Relatlimab

Last updated
Relatlimab
Monoclonal antibody
Type Whole antibody
Source Human
Target Lymphocyte activation gene-3 (LAG-3)
Clinical data
Other namesBMS-986016, relatlimab-rmbw
License data
Routes of
administration
Intravenous
Drug class Antineoplastic
ATC code
  • None
Legal status
Legal status
Identifiers
CAS Number
DrugBank
UNII
KEGG
Chemical and physical data
Formula C6472H9922N1710O2024S38
Molar mass 145288.79 g·mol−1

Relatlimab is a monoclonal antibody designed for the treatment of melanoma. [2] [3] It is used in combination with nivolumab to treat melanoma. [1] [4]

Contents

Relatlimab is a Lymphocyte activation gene-3 (LAG-3) inhibitor. [1] [4] It is under development by Bristol-Myers Squibb. [1] [4] It is made using Chinese hamster ovary cells. [1]

History

As of 2018, relatlimab is undergoing Phase II/III trials. [5]

The combination nivolumab/relatlimab (Opdualag) was approved for medical use in the United States in March 2022. [1] [4]

Names

Relatlimab is the United States Adopted Name (USAN) and the international nonproprietary name (INN). [6] [7] [8]

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References

  1. 1 2 3 4 5 6 "Opdualag- nivolumab and relatlimab-rmbw injection". DailyMed. 18 March 2022. Retrieved 22 March 2022.
  2. Cavagnaro JA, Cosenza ME, eds. (2021). Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals. Boca Raton, Florida: CRC Press. ISBN   978-1-00-047185-4.
  3. Robert C (December 2021). "LAG-3 and PD-1 blockade raises the bar for melanoma". Nature Cancer. 2 (12): 1251–3. doi:10.1038/s43018-021-00276-8. PMID   35121906. S2CID   245407697.
  4. 1 2 3 4 "U.S. Food and Drug Administration Approves First LAG-3-Blocking Antibody Combination, Opdualag (nivolumab and relatlimab-rmbw), as Treatment for Patients with Unresectable or Metastatic Melanoma" (Press release). Bristol Myers Squibb. 18 March 2022. Retrieved 19 March 2022 via Business Wire.
  5. Clinical trial number NCT03704077 for "An Investigational Immuno-therapy Study of Relatlimab Plus Nivolumab Compared to Various Standard-of-Care Therapies in Previously Treated Participants With Recurrent, Advanced or Metastatic Gastric Cancer or Gastroesophageal Junction Adenocarcinoma" at ClinicalTrials.gov
  6. "Relatlimab". American Medical Association. Retrieved 22 March 2022.
  7. Statement On A Nonproprietary Name Adopted By The USAN Council - Relatlimab, American Medical Association.
  8. World Health Organization (2019). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 81". WHO Drug Information. 33 (1). hdl: 10665/330896 .