". Glycoconjugate Journal. 18 (10): 779–87. doi:10.1023/a:1021103501626. PMID   12441667.
  5. ↑ Wang L, Huang H, Nguyen HH, Allen KN, Mariano PS, Dunaway-Mariano D (February 2010). "Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB)". Biochemistry. 49 (6): 1072–81. doi:10.1021/bi902018y. PMC   2844805 . PMID   20050615.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.