| # | Week ending | Film | Box office | Openings |
|---|
| 1 | 4 January 2006 | The Chronicles of Narnia: The Lion, the Witch and the Wardrobe | $11,055,672 | Chicken Little (#4), The Family Stone (#10) |
| 2 | 11 January 2006 | $6,201,264 | Rumour Has It... (#3), Valiant (#10) |
| 3 | 18 January 2006 | $3,812,678 | Nanny McPhee (#2), The Producers (#5) |
| 4 | 25 January 2006 | Memoirs of a Geisha | $4,046,193 | Underworld: Evolution (#2), Get Rich or Die Tryin' (#7) |
| 5 | 1 February 2006 | Big Momma's House 2 | $2,667,816 | Munich (#2), Brokeback Mountain (#4), Keeping Mum (#6) |
| 6 | 8 February 2006 | Walk the Line | $2,988,087 | North Country (#9), The Fog (#10) |
| 7 | 15 February 2006 | $2,497,720 | Jarhead (#2), Just Friends (#3), Casanova (#9) |
| 8 | 22 February 2006 | Date Movie | $2,287,969 | Syriana (#3), Lord of War (#7), Goal! (#9) |
| 9 | 1 March 2006 | Walk the Line | $1,533,100 | Hostel (#3), Derailed (#6), Capote (#10), Imagine Me & You (#13) |
| 10 | 8 March 2006 | Firewall | $1,749,356 | Match Point (#4), Kinky Boots (#8), Rent (#19) |
| 11 | 15 March 2006 | The Pink Panther | $1,863,559 | A History of Violence (#4), The Shaggy Dog (#7), Zathura: A Space Adventure (#13), Hustle & Flow (#14), Dreamer (#18) |
| 12 | 22 March 2006 | When a Stranger Calls | $1,524,237 | Æon Flux (#2), Tristan & Isolde (#8), Yours, Mine and Ours (#10), The Long Weekend (#15) |
| 13 | 29 March 2006 | $956,675 | Cry_Wolf (#7), The Weather Man (#13) |
| 14 | 5 April 2006 | Inside Man | $2,549,495 | V for Vendetta (#2), Basic Instinct 2 (#6), March of the Penguins (#8) |
| 15 | 12 April 2006 | Ice Age 2: The Meltdown | $7,328,412 | She's the Man (#2), The World's Fastest Indian (#4) |
| 16 | 19 April 2006 | $7,593,260 | Scary Movie 4 (#2), Failure to Launch (#3), Water (#12), The Squid and the Whale (#14), Tsotsi (#16), How Much Do You Love Me? (#17) |
| 17 | 26 April 2006 | $5,125,407 | Eight Below (#3), Kokoda (#8), The Hills Have Eyes (#11) |
| 18 | 3 May 2006 | $2,349,829 | Final Destination 3 (#3), American Dreamz (#5), The Ringer (#10), The White Countess (#17) |
| 19 | 10 May 2006 | Mission: Impossible III | $4,923,176 | Hidden (#13), Dave Chappelle's Block Party (#15), The New World (#20) |
| 20 | 17 May 2006 | $2,958,204 | The Benchwarmers (#2), Two for the Money (#7), Where the Truth Lies (#17), On a Clear Day (#20) |
| 21 | 24 May 2006 | The Da Vinci Code | $11,450,544 | Slither (#5) |
| 22 | 31 May 2006 | X-Men: The Last Stand | $8,332,425 | Take the Lead (#3), Candy (#6), Separate Lies (#7), Fanaa (#9), The Three Burials of Melquiades Estrada (#10), Last Holiday (#12), Warren Miller's Higher Ground (#17) |
| 23 | 7 June 2006 | $3,822,006 | Poseidon (#3), RV: Runaway Vacation (#5), The Omen (#6) |
| 24 | 14 June 2006 | Cars | $6,315,434 | The Break-Up (#2), The Caterpillar Wish (#12), Colour Me Kubrick (#15) |
| 25 | 21 June 2006 | The Fast and the Furious: Tokyo Drift | $4,074,273 | Stick It (#6), Just My Luck (#10), Oliver Twist (#17) |
| 26 | 28 June 2006 | Click | $5,933,014 | Over the Hedge (#2), Wah-Wah (#9), Krrish (#17) |
| 27 | 5 July 2006 | Superman Returns | $7,119,955 | Ten Canoes (#9), Tristram Shandy: A Cock and Bull Story (#15) |
| 28 | 12 July 2006 | Pirates of the Caribbean: Dead Man's Chest | $15,866,404 | River Queen (#14) |
| 29 | 19 July 2006 | $9,185,006 | Little Man (#2), Sione's Wedding (#11), Beyond the Sea (#13), Hard Candy (#15) |
| 30 | 26 July 2006 | $4,646,384 | My Super Ex-Girlfriend (#2), Jindabyne (#3), 16 Blocks (#7), The White Masai (#14) |
| 31 | 2 August 2006 | You, Me and Dupree | $3,282,179 | The Lake House (#3), The Libertine (#16) |
| 32 | 9 August 2006 | $2,277,847 | Hoodwinked (#3), The Sentinel (#5), Confetti (#8), Footy Legends (#9), 49 Up (#20) |
| 33 | 16 August 2006 | Miami Vice | $3,265,994 | Kabhi Alvida Naa Kehna (#8), Brick (#14) |
| 34 | 23 August 2006 | $1,624,571 | United 93 (#5), Kenny (#7), Curious George (#9), 2:37 (#11), Chaos (#13) |
| 35 | 30 August 2006 | Snakes on a Plane | $1,344,096 | Fearless (#2), Thank You for Smoking (#6), Unfolding Florence: The Many Lives of Florence Broadhurst (#17) |
| 36 | 6 September 2006 | Silent Hill | $1,000,109 | Clerks II (#5), Friends with Money (#7), Lage Raho Munna Bhai (#16), 48 Shades (#18), Man About Town (#19) |
| 37 | 13 September 2006 | John Tucker Must Die | $1,338,434 | Lady in the Water (#2), DOA: Dead or Alive (#4), Garfield: A Tail of Two Kitties (#13), Stormbreaker (#17) |
| 38 | 20 September 2006 | Monster House | $1,926,092 | Nacho Libre (#2), An Inconvenient Truth (#4), Material Girls (#6), The Wild (#13), The Ant Bully (#18) |
| 39 | 27 September 2006 | Talladega Nights: The Ballad of Ricky Bobby | $2,539,063 | Barnyard (#5), The Wind That Shakes the Barley (#14) |
| 40 | 4 October 2006 | The Devil Wears Prada | $5,449,620 | Step Up (#2), Beerfest (#15), Aquamarine (#17) |
| 41 | 11 October 2006 | $3,733,016 | World Trade Center (#5), A Prairie Home Companion (#15) |
| 42 | 18 October 2006 | The Departed | $3,372,431 | Little Miss Sunshine (#3), The Covenant (#8), Irresistible (#16) |
| 43 | 25 October 2006 | $2,398,491 | BoyTown (#3), Children of Men (#4), Crank (#6), Don (#15) |
| 44 | 1 November 2006 | $1,801,538 | The Grudge 2 (#2), Trust the Man (#10), Mrs. Palfrey at the Claremont (#13), Suburban Mayhem (#14), Fast Food Nation (#15), The Nightmare Before Christmas 3D (#16) |
| 45 | 8 November 2006 | Saw III | $3,395,863 | Flags of Our Fathers (#3), God on My Side (#19) |
| 46 | 15 November 2006 | Jackass Number Two | $3,026,280 | A Good Year (#3), The Wrong Man (#5), Shortbus (#17) |
| 47 | 22 November 2006 | The Prestige | $2,055,078 | The Santa Clause 3: The Escape Clause (#3), The Texas Chainsaw Massacre: The Beginning (#10) |
| 48 | 29 November 2006 | Borat: Cultural Learnings of America for Make Benefit Glorious Nation of Kazakhstan | $6,841,840 | Deck the Halls (#8), The Descent (#9), Catch a Fire (#10), Dhoom 2 (#12), The Black Dahlia (#13) |
| 49 | 6 December 2006 | $4,087,398 | Open Season (#2), The Guardian (#4), Unaccompanied Minors (#8), The Nativity Story (#15), A Scanner Darkly (#18) |
| 50 | 13 December 2006 | Casino Royale | $9,375,310 | Charlotte's Web (#3) |
| 51 | 20 December 2006 | $5,474,998 | Eragon (#2) |
| 52 | 27 December 2006 | Happy Feet | $4,481,329 | Night at the Museum (#3), Flushed Away (#4), The Holiday (#6), The Queen (#9), Babel (#12), Volver (#13), Marie Antoinette (#14), The Valet (#16) |
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