| # | Date | Film | Gross (USD) | Openings in the top ten |
|---|
| 1 | January 6, 2008 | Aliens vs. Predator: Requiem | $1,639,773 | We Own the Night (#9) |
| 2 | January 13, 2008 | National Treasure: Book of Secrets | $1,139,084 | Mr. Woodcock (#9) |
| 3 | January 20, 2008 | I Am Legend | $4,255,085 | |
| 4 | January 27, 2008 | $2,342,608 | The Orphanage (#2), The Bucket List (#3), The Hunting Party (#10) |
| 5 | February 3, 2008 | Cloverfield | $1,544,683 | American Gangster (#5), El Arca (#8) |
| 6 | February 10, 2008 | The Orphanage | $1,235,141 | Sweeney Todd: The Demon Barber of Fleet Street (#3), No Country for Old Men (#7), Atonement (#10) |
| 7 | February 17, 2008 | 27 Dresses | $1,073,328 | Rambo (#3), Juno (#5), Llamando a un Ángel (#10) |
| 8 | February 24, 2008 | Vantage Point | $860,229 | The Eye (#2), Fool's Gold (#5), Fragile (#9) |
| 9 | March 2, 2008 | Meet the Spartans | $1,353,495 | P.S. I Love You (#4), Charlie Wilson's War (#6), The Mist (#7) |
| 10 | March 9, 2008 | 10,000 BC | $4,089,091 | The Spiderwick Chronicles (#2) |
| 11 | March 16, 2008 | $2,981,643 | Horton Hears a Who! (#2), August Rush (#6), La Zona (#8) |
| 12 | March 23, 2008 | $1,650,517 | Under the Same Moon (#3), One Missed Call (#4), Drillbit Taylor (#5), Untraceable (#7) |
| 13 | March 30, 2008 | Jumper | $2,022,488 | I Could Never Be Your Woman (#8) |
| 14 | April 6, 2008 | $1,148,718 | |
| 15 | April 13, 2008 | Casi divas | $853,930 | Shutter (#2) |
| 16 | April 20, 2008 | Street Kings | $765,047 | Ladrón que roba a Ladrón (#6), Definitely, Maybe (#9) |
| 17 | April 27, 2008 | $565,564 | Awake (#5), Death Sentence (#10) |
| 18 | May 4, 2008 | Iron Man | $5,272,729 | Made of Honor (#2), Bella (#8) |
| 19 | May 11, 2008 | $2,363,274 | Speed Racer (#2), 88 Minutes (#4) |
| 20 | May 18, 2008 | The Chronicles of Narnia: Prince Caspian | $6,267,182 | Bordertown (#6) |
| 21 | May 25, 2008 | Indiana Jones and the Kingdom of the Crystal Skull | $4,130,734 | A Guide to Recognizing Your Saints (#7) |
| 22 | June 1, 2008 | $2,075,746 | What Happens in Vegas (#2), Superhero Movie (#4), Déficit (#8) |
| 23 | June 8, 2008 | You Don't Mess with the Zohan | $2,007,900 | Sex and the City (#5) |
| 24 | June 15, 2008 | The Incredible Hulk | $4,437,954 | The Happening (#2) |
| 25 | June 22, 2008 | Kung Fu Panda | $6,153,908 | 21 (#4) |
| 26 | June 29, 2008 | $3,844,563 | Get Smart (#2), Flawless (#9) |
| 27 | July 6, 2008 | WALL-E | $5,391,590 | Wedding Daze (#6), Alone with Her (#8) |
| 28 | July 11, 2008 | Hancock | $4,813,231 | Hellboy II: The Golden Army (#3) |
| 29 | July 20, 2008 | The Dark Knight | $7,027,471 | Nim's Island (#5) |
| 30 | July 27, 2008 | $3,623,230 | Journey to the Center of the Earth (#2), Meet Dave (#3) |
| 31 | August 3, 2008 | The Mummy: Tomb of the Dragon Emperor | $5,154,872 | Over Her Dead Body (#7) |
| 32 | August 10, 2008 | $2,403,902 | The X-Files: I Want to Believe (#4), College Road Trip (#6), Prom Night (#7), The Other Boleyn Girl (#8) |
| 33 | August 17, 2008 | Wanted | $2,286,535 | Star Wars: The Clone Wars (#2), Mad Money (#10) |
| 34 | August 24, 2008 | $1,296,208 | Taken (#2), Amor Letra por Letra (#6) |
| 35 | August 31, 2008 | Taken | $866,755 | Tropic Thunder (#3), REC (#4) |
| 36 | September 7, 2008 | High School Musical: El Desafío | $1,892,347 | Babylon A.D. (#2) |
| 37 | September 14, 2008 | Arráncame la Vida | $1,521,959 | Mamma Mia! (#2), Donkey Xote (#6), The Forbidden Kingdom (#7) |
| 38 | September 21, 2008 | $1,422,163 | Tinker Bell (#2), The Strangers (#3) |
| 39 | September 28, 2008 | $1,024,389 | Eagle Eye (#2), Bangkok Dangerous (#4) |
| 40 | October 5, 2008 | Beverly Hills Chihuahua | $2,053,840 | Mirrors (#2), Nights in Rodanthe (#4) |
| 41 | October 12, 2008 | $1,791,388 | My Mom's New Boyfriend (#6) |
| 42 | October 19, 2008 | $1,240,207 | Bajo la Sal (#2), Blindness (#4), Los Campeones de la Lucha Libre (#7), The Air I Breathe (#9) |
| 43 | October 26, 2008 | $686,801 | Burn After Reading (#2), Max Payne (#3), The House Bunny (#4), Space Chimps (#7), Spam (#8) |
| 44 | November 2, 2008 | High School Musical 3: Senior Year | $1,780,752 | Death Race (#4), Saw V (#7) |
| 45 | November 9, 2008 | $1,019,824 | Pride & Glory (#2), Mr. Magorium's Wonder Emporium (#3) |
| 46 | November 16, 2008 | Quantum of Solace | $2,300,082 | Navidad, S.A. (#2), Urmel aus dem Eis (#10) |
| 47 | November 24, 2008 | Twilight | $2,469,236 | Death Defying Acts (#4), The Duchess (#8) |
| 48 | November 30, 2008 | $1,693,660 | Body of Lies (#2), Disaster Movie (#5), The Women (#6), The Boy in the Striped Pajamas (#10) |
| 49 | December 7, 2008 | Madagascar: Escape 2 Africa | $4,455,100 | Vicky Cristina Barcelona (#5), Solstice (#7) |
| 50 | December 14, 2008 | $3,034,792 | The Day the Earth Stood Still (#2), Mama's Boy (#9) |
| 51 | December 21, 2008 | Bolt | $1,509,342 | Rudo y Cursi (#2), Four Christmases (#5) |
| 52 | December 28, 2008 | $1,556,748 | Australia (#5), The Tale of Despereaux (#6), Volverte a Ver (#7), Free Style (#10) |
