Monoclonal antibody | |
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Type | Whole antibody |
Source | Human |
Target | Lymphocyte activation gene-3 (LAG-3) |
Clinical data | |
Other names | BMS-986016, relatlimab-rmbw |
License data |
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Routes of administration | Intravenous |
Drug class | Antineoplastic |
ATC code |
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Legal status | |
Legal status | |
Identifiers | |
CAS Number | |
DrugBank | |
UNII | |
KEGG | |
Chemical and physical data | |
Formula | C6472H9922N1710O2024S38 |
Molar mass | 145288.79 g·mol−1 |
Relatlimab is a monoclonal antibody designed for the treatment of melanoma. [2] [3] It is used in combination with nivolumab to treat melanoma. [1] [4]
Relatlimab is a Lymphocyte activation gene-3 (LAG-3) inhibitor. [1] [4] It is under development by Bristol-Myers Squibb. [1] [4] It is made using Chinese hamster ovary cells. [1]
As of 2018 [update] , relatlimab is undergoing Phase II/III trials. [5]
The combination nivolumab/relatlimab (Opdualag) was approved for medical use in the United States in March 2022. [1] [4]
Relatlimab is the United States Adopted Name (USAN) and the international nonproprietary name (INN). [6] [7] [8]
Cetuximab, sold under the brand name Erbitux, is an epidermal growth factor receptor (EGFR) inhibitor medication used for the treatment of metastatic colorectal cancer and head and neck cancer. Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion.
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Checkpoint inhibitor therapy is a form of cancer immunotherapy. The therapy targets immune checkpoints, key regulators of the immune system that when stimulated can dampen the immune response to an immunologic stimulus. Some cancers can protect themselves from attack by stimulating immune checkpoint targets. Checkpoint therapy can block inhibitory checkpoints, restoring immune system function. The first anti-cancer drug targeting an immune checkpoint was ipilimumab, a CTLA4 blocker approved in the United States in 2011.
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Nivolumab/relatlimab, sold under the brand name Opdualag, is a fixed-dose combination medication use to treat melanoma. It contains nivolumab, a programmed death receptor-1 (PD-1) blocking antibody, and relatlimab, a lymphocyte activation gene-3 (LAG-3) blocking antibody. It is given by intravenous infusion.