Camrelizumab

Last updated

Camrelizumab
Monoclonal antibody
Type Whole antibody
Source Humanized
Target PD1
Clinical data
Other namesSHR-1210
ATC code
  • None
Identifiers
CAS Number
UNII

Camrelizumab (SHR-1210) (INN [1] ) is an anti-PD-1 immune checkpoint inhibitor that is being investigated for hepatocellular carcinoma, triple-negative breast cancer[3] and Hodgkin lymphoma. [2] PD-1 is programmed cell death protein 1.

The drug is being developed by Jiangsu HengRui Medicine Co., Ltd. As of 2019, camrelizumab is undergoing Phase II/III trials.

References

  1. ↑ World Health Organization (2017). "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended INN: List 77" (PDF). WHO Drug Information. 31 (1).
  2. ↑ Nie J, Wang C, Liu Y, Yang Q, Mei Q, Dong L, et al. (June 2019). "Addition of Low-Dose Decitabine to Anti-PD-1 Antibody Camrelizumab in Relapsed/Refractory Classical Hodgkin Lymphoma". Journal of Clinical Oncology. 37 (17): 1479–1489. doi: 10.1200/JCO.18.02151 . PMID   31039052. S2CID   141482897.{{cite journal}}: CS1 maint: overridden setting (link)

Chen L, Li H, Zhang H, Yang H, et al. (Feb 2025). “Camrelizumab vs Placebo in Combination with Chemotherapy as Neoadjuvant Treatment in Patients with Early or Locally Advanced Triple-Negative Breast Cancer. JAMA 333(8): 673-681. doi:10.1001/jama.2024.23560.

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