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Chronic spontaneous urticaria(CSU) also known as Chronic idiopathic urticaria(CIU) is defined by the presence of wheals, angioedema, or both for more than six weeks. The most common symptoms of chronic spontaneous urticaria are angioedema and hives that are accompanied by itchiness.
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Tse Wen Chang is a Taiwanese immunologist. His early research involving the Immunoglobulin E (IgE) pathway and antibody-based therapeutics lead to the development of omalizumab, a medication that has been approved for the treatment of severe allergic asthma and severe chronic spontaneous urticaria. Chang is a cofounder of Tanox, a biopharmaceutical company specialized in anti-IgE therapies for the treatment of allergic diseases.
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Remibrutinib is a small molecule drug that acts as a Bruton's tyrosine kinase (BTK) inhibitor. It is in development for the treatment of chronic spontaneous urticaria. In November 2023, Novartis announced that the compound "demonstrated clinically meaningful and statistically significant reduction in urticaria activity vs placebo" in a Phase III trial.
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References
- ↑ Novartis Pharma AG (29 October 2014). "Ligelizumab" (PDF). Statement On A Nonproprietary Name Adopted By The USAN Council. American Medical Association.
- ↑ "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 107" (PDF). WHO Drug Information. 26 (2). 2012. Archived (PDF) from the original on 2016-03-04. Retrieved 2020-10-05.
- ↑ Kocatürk E, Maurer M, Metz M, Grattan C (2017-01-10). "Looking forward to new targeted treatments for chronic spontaneous urticaria". Clinical and Translational Allergy. 7: 1. doi: 10.1186/s13601-016-0139-2 . PMC 5223554 . PMID 28078079.
- ↑ "Novartis Ends Phase III Peanut Allergy Trial in Another Flop for Potential Xolair Successor". BioSpace. 2024-01-18. Retrieved 2024-11-29.
- ↑ Maurer M, Giménez-Arnau AM, Sussman G, Metz M, Baker DR, Bauer A, et al. (October 2019). "Ligelizumab for Chronic Spontaneous Urticaria". The New England Journal of Medicine. 381 (14): 1321–1332. doi: 10.1056/NEJMoa1900408 . hdl: 10230/43837 . PMID 31577874.
- ↑ Clinical trial number NCT02477332 for "A Multi-center, Randomized, Double-blind, Placebo, and Active-controlled Phase 2b Dose-finding Study of QGE031 as add-on Therapy to Investigate the Efficacy and Safety in Patients With Chronic Spontaneous Urticaria (CSU)" at ClinicalTrials.gov
- ↑ Parsons, Lucy (2021-01-15). "US breakthrough designation for ligelizumab in chronic spontaneous urticaria - PharmaTimes". pharmatimes.com. Archived from the original on 2023-06-03. Retrieved 2024-11-29.
- ↑ Taylor, Nick Paul (2021-12-20). "Novartis suffers shock setback as Xolair successor fails phase 3 | Fierce Biotech". www.fiercebiotech.com. Retrieved 2024-11-29.
- ↑ Novartis Pharmaceuticals (2023-07-20). A Multi-center, Randomized, Double-blind, Active and Placebo-controlled Study to Investigate the Safety and Efficacy of Ligelizumab (QGE031) in the Treatment of Chronic Spontaneous Urticaria (CSU) in Adolescents and Adults Inadequately Controlled With H1-antihistamines (Report). clinicaltrials.gov. Archived from the original on 2024-10-09. Retrieved 2024-11-29.
- ↑ Novartis Pharmaceuticals (2024-02-26). A Multi-center, Randomized, Double-blind, Active and Placebo-controlled Study to Investigate the Efficacy and Safety of Ligelizumab (QGE031) in the Treatment of Chronic Spontaneous Urticaria (CSU) in Adolescents and Adults Inadequately Controlled With H1-antihistamines (Report). clinicaltrials.gov. Archived from the original on 2024-10-09. Retrieved 2024-11-29.
- ↑ Novartis Pharmaceuticals (2024-06-14). A Multi-center, Randomized, Double-blind, Placebo Controlled Study to Investigate the Efficacy and Safety of Ligelizumab (QGE031) in the Treatment of Chronic Inducible Urticaria (CINDU) in Adolescents and Adults Inadequately Controlled With H1-antihistamines (Report). clinicaltrials.gov. Archived from the original on 2024-05-15. Retrieved 2024-11-29.
- ↑ Novartis Pharmaceuticals (2024-09-13). A 52 Week, Multi-center, Randomized, Double-blind Placebo-controlled Study to Assess the Clinical Efficacy and Safety of Ligelizumab (QGE031) in Decreasing the Sensitivity to Peanuts in Patients With Peanut Allergy (Report). clinicaltrials.gov.
- ↑ Novartis Pharmaceuticals (2024-11-14). A Three-year, Multi-center, Double-blind, Extension Study to Evaluate the Long-term Safety and Efficacy of Ligelizumab in Patients Who Completed Ligelizumab's Phase III Studies in Food Allergy (Report). clinicaltrials.gov.
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