| # | Week ending | Film | Notes | Ref |
|---|
| 1 | January 4, 1961 | Spartacus | Spartacus reached number one in its 13th week of release | [1] |
| 2 | January 11, 1961 | | [2] |
| 3 | January 18, 1961 | Exodus | | [3] |
| 4 | January 25, 1961 | Spartacus | Spartacus returned to number one in its 16th week of release | [4] |
| 5 | February 1, 1961 | Swiss Family Robinson | Swiss Family Robinson grossed $265,000 in the key cities sampled | [5] |
| 6 | February 8, 1961 | The Misfits | | [6] |
| 7 | February 15, 1961 | Exodus | | [6] |
| 8 | February 22, 1961 | The Misfits | | [7] |
| 9 | March 1, 1961 | Exodus | | [8] |
| 10 | March 8, 1961 | | [8] |
| 11 | March 15, 1961 | | [9] |
| 12 | March 22, 1961 | Although Variety listed Exodus as the champ for the week based on their cities sampled, it noted that The Alamo likely grossed more nationally. | [10] |
| 13 | March 29, 1961 | | [11] |
| 14 | April 5, 1961 | | [12] |
| 15 | April 12, 1961 | | [13] |
| 16 | April 19, 1961 | The Absent-Minded Professor | | [14] |
| 17 | April 26, 1961 | | [15] |
| 18 | May 3, 1961 | | [16] |
| 19 | May 10, 1961 | Gone with the Wind (reissue) | Gone with the Wind grossed $250,000 from 17 key cities. | [17] |
| 20 | May 17, 1961 | The Absent-Minded Professor | | [18] |
| 21 | May 24, 1961 | Gone with the Wind (reissue) | | [19] |
| 22 | May 31, 1961 | The Young Savages | The Young Savages grossed around $300,000 from 18 key cities. | [20] |
| 23 | June 7, 1961 | The Pleasure of His Company | | [21] |
| 24 | June 14, 1961 | | [22] |
| 25 | June 21, 1961 | | [23] |
| 26 | June 28, 1961 | | [24] |
| 27 | July 5, 1961 | The Parent Trap | | [25] |
| 28 | July 12, 1961 | Fanny | Fanny opened at Radio City Music Hall where it grossed over $200,000. | [26] |
| 29 | July 19, 1961 | | [27] |
| 30 | July 26, 1961 | Fanny was still grossing $200,000 at Radio City Music Hall | [28] |
| 31 | August 2, 1961 | The Guns of Navarone | | [29] |
| 32 | August 9, 1961 | | [30] |
| 33 | August 16, 1961 | | [31] |
| 34 | August 23, 1961 | | [32] |
| 35 | August 30, 1961 | Come September | | [33] |
| 36 | September 6, 1961 | | [34] |
| 37 | September 13, 1961 | | [34] |
| 38 | September 20, 1961 | | [35] |
| 39 | September 27, 1961 | | [36] |
| 40 | October 4, 1961 | | [37] |
| 41 | October 11, 1961 | The Hustler | The Hustler grossed over $200,000 from 11 key cities | [38] |
| 42 | October 18, 1961 | Breakfast at Tiffany's | Breakfast at Tiffany's reached number one despite playing in only 5 key cities | [39] |
| 43 | October 25, 1961 | | [40] |
| 44 | November 1, 1961 | | [40] |
| 45 | November 8, 1961 | | [41] |
| 46 | November 15, 1961 | | [41] |
| 47 | November 22, 1961 | King of Kings | | [42] |
| 48 | November 29, 1961 | The Comancheros | The Comancheros grossed nearly $300,000 from 21 key cities | [43] |
| 49 | December 6, 1961 | King of Kings | | [44] |
| 50 | December 13, 1961 | | [45] |
| 51 | December 20, 1961 | West Side Story | | [46] |
| 52 | December 27, 1961 | Flower Drum Song | | [47] |
|