Ianalumab

Last updated
Ianalumab
Monoclonal antibody
Type ?
Source Human
Target BAFF receptor
Clinical data
Other namesVAY736
ATC code
  • none
Identifiers
CAS Number
UNII
KEGG

Ianalumab (INN; [1] development code VAY736) is a monoclonal antibody that is being investigated for autoimmune hepatitis, multiple sclerosis, pemphigus vulgaris, rheumatoid arthritis, Sjogren's disease, Immune thrombocytopenic purpura and systemic lupus erythematosus. [2] [3] [4] [5]

This drug is being developed by Novartis. In 2021 ianalumab was undergoing Phase II/III trials. [6] [7] In June 2023 ianalumab was involved in 22 clinical trials, of which 3 were completed, 14 were ongoing, 1 was planned, and 4 were terminated. [8]

References

  1. ↑ World Health Organization (2017). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 117" (PDF). WHO Drug Information. 31 (2).
  2. ↑ "Ianalumab - MorphoSys/Novartis". AdisInsight. Springer Nature Switzerland AG.
  3. ↑ van den Hoogen LL, van Laar JM (February 2020). "Targeted therapies in systemic sclerosis, myositis, antiphospholipid syndrome, and Sjögren's disease". Best Practice & Research. Clinical Rheumatology. 34 (1) 101485. doi: 10.1016/j.berh.2020.101485 . PMID   32067925.
  4. ↑ Narain S, Berman N, Furie R (November 2020). "Biologics in the treatment of Sjogren's syndrome, systemic lupus erythematosus, and lupus nephritis". Current Opinion in Rheumatology. 32 (6): 609–616. doi:10.1097/BOR.0000000000000754. PMID   33002950. S2CID   222150641.
  5. ↑ Novartis Pharmaceuticals (2024-12-10). A Phase 3 Randomized, Double-blind Study of Ianalumab (VAY736) Versus Placebo in Addition to Eltrombopag in Patients With Primary Immune Thrombocytopenia (ITP) Who Had an Insufficient Response or Relapsed After First Line Steroid Treatment (VAYHIT2) (Report). clinicaltrials.gov.
  6. ↑ Clinical trial number NCT03574545 for "Study Comparing Two VAY736 Drug Products in Patients With Rheumatoid Arthritis" at ClinicalTrials.gov
  7. ↑ Clinical trial number NCT03656562 for "Study the Efficacy and Safety of VAY736 and CFZ533 in SLE Patients" at ClinicalTrials.gov
  8. ↑ "Risk Adjusted Net Present Value: What is the current valuation of Novartis's Ianalumab". Pharmaceutical Technology. 30 June 2023.


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