Frexalimab

Frexalimab
Monoclonal antibody
Type	Whole antibody
Target	CD40 ligand
Clinical data
AHFS/Drugs.com	Monograph
License data	US DailyMed: Abelacimab ; US FDA: Abelacimab ;
Legal status
Legal status	Investigational;
Identifiers
PubChem SID	319902621 ;
ChemSpider	none;
KEGG	D10821 ;

Last updated September 20, 2025

Frexalimab (SAR441344) is a second-generation monoclonal antibody that inhibits CD40 ligand. It is in development by Sanofi for the treatment of relapsing multiple sclerosis.^[1]^[2]^[3]^[4]^[5]^[6]

References

↑ Carvalho, Thiago (5 July 2023). "Anti-CD40L antibody frexalimab slows new brain lesions in multiple sclerosis" . Nature Medicine. 29 (8): 1882–1883. doi:10.1038/d41591-023-00060-4. PMID 37407835.
↑ Niebel, Dennis; de Vos, Luka; Fetter, Tanja; Brägelmann, Christine; Wenzel, Jörg (July 2023). "Cutaneous Lupus Erythematosus: An Update on Pathogenesis and Future Therapeutic Directions". American Journal of Clinical Dermatology. 24 (4): 521–540. doi: 10.1007/s40257-023-00774-8 . PMC 10157137 . PMID 37140884.
↑ Ritter, Jacob; Chen, Yidan; Stefanski, Ana-Luisa; Dörner, Thomas (November 2022). "Current and future treatment in primary Sjögren's syndrome – A still challenging development". Joint Bone Spine. 89 (6) 105406. doi:10.1016/j.jbspin.2022.105406. PMID 35537697.
↑ Fadul, Camilo E.; Mao-Draayer, Yang; Ryan, Kathleen A.; Noelle, Randolph J.; Wishart, Heather A.; Channon, Jacqueline Y.; Kasper, Isaac R.; Oliver, Brant; Mielcarz, Daniel W.; Kasper, Lloyd H. (November 2021). "Safety and Immune Effects of Blocking CD40 Ligand in Multiple Sclerosis". Neurology: Neuroimmunology & Neuroinflammation. 8 (6) e1096. doi: 10.1212/NXI.0000000000001096 . PMC 8527364 . PMID 34654708.
↑ Vial, G.; Gensous, N.; Duffau, P. (October 2021). "L'axe CD40-CD40L: implications actuelles et futures en immunologie clinique". La Revue de Médecine Interne. 42 (10): 722–728. doi: 10.1016/j.revmed.2021.02.005 . PMID 33674076.
↑ Cree, Bruce A.C.; Hartung, Hans-Peter; Barnett, Michael (June 2022). "New drugs for multiple sclerosis: new treatment algorithms". Current Opinion in Neurology. 35 (3): 262–270. doi: 10.1097/WCO.0000000000001063 . PMID 35674067.

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[1] Carvalho, Thiago (5 July 2023). "Anti-CD40L antibody frexalimab slows new brain lesions in multiple sclerosis" . Nature Medicine. 29 (8): 1882–1883. doi:10.1038/d41591-023-00060-4. PMID 37407835.

[2] Niebel, Dennis; de Vos, Luka; Fetter, Tanja; Brägelmann, Christine; Wenzel, Jörg (July 2023). "Cutaneous Lupus Erythematosus: An Update on Pathogenesis and Future Therapeutic Directions". American Journal of Clinical Dermatology. 24 (4): 521–540. doi: 10.1007/s40257-023-00774-8 . PMC 10157137 . PMID 37140884.

[3] Ritter, Jacob; Chen, Yidan; Stefanski, Ana-Luisa; Dörner, Thomas (November 2022). "Current and future treatment in primary Sjögren's syndrome – A still challenging development". Joint Bone Spine. 89 (6) 105406. doi:10.1016/j.jbspin.2022.105406. PMID 35537697.

[4] Fadul, Camilo E.; Mao-Draayer, Yang; Ryan, Kathleen A.; Noelle, Randolph J.; Wishart, Heather A.; Channon, Jacqueline Y.; Kasper, Isaac R.; Oliver, Brant; Mielcarz, Daniel W.; Kasper, Lloyd H. (November 2021). "Safety and Immune Effects of Blocking CD40 Ligand in Multiple Sclerosis". Neurology: Neuroimmunology & Neuroinflammation. 8 (6) e1096. doi: 10.1212/NXI.0000000000001096 . PMC 8527364 . PMID 34654708.

[5] Vial, G.; Gensous, N.; Duffau, P. (October 2021). "L'axe CD40-CD40L: implications actuelles et futures en immunologie clinique". La Revue de Médecine Interne. 42 (10): 722–728. doi: 10.1016/j.revmed.2021.02.005 . PMID 33674076.

[6] Cree, Bruce A.C.; Hartung, Hans-Peter; Barnett, Michael (June 2022). "New drugs for multiple sclerosis: new treatment algorithms". Current Opinion in Neurology. 35 (3): 262–270. doi: 10.1097/WCO.0000000000001063 . PMID 35674067.

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